SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PRX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		5 / 11 TYR A 488
ARG A 526
ILE A  67
HIS A 276
PHE A 484
 None
PRX  A 998 (-3.9A)
None
None
None
 1.34A 1fkfA-2p2mA:
undetectable		 1fkfA-2p2mA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		5 / 11 TYR A 488
ARG A 526
ILE A  67
HIS A 276
PHE A 484
 None
PRX  A 998 (-3.9A)
None
None
None
 1.35A 1fkjA-2p2mA:
undetectable		 1fkjA-2p2mA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		4 / 5 GLU A 531
ARG A 515
ASP A 500
THR A 418
 None
PRX  A 998 (-4.0A)
PRX  A 998 (-2.7A)
None
 1.19A 1k4tA-2p2mA:
undetectable		 1k4tA-2p2mA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		4 / 5 GLU A 531
ARG A 515
ASP A 500
THR A 418
 None
PRX  A 998 (-4.0A)
PRX  A 998 (-2.7A)
None
 1.24A 1rr8C-2p2mA:
undetectable		 1rr8C-2p2mA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		4 / 5 GLU A 531
ARG A 515
ASP A 500
THR A 418
 None
PRX  A 998 (-4.0A)
PRX  A 998 (-2.7A)
None
 1.21A 1rrjA-2p2mA:
undetectable		 1rrjA-2p2mA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		4 / 5 PRO A 358
GLY A 556
ASN A 521
GLY A 524
 None
None
PRX  A 998 ( 4.9A)
None
 1.10A 1zlqA-2p2mA:
undetectable		 1zlqA-2p2mA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		5 / 10 THR A 487
THR A 416
LEU A 477
VAL A 274
GLY A 273
 None
PRX  A 998 (-3.7A)
None
None
None
 1.15A 2cp4A-2p2mA:
undetectable		 2cp4A-2p2mA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		5 / 10 TYR A 488
THR A 416
LEU A 477
VAL A 274
GLY A 273
 None
PRX  A 998 (-3.7A)
None
None
None
 1.12A 2cp4A-2p2mA:
undetectable		 2cp4A-2p2mA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		4 / 7 TYR A 488
THR A 416
LEU A 477
VAL A 274
 None
PRX  A 998 (-3.7A)
None
None
 1.07A 2cppA-2p2mA:
undetectable		 2cppA-2p2mA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		5 / 11 TYR A 488
ARG A 526
ILE A  67
HIS A 276
PHE A 484
 None
PRX  A 998 (-3.9A)
None
None
None
 1.34A 2fkeA-2p2mA:
undetectable		 2fkeA-2p2mA:
10.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		5 / 5 VAL A 310
THR A 311
VAL A 386
GLY A 387
TRP A 414
 None
PRX  A 998 (-4.3A)
None
PRX  A 998 (-3.4A)
PRX  A 998 (-3.4A)
 0.17A 2p2fA-2p2mA:
66.8		 2p2fA-2p2mA:
99.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		4 / 4 VAL A 310
THR A 311
VAL A 386
GLY A 387
 None
PRX  A 998 (-4.3A)
None
PRX  A 998 (-3.4A)
 0.13A 2p2fB-2p2mA:
67.0		 2p2fB-2p2mA:
99.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		3 / 3 TRP A  39
GLN A 445
TRP A 414
 None
None
PRX  A 998 (-3.4A)
 1.00A 2vqyA-2p2mA:
undetectable		 2vqyA-2p2mA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		4 / 7 VAL A 386
GLY A 387
THR A 416
ARG A 526
 None
PRX  A 998 (-3.4A)
PRX  A 998 (-3.7A)
PRX  A 998 (-3.9A)
 0.34A 2wd9A-2p2mA:
41.8		 2wd9A-2p2mA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		5 / 8 VAL A 386
GLY A 387
GLN A 415
THR A 416
ARG A 526
 None
PRX  A 998 (-3.4A)
PRX  A 998 (-3.9A)
PRX  A 998 (-3.7A)
PRX  A 998 (-3.9A)
 0.52A 2wd9B-2p2mA:
41.0		 2wd9B-2p2mA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		6 / 10 THR A 264
VAL A 386
GLY A 387
GLN A 415
THR A 416
ARG A 526
 PRX  A 998 ( 4.9A)
None
PRX  A 998 (-3.4A)
PRX  A 998 (-3.9A)
PRX  A 998 (-3.7A)
PRX  A 998 (-3.9A)
 0.66A 2wd9C-2p2mA:
41.0		 2wd9C-2p2mA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		4 / 6 ASP A 517
SER A 267
ARG A 526
GLU A 417
 None
None
PRX  A 998 (-3.9A)
PRX  A 998 ( 4.8A)
 1.21A 4eysA-2p2mA:
2.6		 4eysA-2p2mA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		5 / 9 TYR A 488
THR A 416
LEU A 477
VAL A 274
GLY A 273
 None
PRX  A 998 (-3.7A)
None
None
None
 1.10A 5cp4A-2p2mA:
undetectable		 5cp4A-2p2mA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2p2m ACETYL-COENZYME A
SYNTHETASE
(Salmonella
enterica) 		5 / 12 GLY A 387
TRP A 414
ASP A 411
TYR A 398
ILE A 361
 PRX  A 998 (-3.4A)
PRX  A 998 (-3.4A)
PRX  A 998 (-3.6A)
None
None
 1.46A 6ineA-2p2mA:
undetectable		 6ineA-2p2mA:
16.24