SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PTR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		4 / 7 ARG A 223
ASP A 264
ASP A 260
TYR A 221
 PTR  A 216 ( 2.9A)
None
None
None
 1.41A 1cebA-1gngA:
undetectable		 1cebA-1gngA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4e10 PROTELOMERASE
(Agrobacterium
fabrum) 		4 / 5 GLU A 371
THR A 407
HIS A 367
LEU A 392
 None
PTR  A 405 ( 4.1A)
PTR  A 405 ( 3.5A)
PTR  A 405 ( 4.9A)
 1.38A 1d4fC-4e10A:
undetectable		 1d4fC-4e10A:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 6 VAL X  67
ILE X  80
MET X  85
ARG X 129
 None
None
None
PTR  X 160 ( 3.4A)
 1.06A 1iepA-2dq7X:
32.2		 1iepA-2dq7X:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.08A 1iepB-2qobA:
26.3		 1iepB-2qobA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 7 ILE X  80
MET X  85
ARG X 129
LEU X 137
 None
None
PTR  X 160 ( 3.4A)
STU  X 902 (-4.4A)
 0.83A 1iepB-2dq7X:
32.4		 1iepB-2dq7X:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 7 VAL X  67
ILE X  80
ARG X 129
LEU X 137
 None
None
PTR  X 160 ( 3.4A)
STU  X 902 (-4.4A)
 0.93A 1iepB-2dq7X:
32.4		 1iepB-2dq7X:
44.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4gl9 TYROSINE-PROTEIN
KINASE
(Mus
musculus) 		4 / 4 SER A1016
VAL A1075
PHE A1031
VAL A1010
 None
None
PTR  A1008 ( 4.7A)
PTR  A1008 ( 4.1A)
 1.45A 1o86A-4gl9A:
undetectable		 1o86A-4gl9A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 6 LEU X  17
ILE X  80
MET X  85
ARG X 129
 STU  X 902 (-3.8A)
None
None
PTR  X 160 ( 3.4A)
 0.95A 1opjB-2dq7X:
31.6		 1opjB-2dq7X:
44.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 8 GLU A 372
ARG A 175
GLU A 159
ASP A 365
 None
PTR  A 527 ( 3.3A)
None
None
 1.17A 1s3zA-2hckA:
undetectable
1s3zB-2hckA:
undetectable		 1s3zA-2hckA:
15.38
1s3zB-2hckA:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 9 LEU A 730
VAL A 738
ALA A 756
ALA A 807
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.61A 1xbbA-5fm2A:
33.4		 1xbbA-5fm2A:
32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Sulfolobus
acidocaldarius) 		5 / 12 ILE A  87
ILE A 159
SER A 155
ALA A 162
PHE A  97
 None
None
PTR  A 133 ( 3.4A)
None
None
 1.25A 2ejtA-5mwrA:
undetectable		 2ejtA-5mwrA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 0.72A 2gqgA-2qobA:
27.4		 2gqgA-2qobA:
34.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 6 LEU X  17
VAL X  67
ILE X  80
ARG X 129
 STU  X 902 (-3.8A)
None
None
PTR  X 160 ( 3.4A)
 0.83A 2hyyA-2dq7X:
32.2		 2hyyA-2dq7X:
46.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.03A 2hyyD-2qobA:
26.4		 2hyyD-2qobA:
33.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
ILE A 673
ILE A 697
THR A 699
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 0.95A 2hyyD-2qobA:
26.4		 2hyyD-2qobA:
33.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
ALA A 756
LYS A 758
LEU A 802
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.47A 2itoA-5fm2A:
33.4		 2itoA-5fm2A:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		3 / 3 ALA A 651
GLY A 705
SER A 763
 PTR  A 701 ( 4.7A)
None
None
 0.28A 2ivuA-2qobA:
33.4		 2ivuA-2qobA:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2rsy TYROSINE-PROTEIN
KINASE CSK
(Rattus
norvegicus) 		4 / 7 PHE A  83
LEU A 149
LEU A 152
ARG A 107
 None
None
None
PTR  B 314 ( 4.4A)
 0.99A 2jn3A-2rsyA:
undetectable		 2jn3A-2rsyA:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.94A 2pl0A-2qobA:
18.3		 2pl0A-2qobA:
38.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens) 		4 / 6 SER A 229
ARG A 189
ARG A 192
ILE A 197
 None
PTR  A 185 ( 3.6A)
PTR  A 185 ( 3.1A)
None
 1.15A 2qeiA-1cm8A:
0.0		 2qeiA-1cm8A:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 9 VAL A 635
ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.47A 2xp2A-2qobA:
34.3		 2xp2A-2qobA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		9 / 12 LYS A 625
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
SER A 763
 None
PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 1.02A 2y6oA-2qobA:
