SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PPV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		5 / 12 MET A  12
GLY A  29
HIS A  26
ASP A 195
ASP A 196
 None
PPV  A 701 (-3.7A)
PPV  A 701 (-3.8A)
MG  A 704 (-2.7A)
MG  A 704 (-2.6A)
 1.40A 1a4lD-5fllA:
undetectable		 1a4lD-5fllA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4rl4 GTP CYCLOHYDROLASE-2
(Helicobacter
pylori) 		4 / 4 SER A  63
GLU A  92
SER A  53
ASP A  67
 None
None
PPV  A 201 ( 4.8A)
None
 1.47A 1h1dA-4rl4A:
2.4		 1h1dA-4rl4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 8 HIS A 876
ILE A 877
VAL A 627
SER A 621
 None
None
None
PPV  A1001 (-2.9A)
 1.15A 1kb9A-3pihA:
undetectable
1kb9C-3pihA:
undetectable
1kb9D-3pihA:
undetectable
1kb9E-3pihA:
undetectable		 1kb9A-3pihA:
20.24
1kb9C-3pihA:
18.10
1kb9D-3pihA:
13.32
1kb9E-3pihA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		3 / 3 ASP A 198
HIS A  53
ASP A 195
 None
PPV  A 701 (-4.0A)
MG  A 704 (-2.7A)
 0.82A 1nw5A-5fllA:
undetectable		 1nw5A-5fllA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		4 / 5 GLY A  70
ILE A  71
VAL A  23
SER A 164
 None
None
PPV  A1339 (-4.0A)
PPV  A1339 (-3.2A)
 1.15A 1rs7A-5fo1A:
undetectable		 1rs7A-5fo1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		4 / 7 ASP A 195
TYR A 199
ASP A 196
HIS A  26
 MG  A 704 (-2.7A)
WAQ  A 700 (-4.6A)
MG  A 704 (-2.6A)
PPV  A 701 (-3.8A)
 1.32A 1t03A-5fllA:
undetectable		 1t03A-5fllA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4rl4 GTP CYCLOHYDROLASE-2
(Helicobacter
pylori) 		4 / 5 SER A  63
GLU A  92
SER A  53
ASP A  67
 None
None
PPV  A 201 ( 4.8A)
None
 1.45A 1vidA-4rl4A:
undetectable		 1vidA-4rl4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		5 / 12 HIS A  28
GLY A  30
HIS A  31
GLY A 123
LEU A 155
 PPV  A1339 (-3.7A)
None
PPV  A1339 (-3.8A)
None
None
 0.78A 2x1lB-5fo1A:
3.7		 2x1lB-5fo1A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 4 SER A  33
GLY A  34
GLY A 838
GLY A 808
 PPV  A1002 (-3.1A)
PPV  A1002 (-3.1A)
PPV  A1002 (-4.2A)
PPV  A1002 ( 4.3A)
 0.82A 3bogB-3pihA:
undetectable
3bogD-3pihA:
undetectable		 3bogB-3pihA:
undetectable
3bogD-3pihA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 LEU A  14
GLY A 543
VAL A 797
SER A  38
ILE A 669
 None
None
None
PPV  A1002 (-2.7A)
None
 0.98A 3frqB-3pihA:
undetectable		 3frqB-3pihA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 10 SER A 441
LEU A 331
ILE A 537
SER A 446
GLY A 467
 PPV  A 603 (-2.7A)
None
None
None
None
 1.11A 3ik6B-5xexA:
undetectable
3ik6E-5xexA:
undetectable		 3ik6B-5xexA:
17.67
3ik6E-5xexA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		4 / 6 GLY A  70
ILE A  71
VAL A  23
SER A 164
 None
None
PPV  A1339 (-4.0A)
PPV  A1339 (-3.2A)
 1.09A 4kcnA-5fo1A:
undetectable		 4kcnA-5fo1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4rl4 GTP CYCLOHYDROLASE-2
(Helicobacter
pylori) 		4 / 4 SER A  63
GLU A  92
SER A  53
ASP A  67
 None
None
PPV  A 201 ( 4.8A)
None
 1.46A 4xucA-4rl4A:
2.3		 4xucA-4rl4A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5fll 6-CARBOXYHEXANOATE-C
OA LIGASE
(Bacillus
subtilis) 		5 / 12 LEU A  46
GLU A  66
VAL A  10
HIS A  26
GLY A 143
 None
None
None
PPV  A 701 (-3.8A)
None
 1.24A 4ydqA-5fllA:
undetectable		 4ydqA-5fllA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		3 / 3 SER A 621
GLU A 865
GLU A 526
 PPV  A1001 (-2.9A)
None
None
 0.87A 4ymgB-3pihA:
undetectable		 4ymgB-3pihA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		7 / 9 ASP A  82
ARG A 178
ASN A 224
SER A 228
GLU A 232
ARG A 310
TYR A 311
 MG  A 902 ( 2.5A)
PPV  A 904 (-2.9A)
MG  A 903 ( 2.7A)
MG  A 903 ( 2.3A)
MG  A 903 ( 2.7A)
PPV  A 904 (-3.9A)
PPV  A 904 (-4.4A)
 0.95A 5dz2A-4okmA:
36.3		 5dz2A-4okmA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_B_212B404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		7 / 9 ASP A  82
ARG A 178
ASN A 224
SER A 228
GLU A 232
ARG A 310
TYR A 311
 MG  A 902 ( 2.5A)
