SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PPS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3R_A_LDPA297_1
(MONOAMINE-SULFATING
PHENOL
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PRO X  47
PHE X  81
LYS X 106
HIS X 108
HIS X 149
 PPS  X1501 (-4.3A)
NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 (-4.0A)
 0.36A 2a3rA-2zyvX:
45.5		 2a3rA-2zyvX:
57.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3R_B_LDPB297_1
(MONOAMINE-SULFATING
PHENOL
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PRO X  47
PHE X  81
LYS X 106
HIS X 108
HIS X 149
 PPS  X1501 (-4.3A)
NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 (-4.0A)
 0.34A 2a3rB-2zyvX:
45.6		 2a3rB-2zyvX:
57.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 10 PHE X  21
PRO X  47
LYS X  48
HIS X 108
MET X 145
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 3.7A)
None
 0.94A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PHE X  21
PRO X  47
LYS X  48
HIS X 108
PHE X 142
MET X 248
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 1.02A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PHE X  21
PRO X  47
LYS X  48
HIS X 108
PHE X 142
PHE X   8
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 1.30A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PRO X  47
LYS X  48
HIS X 108
PHE X 142
ALA X 146
PHE X   8
 PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
NPO  X1601 ( 4.1A)
None
 1.27A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PRO X  47
LYS X  48
LYS X 106
HIS X 108
ALA X 146
MET X 145
 PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 ( 4.1A)
None
 1.48A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		7 / 10 PRO X  47
LYS X  48
LYS X 106
HIS X 108
PHE X 142
ALA X 146
MET X 248
 PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
NPO  X1601 ( 4.1A)
None
 0.39A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 10 PHE X  21
PRO X  47
HIS X 108
PHE X 142
PHE X   8
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 1.37A 2d06B-2zyvX:
45.4		 2d06B-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PHE X  21
PRO X  47
HIS X 108
PHE X 142
TYR X 240
MET X 248
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
None
 1.03A 2d06B-2zyvX:
45.4		 2d06B-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 10 PRO X  47
HIS X 108
PHE X 142
ALA X 146
PHE X   8
 PPS  X1501 (-4.3A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
NPO  X1601 ( 4.1A)
None
 1.32A 2d06B-2zyvX:
45.4		 2d06B-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		7 / 10 PRO X  47
LYS X 106
HIS X 108
PHE X 142
ALA X 146
TYR X 240
MET X 248
 PPS  X1501 (-4.3A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
NPO  X1601 ( 4.1A)
None
None
 0.42A 2d06B-2zyvX:
45.4		 2d06B-2zyvX:
58.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 2ofx BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 12 ASN A  96
GLY A  88
ASP A  89
PHE A 101
GLY A 100
 None
PPS  A1100 (-3.6A)
PPS  A1100 (-2.7A)
PPS  A1100 (-3.5A)
None
 1.48A 2fqyA-2ofxA:
4.2		 2fqyA-2ofxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		4 / 4 VAL X 135
PHE X 192
VAL X  54
TRP X  53
 None
GOL  X1004 (-3.7A)
None
PPS  X1501 (-3.3A)
 1.48A 2y00A-2zyvX:
0.0		 2y00A-2zyvX:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 3cr7 ADENYLYL-SULFATE
KINASE
(Penicillium
chrysogenum) 		4 / 8 SER A 107
PHE A 105
VAL A  90
LEU A  69
 PPS  A2002 (-4.9A)
PPS  A2002 (-4.6A)
None
None
 1.11A 3jq7C-3cr7A:
2.2		 3jq7C-3cr7A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 3cr7 ADENYLYL-SULFATE
KINASE
(Penicillium
chrysogenum) 		4 / 7 ARG A  66
ASP A  72
PHE A  75
ARG A  80
 PPS  A2002 (-4.0A)
None
PPS  A2002 (-3.5A)
PPS  A2002 (-3.3A)
 1.50A 3kivA-3cr7A:
undetectable		 3kivA-3cr7A:
15.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PHE X  81
LYS X 106
HIS X 108
PHE X 142
MET X 248
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 0.32A 4jvlA-2zyvX:
44.9		 4jvlA-2zyvX:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JVL_B_ESTB302_1
(ESTROGEN
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PHE X  81
LYS X 106
HIS X 108
PHE X 142
MET X 248
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 0.35A 4jvlB-2zyvX:
44.6		 4jvlB-2zyvX:
56.61