31.8		 2y6oA-2qobA:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		9 / 12 LYS A 625
ALA A 651
LYS A 653
GLU A 670
MET A 674
ILE A 697
GLY A 705
LEU A 753
SER A 763
 None
PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 1.08A 2y6oA-2qobA:
31.8		 2y6oA-2qobA:
73.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
ILE A 683
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
 0.66A 2y7jA-2qobA:
25.5		 2y7jA-2qobA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 10 VAL A 635
ALA A 651
ILE A 683
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
 0.59A 2y7jB-2qobA:
20.0		 2y7jB-2qobA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 10 VAL A 635
ALA A 651
ILE A 683
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
 0.64A 2y7jC-2qobA:
25.5		 2y7jC-2qobA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 10 VAL A 635
ALA A 651
ILE A 683
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
 0.57A 2y7jD-2qobA:
25.9		 2y7jD-2qobA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 8 ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.38A 2yfxA-2qobA:
33.8		 2yfxA-2qobA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		9 / 12 ALA A 651
LYS A 653
GLU A 670
MET A 674
ILE A 697
THR A 699
MET A 702
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
PTR  A 701 ( 3.5A)
None
None
 0.75A 2zvaA-2qobA:
34.4		 2zvaA-2qobA:
37.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2
(Homo
sapiens) 		5 / 12 ARG A  79
PHE A  74
GLY A  77
ILE A  86
PHE A  72
 None
None
PTR  B 512 ( 3.1A)
None
None
 1.48A 3a25A-2mfqA:
undetectable		 3a25A-2mfqA:
17.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
LEU A 685
THR A 699
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 0.69A 3bbtB-2qobA:
25.1		 3bbtB-2qobA:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
GLY A 731
ALA A 756
LYS A 758
VAL A 804
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.74A 3c7qA-5fm2A:
32.2		 3c7qA-5fm2A:
41.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		4 / 6 ARG A 309
ILE A 198
ARG A 161
SER A 184
 None
PTR  A 197 ( 3.6A)
None
None
 1.42A 3ckzA-4e7wA:
undetectable		 3ckzA-4e7wA:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 10 LEU A 730
VAL A 738
ALA A 756
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.66A 3g0fB-5fm2A:
32.0		 3g0fB-5fm2A:
42.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.63A 3g5dB-5fm2A:
33.1		 3g5dB-5fm2A:
31.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 635
ALA A 651
GLU A 670
ILE A 683
THR A 699
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 0.89A 3gcsA-2qobA:
20.7		 3gcsA-2qobA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 635
ALA A 651
ILE A 683
THR A 699
HIS A 744
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 0.99A 3gcsA-2qobA:
20.7		 3gcsA-2qobA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		3 / 3 MET A 918
MET A 970
PHE A 961
 PTR  A 928 (-4.9A)
None
None
 1.23A 3gn8A-5fm2A:
undetectable		 3gn8A-5fm2A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A 651
GLU A 670
ILE A 683
THR A 699
HIS A 744
ASP A 764
 PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.26A 3gp0A-2qobA:
21.9		 3gp0A-2qobA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
GLU A 670
ILE A 683
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.01A 3gp0A-2qobA:
21.9		 3gp0A-2qobA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 627
ALA A 651
ILE A 683
THR A 699
ASP A 764
 None
PTR  A 701 ( 4.7A)
None
None
None
 0.76A 3hecA-2qobA:
21.1		 3hecA-2qobA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 627
ALA A 651
LYS A 653
GLU A 670
ILE A 683
 None
PTR  A 701 ( 4.7A)
None
None
None
 0.87A 3hecA-2qobA:
21.1		 3hecA-2qobA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 627
ALA A 651
LYS A 653
ILE A 683
ASP A 764
 None
PTR  A 701 ( 4.7A)
None
None
None
 0.78A 3hecA-2qobA:
21.1		 3hecA-2qobA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 627
VAL A 635
ALA A 651
LYS A 653
GLU A 670
ILE A 683
THR A 699
 None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 0.84A 3hegA-2qobA:
