SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PQQ'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C4D_B_DVAB8_0 (GRAMICIDIN A)	1kb0	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Comamonas testosteroni)	3 / 3	TRP A 479 VAL A  69 TRP A 541	PQQ  A1800 (-4.8A) None GOL  A1823 (-4.9A)	1.18A	1c4dA-1kb0A: undetectable 1c4dB-1kb0A: undetectable	1c4dA-1kb0A: 2.73 1c4dB-1kb0A: 2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EII_A_RTLA135_0 (CELLULAR RETINOL-BINDING PROTEIN II)	1otw	COENZYME PQQ SYNTHESIS PROTEIN C (Klebsiella pneumoniae)	5 / 12	THR A 146 ALA A 150 ILE A  43 PHE A 149 LEU A 218	PQQ  A 500 (-3.7A) PEO  A 600 (-3.1A) None None None	1.23A	1eiiA-1otwA: undetectable	1eiiA-1otwA: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FOH_A_IPHA802_0 (PHENOL HYDROXYLASE)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	5 / 10	ASP A 106 GLY A 531 VAL A 108 ARG A  52 GLY A 534	None PQQ  A 602 (-3.2A) PQQ  A 602 (-4.8A) None None	1.42A	1fohA-4maeA: undetectable	1fohA-4maeA: 22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FOH_B_IPHB802_0 (PHENOL HYDROXYLASE)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	5 / 10	ASP A 106 GLY A 531 VAL A 108 ARG A  52 GLY A 534	None PQQ  A 602 (-3.2A) PQQ  A 602 (-4.8A) None None	1.42A	1fohB-4maeA: undetectable	1fohB-4maeA: 22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1M4I_A_KANA500_1 (AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERA SE)	1yiq	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Pseudomonas putida)	4 / 8	ASP A 390 ASP A 297 THR A 294 ASP A 300	PQQ  A 801 (-3.2A) None None CA  A 802 (-3.1A)	0.89A	1m4iA-1yiqA: undetectable	1m4iA-1yiqA: 15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXD_A_ACRA732_1 (ALPHA AMYLASE)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	5 / 9	GLY A 573 GLU A  55 GLY A  53 GLY A 518 GLY A  56	None PQQ  A 701 (-2.6A) None None None	1.10A	1mxdA-1lrwA: 0.0	1mxdA-1lrwA: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXD_A_ACRA732_1 (ALPHA AMYLASE)	1w6s	METHANOL DEHYDROGENASE SUBUNIT 1 (Methylobacterium extorquens)	5 / 9	GLY A 573 GLU A  55 GLY A  53 GLY A 518 GLY A  56	None PQQ  A1596 (-2.7A) None None None	1.12A	1mxdA-1w6sA: undetectable	1mxdA-1w6sA: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXD_A_ACRA732_1 (ALPHA AMYLASE)	2d0v	METHANOL DEHYDROGENASE LARGE SUBUNIT (Hyphomicrobium denitrificans)	5 / 9	GLY A 573 GLU A  55 GLY A  53 GLY A 518 GLY A  56	None PQQ  A 601 (-2.7A) None None None	1.07A	1mxdA-2d0vA: undetectable	1mxdA-2d0vA: 20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXD_A_ACRA732_1 (ALPHA AMYLASE)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	5 / 9	GLY A 569 GLU A  55 GLY A  53 GLY A 509 GLY A  56	None PQQ  A 602 (-2.5A) None None None	1.06A	1mxdA-4maeA: undetectable	1mxdA-4maeA: 22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXD_A_ACRA732_1 (ALPHA AMYLASE)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	5 / 9	GLY A 604 GLU A  86 GLY A  84 GLY A 549 GLY A  87	None PQQ  A 701 (-2.5A) None None None	1.15A	1mxdA-5xm3A: undetectable	1mxdA-5xm3A: 10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXG_A_ACRA442_1 (ALPHA AMYLASE)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	5 / 11	GLY A 573 GLU A  55 GLY A  53 GLY A 518 GLY A  56	None PQQ  A 701 (-2.6A) None None None	1.08A	1mxgA-1lrwA: undetectable	1mxgA-1lrwA: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXG_A_ACRA442_1 (ALPHA AMYLASE)	1w6s	METHANOL DEHYDROGENASE SUBUNIT 1 (Methylobacterium extorquens)	5 / 11	GLY A 573 GLU A  55 GLY A  53 GLY A 518 GLY A  56	None PQQ  A1596 (-2.7A) None None None	1.10A	1mxgA-1w6sA: undetectable	1mxgA-1w6sA: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXG_A_ACRA442_1 (ALPHA AMYLASE)	2d0v	METHANOL DEHYDROGENASE LARGE SUBUNIT (Hyphomicrobium denitrificans)	5 / 11	GLY A 573 GLU A  55 GLY A  53 GLY A 518 GLY A  56	None PQQ  A 601 (-2.7A) None None None	1.05A	1mxgA-2d0vA: undetectable	1mxgA-2d0vA: 20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXG_A_ACRA442_1 (ALPHA AMYLASE)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	5 / 11	GLY A 569 GLU A  55 GLY A  53 GLY A 509 GLY A  56	None PQQ  A 602 (-2.5A) None None None	1.04A	1mxgA-4maeA: undetectable	1mxgA-4maeA: 22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXG_A_ACRA442_1 (ALPHA AMYLASE)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	5 / 11	GLY A 604 GLU A  86 GLY A  84 GLY A 549 GLY A  87	None PQQ  A 701 (-2.5A) None None None	1.13A	1mxgA-5xm3A: undetectable	1mxgA-5xm3A: 10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N2X_A_SAMA401_0 (S-ADENOSYL-METHYLTRA NSFERASE MRAW)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	5 / 12	THR A  57 GLY A 518 GLU A  55 GLY A 396 VAL A 575	None None PQQ  A 701 (-2.6A) None None	1.26A	1n2xA-1lrwA: undetectable	1n2xA-1lrwA: 19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PK7_B_ADNB1246_1 (PURINE NUCLEOSIDE PHOSPHORYLASE)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	4 / 8	ARG A  99 GLY A  53 VAL A 107 ILE A 517	None None PQQ  A 701 (-4.7A) None	0.64A	1pk7B-1lrwA: undetectable	1pk7B-1lrwA: 17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TV8_B_SAMB2501_0 (MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A)	1yiq	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Pseudomonas putida)	4 / 7	THR A 302 THR A 304 SER A 239 MET A 519	PQQ  A 801 ( 4.5A) None None None	1.16A	1tv8B-1yiqA: undetectable	1tv8B-1yiqA: 21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZLQ_A_ACTA1502_0 (NICKEL-BINDING PERIPLASMIC PROTEIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 5	TRP A 440 PRO A 441 GLY A 557 GLY A 529	PQQ  A1608 (-4.1A) None None None	1.04A	1zlqA-4cvcA: undetectable	1zlqA-4cvcA: 23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DPM_A_SAMA300_0 (PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1))	1yiq	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Pseudomonas putida)	5 / 12	GLY A 234 GLY A 256 ALA A 177 PHE A 223 PRO A 203	None None PQQ  A 801 (-2.9A) None None	1.10A	2dpmA-1yiqA: undetectable	2dpmA-1yiqA: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FN1_B_SALB503_1 (SALICYLATE SYNTHETASE, IRP9)	1kv9	TYPE II QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Pseudomonas putida)	5 / 11	ILE A 154 GLY A 112 HIS A  21 THR A 155 GLY A 123	None None None PQQ  A 801 (-2.8A) None	1.30A	2fn1B-1kv9A: undetectable	2fn1B-1kv9A: 23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HS1_B_017B203_1 (HIV-1 PROTEASE)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	4 / 7	GLU A  55 PRO A 157 MET A  16 GLY A  56	PQQ  A 602 (-2.5A) None None None	1.21A	2hs1B-4maeA: undetectable	2hs1B-4maeA: 10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HS1_B_017B203_1 (HIV-1 PROTEASE)	4tqo	METHANOL DEHYDROGENASE PROTEIN, LARGE SUBUNIT (Methylococcus capsulatus)	4 / 7	GLU B  83 PRO B 190 MET B  44 GLY B  84	PQQ  B 702 (-2.9A) None None None	1.26A	2hs1B-4tqoB: undetectable	2hs1B-4tqoB: 