SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PX4'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 11 ALA C 154
THR C 131
LEU C  53
LEU C 124
GLY C 123
 PX4  C 303 ( 3.9A)
PX4  C 303 ( 4.8A)
None
None
None
 1.06A 1b02A-5h35C:
undetectable		 1b02A-5h35C:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 10 ALA C 156
THR C 155
ALA C 154
GLY C 161
ALA C 105
 None
None
PX4  C 303 ( 3.9A)
None
None
 1.05A 2f16K-5h35C:
undetectable
2f16L-5h35C:
undetectable		 2f16K-5h35C:
22.94
2f16L-5h35C:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 10 ALA C 156
THR C 155
ALA C 154
GLY C 161
ALA C 105
 None
None
PX4  C 303 ( 3.9A)
None
None
 1.05A 2f16Y-5h35C:
undetectable
2f16Z-5h35C:
undetectable		 2f16Y-5h35C:
22.94
2f16Z-5h35C:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 8 GLY C 132
GLY C 133
ALA C  44
PHE C 104
PHE C  16
 PX4  C 303 ( 4.6A)
None
None
None
None
 1.31A 2ha4A-5h35C:
undetectable		 2ha4A-5h35C:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 9 PHE C  16
ALA C  44
GLY C  45
GLY C 132
ILE C 136
 None
None
None
PX4  C 303 ( 4.6A)
None
 1.19A 2v7bB-5h35C:
undetectable		 2v7bB-5h35C:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT
(Escherichia
coli) 		4 / 7 MET A  71
LEU A  74
SER A 143
GLY A 495
 None
None
None
PX4  A 602 ( 4.1A)
 1.06A 3hcnA-5mrwA:
undetectable		 3hcnA-5mrwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5h36 UNCHARACTERIZED
PROTEIN TRIC
(Rhodobacter
sphaeroides) 		4 / 7 ALA E 156
ALA E 108
ALA E 127
THR E 128
 None
None
PX4  E 301 ( 4.8A)
None
 0.85A 4du2A-5h36E:
undetectable		 4du2A-5h36E:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5h36 UNCHARACTERIZED
PROTEIN TRIC
(Rhodobacter
sphaeroides) 		4 / 7 ALA E 156
ALA E 108
ALA E 127
THR E 128
 None
None
PX4  E 301 ( 4.8A)
None
 0.82A 4du2B-5h36E:
undetectable		 4du2B-5h36E:
18.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 4mvu ION TRANSPORT
PROTEIN
(Arcobacter
butzleri) 		4 / 6 THR A1162
GLY A1164
GLU A1165
PHE A1167
 PX4  A1303 (-3.8A)
PX4  A1303 (-3.3A)
PX4  A1303 ( 4.5A)
None
 0.25A 5kmfA-4mvuA:
24.2
5kmfC-4mvuA:
24.8		 5kmfA-4mvuA:
98.31
5kmfC-4mvuA:
98.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA
(Arcobacter
butzleri;
Homo
sapiens) 		4 / 6 THR A1665
GLY A1667
GLU A1668
PHE A1670
 PX4  A1802 (-4.2A)
PX4  A1802 (-3.3A)
PX4  A1802 (-3.5A)
PX4  A1802 (-4.4A)
 0.87A 5kmfA-5ek0A:
19.4
5kmfC-5ek0A:
19.7		 5kmfA-5ek0A:
81.40
5kmfC-5ek0A:
81.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 9 ALA C 156
THR C 155
ALA C 154
GLY C 161
ALA C 105
 None
None
PX4  C 303 ( 3.9A)
None
None
 1.06A 5l5zK-5h35C:
undetectable
5l5zL-5h35C:
undetectable		 5l5zK-5h35C:
25.10
5l5zL-5h35C:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5h35 MEMBRANE PROTEIN
TRIC
(Sulfolobus
solfataricus) 		5 / 9 ALA C 156
THR C 155
ALA C 154
GLY C 161
ALA C 105
 None
None
PX4  C 303 ( 3.9A)
None
None
 1.05A 5l5zY-5h35C:
undetectable
5l5zZ-5h35C:
undetectable		 5l5zY-5h35C:
25.10
5l5zZ-5h35C:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT
POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT
(Escherichia
coli;
Escherichia
coli) 		5 / 10 TRP A 364
MET A 383
GLY A 374
GLY A 369
LEU B 662
 PX4  A 603 (-3.4A)
None
None
None
None
 0.90A 6hqbA-5mrwA:
3.5
6hqbJ-5mrwA:
undetectable		 6hqbA-5mrwA:
9.04
6hqbJ-5mrwA:
5.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4mvu ION TRANSPORT
PROTEIN
(Arcobacter
butzleri) 		4 / 6 MET A1174
THR A1175
LEU A1176
MET A1209
 PX4  A1304 ( 4.8A)
None
None
PX4  A1304 ( 4.6A)
 0.71A 6mvxA-4mvuA:
22.3
6mvxB-4mvuA:
22.8
6mvxC-4mvuA:
22.5		 6mvxA-4mvuA:
99.58
6mvxB-4mvuA:
99.58
6mvxC-4mvuA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA
(Homo
sapiens;
Arcobacter
butzleri) 		4 / 6 MET A1677
THR A1678
LEU A1679
MET A1712
 PX4  A1806 ( 4.3A)
PX4  A1806 ( 4.8A)
None
PX4  A1806 ( 4.6A)
 0.66A 6mvxA-5ek0A:
18.7
6mvxB-5ek0A:
18.8
6mvxC-5ek0A:
18.9		 6mvxA-5ek0A:
82.39
6mvxB-5ek0A:
82.39
6mvxC-5ek0A:
82.39