PPV  A 904 (-2.9A)
MG  A 903 ( 2.7A)
MG  A 903 ( 2.3A)
MG  A 903 ( 2.7A)
PPV  A 904 (-3.9A)
PPV  A 904 (-4.4A)
 0.90A 5dz2B-4okmA:
36.0		 5dz2B-4okmA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4rl4 GTP CYCLOHYDROLASE-2
(Helicobacter
pylori) 		4 / 6 LYS A 154
TYR A 130
GLY A  93
GLU A  92
 PPV  A 201 (-2.8A)
None
None
None
 1.35A 5emlA-4rl4A:
undetectable		 5emlA-4rl4A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		7 / 10 ARG A 178
ASN A 224
SER A 228
LYS A 231
GLU A 232
ARG A 310
TYR A 311
 PPV  A 904 (-2.9A)
MG  A 903 ( 2.7A)
MG  A 903 ( 2.3A)
PPV  A 904 (-2.8A)
MG  A 903 ( 2.7A)
PPV  A 904 (-3.9A)
PPV  A 904 (-4.4A)
 0.50A 5ermA-4okmA:
23.8		 5ermA-4okmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 10 ASP A  82
ARG A 178
ASN A 224
ARG A 310
TYR A 311
 MG  A 902 ( 2.5A)
PPV  A 904 (-2.9A)
MG  A 903 ( 2.7A)
PPV  A 904 (-3.9A)
PPV  A 904 (-4.4A)
 1.45A 5ermA-4okmA:
23.8		 5ermA-4okmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_B_210B704_1
(FUSICOCCADIENE
SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		7 / 9 ARG A 178
ASN A 224
SER A 228
LYS A 231
GLU A 232
ARG A 310
TYR A 311
 PPV  A 904 (-2.9A)
MG  A 903 ( 2.7A)
MG  A 903 ( 2.3A)
PPV  A 904 (-2.8A)
MG  A 903 ( 2.7A)
PPV  A 904 (-3.9A)
PPV  A 904 (-4.4A)
 0.52A 5ermB-4okmA:
24.5		 5ermB-4okmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_B_210B704_1
(FUSICOCCADIENE
SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 9 ASP A  82
ARG A 178
ASN A 224
SER A 228
ARG A 310
 MG  A 902 ( 2.5A)
PPV  A 904 (-2.9A)
MG  A 903 ( 2.7A)
MG  A 903 ( 2.3A)
PPV  A 904 (-3.9A)
 0.82A 5ermB-4okmA:
24.5		 5ermB-4okmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4rl4 GTP CYCLOHYDROLASE-2
(Helicobacter
pylori) 		4 / 5 SER A  63
GLU A  92
SER A  53
ASP A  67
 None
None
PPV  A 201 ( 4.8A)
None
 1.46A 5fhrA-4rl4A:
undetectable		 5fhrA-4rl4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4rl4 GTP CYCLOHYDROLASE-2
(Helicobacter
pylori) 		4 / 5 SER A  63
GLU A  92
SER A  53
ASP A  67
 None
None
PPV  A 201 ( 4.8A)
None
 1.49A 5fhrB-4rl4A:
undetectable		 5fhrB-4rl4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		5 / 12 GLY A  30
HIS A  31
LEU A  34
GLY A 123
LEU A 155
 None
PPV  A1339 (-3.8A)
None
None
None
 1.11A 5hg0B-5fo1A:
12.5		 5hg0B-5fo1A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		5 / 12 HIS A  28
GLY A  30
HIS A  31
LEU A  34
GLY A 123
 PPV  A1339 (-3.7A)
None
PPV  A1339 (-3.8A)
None
None
 0.44A 5hg0B-5fo1A:
12.5		 5hg0B-5fo1A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 GLY A 884
ASN A 599
GLY A 452
GLY A 622
HIS A 866
 None
None
None
PPV  A1001 (-3.4A)
None
 1.21A 5hikA-3pihA:
2.5		 5hikA-3pihA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 6 GLY A 647
THR A 630
GLU A 629
SER A 625
 None
None
None
PPV  A1001 ( 4.2A)
 1.13A 5ny7A-3pihA:
undetectable		 5ny7A-3pihA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 12 PHE A  55
ILE A  59
LEU A  71
GLY A 182
LEU A  78
 None
None
None
PPV  A 904 ( 3.8A)
None
 1.01A 5zwrA-4okmA:
undetectable		 5zwrA-4okmA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		5 / 9 PHE A  84
VAL A  27
HIS A  28
ILE A  50
ARG A  77
 None
None
PPV  A1339 (-3.7A)
None
None
 1.33A 6c2mC-5fo1A:
undetectable		 6c2mC-5fo1A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		4 / 5 GLY A  22
HIS A  31
SER A 163
SER A 164
 PPV  A1339 ( 3.8A)
PPV  A1339 (-3.8A)
PPV  A1339 (-4.7A)
PPV  A1339 (-3.2A)
 0.49A 6jmjA-5fo1A:
10.7		 6jmjA-5fo1A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		5 / 7 GLY A  22
PHE A  24
HIS A  31
SER A 163
SER A 164
 PPV  A1339 ( 3.8A)
PPV  A1339 (-4.7A)
PPV  A1339 (-3.8A)
PPV  A1339 (-4.7A)
PPV  A1339 (-3.2A)
 0.75A 6jnhA-5fo1A:
10.7		 6jnhA-5fo1A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		4 / 6 GLY A  22
HIS A  31
SER A 163
SER A 164
 PPV  A1339 ( 3.8A)
PPV  A1339 (-3.8A)
PPV  A1339 (-4.7A)
PPV  A1339 (-3.2A)
 0.53A 6jogA-5fo1A:
10.8		 6jogA-5fo1A:
22.81