9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYR_B_SVRB401_2 (NAD-DEPENDENT DEACETYLASE SIRTUIN-5)	3das	PUTATIVE OXIDOREDUCTASE (Streptomyces coelicolor)	4 / 6	ARG A 311 GLN A 205 ASN A 203 LEU A 215	PQQ  A4331 (-2.9A) PQQ  A4331 (-3.0A) PQQ  A4331 (-3.9A) None	1.26A	2nyrA-3dasA: undetectable	2nyrA-3dasA: 22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_A_KLNA1501_1 (CYTOCHROME P450 3A4)	3das	PUTATIVE OXIDOREDUCTASE (Streptomyces coelicolor)	5 / 10	ASP A 329 ARG A 311 ILE A 268 ILE A 288 GLY A 282	PQQ  A4331 ( 4.9A) PQQ  A4331 (-2.9A) None None ARA  A 349 (-4.1A)	1.30A	2v0mA-3dasA: undetectable	2v0mA-3dasA: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XDC_F_DVAF8_0 (GRAMICIDIN A)	1kb0	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Comamonas testosteroni)	3 / 3	TRP A 541 VAL A  69 TRP A 479	GOL  A1823 (-4.9A) None PQQ  A1800 (-4.8A)	1.22A	2xdcE-1kb0A: undetectable 2xdcF-1kb0A: undetectable	2xdcE-1kb0A: 2.73 2xdcF-1kb0A: 2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y5M_F_DVAF8_0 (VAL-GRAMICIDIN A)	1kb0	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Comamonas testosteroni)	3 / 3	TRP A 541 VAL A  69 TRP A 479	GOL  A1823 (-4.9A) None PQQ  A1800 (-4.8A)	1.18A	2y5mE-1kb0A: undetectable 2y5mF-1kb0A: undetectable	2y5mE-1kb0A: 2.73 2y5mF-1kb0A: 2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y6N_D_DVAD8_0 (VAL-GRAMICIDIN A)	1kb0	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Comamonas testosteroni)	3 / 3	TRP A 541 VAL A  69 TRP A 479	GOL  A1823 (-4.9A) None PQQ  A1800 (-4.8A)	1.18A	2y6nC-1kb0A: undetectable 2y6nD-1kb0A: undetectable	2y6nC-1kb0A: 2.73 2y6nD-1kb0A: 2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y6N_F_DVAF8_0 (VAL-GRAMICIDIN A)	1kb0	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Comamonas testosteroni)	3 / 3	TRP A 541 VAL A  69 TRP A 479	GOL  A1823 (-4.9A) None PQQ  A1800 (-4.8A)	1.18A	2y6nE-1kb0A: undetectable 2y6nF-1kb0A: undetectable	2y6nE-1kb0A: 2.73 2y6nF-1kb0A: 2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZTH_A_SAMA305_0 (CATECHOL O-METHYLTRANSFERASE)	1kv9	TYPE II QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Pseudomonas putida)	5 / 12	GLY A  22 MET A 235 TYR A  25 HIS A  21 ARG A 111	None None None None PQQ  A 801 (-3.3A)	1.35A	2zthA-1kv9A: undetectable	2zthA-1kv9A: 17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZM_A_SAMA401_1 (UNCHARACTERIZED PROTEIN MJ0883)	2d0v	METHANOL DEHYDROGENASE LARGE SUBUNIT (Hyphomicrobium denitrificans)	3 / 3	ARG A 109 ASP A 330 ASN A 394	PQQ  A 601 (-3.2A) None PQQ  A 601 (-3.5A)	0.83A	2zzmA-2d0vA: undetectable	2zzmA-2d0vA: 18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZM_A_SAMA401_1 (UNCHARACTERIZED PROTEIN MJ0883)	4tqo	METHANOL DEHYDROGENASE PROTEIN, LARGE SUBUNIT (Methylococcus capsulatus)	3 / 3	ARG B 137 ASP B 357 ASN B 421	PQQ  B 702 (-3.0A) None PQQ  B 702 (-3.7A)	0.80A	2zzmA-4tqoB: undetectable	2zzmA-4tqoB: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZM_A_SAMA401_1 (UNCHARACTERIZED PROTEIN MJ0883)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	3 / 3	ARG A 140 ASP A 361 ASN A 425	PQQ  A 701 (-3.3A) None PQQ  A 701 (-3.4A)	0.83A	2zzmA-5xm3A: undetectable	2zzmA-5xm3A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A51_B_VDYB6178_1 (VITAMIN D HYDROXYLASE)	1kv9	TYPE II QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Pseudomonas putida)	5 / 12	THR A 527 LEU A 528 ASN A 382 VAL A  96 LEU A 125	None None PQQ  A 801 (-3.2A) None None	1.25A	3a51B-1kv9A: 0.0	3a51B-1kv9A: 20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AOC_C_ERYC3402_1 (ACRIFLAVINE RESISTANCE PROTEIN B)	1kv9	TYPE II QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Pseudomonas putida)	3 / 3	THR A 145 SER A 153 LYS A 100	None PQQ  A 801 ( 4.8A) None	1.10A	3aocC-1kv9A: 0.0	3aocC-1kv9A: 21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B9M_A_SALA1200_1 (SERUM ALBUMIN)	4tqo	METHANOL DEHYDROGENASE PROTEIN, LARGE SUBUNIT (Methylococcus capsulatus)	4 / 5	ILE B 424 HIS B 540 ARG B 137 GLY B 498	None None PQQ  B 702 (-3.0A) None	1.27A	3b9mA-4tqoB: undetectable	3b9mA-4tqoB: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_C_SVRC507_2 (PHOSPHOLIPASE A2)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	4 / 6	VAL A 108 VAL A 107 GLN A  95 ARG A  52	PQQ  A 602 (-4.8A) None None None	1.23A	3bjwF-4maeA: undetectable	3bjwF-4maeA: 13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CL9_A_MTXA602_2 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (DHFR-TS))	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	4 / 4	VAL A 416 ARG A 362 ILE A 365 THR A 407	None PQQ  A 701 (-2.8A) None None	1.15A	3cl9A-5xm3A: undetectable	3cl9A-5xm3A: 10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E23_A_SAMA221_1 (UNCHARACTERIZED PROTEIN RPA2492)	1flg	PROTEIN (QUINOPROTEIN ETHANOL DEHYDROGENASE) (Pseudomonas aeruginosa)	3 / 3	TYR A 152 ASP A 178 HIS A 242	None PQQ  A 701 (-3.5A) None	0.95A	3e23A-1flgA: undetectable	3e23A-1flgA: 17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FRQ_A_ERYA195_1 (REPRESSOR PROTEIN MPHR(A))	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	4 / 5	ASN A 256 ARG A 326 ASN A 304 HIS A 323	CE  A 601 ( 3.4A) PQQ  A 602 (-2.7A) None None	1.49A	3frqA-4maeA: undetectable	3frqA-4maeA: 15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JX1_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.41A	3jx1A-4cvcA: undetectable 3jx1B-4cvcA: undetectable	3jx1A-4cvcA: 20.14 3jx1B-4cvcA: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K13_A_THHA642_0 (5-METHYLTETRAHYDROFO LATE-HOMOCYSTEINE METHYLTRANSFERASE)	1kb0	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Comamonas testosteroni)	5 / 12	ASN A 263 GLY A 262 VAL A 416 GLY A 391 ASN A 394	CA  A 801 ( 2.8A) None None None PQQ  A1800 (-3.1A)	1.10A	3k13A-1kb0A: undetectable	3k13A-1kb0A: 18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K13_B_THHB643_0 (5-METHYLTETRAHYDROFO LATE-HOMOCYSTEINE METHYLTRANSFERASE)	1kb0	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Comamonas testosteroni)	5 / 12	ASN A 263 GLY A 262 VAL A 416 GLY A 391 ASN A 394	CA  A 801 ( 2.8A) None None None PQQ  A1800 (-3.1A)	1.09A	3k13B-1kb0A: undetectable	3k13B-1kb0A: 18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LSL_A_PZIA801_0 (GLUTAMATE RECEPTOR 2)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	4 / 8	ILE A 517 GLY A 539 SER A 558 ASN A 394	None PQQ  A 701 (-3.4A) None PQQ  A 701 ( 3.9A)	0.86A	3lslA-1lrwA: undetectable 3lslD-1lrwA: undetectable	3lslA-1lrwA: 17.30 3lslD-1lrwA: 17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LSL_D_PZID801_0 (GLUTAMATE RECEPTOR 2)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	4 / 8	SER A 558 ASN A 394 ILE A 517 GLY A 539	None PQQ  A 701 ( 3.9A) None PQQ  A 701 (-3.4A)	0.79A	3lslA-1lrwA: undetectable 3lslD-1lrwA: undetectable	3lslA-1lrwA: 17.30 3lslD-1lrwA: 17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MG0_H_BO2H1400_1 (PROTEASOME COMPONENT PUP1 PROTEASOME COMPONENT PUP3)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	