17.7		 3hegA-2qobA:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 7 LEU X  17
ILE X  80
MET X  85
ARG X 129
 STU  X 902 (-3.8A)
None
None
PTR  X 160 ( 3.4A)
 0.83A 3ik3B-2dq7X:
32.1		 3ik3B-2dq7X:
44.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		8 / 12 ALA A 651
LYS A 653
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 0.86A 3k54A-2qobA:
27.6		 3k54A-2qobA:
32.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		8 / 12 ALA A 651
LYS A 653
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
SER A 763
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 0.77A 3k54A-2qobA:
27.6		 3k54A-2qobA:
32.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
ALA A 756
LYS A 758
TYR A 806
GLY A 810
LEU A 881
SER A 891
 PP1  A2012 (-4.6A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.64A 3k54A-5fm2A:
31.8		 3k54A-5fm2A:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 11 ALA A 651
LYS A 653
MET A 702
GLY A 705
LEU A 753
SER A 763
 PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.52A 3miyA-2qobA:
27.5		 3miyA-2qobA:
38.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 9 ALA A 651
LYS A 653
MET A 702
GLY A 705
LEU A 753
SER A 763
 PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.51A 3miyB-2qobA:
33.0		 3miyB-2qobA:
38.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 9 ALA A 756
LYS A 758
GLY A 810
LEU A 881
SER A 891
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.51A 3miyB-5fm2A:
31.7		 3miyB-5fm2A:
32.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.03A 3ms9A-2qobA:
26.4		 3ms9A-2qobA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 6 LYS X  39
VAL X  67
ILE X  80
ARG X 129
 STU  X 902 (-3.1A)
None
None
PTR  X 160 ( 3.4A)
 1.05A 3ms9A-2dq7X:
31.7		 3ms9A-2dq7X:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 6 VAL X  67
ILE X  80
MET X  85
ARG X 129
 None
None
None
PTR  X 160 ( 3.4A)
 0.89A 3ms9A-2dq7X:
31.7		 3ms9A-2dq7X:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 7 LYS X  39
VAL X  67
ILE X  80
ARG X 129
 STU  X 902 (-3.1A)
None
None
PTR  X 160 ( 3.4A)
 1.07A 3ms9B-2dq7X:
31.9		 3ms9B-2dq7X:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2z8c INSULIN RECEPTOR
(Homo
sapiens) 		4 / 7 VAL A1050
VAL A1060
MET A1079
ARG A1131
 None
None
None
PTR  A1163 ( 3.6A)
 0.77A 3ms9B-2z8cA:
28.7		 3ms9B-2z8cA:
38.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.08A 3mssA-2qobA:
26.5		 3mssA-2qobA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 6 VAL X  67
ILE X  80
MET X  85
ARG X 129
 None
None
None
PTR  X 160 ( 3.4A)
 0.93A 3mssA-2dq7X:
31.9		 3mssA-2dq7X:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 7 VAL X  67
ILE X  80
MET X  85
ARG X 129
 None
None
None
PTR  X 160 ( 3.4A)
 1.08A 3mssB-2dq7X:
32.0		 3mssB-2dq7X:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.08A 3mssC-2qobA:
26.5		 3mssC-2qobA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 6 VAL X  67
ILE X  80
MET X  85
ARG X 129
 None
None
None
PTR  X 160 ( 3.4A)
 0.98A 3mssC-2dq7X:
31.9		 3mssC-2dq7X:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.61A 3octA-5fm2A:
31.4		 3octA-5fm2A:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 627
GLY A 628
VAL A 635
ALA A 651
ILE A 683
THR A 699
LEU A 753
 None
None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 1.07A 3ohtA-2qobA:
5.7		 3ohtA-2qobA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 627
GLY A 628
VAL A 635
ALA A 651
LYS A 653
ILE A 683
LEU A 753
 None
None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 1.17A 3ohtA-2qobA:
5.7		 3ohtA-2qobA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 GLY A 731
VAL A 738
ALA A 756
LEU A 779
ILE A 788
GLY A 810
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
None
PTR  A 809 (-2.4A)
 0.85A 3ohtB-5fm2A:
16.5		 3ohtB-5fm2A:
24.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		6 / 9 LEU X  17
LYS X  39
ILE X  80
MET X  85
ARG X 129
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
None
None
PTR  X 160 ( 3.4A)
STU  X 902 (-4.4A)
 0.87A 3oxzA-2dq7X:
