SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PTE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 501
GLY A  75
GLY A  74
THR A 497
ASN A  93
 None
None
None
None
PTE  A 609 (-3.3A)
 1.17A 1likA-1aorA:
undetectable		 1likA-1aorA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE
(Pyrococcus
furiosus) 		3 / 3 ASP A 489
ARG A 444
LYS A 450
 PTE  A 609 (-3.5A)
PTE  A 609 (-3.1A)
PTE  A 609 (-2.6A)
 1.28A 3wipG-1aorA:
0.0		 3wipG-1aorA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 100
GLY A  95
GLY A  75
GLY A 492
GLU A 308
 None
PTE  A 609 (-3.5A)
None
None
None
 1.17A 5c0oE-1aorA:
undetectable		 5c0oE-1aorA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 190
ILE A  61
ALA A 184
GLY A 185
ALA A  92
 None
None
None
PTE  A 609 (-3.7A)
PTE  A 609 (-3.0A)
 0.91A 5kb6A-1aorA:
undetectable		 5kb6A-1aorA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 190
ILE A  61
ALA A 184
GLY A 185
ALA A  92
 None
None
None
PTE  A 609 (-3.7A)
PTE  A 609 (-3.0A)
 0.87A 5kb6B-1aorA:
undetectable		 5kb6B-1aorA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 426
SER A 314
ARG A 186
ILE A 449
LEU A 238
 None
PTE  A 609 ( 4.1A)
None
PTE  A 609 (-3.7A)
None
 1.32A 5ljbA-1aorA:
undetectable		 5ljbA-1aorA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE
(Pyrococcus
furiosus) 		4 / 5 ILE A 250
HIS A 435
HIS A 448
TYR A 427
 None
None
PTE  A 609 (-4.5A)
None
 1.46A 5ocsA-1aorA:
undetectable		 5ocsA-1aorA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE
(Pyrococcus
furiosus) 		4 / 5 ILE A 250
HIS A 435
HIS A 448
TYR A 427
 None
None
PTE  A 609 (-4.5A)
None
 1.45A 5ocsC-1aorA:
undetectable		 5ocsC-1aorA:
20.79