5 / 11	SER A 273 THR A 275 GLY A 177 THR A 236 ASP A 301	None None None PQQ  A 602 (-3.1A) CE  A 601 ( 2.3A)	1.32A	3mg0H-4maeA: undetectable 3mg0I-4maeA: undetectable	3mg0H-4maeA: 15.77 3mg0I-4maeA: 16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N5Y_A_H4BA760_1 (NITRIC OXIDE SYNTHASE)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.43A	3n5yA-4cvcA: undetectable 3n5yB-4cvcA: undetectable	3n5yA-4cvcA: 19.93 3n5yB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N5Y_B_H4BB760_1 (NITRIC OXIDE SYNTHASE)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	TRP A 270 PHE A 338 ARG A 438 TRP A 440	PQQ  A1608 (-3.3A) None None PQQ  A1608 (-4.1A)	1.43A	3n5yA-4cvcA: undetectable 3n5yB-4cvcA: undetectable	3n5yA-4cvcA: 19.93 3n5yB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NLI_B_H4BB600_1 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 6	TRP A 270 PHE A 338 ARG A 438 TRP A 440	PQQ  A1608 (-3.3A) None None PQQ  A1608 (-4.1A)	1.40A	3nliA-4cvcA: undetectable 3nliB-4cvcA: undetectable	3nliA-4cvcA: 23.38 3nliB-4cvcA: 23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NLU_B_H4BB600_1 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 5	TRP A 270 PHE A 338 ARG A 438 TRP A 440	PQQ  A1608 (-3.3A) None None PQQ  A1608 (-4.1A)	1.38A	3nluA-4cvcA: 0.0 3nluB-4cvcA: 0.0	3nluA-4cvcA: 23.60 3nluB-4cvcA: 23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NNY_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.42A	3nnyA-4cvcA: undetectable 3nnyB-4cvcA: undetectable	3nnyA-4cvcA: 19.93 3nnyB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PNH_B_H4BB600_1 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 6	TRP A 270 PHE A 338 ARG A 438 TRP A 440	PQQ  A1608 (-3.3A) None None PQQ  A1608 (-4.1A)	1.41A	3pnhA-4cvcA: undetectable 3pnhB-4cvcA: undetectable	3pnhA-4cvcA: 22.22 3pnhB-4cvcA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PP7_B_SVRB499_1 (PYRUVATE KINASE)	1flg	PROTEIN (QUINOPROTEIN ETHANOL DEHYDROGENASE) (Pseudomonas aeruginosa)	5 / 10	THR A 290 ASN A 266 GLY A 177 GLY A 292 ALA A 264	None CA  A 751 ( 3.2A) PQQ  A 701 (-3.7A) None None	1.47A	3pp7B-1flgA: undetectable	3pp7B-1flgA: 21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RQJ_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 6	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.42A	3rqjA-4cvcA: undetectable 3rqjB-4cvcA: undetectable	3rqjA-4cvcA: 19.93 3rqjB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RQL_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.39A	3rqlA-4cvcA: undetectable 3rqlB-4cvcA: undetectable	3rqlA-4cvcA: 19.93 3rqlB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RQM_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.41A	3rqmA-4cvcA: undetectable 3rqmB-4cvcA: undetectable	3rqmA-4cvcA: 19.93 3rqmB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RQM_B_H4BB760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	TRP A 270 PHE A 338 ARG A 438 TRP A 440	PQQ  A1608 (-3.3A) None None PQQ  A1608 (-4.1A)	1.41A	3rqmA-4cvcA: undetectable 3rqmB-4cvcA: undetectable	3rqmA-4cvcA: 19.93 3rqmB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RQO_A_H4BA600_1 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 6	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.38A	3rqoA-4cvcA: undetectable 3rqoB-4cvcA: undetectable	3rqoA-4cvcA: 23.32 3rqoB-4cvcA: 23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RQO_B_H4BB600_1 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 6	TRP A 270 PHE A 338 ARG A 438 TRP A 440	PQQ  A1608 (-3.3A) None None PQQ  A1608 (-4.1A)	1.39A	3rqoA-4cvcA: undetectable 3rqoB-4cvcA: undetectable	3rqoA-4cvcA: 23.32 3rqoB-4cvcA: 23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3M_A_DLUA398_1 (PFV INTEGRASE)	1flg	PROTEIN (QUINOPROTEIN ETHANOL DEHYDROGENASE) (Pseudomonas aeruginosa)	4 / 8	ASP A 316 GLY A 319 GLU A 179 ARG A 111	CA  A 751 (-3.3A) None CA  A 751 (-2.6A) PQQ  A 701 (-3.3A)	0.86A	3s3mA-1flgA: undetectable	3s3mA-1flgA: 20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3M_A_DLUA398_1 (PFV INTEGRASE)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	4 / 8	ASP A 303 GLY A 306 GLU A 177 ARG A 109	CA  A 702 (-3.4A) None CA  A 702 ( 2.1A) PQQ  A 701 (-3.5A)	0.95A	3s3mA-1lrwA: undetectable	3s3mA-1lrwA: 21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3M_A_DLUA398_1 (PFV INTEGRASE)	1w6s	METHANOL DEHYDROGENASE SUBUNIT 1 (Methylobacterium extorquens)	4 / 8	ASP A 303 GLY A 306 GLU A 177 ARG A 109	PQQ  A1596 (-3.9A) None CA  A1599 ( 2.3A) PQQ  A1596 (-3.3A)	0.98A	3s3mA-1w6sA: undetectable	3s3mA-1w6sA: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3M_A_DLUA398_1 (PFV INTEGRASE)	2d0v	METHANOL DEHYDROGENASE LARGE SUBUNIT (Hyphomicrobium denitrificans)	4 / 8	ASP A 303 GLY A 306 GLU A 177 ARG A 109	CA  A 775 ( 3.4A) None CA  A 775 ( 2.1A) PQQ  A 601 (-3.2A)	0.94A	3s3mA-2d0vA: undetectable	3s3mA-2d0vA: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3M_A_DLUA398_1 (PFV INTEGRASE)	4aah	METHANOL DEHYDROGENASE (Methylophilus methylotrophus)	4 / 8	ASP A 297 GLY A 300 GLU A 171 ARG A 109	CA  A 702 (-3.6A) None CA  A 702 ( 2.3A) PQQ  A 701 (-3.6A)	0.99A	3s3mA-4aahA: undetectable	3s3mA-4aahA: 20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3M_A_DLUA398_1 (PFV INTEGRASE)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	5 / 8	ASP A 299 ASP A 301 GLY A 302 GLU A 172 ARG A 110	15P  A 603 (-2.7A) CE  A 601 ( 2.3A) None CE  A 601 (-2.5A) PQQ  A 602 (-3.3A)	1.41A	3s3mA-4maeA: undetectable	3s3mA-4maeA: 21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3M_A_DLUA398_1 (PFV INTEGRASE)	4tqo	METHANOL DEHYDROGENASE PROTEIN, LARGE SUBUNIT (Methylococcus capsulatus)	4 / 8	ASP B 331 GLY B 334 GLU B 205 ARG B 137	CA  B 701 ( 3.1A) None CA  B 701 ( 2.2A) PQQ  B 702 (-3.0A)	0.93A	3s3mA-4tqoB: undetectable	3s3mA-4tqoB: 21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3M_A_DLUA398_1 (PFV INTEGRASE)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	4 / 8	ASP A 334 GLY A 337 GLU A 208 ARG A 140	MG  A 702 (-3.5A) None MG  A 702 ( 2.2A) PQQ  A 701 (-3.3A)	0.95A	3s3mA-5xm3A: undetectable	3s3mA-5xm3A: 11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SXJ_A_SAMA258_0 (PUTATIVE METHYLTRANSFERASE)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	5 / 12	ARG A 178 GLN A 196 GLY A 171 GLY A 235 GLU A 151	None None PQQ  A 602 (-3.1A) None None	1.07A	3sxjA-4maeA: undetectable	3sxjA-4maeA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SXJ_A_SAMA258_0 (PUTATIVE METHYLTRANSFERASE)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	5 / 12	GLN A 196 GLY A 171 GLY A 235 GLU A 151 TYR A 425	None PQQ  A 602 (-3.1A) None None None	1.03A	3sxjA-4maeA: undetectable	3sxjA-4maeA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SXJ_B_SAMB258_0 (PUTATIVE METHYLTRANSFERASE)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	5 / 12	ARG A 178 GLN A 196 GLY A 171 GLY A 235 GLU A 151	None None PQQ  A 602 (-3.1A) None None	1.07A	3sxjB-4maeA: undetectable	