32.5		 3oxzA-2dq7X:
44.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.08A 3pyyA-2qobA:
26.7		 3pyyA-2qobA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 5 LYS X  39
ILE X  80
MET X  85
ARG X 129
 STU  X 902 (-3.1A)
None
None
PTR  X 160 ( 3.4A)
 0.98A 3pyyB-2dq7X:
31.8		 3pyyB-2dq7X:
43.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 5mqs BETA-L-ARABINOBIOSID
ASE
(Bacteroides
thetaiotaomicron) 		4 / 5 SER A 367
ARG A 332
PRO A 370
VAL A 394
 None
PTR  A 372 ( 2.6A)
None
None
 1.38A 3sufC-5mqsA:
undetectable		 3sufC-5mqsA:
12.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.66A 3sxrA-2qobA:
32.1		 3sxrA-2qobA:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
TYR A 806
GLY A 810
LEU A 881
SER A 891
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.73A 3sxrB-5fm2A:
31.5		 3sxrB-5fm2A:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A 651
ILE A 697
THR A 699
MET A 702
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
PTR  A 701 ( 3.5A)
None
None
 0.26A 3ue4A-2qobA:
26.7		 3ue4A-2qobA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.84A 3ue4B-2qobA:
27.4		 3ue4B-2qobA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
GLY A 731
ALA A 756
LEU A 779
VAL A 804
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
 0.80A 3wzdA-5fm2A:
32.7		 3wzdA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
GLY A 731
ALA A 756
VAL A 804
GLY A 810
PHE A 893
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
 0.96A 3wzdA-5fm2A:
32.7		 3wzdA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
 0.63A 3wzdA-5fm2A:
32.7		 3wzdA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
VAL A 804
GLY A 810
PHE A 893
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
 0.85A 3wzdA-5fm2A:
32.7		 3wzdA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
LEU A 779
VAL A 804
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
 0.53A 3wzeA-5fm2A:
33.1		 3wzeA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
LEU A 865
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
None
 0.70A 3wzeA-5fm2A:
33.1		 3wzeA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 VAL A 738
ALA A 756
LYS A 758
LEU A 779
VAL A 804
GLY A 810
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
 0.68A 3wzeA-5fm2A:
33.1		 3wzeA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.42A 3zbfA-2qobA:
34.7		 3zbfA-2qobA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		8 / 12 LEU X  17
ALA X  37
LYS X  39
GLU X  54
THR X  82
ARG X 129
LEU X 137
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-4.1A)
PTR  X 160 ( 3.4A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.85A 3zosA-2dq7X:
29.9		 3zosA-2dq7X:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		8 / 12 LEU X  17
ALA X  37
LYS X  39
THR X  82
HIS X 128
ARG X 129
LEU X 137
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
None
PTR  X 160 ( 3.4A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.84A 3zosA-2dq7X:
29.9		 3zosA-2dq7X:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 9 ILE A 673
MET A 674
ILE A 682
ILE A 683
MET A 702
 None
None
None
None
PTR  A 701 ( 3.5A)
 0.77A 3zosA-2qobA:
24.3		 3zosA-2qobA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
VAL A 804
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.66A 4ag8A-5fm2A:
32.9		 4ag8A-5fm2A:
41.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
LEU A 779
VAL A 804
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
 0.65A 4agcA-5fm2A:
32.4		 4agcA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
VAL A 804
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.61A 4agcA-5fm2A:
32.4		 4agcA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 11 LEU A 730
ALA A 756
VAL A 804
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.52A 4agdA-5fm2A:
32.3		 4agdA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 9 VAL A 635
ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.43A 4anqA-2qobA:
34.1		 4anqA-2qobA:
32.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 9 VAL A 635
ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.41A 4ansA-2qobA:
34.0		 4ansA-2qobA:
32.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 LEU A 730
VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
LEU A 865
HIS A 872
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
None
 0.81A 4asdA-5fm2A:
32.5		 4asdA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
LEU A 779
VAL A 804
GLY A 810
HIS A 872
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
 0.78A 4asdA-5fm2A:
32.5		 4asdA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
ILE A 673
ILE A 683
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 0.77A 4bkjA-2qobA:
24.6		 4bkjA-2qobA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 4 LYS X  39
LEU X  61
MET X  85
ARG X 129
 STU  X 902 (-3.1A)
None
None
PTR  X 160 ( 3.4A)
 1.15A 4bkjA-2dq7X:
29.7		 4bkjA-2dq7X:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		8 / 12 VAL A 635
ALA A 651
GLU A 670
ILE A 673
MET A 674
ILE A 683
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 1.06A 4bkjB-2qobA:
24.7		 4bkjB-2qobA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
ILE A 673
MET A 674
ILE A 683
THR A 699
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.16A 4bkjB-2qobA:
24.7		 4bkjB-2qobA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		5 / 5 LYS X  39
LEU X  61
TYR X  84
MET X  85
ARG X 129
 STU  X 902 (-3.1A)
None
STU  X 902 (-4.6A)
None
PTR  X 160 ( 3.4A)
 1.17A 4bkjB-2dq7X:
29.9		 4bkjB-2dq7X:
35.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5mqs BETA-L-ARABINOBIOSID
ASE
(Bacteroides
thetaiotaomicron) 		4 / 6 HIS A  77
SER A 367
GLU A 397
ASP A 458
 PTR  A 372 ( 4.0A)
None
None
None
 1.39A 4blvA-5mqsA:
undetectable		 4blvA-5mqsA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 651
LYS A 653
GLU A 670
ILE A 697
THR A 699
HIS A 744
ASP A 764
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 1.18A 4c8bA-2qobA:
27.4		 4c8bA-2qobA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 651
LYS A 653
ILE A 697
THR A 699
HIS A 744
LEU A 753
ASP A 764
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 0.92A 4c8bA-2qobA:
27.4		 4c8bA-2qobA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 11 GLY A 628
GLY A 630
VAL A 635
ALA A 651
GLY A 705
LEU A 753
 None
None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
 0.92A 4ckiA-2qobA:
33.6		 4ckiA-2qobA:
29.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
GLU A 670
ILE A 673
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.94A 4csvA-2qobA:
27.5		 4csvA-2qobA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
THR A 699
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
 0.44A 4hjoA-2qobA:
30.1		 4hjoA-2qobA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 LEU A 730
GLY A 731
VAL A 738
ALA A 756
LYS A 758
LEU A 802
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.60A 4i22A-5fm2A:
28.7		 4i22A-5fm2A:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 2xkk TOPOISOMERASE IV
(Acinetobacter
baumannii) 		3 / 3 GLY A1106
GLU A1126
THR A1125
 None
None
PTR  A1124 ( 3.8A)
 0.53A 4kouA-2xkkA:
undetectable		 4kouA-2xkkA:
13.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
LYS A 653
GLY A 705
SER A 709
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.68A 4mkcA-2qobA:
34.2		 4mkcA-2qobA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 0.68A 4mxoA-2qobA:
28.1		 4mxoA-2qobA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
 0.48A 4mxoA-5fm2A:
33.3		 4mxoA-5fm2A:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 0.71A 4mxxA-2qobA:
28.0		 4mxxA-2qobA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
LYS A 653
THR A 699
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
PTR  A 701 ( 3.5A)
None
None
 0.61A 4mxxB-2qobA:
26.3		 4mxxB-2qobA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.72A 4mxxB-5fm2A:
30.9		 4mxxB-5fm2A:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
GLU A 775
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.63A 4mxyB-5fm2A:
33.3		 4mxyB-5fm2A:
31.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
