SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PT5'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5egi UNCHARACTERIZED
PROTEIN Y57A10A.10
(Caenorhabditis
elegans) 		4 / 8 LEU A  75
ALA A 164
HIS A  34
MET A  38
 None
PT5  A 301 (-4.0A)
None
PT5  A 301 ( 3.8A)
 1.07A 2wekA-5egiA:
undetectable		 2wekA-5egiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 5egi UNCHARACTERIZED
PROTEIN Y57A10A.10
(Caenorhabditis
elegans) 		4 / 6 PHE A 228
ALA A 196
ALA A 164
THR A 160
 None
None
PT5  A 301 (-4.0A)
None
 1.08A 4dtzB-5egiA:
undetectable		 4dtzB-5egiA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5egi UNCHARACTERIZED
PROTEIN Y57A10A.10
(Caenorhabditis
elegans) 		5 / 12 LEU A  80
SER A 138
HIS A 139
LEU A  75
ALA A 161
 None
None
None
None
PT5  A 301 ( 4.2A)
 1.02A 6djzC-5egiA:
undetectable		 6djzC-5egiA:
22.46