SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PUT'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IGX_A_EPAA700_1 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	1a99	PUTRESCINE-BINDING PROTEIN (Escherichia coli)	5 / 12	PHE A 276 TYR A 223 PHE A 266 GLY A 141 GLY A 246	PUT A 371 (-4.0A) None None None None	1.10A	1igxA-1a99A: undetectable	1igxA-1a99A: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PBF_A_BHAA396_0 (P-HYDROXYBENZOATE HYDROXYLASE)	1a99	PUTRESCINE-BINDING PROTEIN (Escherichia coli)	5 / 9	TRP A 37 LEU A 348 SER A 87 ARG A 91 ALA A 182	PUT A 371 (-3.7A) None None None None	1.46A	1pbfA-1a99A: 0.0	1pbfA-1a99A: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S3Z_B_RIOB501_0 (AMINOGLYCOSIDE 6'-N-ACETYLTRANSFERA SE)	6f9g	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU (Pseudomonas putida)	4 / 8	TYR A 152 VAL A 211 TRP A 186 GLU A 164	PUT A 401 ( 3.5A) None PUT A 401 (-3.5A) None	1.30A	1s3zA-6f9gA: undetectable 1s3zB-6f9gA: undetectable	1s3zA-6f9gA: undetectable 1s3zB-6f9gA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BDM_A_TMIA502_1 (CYTOCHROME P450 2B4)	1jl0	S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME (Homo sapiens)	5 / 12	LEU A 180 ILE A 268 LEU A 177 THR A 176 LEU A 284	None None None PUT A 401 (-3.7A) None	1.06A	2bdmA-1jl0A: 0.0	2bdmA-1jl0A: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NV4_B_SAMB202_0 (UPF0066 PROTEIN AF_0241)	6f9g	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU (Pseudomonas putida)	5 / 12	GLN A 191 TYR A 120 PRO A 219 GLY A 231 LEU A 187	None PUT A 401 (-4.2A) None None None	1.35A	2nv4B-6f9gA: undetectable	2nv4B-6f9gA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HAV_A_SRYA403_1 (AMINOGLYCOSIDE PHOSPHOTRANSFERASE)	1a99	PUTRESCINE-BINDING PROTEIN (Escherichia coli)	4 / 8	ASP A 310 ASP A 247 ASP A 278 TYR A 336	None PUT A 371 (-3.0A) PUT A 371 (-3.1A) None	0.80A	3havA-1a99A: undetectable	3havA-1a99A: 21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JQ7_C_DX2C270_1 (PTERIDINE REDUCTASE 1)	1jl0	S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME (Homo sapiens)	4 / 8	SER A 109 ASP A 174 TYR A 318 LEU A 13	None PUT A 401 (-3.4A) PUT A 401 (-4.0A) PUT A 401 (-4.4A)	1.04A	3jq7C-1jl0A: undetectable	3jq7C-1jl0A: 20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q70_A_RITA2001_2 (CANDIDAPEPSIN-2)	6f9g	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU (Pseudomonas putida)	4 / 6	THR A 188 SER A 215 TYR A 202 ASP A 173	None PUT A 401 ( 4.2A) None None	1.05A	3q70A-6f9gA: undetectable	3q70A-6f9gA: 11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XNX_A_41XA707_1 (TRANSPORTER)	1a99	PUTRESCINE-BINDING PROTEIN (Escherichia coli)	5 / 11	PHE A 266 ASP A 247 TYR A 314 GLY A 139 GLY A 334	None PUT A 371 (-3.0A) PUT A 371 (-4.9A) None None	1.13A	4xnxA-1a99A: 0.0	4xnxA-1a99A: 19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_B_ACTB309_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	1a99	PUTRESCINE-BINDING PROTEIN (Escherichia coli)	3 / 3	TYR A 40 ALA A 136 TYR A 314	PUT A 371 (-3.7A) None PUT A 371 (-4.9A)	0.79A	5uunB-1a99A: 0.0	5uunB-1a99A: 22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V1S_B_SAMB604_0 (RADICAL SAM)	1jl0	S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME (Homo sapiens)	5 / 9	LEU A 180 THR A 241 SER A 69 TYR A 112 SER A 113	None None None None PUT A 401 ( 4.3A)	1.35A	5v1sB-1jl0A: undetectable	5v1sB-1jl0A: 20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6bm7	INACTIVE S-ADENOSYLMETHIONINE DECARBOXYLASE PROZYME (Trypanosoma brucei)	4 / 8	ARG E 86 ARG E 235 VAL E 205 GLN E 197	None None None PUT E 401 ( 4.6A)	1.25A	6fbvD-6bm7E: undetectable	6fbvD-6bm7E: undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6FU4_A_HSMA401_1 (PROBABLE CHEMOTAXIS TRANSDUCER)	6f9g	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU (Pseudomonas putida)	7 / 9	TYR A 120 TYR A 152 GLU A 164 TRP A 186 TYR A 202 ASP A 204 ASP A 233	PUT A 401 (-4.2A) PUT A 401 ( 3.5A) None PUT A 401 (-3.5A) None PUT A 401 (-2.7A) PUT A 401 (-2.9A)	0.54A	6fu4A-6f9gA: 37.0	6fu4A-6f9gA: 68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6FU4_B_HSMB401_1 (PROBABLE CHEMOTAXIS TRANSDUCER)	6f9g	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU (Pseudomonas putida)	7 / 9	TYR A 120 TYR A 152 GLU A 164 TRP A 186 TYR A 202 ASP A 204 ASP A 233	PUT A 401 (-4.2A) PUT A 401 ( 3.5A) None PUT A 401 (-3.5A) None PUT A 401 (-2.7A) PUT A 401 (-2.9A)	0.48A	6fu4B-6f9gA: 37.2	6fu4B-6f9gA: 68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6FU4_C_HSMC401_1 (PROBABLE CHEMOTAXIS TRANSDUCER)	6f9g	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU (Pseudomonas putida)	7 / 9	TYR A 120 TYR A 152 GLU A 164 TRP A 186 TYR A 202 ASP A 204 ASP A 233	PUT A 401 (-4.2A) PUT A 401 ( 3.5A) None PUT A 401 (-3.5A) None PUT A 401 (-2.7A) PUT A 401 (-2.9A)	0.55A	6fu4C-6f9gA: 37.1	6fu4C-6f9gA: 68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6FU4_D_HSMD401_1 (PROBABLE CHEMOTAXIS TRANSDUCER)	6f9g	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU (Pseudomonas putida)	7 / 9	TYR A 120 TYR A 152 GLU A 164 TRP A 186 TYR A 202 ASP A 204 ASP A 233	PUT A 401 (-4.2A) PUT A 401 ( 3.5A) None PUT A 401 (-3.5A) None PUT A 401 (-2.7A) PUT A 401 (-2.9A)	0.49A	6fu4D-6f9gA: 36.8	6fu4D-6f9gA: 68.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IGX_A_EPAA700_1","PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1","1a99","PUTRESCINE-BINDING PROTEIN","Escherichia coli",5,"PHE A 276;TYR A 223;PHE A 266;GLY A 141;GLY A 246","PUT A 371 (-4.0A);None;None;None;None","1.10A","1igxA-1a99A:undetectable",null],["1PBF_A_BHAA396_0","P-HYDROXYBENZOATE HYDROXYLASE","1a99","PUTRESCINE-BINDING PROTEIN","Escherichia coli",5,"TRP A  37;LEU A 348;SER A  87;ARG A  91;ALA A 182","PUT A 371 (-3.7A);None;None;None;None","1.46A","1pbfA-1a99A:0.0","1igxA-1a99A:19.44"],["1S3Z_B_RIOB501_0","AMINOGLYCOSIDE 6'-N-ACETYLTRANSFERASE","6f9g","METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU","Pseudomonas putida",4,"TYR A 152;VAL A 211;TRP A 186;GLU A 164","PUT A 401 ( 3.5A);None;PUT A 401 (-3.5A);None","1.30A","1s3zA-6f9gA:undetectable;1s3zB-6f9gA:undetectable","1pbfA-1a99A:21.10"],["2BDM_A_TMIA502_1","CYTOCHROME P450 2B4","1jl0","S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME","Homo sapiens",5,"LEU A 180;ILE A 268;LEU A 177;THR A 176;LEU A 284","None;None;None;PUT A 401 (-3.7A);None","1.06A","2bdmA-1jl0A:0.0","1s3zA-6f9gA:undetectable;1s3zB-6f9gA:undetectable"],["2NV4_B_SAMB202_0","UPF0066 PROTEIN AF_0241","6f9g","METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU","Pseudomonas putida",5,"GLN A 191;TYR A 120;PRO A 219;GLY A 231;LEU A 187","None;PUT A 401 (-4.2A);None;None;None","1.35A","2nv4B-6f9gA:undetectable","2bdmA-1jl0A:21.05"],["3HAV_A_SRYA403_1","AMINOGLYCOSIDE