SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PTY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1l8j ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 12 PHE A  19
SER A  17
TYR A  27
PHE A 114
VAL A 116
 None
None
None
PTY  A 200 ( 4.8A)
None
 1.35A 1q23C-1l8jA:
0.0		 1q23C-1l8jA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 12 PHE B  19
SER B  17
TYR B  27
PHE B 114
VAL B 116
 None
None
None
PTY  B 200 ( 4.9A)
PTY  B 200 (-4.9A)
 1.31A 1q23C-4v3dB:
undetectable		 1q23C-4v3dB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1l8j ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 11 PHE A  19
SER A  17
TYR A  27
PHE A 114
VAL A 116
 None
None
None
PTY  A 200 ( 4.8A)
None
 1.33A 1q23L-1l8jA:
0.0		 1q23L-1l8jA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 11 PHE B  19
SER B  17
TYR B  27
PHE B 114
VAL B 116
 None
None
None
PTY  B 200 ( 4.9A)
PTY  B 200 (-4.9A)
 1.29A 1q23L-4v3dB:
undetectable		 1q23L-4v3dB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		3 / 3 PHE A1572
TYR A1618
TYR A1614
 PTY  A 400 (-4.6A)
None
None
 0.95A 1x70B-3pg7A:
undetectable		 1x70B-3pg7A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 1l8j ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		4 / 6 VAL A  40
GLN A  66
GLY A  68
ARG A  64
 None
None
PTY  A 200 (-4.2A)
None
 1.06A 3bjwE-1l8jA:
undetectable		 3bjwE-1l8jA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3zuy TRANSPORTER
(Neisseria
meningitidis) 		3 / 3 SER A 297
GLY A 234
GLY A 262
 None
PTY  A1319 (-3.5A)
NA  A1311 ( 4.7A)
 0.56A 3bogA-3zuyA:
undetectable
3bogC-3zuyA:
undetectable		 3bogA-3zuyA:
undetectable
3bogC-3zuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3zuy TRANSPORTER
(Neisseria
meningitidis) 		4 / 4 SER A 297
GLY A 298
GLY A 234
GLY A 262
 None
None
PTY  A1319 (-3.5A)
NA  A1311 ( 4.7A)
 0.76A 3bogB-3zuyA:
undetectable
3bogD-3zuyA:
undetectable		 3bogB-3zuyA:
undetectable
3bogD-3zuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		5 / 12 ILE A1620
ALA A1655
GLN A1702
LEU A1705
VAL A1622
 PTY  A 400 (-3.8A)
None
None
None
None
 1.19A 3ix9A-3pg7A:
undetectable		 3ix9A-3pg7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 12 LEU B 161
SER B  17
ARG B 156
GLY B  78
LEU B  79
 PTY  B 200 (-4.4A)
None
None
None
PTY  B 200 ( 4.9A)
 0.99A 3j6pB-4v3dB:
undetectable		 3j6pB-4v3dB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3zuy TRANSPORTER
(Neisseria
meningitidis) 		5 / 12 GLY A  73
ALA A 243
ALA A 244
THR A 258
LEU A 257
 None
None
None
PTY  A1319 (-4.0A)
None
 1.03A 3mteB-3zuyA:
undetectable		 3mteB-3zuyA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
HB3VAR03 CIDRA
DOMAIN
(Homo
sapiens;
Plasmodium
falciparum) 		5 / 12 TYR B  72
PHE A 656
PHE B 114
VAL B 116
PHE B 123
 PTY  B 200 (-3.6A)
PTY  B 200 ( 4.9A)
PTY  B 200 ( 4.9A)
PTY  B 200 (-4.9A)
PTY  B 200 ( 4.4A)
 1.46A 3nbrA-4v3dB:
undetectable		 3nbrA-4v3dB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
HB3VAR03 CIDRA
DOMAIN
(Homo
sapiens;
Plasmodium
falciparum) 		5 / 12 TYR B  72
PHE A 656
PHE B 114
VAL B 116
VAL B 124
 PTY  B 200 (-3.6A)
PTY  B 200 ( 4.9A)
PTY  B 200 ( 4.9A)
PTY  B 200 (-4.9A)
None
 1.39A 3nbrA-4v3dB:
undetectable		 3nbrA-4v3dB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3zuy TRANSPORTER
(Neisseria
meningitidis) 		5 / 12 GLY A  73
ALA A 243
ALA A 244
THR A 258
LEU A 257
 None
None
None
PTY  A1319 (-4.0A)
None
 0.97A 3p2kA-3zuyA:
undetectable		 3p2kA-3zuyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 11 PHE B  19
SER B  17
TYR B  27
PHE B 114
VAL B 116
 None
None
None
PTY  B 200 ( 4.9A)
PTY  B 200 (-4.9A)
 1.35A 3u9fN-4v3dB:
undetectable
3u9fO-4v3dB:
undetectable		 3u9fN-4v3dB:
21.62
3u9fO-4v3dB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 12 PHE B  19
SER B  17
TYR B  27
PHE B 114
VAL B 116
 None
None
None
PTY  B 200 ( 4.9A)
PTY  B 200 (-4.9A)
 1.32A 3u9fP-4v3dB:
undetectable
3u9fS-4v3dB:
undetectable		 3u9fP-4v3dB:
21.62
3u9fS-4v3dB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		4 / 6 HIS B  36
TYR B 172
GLN B  54
HIS B  39
 None
PTY  B 200 (-4.2A)
None
PTY  B 200 (-3.9A)
 1.36A 5kkzA-4v3dB:
undetectable
5kkzG-4v3dB:
undetectable		 5kkzA-4v3dB:
17.53
5kkzG-4v3dB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		4 / 9 ILE A1658
VAL A1665
THR A1627
ASP A1623
 PTY  A 400 ( 4.8A)
None
None
None
 0.91A 5lg3I-3pg7A:
undetectable		 5lg3I-3pg7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		5 / 12 LEU B  41
ILE B  50
PHE B 164
VAL B 124
GLY B  68
 PTY  B 200 ( 3.9A)
None
PTY  B 200 (-4.0A)
None
PTY  B 200 ( 4.8A)
 1.24A 6a7pA-4v3dB:
undetectable		 6a7pA-4v3dB:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 4v3d ENDOTHELIAL PROTEIN
C RECEPTOR
(Homo
sapiens) 		4 / 5 GLY B  29
LEU B  14
TYR B  18
GLN B  28
 PTY  B 200 ( 4.9A)
None
None
NAG  B 205 ( 4.3A)
 1.07A 6ji6A-4v3dB:
undetectable		 6ji6A-4v3dB:
22.43