SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PPY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		4 / 7 LEU A 132
PHE A 218
SER A 214
MET A 188
 None
PPY  A 246 (-4.6A)
PPY  A 246 ( 3.7A)
None
 0.94A 1wrlA-3h7jA:
undetectable
1wrlB-3h7jA:
undetectable		 1wrlA-3h7jA:
18.38
1wrlB-3h7jA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 5 LEU A 207
GLY A 239
PRO A 250
VAL A 233
 None
PPY  A5003 ( 4.1A)
None
None
 0.82A 2aojA-2q5oA:
undetectable		 2aojA-2q5oA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 7 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.83A 2v2gA-4dqdA:
undetectable
2v2gB-4dqdA:
undetectable		 2v2gA-4dqdA:
21.25
2v2gB-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 7 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.87A 2v2gA-4dqdA:
undetectable
2v2gB-4dqdA:
undetectable		 2v2gA-4dqdA:
21.25
2v2gB-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 7 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.85A 2v2gC-4dqdA:
undetectable
2v2gD-4dqdA:
undetectable		 2v2gC-4dqdA:
21.25
2v2gD-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 7 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.87A 2v2gC-4dqdA:
undetectable
2v2gD-4dqdA:
undetectable		 2v2gC-4dqdA:
21.25
2v2gD-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 8 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.87A 2v32A-4dqdA:
undetectable
2v32B-4dqdA:
undetectable		 2v32A-4dqdA:
21.25
2v32B-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 8 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.87A 2v32A-4dqdA:
undetectable
2v32B-4dqdA:
undetectable		 2v32A-4dqdA:
21.25
2v32B-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 8 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.83A 2v32C-4dqdA:
undetectable
2v32D-4dqdA:
undetectable		 2v32C-4dqdA:
21.25
2v32D-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 8 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.86A 2v32C-4dqdA:
undetectable
2v32D-4dqdA:
undetectable		 2v32C-4dqdA:
21.25
2v32D-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		5 / 12 LEU A 131
VAL A 137
ILE A 152
TYR A 177
MET A 179
 None
None
None
None
PPY  A 246 ( 4.3A)
 1.20A 2weyA-3h7jA:
undetectable		 2weyA-3h7jA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 ASN A 364
ASP A 389
ARG A 214
 None
None
PPY  A5003 (-3.3A)
 0.93A 3k13C-2q5oA:
undetectable		 3k13C-2q5oA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 GLY A 394
ARG A  60
ALA A  57
ALA A  58
ASP A  56
 PPY  A5003 (-3.5A)
PPY  A5003 (-4.2A)
None
None
None
 1.09A 3keeA-2q5oA:
undetectable		 3keeA-2q5oA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 ALA A 118
GLY A  37
ALA A 220
SER A  93
HIS A 244
 PPY  A 401 (-3.6A)
None
PPY  A 401 (-3.4A)
None
PPY  A 401 (-3.6A)
 1.18A 3mg02-4dqdA:
undetectable
3mg0V-4dqdA:
undetectable		 3mg02-4dqdA:
19.95
3mg0V-4dqdA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		3 / 3 ALA A 220
VAL A 246
GLN A 242
 PPY  A 401 (-3.4A)
None
None
 0.70A 3of4B-4dqdA:
undetectable		 3of4B-4dqdA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 5 ILE A 376
ARG A 214
ASP A 245
VAL A 367
 None
PPY  A5003 (-3.3A)
None
None
 1.15A 4nkxC-2q5oA:
undetectable		 4nkxC-2q5oA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 5 ILE A 376
ARG A 214
ASP A 245
VAL A 367
 None
PPY  A5003 (-3.3A)
None
None
 1.15A 4nkxD-2q5oA:
undetectable		 4nkxD-2q5oA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 GLN A  44
LEU A  95
GLY A 221
TYR A 168
GLY A 245
 None
PPY  A 401 (-4.1A)
None
PPY  A 401 (-3.8A)
PPY  A 401 (-3.6A)
 1.25A 5e3iA-4dqdA:
4.0		 5e3iA-4dqdA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 GLY A 535
LEU A 384
ILE A 376
GLY A 241
THR A 235
 None
None
None
PPY  A5003 (-4.3A)
None
 1.12A 5eskA-2q5oA:
undetectable		 5eskA-2q5oA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 6 GLY A 217
TYR A 216
LEU A 242
VAL A 222
 None
None
PPY  A5003 ( 4.7A)
None
 0.87A 5x80A-2q5oA:
undetectable
5x80B-2q5oA:
undetectable		 5x80A-2q5oA:
18.46
5x80B-2q5oA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 LEU A 118
SER A  97
THR A  71
PHE A  77
TYR A 160
 None
None
PPY  A5001 ( 4.2A)
None
None
 1.40A 6drxA-2q5oA:
undetectable		 6drxA-2q5oA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 11 SER A  63
GLY A 241
GLY A 394
ASP A 392
ASP A 389
 None
PPY  A5003 (-4.3A)
PPY  A5003 (-3.5A)
None
None
 1.14A 6i5zD-2q5oA:
undetectable		 6i5zD-2q5oA:
21.15