PHOSPHOTRANSFERASE","1a99","PUTRESCINE-BINDING PROTEIN","Escherichia coli",4,"ASP A 310;ASP A 247;ASP A 278;TYR A 336","None;PUT A 371 (-3.0A);PUT A 371 (-3.1A);None","0.80A","3havA-1a99A:undetectable","2nv4B-6f9gA:undetectable"],["3JQ7_C_DX2C270_1","PTERIDINE REDUCTASE 1","1jl0","S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME","Homo sapiens",4,"SER A 109;ASP A 174;TYR A 318;LEU A  13","None;PUT A 401 (-3.4A);PUT A 401 (-4.0A);PUT A 401 (-4.4A)","1.04A","3jq7C-1jl0A:undetectable","3havA-1a99A:21.08"],["3Q70_A_RITA2001_2","CANDIDAPEPSIN-2","6f9g","METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU","Pseudomonas putida",4,"THR A 188;SER A 215;TYR A 202;ASP A 173","None;PUT A 401 ( 4.2A);None;None","1.05A","3q70A-6f9gA:undetectable","3jq7C-1jl0A:20.58"],["4XNX_A_41XA707_1","TRANSPORTER","1a99","PUTRESCINE-BINDING PROTEIN","Escherichia coli",5,"PHE A 266;ASP A 247;TYR A 314;GLY A 139;GLY A 334","None;PUT A 371 (-3.0A);PUT A 371 (-4.9A);None;None","1.13A","4xnxA-1a99A:0.0","3q70A-6f9gA:11.68"],["5UUN_B_ACTB309_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN","1a99","PUTRESCINE-BINDING PROTEIN","Escherichia coli",3,"TYR A  40;ALA A 136;TYR A 314","PUT A 371 (-3.7A);None;PUT A 371 (-4.9A)","0.79A","5uunB-1a99A:0.0","4xnxA-1a99A:19.85"],["5V1S_B_SAMB604_0","RADICAL SAM","1jl0","S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME","Homo sapiens",5,"LEU A 180;THR A 241;SER A  69;TYR A 112;SER A 113","None;None;None;None;PUT A 401 ( 4.3A)","1.35A","5v1sB-1jl0A:undetectable","5uunB-1a99A:22.38"],["6FBV_D_FI8D1904_1","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA'","6bm7","INACTIVE S-ADENOSYLMETHIONINE DECARBOXYLASE PROZYME","Trypanosoma brucei",4,"ARG E  86;ARG E 235;VAL E 205;GLN E 197","None;None;None;PUT E 401 ( 4.6A)","1.25A","6fbvD-6bm7E:undetectable","5v1sB-1jl0A:20.62"],["6FU4_A_HSMA401_1","PROBABLE CHEMOTAXIS TRANSDUCER","6f9g","METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU","Pseudomonas putida",7,"TYR A 120;TYR A 152;GLU A 164;TRP A 186;TYR A 202;ASP A 204;ASP A 233","PUT A 401 (-4.2A);PUT A 401 ( 3.5A);None;PUT A 401 (-3.5A);None;PUT A 401 (-2.7A);PUT A 401 (-2.9A)","0.54A","6fu4A-6f9gA:37.0","6fbvD-6bm7E:undetectable"],["6FU4_B_HSMB401_1","PROBABLE CHEMOTAXIS TRANSDUCER","6f9g","METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU","Pseudomonas putida",7,"TYR A 120;TYR A 152;GLU A 164;TRP A 186;TYR A 202;ASP A 204;ASP A 233","PUT A 401 (-4.2A);PUT A 401 ( 3.5A);None;PUT A 401 (-3.5A);None;PUT A 401 (-2.7A);PUT A 401 (-2.9A)","0.48A","6fu4B-6f9gA:37.2","6fu4A-6f9gA:68.75"],["6FU4_C_HSMC401_1","PROBABLE CHEMOTAXIS TRANSDUCER","6f9g","METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU","Pseudomonas putida",7,"TYR A 120;TYR A 152;GLU A 164;TRP A 186;TYR A 202;ASP A 204;ASP A 233","PUT A 401 (-4.2A);PUT A 401 ( 3.5A);None;PUT A 401 (-3.5A);None;PUT A 401 (-2.7A);PUT A 401 (-2.9A)","0.55A","6fu4C-6f9gA:37.1","6fu4B-6f9gA:68.75"],["6FU4_D_HSMD401_1","PROBABLE CHEMOTAXIS TRANSDUCER","6f9g","METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU","Pseudomonas putida",7,"TYR A 120;TYR A 152;GLU A 164;TRP A 186;TYR A 202;ASP A 204;ASP A 233","PUT A 401 (-4.2A);PUT A 401 ( 3.5A);None;PUT A 401 (-3.5A);None;PUT A 401 (-2.7A);PUT A 401 (-2.9A)","0.49A","6fu4D-6f9gA:36.8","6fu4C-6f9gA:68.75"]]