3sxjB-4maeA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SXJ_B_SAMB258_0 (PUTATIVE METHYLTRANSFERASE)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	5 / 12	GLN A 196 GLY A 171 GLY A 235 GLU A 151 TYR A 425	None PQQ  A 602 (-3.1A) None None None	1.03A	3sxjB-4maeA: undetectable	3sxjB-4maeA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T7S_C_SAMC300_0 (PUTATIVE METHYLTRANSFERASE)	1kv9	TYPE II QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Pseudomonas putida)	5 / 12	GLY A 229 GLY A 227 SER A 270 ALA A 172 ASN A 250	None None None PQQ  A 801 (-3.0A) CA  A 802 ( 2.9A)	1.40A	3t7sC-1kv9A: undetectable	3t7sC-1kv9A: 16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T7S_C_SAMC300_0 (PUTATIVE METHYLTRANSFERASE)	1yiq	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Pseudomonas putida)	5 / 12	GLY A 234 GLY A 232 SER A 275 ALA A 177 ASN A 255	None None None PQQ  A 801 (-2.9A) CA  A 802 ( 3.0A)	1.38A	3t7sC-1yiqA: undetectable	3t7sC-1yiqA: 15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UBO_A_ADNA353_1 (ADENOSINE KINASE)	1w6s	METHANOL DEHYDROGENASE SUBUNIT 1 (Methylobacterium extorquens)	5 / 12	ILE A 171 GLY A 172 ASN A 242 ARG A 109 THR A 127	None None None PQQ  A1596 (-3.3A) None	0.98A	3uboA-1w6sA: undetectable	3uboA-1w6sA: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UFU_B_H4BB760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	TRP A 270 PHE A 338 ARG A 438 TRP A 440	PQQ  A1608 (-3.3A) None None PQQ  A1608 (-4.1A)	1.42A	3ufuA-4cvcA: undetectable 3ufuB-4cvcA: undetectable	3ufuA-4cvcA: 19.93 3ufuB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UFV_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.43A	3ufvA-4cvcA: undetectable 3ufvB-4cvcA: undetectable	3ufvA-4cvcA: 19.93 3ufvB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UFV_B_H4BB760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	TRP A 270 PHE A 338 ARG A 438 TRP A 440	PQQ  A1608 (-3.3A) None None PQQ  A1608 (-4.1A)	1.42A	3ufvA-4cvcA: undetectable 3ufvB-4cvcA: undetectable	3ufvA-4cvcA: 19.93 3ufvB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UFW_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 6	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.42A	3ufwA-4cvcA: undetectable 3ufwB-4cvcA: undetectable	3ufwA-4cvcA: 19.93 3ufwB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UQ6_A_ADNA401_1 (ADENOSINE KINASE, PUTATIVE)	1kb0	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Comamonas testosteroni)	5 / 12	ILE A 192 LEU A 288 GLY A 262 GLY A 242 GLY A 182	None None None None PQQ  A1800 (-3.2A)	0.89A	3uq6A-1kb0A: undetectable	3uq6A-1kb0A: 19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UZZ_B_ASDB501_1 (3-OXO-5-BETA-STEROID 4-DEHYDROGENASE)	1otw	COENZYME PQQ SYNTHESIS PROTEIN C (Klebsiella pneumoniae)	4 / 8	TYR A 175 HIS A 154 LEU A 218 MET A 221	PQQ  A 500 (-4.3A) PQQ  A 500 ( 4.2A) None None	1.36A	3uzzB-1otwA: undetectable	3uzzB-1otwA: 18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V3O_A_T1CA404_1 (TETX2 PROTEIN)	1w6s	METHANOL DEHYDROGENASE SUBUNIT 1 (Methylobacterium extorquens)	5 / 12	ASN A 394 HIS A 393 GLY A 410 ALA A  57 GLY A  56	PQQ  A1596 (-3.6A) None None None None	1.16A	3v3oA-1w6sA: undetectable	3v3oA-1w6sA: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V3O_A_T1CA404_1 (TETX2 PROTEIN)	2d0v	METHANOL DEHYDROGENASE LARGE SUBUNIT (Hyphomicrobium denitrificans)	5 / 12	ASN A 108 GLY A 539 ALA A 176 GLY A 175 ASN A 261	None PQQ  A 601 (-3.4A) PQQ  A 601 (-3.3A) PQQ  A 601 (-3.2A) CA  A 775 (-2.8A)	1.20A	3v3oA-2d0vA: undetectable	3v3oA-2d0vA: 20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V3O_A_T1CA404_1 (TETX2 PROTEIN)	2d0v	METHANOL DEHYDROGENASE LARGE SUBUNIT (Hyphomicrobium denitrificans)	5 / 12	ASN A 394 HIS A 393 GLY A 410 ALA A  57 GLY A  56	PQQ  A 601 (-3.5A) None None None None	1.18A	3v3oA-2d0vA: undetectable	3v3oA-2d0vA: 20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V3O_A_T1CA404_1 (TETX2 PROTEIN)	4aah	METHANOL DEHYDROGENASE (Methylophilus methylotrophus)	5 / 12	ASN A 387 HIS A 386 GLY A 403 ALA A  57 GLY A  56	PQQ  A 701 (-3.5A) None None None None	1.15A	3v3oA-4aahA: undetectable	3v3oA-4aahA: 22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V3O_A_T1CA404_1 (TETX2 PROTEIN)	4tqo	METHANOL DEHYDROGENASE PROTEIN, LARGE SUBUNIT (Methylococcus capsulatus)	5 / 12	ASN B 136 GLY B 560 ALA B 204 GLY B 203 ASN B 289	None PQQ  B 702 (-3.6A) PQQ  B 702 (-3.0A) PQQ  B 702 (-3.1A) CA  B 701 ( 2.8A)	1.21A	3v3oA-4tqoB: undetectable	3v3oA-4tqoB: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V3O_A_T1CA404_1 (TETX2 PROTEIN)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	5 / 12	ASN A 264 GLY A 233 ALA A 207 GLY A 210 ASN A 292	None None PQQ  A 701 (-3.0A) None MG  A 702 ( 3.0A)	1.16A	3v3oA-5xm3A: undetectable	3v3oA-5xm3A: 11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V3O_B_T1CB405_1 (TETX2 PROTEIN)	1w6s	METHANOL DEHYDROGENASE SUBUNIT 1 (Methylobacterium extorquens)	5 / 12	ASN A 394 HIS A 393 GLY A 410 ALA A  57 GLY A  56	PQQ  A1596 (-3.6A) None None None None	1.19A	3v3oB-1w6sA: undetectable	3v3oB-1w6sA: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V3O_B_T1CB405_1 (TETX2 PROTEIN)	4aah	METHANOL DEHYDROGENASE (Methylophilus methylotrophus)	5 / 12	ASN A 387 HIS A 386 GLY A 403 ALA A  57 GLY A  56	PQQ  A 701 (-3.5A) None None None None	1.20A	3v3oB-4aahA: undetectable	3v3oB-4aahA: 22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V3O_B_T1CB405_1 (TETX2 PROTEIN)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	5 / 12	ASN A 264 GLY A 233 ALA A 207 GLY A 210 ASN A 292	None None PQQ  A 701 (-3.0A) None MG  A 702 ( 3.0A)	1.23A	3v3oB-5xm3A: undetectable	3v3oB-5xm3A: 11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VAQ_A_ADNA401_1 (PUTATIVE ADENOSINE KINASE)	1kb0	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Comamonas testosteroni)	5 / 12	ILE A 192 LEU A 288 GLY A 262 GLY A 242 GLY A 182	None None None None PQQ  A1800 (-3.2A)	0.85A	3vaqA-1kb0A: undetectable	3vaqA-1kb0A: 19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VAS_A_ADNA401_1 (PUTATIVE ADENOSINE KINASE)	1kb0	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Comamonas testosteroni)	5 / 12	ILE A 192 LEU A 288 GLY A 262 GLY A 242 GLY A 182	None None None None PQQ  A1800 (-3.2A)	0.87A	3vasA-1kb0A: undetectable	3vasA-1kb0A: 19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6N_A_T1CA392_1 (TETX2 PROTEIN)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	5 / 11	ASN A 264 GLY A 233 ALA A 207 GLY A 210 ASN A 292	None None PQQ  A 701 (-3.0A) None MG  A 702 ( 3.0A)	1.30A	4a6nA-5xm3A: undetectable	4a6nA-5xm3A: 13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CTW_A_H4BA1718_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.43A	4ctwA-4cvcA: undetectable 4ctwB-4cvcA: undetectable	4ctwA-4cvcA: 19.93 4ctwB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CTW_B_H4BB1720_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	TRP A 270 PHE A 338 ARG A 438 TRP A 440	PQQ  A1608 (-3.3A) None None