SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PT1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASN A  35
ASP A 111
ASN A 130
ASP A 199
SER A 236
 CL  A 315 (-3.6A)
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
None
 0.77A 1q8jA-3tr9A:
5.2		 1q8jA-3tr9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASP A  67
ASN A 130
ASP A 199
GLY A 234
SER A 236
 None
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 1.24A 1q8jA-3tr9A:
5.2		 1q8jA-3tr9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASP A 111
ASN A 130
ASP A 199
GLY A 234
SER A 236
 PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 0.72A 1q8jA-3tr9A:
5.2		 1q8jA-3tr9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		3 / 3 MET A 240
ASN A 206
GLN A 132
 PT1  A1001 ( 4.2A)
None
PT1  A1001 ( 3.4A)
 1.01A 1xoqB-3tr9A:
undetectable		 1xoqB-3tr9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASP A  67
ASN A 130
ASP A 199
GLY A 234
SER A 236
 None
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 1.27A 2ycjA-3tr9A:
21.8		 2ycjA-3tr9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASP A 111
ASN A 130
ASP A 199
GLY A 234
SER A 236
 PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 0.83A 2ycjA-3tr9A:
21.8		 2ycjA-3tr9A:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 8 PHE A  41
GLY A 203
LYS A 238
SER A 239
 PT1  A1001 ( 3.6A)
PT1  A1001 (-3.6A)
PT1  A1001 (-2.6A)
PT1  A1001 (-2.7A)
 0.66A 3tzfB-3tr9A:
37.7		 3tzfB-3tr9A:
40.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASN A  35
ASP A 111
ASP A 199
GLY A 234
SER A 236
 CL  A 315 (-3.6A)
PT1  A1001 ( 3.4A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 0.83A 4djeA-3tr9A:
21.7		 4djeA-3tr9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASP A  67
ASN A 130
ASP A 199
GLY A 234
SER A 236
 None
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 1.15A 4djeB-3tr9A:
21.8		 4djeB-3tr9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		6 / 12 ASP A  67
ASP A 111
ASN A 130
ASP A 199
GLY A 234
SER A 236
 None
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
PT1  A1001 (-3.9A)
None
 0.82A 4djeB-3tr9A:
21.8		 4djeB-3tr9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		5 / 12 ASP A  67
ASP A 111
ASN A 130
GLY A 234
SER A 236
 None
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.9A)
None
 0.80A 4djfB-3tr9A:
21.9		 4djfB-3tr9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 5 ASN A  35
ASP A 111
ASN A 130
ASP A 199
 CL  A 315 (-3.6A)
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
 0.76A 5vooA-3tr9A:
8.3		 5vooA-3tr9A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 5 ASN A  35
ASP A 111
ASN A 130
ASP A 199
 CL  A 315 (-3.6A)
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
 0.77A 5vooC-3tr9A:
19.4		 5vooC-3tr9A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 5 ASN A  35
ASP A 111
ASN A 130
ASP A 199
 CL  A 315 (-3.6A)
PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
 0.87A 5vooE-3tr9A:
19.3		 5vooE-3tr9A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		3 / 3 ASP A 111
ASN A 130
ASP A 199
 PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
 0.26A 5vopA-3tr9A:
19.4		 5vopA-3tr9A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		3 / 3 ASP A 111
ASN A 130
ASP A 199
 PT1  A1001 ( 3.4A)
PT1  A1001 ( 2.9A)
PT1  A1001 (-3.3A)
 0.21A 5vopB-3tr9A:
19.3		 5vopB-3tr9A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3tr9 DIHYDROPTEROATE
SYNTHASE
(Coxiella
burnetii) 		4 / 5 HIS A 274
ASP A 111
GLY A  69
ASN A  35
 CL  A 315 (-4.4A)
PT1  A1001 ( 3.4A)
None
CL  A 315 (-3.6A)
 1.14A 5x7pB-3tr9A:
3.3		 5x7pB-3tr9A:
12.70