GLU A 775
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.63A 4mxzB-5fm2A:
33.3		 4mxzB-5fm2A:
31.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2z8c INSULIN RECEPTOR
(Homo
sapiens) 		5 / 11 PHE A1256
SER A1194
GLU A1047
GLU A1043
ASP A1150
 None
None
None
PTR  A1163 ( 4.6A)
None
 1.47A 4qb9F-2z8cA:
undetectable		 4qb9F-2z8cA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		5 / 12 ALA X  37
GLU X  54
MET X  58
ARG X 129
ALA X 147
 STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
PTR  X 160 ( 3.4A)
STU  X 902 ( 4.1A)
 0.70A 4qrcA-2dq7X:
31.7		 4qrcA-2dq7X:
34.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2z8c INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A1028
GLU A1047
MET A1051
LEU A1123
ARG A1131
 S91  A   1 (-3.2A)
None
None
None
PTR  A1163 ( 3.6A)
 0.99A 4qrcA-2z8cA:
31.4		 4qrcA-2z8cA:
37.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
LYS A 653
GLU A 670
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.02A 4r7iA-2qobA:
31.7		 4r7iA-2qobA:
29.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		4 / 5 LEU X  17
VAL X  67
TYR X  84
ARG X 129
 STU  X 902 (-3.8A)
None
STU  X 902 (-4.6A)
PTR  X 160 ( 3.4A)
 0.69A 4r7iA-2dq7X:
31.6		 4r7iA-2dq7X:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2z8c INSULIN RECEPTOR
(Homo
sapiens) 		4 / 5 LEU A1002
VAL A1060
VAL A1074
ARG A1131
 S91  A   1 ( 4.1A)
None
None
PTR  A1163 ( 3.6A)
 0.96A 4r7iA-2z8cA:
30.9		 4r7iA-2z8cA:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 651
LYS A 653
ILE A 697
THR A 699
SER A 706
 PTR  A 701 ( 4.7A)
None
None
None
None
 0.52A 4rzvA-2qobA:
26.4		 4rzvA-2qobA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 651
LYS A 653
THR A 699
SER A 706
PHE A 765
 PTR  A 701 ( 4.7A)
None
None
None
None
 0.92A 4rzvA-2qobA:
26.4		 4rzvA-2qobA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 635
ALA A 651
LYS A 653
THR A 699
SER A 706
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 0.73A 4rzvB-2qobA:
25.9		 4rzvB-2qobA:
27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		7 / 10 LEU X  17
VAL X  25
LEU X  61
VAL X  67
TYR X  84
ARG X 129
ILE X 146
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
None
None
STU  X 902 (-4.6A)
PTR  X 160 ( 3.4A)
None
 0.83A 4u0iA-2dq7X:
31.3		 4u0iA-2dq7X:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 11 LEU A 730
GLY A 733
VAL A 738
ALA A 756
TYR A 806
GLY A 810
ASN A 879
LEU A 881
 PP1  A2012 (-4.6A)
None
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PTR  A 809 (-2.4A)
None
PP1  A2012 (-4.6A)
 0.62A 4u5jA-5fm2A:
34.5		 4u5jA-5fm2A:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 9 VAL A 635
ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.36A 4u5jB-2qobA:
28.1		 4u5jB-2qobA:
39.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 9 LEU A 730
VAL A 738
ALA A 756
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.52A 4u5jB-5fm2A:
33.4		 4u5jB-5fm2A:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		5 / 8 MET X  58
TYR X  84
ARG X 129
LEU X 137
ILE X 146
 None
STU  X 902 (-4.6A)
PTR  X 160 ( 3.4A)
STU  X 902 (-4.4A)
None
 1.20A 4v04A-2dq7X:
30.1		 4v04A-2dq7X:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		8 / 10 LEU X  17
VAL X  25
LYS X  39
MET X  58
TYR X  84
ARG X 129
LEU X 137
ILE X 146
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.6A)
PTR  X 160 ( 3.4A)
STU  X 902 (-4.4A)
None
 1.10A 4v04B-2dq7X:
30.8		 4v04B-2dq7X:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 11 ALA A 651
THR A 699
MET A 702
GLY A 705
ASN A 751
LEU A 753
 PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.30A 4wa9A-2qobA:
29.0		 4wa9A-2qobA:
34.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
THR A 699
MET A 702
GLY A 705
ASN A 751
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.77A 4wa9B-2qobA:
32.1		 4wa9B-2qobA:
34.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
ALA A 756
LYS A 758
LEU A 802
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.49A 4wkqA-5fm2A:
33.2		 4wkqA-5fm2A:
30.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 9 VAL A 635
ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.49A 5aaaA-2qobA:
34.5		 5aaaA-2qobA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 10 VAL A 635
ALA A 651
LYS A 653
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.88A 5aabA-2qobA:
34.2		 5aabA-2qobA:
33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 10 VAL A 635
ALA A 651
LYS A 653
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.90A 5aacA-2qobA:
34.0		 5aacA-2qobA:
33.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens) 		4 / 5 ARG A  73
ARG A 152
LEU A 174
VAL A 186
 TPO  A 183 ( 2.8A)
TPO  A 183 ( 2.8A)
None
PTR  A 185 ( 2.8A)
 0.95A 5cshB-1cm8A:
29.4		 5cshB-1cm8A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4e10 PROTELOMERASE
(Agrobacterium
fabrum) 		4 / 8 HIS A 367
ARG A 255
HIS A 394
THR A 401
 PTR  A 405 ( 3.5A)
PTR  A 405 ( 4.2A)
PTR  A 405 ( 3.9A)
DT  A 501 (-2.9A)
 1.31A 5db5A-4e10A:
undetectable
5db5B-4e10A:
undetectable		 5db5A-4e10A:
21.38
5db5B-4e10A:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 635
ALA A 651
ILE A 697
THR A 699
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 0.60A 5h2uB-2qobA:
24.2		 5h2uB-2qobA:
33.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 635
ALA A 651
ILE A 683
ILE A 697
THR A 699
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 0.54A 5hesA-2qobA:
11.7		 5hesA-2qobA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 GLY A 630
VAL A 635
ALA A 651
ILE A 697
THR A 699
 None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
 0.74A 5hieA-2qobA:
26.2		 5hieA-2qobA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 GLY A 630
VAL A 635
ALA A 651
ILE A 697
THR A 699
 None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
 0.76A 5hieB-2qobA:
26.3		 5hieB-2qobA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		5 / 12 GLY A 630
VAL A 635
ALA A 651
ILE A 697
THR A 699
 None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
 0.75A 5hieD-2qobA:
26.3		 5hieD-2qobA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 651
GLU A 670
ILE A 683
ILE A 697
THR A 699
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 0.57A 5i9xA-2qobA:
37.5		 5i9xA-2qobA:
68.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 ALA A 756
GLU A 775
ILE A 788
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.55A 5i9xA-5fm2A:
31.8		 5i9xA-5fm2A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 ALA A 756
ILE A 788
TYR A 806
GLY A 810
LEU A 881
SER A 891
 PP1  A2012 (-3.2A)
None
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.67A 5i9xA-5fm2A:
31.8		 5i9xA-5fm2A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		8 / 12 ALA A 651
LYS A 653
GLU A 670
MET A 674
THR A 699
GLY A 705
LEU A 753
SER A 763
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 0.74A 5i9yA-2qobA:
29.2		 5i9yA-2qobA:
68.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLU A 818
LEU A 881
SER A 891
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 ( 4.7A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.76A 5i9yA-5fm2A:
25.1		 5i9yA-5fm2A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLY A 810
LEU A 881
SER A 891
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.60A 5i9yA-5fm2A:
25.1		 5i9yA-5fm2A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		3 / 3 ILE A 683
ILE A 697
MET A 702
 None
None
PTR  A 701 ( 3.5A)
 0.39A 5i9yA-2qobA:
29.2		 5i9yA-2qobA:
68.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 GLY A 731
VAL A 738
ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLY A 810
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
 0.64A 5mafA-5fm2A:
26.3		 5mafA-5fm2A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens) 		4 / 5 ARG A  73
ARG A 152
LEU A 174
VAL A 186
 TPO  A 183 ( 2.8A)
TPO  A 183 ( 2.8A)
None
PTR  A 185 ( 2.8A)
 1.00A 5os7B-1cm8A:
29.8		 5os7B-1cm8A:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		6 / 12 GLY A 630
VAL A 635
ALA A 651
ILE A 697
THR A 699
PHE A 765
 None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 0.86A 5p9iA-2qobA:
25.2		 5p9iA-2qobA:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		9 / 12 VAL A 635
ALA A 651
LYS A 653
ILE A 697
THR A 699
GLY A 705
LEU A 753
SER A 763
PHE A 765
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
None
None
 1.06A 5p9iA-2qobA:
25.2		 5p9iA-2qobA:
32.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		5 / 12 ARG X 153
PHE X 168
PHE X 253
ALA X 119
ILE X 146
 PTR  X 160 ( 3.7A)
None
None
None
None
 1.20A 5vc0A-2dq7X:
undetectable		 5vc0A-2dq7X:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 VAL A 738
ALA A 756
LYS A 758
LEU A 802
GLY A 810
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
 0.55A 5yu9C-5fm2A:
28.3		 5yu9C-5fm2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens) 		3 / 3 LYS A 186
LEU A 174
ARG A 152
 PTR  A 185 ( 3.6A)
None
TPO  A 183 ( 2.8A)
 0.72A 5yw0A-1cm8A:
0.0		 5yw0A-1cm8A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
GLY A 731
ALA A 756
VAL A 804
TYR A 806
ALA A 807
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
None
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
 0.75A 5zv2A-5fm2A:
34.7		 5zv2A-5fm2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
VAL A 804
TYR A 806
ALA A 807
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
None
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
 0.58A 5zv2A-5fm2A:
34.7		 5zv2A-5fm2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
VAL A 804
ALA A 807
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
 0.63A 5zv2B-5fm2A:
34.1		 5zv2B-5fm2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		3 / 3 GLY X 181
THR X 161
GLU X 159
 PTR  X 160 ( 4.9A)
PTR  X 160 ( 4.1A)
PTR  X 160 ( 4.6A)
 0.51A 6b58A-2dq7X:
undetectable		 6b58A-2dq7X:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 651
MET A 674
ILE A 683
THR A 699
MET A 702
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
PTR  A 701 ( 3.5A)
None
None
 0.74A 6bsdA-2qobA:
23.9		 6bsdA-2qobA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
ILE A 683
THR A 699
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
PTR  A 701 ( 3.5A)
None
None
 0.68A 6bsdA-2qobA:
23.9		 6bsdA-2qobA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		4 / 6 LEU A1024
VAL A1037
ARG A1041
SER A1043
 None
PTR  A1035 ( 3.1A)
None
None
 0.82A 6f6jA-6c7yA:
undetectable		 6f6jA-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Sulfolobus
acidocaldarius) 		3 / 3 LEU A 193
LEU A 137
ARG A  86
 None
PTR  A 133 ( 3.6A)
PTR  A 133 ( 4.3A)
 0.60A 6fgcA-5mwrA:
undetectable		 6fgcA-5mwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Sulfolobus
acidocaldarius) 		3 / 3 LEU A 193
LEU A 137
ARG A  86
 None
PTR  A 133 ( 3.6A)
PTR  A 133 ( 4.3A)
 0.65A 6fgdA-5mwrA:
undetectable		 6fgdA-5mwrA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		10 / 12 VAL A 635
ALA A 651
LYS A 653
GLU A 670
MET A 674
ILE A 697
THR A 699
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
PTR  A 701 ( 3.5A)
None
None
 0.60A 6fnmA-2qobA:
30.9		 6fnmA-2qobA:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		8 / 12 VAL A 635
ALA A 651
LYS A 653
GLU A 670
MET A 702
GLY A 705
LEU A 753
SER A 763
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
PTR  A 701 ( 3.5A)
None
None
None
 0.77A 6fnmA-2qobA:
30.9		 6fnmA-2qobA:
69.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens) 		4 / 5 ARG A  73
ARG A 152
LEU A 174
VAL A 186
 TPO  A 183 ( 2.8A)
TPO  A 183 ( 2.8A)
None
PTR  A 185 ( 2.8A)
 1.00A 6gmdA-1cm8A:
29.8		 6gmdA-1cm8A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.04A 6hd4A-2qobA:
26.1		 6hd4A-2qobA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2qob EPHRIN RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 635
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.02A 6hd4B-2qobA:
26.2		 6hd4B-2qobA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens) 		5 / 7 ILE X  80
MET X  85
GLY X  88
ARG X 129
ALA X 147
 None
None
STU  X 902 (-3.5A)
PTR  X 160 ( 3.4A)
STU  X 902 ( 4.1A)
 0.82A 6hd6B-2dq7X:
31.6		 6hd6B-2dq7X:
17.96