PQQ  A1608 (-4.1A)	1.45A	4ctwA-4cvcA: undetectable 4ctwB-4cvcA: undetectable	4ctwA-4cvcA: 19.93 4ctwB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CTX_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.43A	4ctxA-4cvcA: undetectable 4ctxB-4cvcA: undetectable	4ctxA-4cvcA: 19.93 4ctxB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CX5_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.42A	4cx5A-4cvcA: undetectable 4cx5B-4cvcA: undetectable	4cx5A-4cvcA: 19.93 4cx5B-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CX5_B_H4BB760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	TRP A 270 PHE A 338 ARG A 438 TRP A 440	PQQ  A1608 (-3.3A) None None PQQ  A1608 (-4.1A)	1.42A	4cx5A-4cvcA: undetectable 4cx5B-4cvcA: undetectable	4cx5A-4cvcA: 19.93 4cx5B-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D7O_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.46A	4d7oA-4cvcA: undetectable 4d7oB-4cvcA: undetectable	4d7oA-4cvcA: 19.93 4d7oB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D7O_B_H4BB760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	TRP A 270 PHE A 338 ARG A 438 TRP A 440	PQQ  A1608 (-3.3A) None None PQQ  A1608 (-4.1A)	1.45A	4d7oA-4cvcA: undetectable 4d7oB-4cvcA: undetectable	4d7oA-4cvcA: 19.93 4d7oB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E47_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 701 (-2.8A) None None CA  A 702 (-3.1A) PQQ  A 701 (-3.7A)	1.21A	4e47A-1lrwA: undetectable	4e47A-1lrwA: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E47_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	2d0v	METHANOL DEHYDROGENASE LARGE SUBUNIT (Hyphomicrobium denitrificans)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 601 (-3.3A) None None CA  A 775 (-2.8A) PQQ  A 601 (-3.3A)	1.24A	4e47A-2d0vA: undetectable	4e47A-2d0vA: 16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E47_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	4tqo	METHANOL DEHYDROGENASE PROTEIN, LARGE SUBUNIT (Methylococcus capsulatus)	5 / 11	ALA B 204 GLY B 267 GLY B 286 ASN B 289 TRP B 271	PQQ  B 702 (-3.0A) None None CA  B 701 ( 2.8A) PQQ  B 702 (-3.5A)	1.22A	4e47A-4tqoB: undetectable	4e47A-4tqoB: 19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E47_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	5 / 11	ALA A 207 GLY A 270 GLY A 289 ASN A 292 TRP A 274	PQQ  A 701 (-3.0A) None None MG  A 702 ( 3.0A) PQQ  A 701 (-3.4A)	1.23A	4e47A-5xm3A: undetectable	4e47A-5xm3A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E47_B_SAMB800_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 701 (-2.8A) None None CA  A 702 (-3.1A) PQQ  A 701 (-3.7A)	1.24A	4e47B-1lrwA: undetectable	4e47B-1lrwA: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E47_B_SAMB800_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	2d0v	METHANOL DEHYDROGENASE LARGE SUBUNIT (Hyphomicrobium denitrificans)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 601 (-3.3A) None None CA  A 775 (-2.8A) PQQ  A 601 (-3.3A)	1.28A	4e47B-2d0vA: undetectable	4e47B-2d0vA: 16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E47_B_SAMB800_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	4tqo	METHANOL DEHYDROGENASE PROTEIN, LARGE SUBUNIT (Methylococcus capsulatus)	5 / 11	ALA B 204 GLY B 267 GLY B 286 ASN B 289 TRP B 271	PQQ  B 702 (-3.0A) None None CA  B 701 ( 2.8A) PQQ  B 702 (-3.5A)	1.25A	4e47B-4tqoB: undetectable	4e47B-4tqoB: 19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E47_B_SAMB800_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	5 / 11	ALA A 207 GLY A 270 GLY A 289 ASN A 292 TRP A 274	PQQ  A 701 (-3.0A) None None MG  A 702 ( 3.0A) PQQ  A 701 (-3.4A)	1.27A	4e47B-5xm3A: undetectable	4e47B-5xm3A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E47_C_SAMC800_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 701 (-2.8A) None None CA  A 702 (-3.1A) PQQ  A 701 (-3.7A)	1.26A	4e47C-1lrwA: undetectable	4e47C-1lrwA: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E47_C_SAMC800_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	2d0v	METHANOL DEHYDROGENASE LARGE SUBUNIT (Hyphomicrobium denitrificans)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 601 (-3.3A) None None CA  A 775 (-2.8A) PQQ  A 601 (-3.3A)	1.29A	4e47C-2d0vA: undetectable	4e47C-2d0vA: 16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EYS_A_ACTA402_0 (MCCC FAMILY PROTEIN)	1otw	COENZYME PQQ SYNTHESIS PROTEIN C (Klebsiella pneumoniae)	4 / 6	ASP A  83 ASP A  61 ARG A  80 GLU A 147	None PQQ  A 500 ( 4.5A) PQQ  A 500 ( 4.9A) PQQ  A 500 ( 4.1A)	1.09A	4eysA-1otwA: undetectable	4eysA-1otwA: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGL_C_CLQC303_0 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	4 / 5	GLY A 170 GLY A 171 ASN A 256 GLU A 151	PQQ  A 602 (-3.6A) PQQ  A 602 (-3.1A) CE  A 601 ( 3.4A) None	1.26A	4fglC-4maeA: undetectable	4fglC-4maeA: 19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G0U_F_ASWF101_1 (DNA TOPOISOMERASE 2-BETA)	3das	PUTATIVE OXIDOREDUCTASE (Streptomyces coelicolor)	4 / 6	PRO A 254 GLY A 221 ALA A 242 GLN A 205	None CA  A 351 ( 4.6A) None PQQ  A4331 (-3.0A)	1.07A	4g0uA-3dasA: undetectable	4g0uA-3dasA: 19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HTF_A_SAMA301_0 (S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE)	1flg	PROTEIN (QUINOPROTEIN ETHANOL DEHYDROGENASE) (Pseudomonas aeruginosa)	5 / 12	GLY A 244 GLY A 245 GLY A 265 SER A 176 TRP A 270	None None None PQQ  A 701 (-2.6A) None	0.94A	4htfA-1flgA: undetectable	4htfA-1flgA: 18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IB4_A_ERMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562)	1yiq	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Pseudomonas putida)	4 / 7	ASP A 111 THR A 160 GLN A 561 LEU A  56	None PQQ  A 801 (-2.6A) None None	1.09A	4ib4A-1yiqA: undetectable	4ib4A-1yiqA: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 701 (-2.8A) None None CA  A 702 (-3.1A) PQQ  A 701 (-3.7A)	1.22A	4jdsA-1lrwA: undetectable	4jdsA-1lrwA: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	1w6s	METHANOL DEHYDROGENASE SUBUNIT 1 (Methylobacterium extorquens)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A1596 (-3.2A) None None CA  A1599 ( 3.5A) PQQ  A1596 (-3.6A)	1.28A	4jdsA-1w6sA: undetectable	4jdsA-1w6sA: 16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	2d0v	METHANOL DEHYDROGENASE LARGE SUBUNIT (Hyphomicrobium denitrificans)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 601 (-3.3A) None None CA  A 775 (-2.8A) PQQ  A 601 (-3.3A)	1.25A	4jdsA-2d0vA: undetectable	4jdsA-2d0vA: 16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	4aah	METHANOL DEHYDROGENASE (Methylophilus methylotrophus)	5 / 11	ALA A 170 GLY A 233 GLY A 252 ASN A 255 TRP A 237	PQQ  A 701 (-3.4A) None None CA  A 702 ( 3.0A) PQQ  A 701 (-3.4A)	1.31A	4jdsA-4aahA: undetectable	4jdsA-4aahA: 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	4tqo	METHANOL DEHYDROGENASE PROTEIN, LARGE SUBUNIT (Methylococcus capsulatus)	5 / 11	ALA B 204 GLY B 267 