SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PTT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 ASN A  92
GLY A  74
ASP A  90
ILE A 533
GLY A 483
 PTT  A 800 (-3.5A)
None
None
None
None
 1.13A 1q8jB-1b25A:
undetectable		 1q8jB-1b25A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 8 THR A  95
LEU A  93
VAL A 174
THR A 141
 None
PTT  A 800 (-4.6A)
None
None
 1.06A 1uyuA-1b25A:
0.0		 1uyuA-1b25A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 9 GLY A  91
GLY A 183
MET A 187
VAL A 190
ILE A 433
 PTT  A 800 (-3.2A)
PTT  A 800 (-3.4A)
None
None
None
 1.49A 3owxA-1b25A:
undetectable		 3owxA-1b25A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 11 HIS A 100
GLY A 157
SER A 176
GLY A  73
ASN A  92
 None
None
None
None
PTT  A 800 (-3.5A)
 1.48A 3v3nA-1b25A:
undetectable		 3v3nA-1b25A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 11 HIS A 100
GLY A 157
SER A 176
GLY A  73
ASN A  92
 None
None
None
None
PTT  A 800 (-3.5A)
 1.48A 3v3nD-1b25A:
0.0		 3v3nD-1b25A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 VAL A 199
ALA A  97
LEU A  93
PHE A  60
LEU A  58
 None
None
PTT  A 800 (-4.6A)
None
None
 1.07A 4eckB-1b25A:
undetectable		 4eckB-1b25A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 7 ASN A 329
VAL A 294
GLU A 304
ARG A 282
 None
None
PTT  A 800 (-3.5A)
None
 1.27A 4mv7A-1b25A:
undetectable		 4mv7A-1b25A:
22.98