SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PRF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3uxj NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE
(Vibrio
cholerae) 		4 / 7 ARG A 239
GLU A 234
PRO A 269
ALA A 257
 None
PRF  A1194 (-3.0A)
None
None
 1.12A 2ejgA-3uxjA:
undetectable		 2ejgA-3uxjA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3uxj NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE
(Vibrio
cholerae) 		4 / 5 ARG A 271
ASP A  60
ILE A 267
GLU A 238
 None
None
PRF  A1194 (-4.8A)
None
 1.39A 2xrzA-3uxjA:
undetectable
2xrzB-3uxjA:
undetectable		 2xrzA-3uxjA:
20.79
2xrzB-3uxjA:
20.79