GLY B 286 ASN B 289 TRP B 271	PQQ  B 702 (-3.0A) None None CA  B 701 ( 2.8A) PQQ  B 702 (-3.5A)	1.23A	4jdsA-4tqoB: undetectable	4jdsA-4tqoB: 19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	5 / 11	ALA A 207 GLY A 270 GLY A 289 ASN A 292 TRP A 274	PQQ  A 701 (-3.0A) None None MG  A 702 ( 3.0A) PQQ  A 701 (-3.4A)	1.24A	4jdsA-5xm3A: undetectable	4jdsA-5xm3A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_B_SAMB401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 701 (-2.8A) None None CA  A 702 (-3.1A) PQQ  A 701 (-3.7A)	1.20A	4jdsB-1lrwA: undetectable	4jdsB-1lrwA: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_B_SAMB401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	1w6s	METHANOL DEHYDROGENASE SUBUNIT 1 (Methylobacterium extorquens)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A1596 (-3.2A) None None CA  A1599 ( 3.5A) PQQ  A1596 (-3.6A)	1.26A	4jdsB-1w6sA: undetectable	4jdsB-1w6sA: 16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_B_SAMB401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	2d0v	METHANOL DEHYDROGENASE LARGE SUBUNIT (Hyphomicrobium denitrificans)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 601 (-3.3A) None None CA  A 775 (-2.8A) PQQ  A 601 (-3.3A)	1.23A	4jdsB-2d0vA: undetectable	4jdsB-2d0vA: 16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_B_SAMB401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	4aah	METHANOL DEHYDROGENASE (Methylophilus methylotrophus)	5 / 11	ALA A 170 GLY A 233 GLY A 252 ASN A 255 TRP A 237	PQQ  A 701 (-3.4A) None None CA  A 702 ( 3.0A) PQQ  A 701 (-3.4A)	1.29A	4jdsB-4aahA: undetectable	4jdsB-4aahA: 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_B_SAMB401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	4tqo	METHANOL DEHYDROGENASE PROTEIN, LARGE SUBUNIT (Methylococcus capsulatus)	5 / 11	ALA B 204 GLY B 267 GLY B 286 ASN B 289 TRP B 271	PQQ  B 702 (-3.0A) None None CA  B 701 ( 2.8A) PQQ  B 702 (-3.5A)	1.21A	4jdsB-4tqoB: undetectable	4jdsB-4tqoB: 19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_B_SAMB401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	5 / 11	ALA A 207 GLY A 270 GLY A 289 ASN A 292 TRP A 274	PQQ  A 701 (-3.0A) None None MG  A 702 ( 3.0A) PQQ  A 701 (-3.4A)	1.22A	4jdsB-5xm3A: undetectable	4jdsB-5xm3A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_C_SAMC401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 701 (-2.8A) None None CA  A 702 (-3.1A) PQQ  A 701 (-3.7A)	1.27A	4jdsC-1lrwA: undetectable	4jdsC-1lrwA: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_C_SAMC401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	2d0v	METHANOL DEHYDROGENASE LARGE SUBUNIT (Hyphomicrobium denitrificans)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 601 (-3.3A) None None CA  A 775 (-2.8A) PQQ  A 601 (-3.3A)	1.31A	4jdsC-2d0vA: undetectable	4jdsC-2d0vA: 16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JLG_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	5 / 12	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 701 (-2.8A) None None CA  A 702 (-3.1A) PQQ  A 701 (-3.7A)	1.15A	4jlgA-1lrwA: 0.0	4jlgA-1lrwA: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JLG_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	2d0v	METHANOL DEHYDROGENASE LARGE SUBUNIT (Hyphomicrobium denitrificans)	5 / 12	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 601 (-3.3A) None None CA  A 775 (-2.8A) PQQ  A 601 (-3.3A)	1.17A	4jlgA-2d0vA: undetectable	4jlgA-2d0vA: 16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JSI_A_H4BA802_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.41A	4jsiA-4cvcA: undetectable 4jsiB-4cvcA: undetectable	4jsiA-4cvcA: 19.93 4jsiB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KCN_A_H4BA802_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 6	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.44A	4kcnA-4cvcA: undetectable 4kcnB-4cvcA: undetectable	4kcnA-4cvcA: 19.93 4kcnB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKV_B_AERB601_2 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1kv9	TYPE II QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Pseudomonas putida)	4 / 5	TYR A 651 ARG A 655 ASP A 430 VAL A 525	None None None PQQ  A 801 (-4.5A)	1.11A	4nkvB-1kv9A: 0.0	4nkvB-1kv9A: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OBW_A_SAMA602_0 (2-METHOXY-6-POLYPREN YL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL)	1kb0	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Comamonas testosteroni)	5 / 12	ASN A 427 ALA A 184 GLY A 183 SER A 163 GLY A 262	None PQQ  A1800 (-3.2A) PQQ  A1800 (-3.7A) None None	1.22A	4obwA-1kb0A: undetectable	4obwA-1kb0A: 16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ODR_B_FK5B201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A CHIMERA)	1otw	COENZYME PQQ SYNTHESIS PROTEIN C (Klebsiella pneumoniae)	5 / 11	LEU A 148 LEU A 211 LEU A 215 TYR A 128 ILE A  57	None None None PQQ  A 500 (-4.6A) PQQ  A 500 ( 4.1A)	1.05A	4odrA-1otwA: undetectable 4odrB-1otwA: undetectable	4odrA-1otwA: 16.14 4odrB-1otwA: 16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PST_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	1otw	COENZYME PQQ SYNTHESIS PROTEIN C (Klebsiella pneumoniae)	3 / 3	ILE A  57 ASP A 186 ARG A  50	PQQ  A 500 ( 4.1A) None PQQ  A 500 (-2.5A)	0.79A	4pstA-1otwA: undetectable	4pstA-1otwA: 20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QC6_B_KANB201_1 (BIFUNCTIONAL AAC/APH)	1flg	PROTEIN (QUINOPROTEIN ETHANOL DEHYDROGENASE) (Pseudomonas aeruginosa)	5 / 12	GLY A 177 GLU A  61 GLN A 249 ASP A 316 GLU A 179	PQQ  A 701 (-3.7A) PQQ  A 701 (-2.4A) None CA  A 751 (-3.3A) CA  A 751 (-2.6A)	1.50A	4qc6B-1flgA: 0.2	4qc6B-1flgA: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QYQ_C_3CJC607_1 (LACTOPEROXIDASE)	1flg	PROTEIN (QUINOPROTEIN ETHANOL DEHYDROGENASE) (Pseudomonas aeruginosa)	4 / 6	ASP A 343 HIS A 341 GLU A 322 ARG A 344	None None None PQQ  A 701 (-2.7A)	1.15A	4qyqC-1flgA: 0.0	4qyqC-1flgA: 22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QYQ_C_3CJC607_1 (LACTOPEROXIDASE)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	4 / 6	ASP A 325 HIS A 323 GLU A 305 ARG A 326	None None None PQQ  A 602 (-2.7A)	1.23A	4qyqC-4maeA: undetectable	4qyqC-4maeA: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R29_B_SAMB301_0 (UNCHARACTERIZED PROTEIN)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 METHANOL DEHYDROGENASE SUBUNIT 2 (Paracoccus denitrificans; Paracoccus denitrificans)	5 / 12	SER B  43 GLY B  41 ALA A 176 GLY A 182 TYR A 183	None None PQQ  A 701 (-2.8A) None None	1.26A	4r29B-1lrwB: undetectable	4r29B-1lrwB: 15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R29_C_SAMC301_0 (UNCHARACTERIZED PROTEIN)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 METHANOL DEHYDROGENASE SUBUNIT 2 (Paracoccus denitrificans; Paracoccus denitrificans)	5 / 12	SER B  43 GLY B  41 ALA A 176 GLY A 182 TYR A 183	None None PQQ  A 701 (-2.8A) None None	1.20A	4r29C-1lrwB: undetectable	4r29C-1lrwB: 15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTM_A_SAMA301_0 (DNA ADENINE METHYLASE)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	5 / 12	GLY A 182 GLY A 240 GLY A 175 ALA A 176 ILE A 152	None None PQQ  A 701 (-3.7A) PQQ  A 701 (-2.8A) None	0.90A	4rtmA-1lrwA: undetectable	4rtmA-1lrwA: 18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTM_A_SAMA301_0 (DNA ADENINE METHYLASE)	4tqo	METHANOL DEHYDROGENASE PROTEIN, LARGE SUBUNIT (Methylococcus capsulatus)	5 / 12	GLY B 210 GLY B 268 GLY B 203 ALA B 204 ILE B 180	None None PQQ  B 702 (-3.1A) PQQ  B 702 (-3.0A) None	0.95A	4rtmA-4tqoB: undetectable	4rtmA-4tqoB: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTM_A_SAMA301_0 (DNA ADENINE METHYLASE)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	5 / 12	GLY A 213 GLY A 271 GLY A 206 ALA A 207 ILE A 183	None None PQQ  A 701 (-3.7A) PQQ  A 701 (-3.0A) None	1.03A	4rtmA-5xm3A: undetectable	4rtmA-5xm3A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RVD_A_SAMA502_0 (D-MYCAROSE 3-C-METHYLTRANSFERAS E)	1flg	PROTEIN (QUINOPROTEIN ETHANOL DEHYDROGENASE) (Pseudomonas aeruginosa)	5 / 12	PRO A 247 ALA A 246 ARG A 209 HIS A 173 ILE A 172	None PQQ  A 701 ( 4.2A) None None None	1.11A	4rvdA-1flgA: undetectable	4rvdA-1flgA: 23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RVG_A_SAMA503_0 (D-MYCAROSE 3-C-METHYLTRANSFERAS E)	1flg	PROTEIN (QUINOPROTEIN ETHANOL DEHYDROGENASE) (Pseudomonas aeruginosa)	5 / 12	PRO A 247 ALA A 246 ARG A 209 HIS A 173 ILE A 172	None PQQ  A 701 ( 4.2A) None None None	1.13A	4rvgA-1flgA: undetectable	4rvgA-1flgA: 23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V3Y_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.44A	4v3yA-4cvcA: undetectable 4v3yB-4cvcA: undetectable	4v3yA-4cvcA: 19.93 4v3yB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V3Z_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 6	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.44A	4v3zA-4cvcA: undetectable 4v3zB-4cvcA: undetectable	4v3zA-4cvcA: 19.93 4v3zB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AYF_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	5 / 11	ALA A 176 GLY A 239 GLY A 258 ASN A 261 TRP A 243	PQQ  A 701 (-2.8A) None None CA  A 702 (-3.1A) PQQ  A 701 (-3.7A)	1.29A	5ayfA-1lrwA: undetectable	5ayfA-1lrwA: 17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AYF_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	4tqo	METHANOL DEHYDROGENASE PROTEIN, LARGE SUBUNIT (Methylococcus capsulatus)	5 / 11	ALA B 204 GLY B 267 GLY B 286 ASN B 289 TRP B 271	PQQ  B 702 (-3.0A) None None CA  B 701 ( 2.8A) PQQ  B 702 (-3.5A)	1.27A	5ayfA-4tqoB: undetectable	5ayfA-4tqoB: 18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AYF_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	5 / 11	ALA A 207 GLY A 270 GLY A 289 ASN A 292 TRP A 274	PQQ  A 701 (-3.0A) None None MG  A 702 ( 3.0A) PQQ  A 701 (-3.4A)	1.28A	5ayfA-5xm3A: undetectable	5ayfA-5xm3A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BXN_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	5 / 11	SER A 273 THR A 275 GLY A 177 THR A 236 ASP A 301	None None None PQQ  A 602 (-3.1A) CE  A 601 ( 2.3A)	1.28A	5bxnV-4maeA: undetectable 5bxnW-4maeA: undetectable	5bxnV-4maeA: 16.81 5bxnW-4maeA: 17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E4D_B_BEZB202_0 (HYDROXYNITRILE LYASE)	1kb0	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Comamonas testosteroni)	4 / 7	VAL A 120 THR A 167 ARG A  67 LEU A 547	None PQQ  A1800 (-2.9A) HEC  A 802 (-4.2A) None	0.92A	5e4dA-1kb0A: 0.0 5e4dB-1kb0A: 0.0	5e4dA-1kb0A: 15.20 5e4dB-1kb0A: 15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EWU_A_BEZA1401_0 (MAGNESIUM-CHELATASE SUBUNIT CHLH, CHLOROPLASTIC)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	4 / 6	TRP A 571 GLY A 588 THR A 469 VAL A 467	PQQ  A 701 (-4.6A) None None None	1.11A	5ewuA-5xm3A: undetectable	5ewuA-5xm3A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	1yiq	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Pseudomonas putida)	5 / 12	GLY A 540 GLU A  63 VAL A  62 PRO A  78 GLY A 106	None PQQ  A 801 (-2.5A) None None HEM  A 901 (-3.3A)	1.02A	5f9zA-1yiqA: undetectable	5f9zA-1yiqA: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FSA_B_X2NB590_1 (CYP51 VARIANT1)	1w6s	METHANOL DEHYDROGENASE SUBUNIT 1 (Methylobacterium extorquens)	5 / 12	GLY A 428 GLN A 429 LEU A 129 ILE A 517 GLY A 539	None None None None PQQ  A1596 (-3.5A)	1.05A	5fsaB-1w6sA: undetectable	5fsaB-1w6sA: 21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GQB_A_GCSA605_1 (CHITINASE)	1otw	COENZYME PQQ SYNTHESIS PROTEIN C (Klebsiella pneumoniae)	3 / 3	TRP A  46 ILE A 153 SER A 156	None PQQ  A 500 (-3.6A) None	0.87A	5gqbA-1otwA: undetectable	5gqbA-1otwA: 16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HG0_A_SAMA301_0 (PANTOTHENATE SYNTHETASE)	4aah	METHANOL DEHYDROGENASE (Methylophilus methylotrophus)	5 / 12	GLY A 563 GLN A 388 VAL A 390 GLY A 506 LEU A  51	None PQQ  A 701 ( 4.8A) None None None	1.09A	5hg0A-4aahA: undetectable	5hg0A-4aahA: 19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HG0_A_SAMA301_0 (PANTOTHENATE SYNTHETASE)	4aah	METHANOL DEHYDROGENASE (Methylophilus methylotrophus)	5 / 12	GLY A 564 GLN A 388 VAL A 390 GLY A 506 LEU A  51	None PQQ  A 701 ( 4.8A) None None None	1.03A	5hg0A-4aahA: undetectable	5hg0A-4aahA: 19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HPW_C_3CJC609_1 (LACTOPEROXIDASE)	1flg	PROTEIN (QUINOPROTEIN ETHANOL DEHYDROGENASE) (Pseudomonas aeruginosa)	4 / 6	ASP A 343 HIS A 341 GLU A 322 ARG A 344	None None None PQQ  A 701 (-2.7A)	1.14A	5hpwC-1flgA: 0.0	5hpwC-1flgA: 22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HPW_C_3CJC609_1 (LACTOPEROXIDASE)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	4 / 6	ASP A 325 HIS A 323 GLU A 305 ARG A 326	None None None PQQ  A 602 (-2.7A)	1.23A	5hpwC-4maeA: undetectable	5hpwC-4maeA: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGI_A_ZITA402_1 (MACROLIDE 2'-PHOSPHOTRANSFERAS E)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	5 / 12	ILE A 508 VAL A 107 ALA A 103 GLY A 171 THR A 236	None None None PQQ  A 602 (-3.1A) PQQ  A 602 (-3.1A)	1.19A	5igiA-4maeA: undetectable	5igiA-4maeA: 21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGY_A_ERYA403_1 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	1otw	COENZYME PQQ SYNTHESIS PROTEIN C (Klebsiella pneumoniae)	4 / 6	TYR A 128 ASP A 186 ILE A  81 TYR A 175	PQQ  A 500 (-4.6A) None None PQQ  A 500 (-4.3A)	1.20A	5igyA-1otwA: undetectable	5igyA-1otwA: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IH0_A_ERYA404_1 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	1otw	COENZYME PQQ SYNTHESIS PROTEIN C (Klebsiella pneumoniae)	4 / 6	TYR A 128 ASP A 186 ILE A  81 TYR A 175	PQQ  A 500 (-4.6A) None None PQQ  A 500 (-4.3A)	1.30A	5ih0A-1otwA: undetectable	5ih0A-1otwA: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KC4_A_RBFA201_1 (RIBOFLAVIN TRANSPORTER RIBU)	3das	PUTATIVE OXIDOREDUCTASE (Streptomyces coelicolor)	5 / 12	GLU A 159 GLY A 221 ASN A 203 ALA A 217 ASN A 229	None CA  A 351 ( 4.6A) PQQ  A4331 (-3.9A) None CA  A 350 ( 4.4A)	1.00A	5kc4A-3dasA: undetectable	5kc4A-3dasA: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O96_D_SAMD501_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E)	3das	PUTATIVE OXIDOREDUCTASE (Streptomyces coelicolor)	5 / 10	ARG A 311 ILE A 176 GLY A 156 GLY A 143 ALA A 217	PQQ  A4331 (-2.9A) None None None None	1.01A	5o96C-3dasA: undetectable 5o96D-3dasA: undetectable	5o96C-3dasA: 23.88 5o96D-3dasA: 23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TTF_C_SAMC1505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	3das	PUTATIVE OXIDOREDUCTASE (Streptomyces coelicolor)	5 / 12	GLY A  81 SER A 266 ASN A 141 HIS A 140 PHE A 220	None None None PQQ  A4331 (-3.9A) PQQ  A4331 (-3.5A)	1.16A	5ttfC-3dasA: undetectable	5ttfC-3dasA: 23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UO8_B_H4BB502_1 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 6	TRP A 270 PHE A 338 ARG A 438 TRP A 440	PQQ  A1608 (-3.3A) None None PQQ  A1608 (-4.1A)	1.42A	5uo8A-4cvcA: undetectable 5uo8B-4cvcA: undetectable	5uo8A-4cvcA: 22.09 5uo8B-4cvcA: 22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UOC_C_H4BC502_1 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 5	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.49A	5uocC-4cvcA: 0.0 5uocD-4cvcA: 0.0	5uocC-4cvcA: 22.09 5uocD-4cvcA: 22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V0V_A_8QPA613_1 (SERUM ALBUMIN)	1yiq	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Pseudomonas putida)	4 / 8	ARG A  60 PHE A 179 THR A 160 GLY A 106	HEM  A 901 (-3.9A) None PQQ  A 801 (-2.6A) HEM  A 901 (-3.3A)	0.95A	5v0vA-1yiqA: 2.2	5v0vA-1yiqA: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOP_A_C2FA3001_0 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	1kb0	QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE (Comamonas testosteroni)	5 / 12	ASN A 263 GLY A 262 VAL A 416 GLY A 391 ASN A 394	CA  A 801 ( 2.8A) None None None PQQ  A1800 (-3.1A)	1.05A	5vopA-1kb0A: undetectable	5vopA-1kb0A: 18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VUM_A_H4BA802_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.45A	5vumA-4cvcA: undetectable 5vumB-4cvcA: undetectable	5vumA-4cvcA: 19.93 5vumB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VUO_A_H4BA802_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.46A	5vuoA-4cvcA: undetectable 5vuoB-4cvcA: undetectable	5vuoA-4cvcA: 19.93 5vuoB-4cvcA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_A_ACRA1431_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	4mae	METHANOL DEHYDROGENASE (Methylacidiphilu m fumariolicum)	4 / 7	ASN A 406 ASP A 388 ASP A 301 GLY A 302	None PQQ  A 602 (-2.7A) CE  A 601 ( 2.3A) None	1.13A	5x7pA-4maeA: undetectable	5x7pA-4maeA: 18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_B_ACRB1471_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	3das	PUTATIVE OXIDOREDUCTASE (Streptomyces coelicolor)	5 / 12	ARG A 144 ASP A  51 GLY A  81 LEU A  83 ASN A 203	None None None None PQQ  A4331 (-3.9A)	1.20A	5x7pB-3dasA: 0.0	5x7pB-3dasA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6K_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	3 / 3	MET A 278 ASP A 303 ARG A 109	None CA  A 702 (-3.4A) PQQ  A 701 (-3.5A)	1.19A	5z6kA-1lrwA: undetectable	5z6kA-1lrwA: 14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6K_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	2d0v	METHANOL DEHYDROGENASE LARGE SUBUNIT (Hyphomicrobium denitrificans)	3 / 3	MET A 278 ASP A 303 ARG A 109	None CA  A 775 ( 3.4A) PQQ  A 601 (-3.2A)	1.22A	5z6kA-2d0vA: undetectable	5z6kA-2d0vA: 13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6K_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	4aah	METHANOL DEHYDROGENASE (Methylophilus methylotrophus)	3 / 3	MET A 272 ASP A 297 ARG A 109	None CA  A 702 (-3.6A) PQQ  A 701 (-3.6A)	1.14A	5z6kA-4aahA: undetectable	5z6kA-4aahA: 12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6K_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	4tqo	METHANOL DEHYDROGENASE PROTEIN, LARGE SUBUNIT (Methylococcus capsulatus)	3 / 3	MET B 306 ASP B 331 ARG B 137	None CA  B 701 ( 3.1A) PQQ  B 702 (-3.0A)	1.19A	5z6kA-4tqoB: undetectable	5z6kA-4tqoB: 13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6K_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	5xm3	GLUCOSE DEHYDROGENASE (Methylophaga aminisulfidivora ns)	3 / 3	MET A 309 ASP A 334 ARG A 140	None MG  A 702 (-3.5A) PQQ  A 701 (-3.3A)	1.19A	5z6kA-5xm3A: undetectable	5z6kA-5xm3A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AUW_A_H4BA802_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.44A	6auwA-4cvcA: undetectable 6auwB-4cvcA: undetectable	6auwA-4cvcA: 9.44 6auwB-4cvcA: 9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B58_A_ACTA609_0 (FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT)	1otw	COENZYME PQQ SYNTHESIS PROTEIN C (Klebsiella pneumoniae)	3 / 3	HIS A  30 HIS A  24 ARG A  50	None PQQ  A 500 (-3.7A) PQQ  A 500 (-2.5A)	1.13A	6b58A-1otwA: undetectable	6b58A-1otwA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CID_A_H4BA802_0 (NITRIC OXIDE SYNTHASE, BRAIN)	4cvc	ALCOHOL DEHYDROGENASE (Pseudogluconobac ter saccharoketogene s)	4 / 7	ARG A 438 TRP A 440 TRP A 270 PHE A 338	None PQQ  A1608 (-4.1A) PQQ  A1608 (-3.3A) None	1.46A	6cidA-4cvcA: undetectable 6cidB-4cvcA: undetectable	6cidA-4cvcA: 8.57 6cidB-4cvcA: 8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGD_A_ACTA812_0 (GEPHYRIN)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	4 / 6	ARG A  99 PHE A  71 VAL A 107 PRO A  70	None None PQQ  A 701 (-4.7A) None	1.27A	6fgdA-1lrwA: undetectable	6fgdA-1lrwA: 22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_H_PCFH604_0 (CYTOCHROME B-C1 COMPLEX SUBUNIT 8 CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL)	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	4 / 8	GLY A 539 GLY A 555 SER A 558 ALA A 561	PQQ  A 701 (-3.4A) None None None	0.57A	6hu9H-1lrwA: undetectable 6hu9e-1lrwA: 0.0	6hu9H-1lrwA: 8.97 6hu9e-1lrwA: 11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6I5Z_D_SAMD401_0 (O-METHYLTRANSFERASE 1)	1w6s	METHANOL DEHYDROGENASE SUBUNIT 1 (Methylobacterium extorquens)	5 / 11	GLY A 557 GLY A 555 VAL A 543 MET A 438 ASP A 303	None None None None PQQ  A1596 (-3.9A)	1.09A	6i5zD-1w6sA: undetectable	6i5zD-1w6sA: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6N7F_A_RBFA502_0 (PUTATIVE GLUTATHIONE REDUCTASE (GR))	1lrw	METHANOL DEHYDROGENASE SUBUNIT 1 (Paracoccus denitrificans)	4 / 7	GLY A  49 HIS A  68 GLU A  55 GLY A  53	None None PQQ  A 701 (-2.6A) None	0.95A	6n7fA-1lrwA: undetectable	6n7fA-1lrwA: 8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6N7F_A_RBFA502_0 (PUTATIVE GLUTATHIONE REDUCTASE (GR))	1w6s	METHANOL DEHYDROGENASE SUBUNIT 1 (Methylobacterium extorquens)	4 / 7	GLY A  49 HIS A  68 GLU A  55 GLY A  53	None None PQQ  A1596 (-2.7A) None	0.90A	6n7fA-1w6sA: undetectable	6n7fA-1w6sA: 9.19