SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PPO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.00A 4jksA-1d6nA:
undetectable		 4jksA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.00A 4jksB-1d6nA:
undetectable		 4jksB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.00A 4jkuA-1d6nA:
undetectable		 4jkuA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.99A 4k8cA-1d6nA:
undetectable		 4k8cA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.98A 4k8cB-1d6nA:
undetectable		 4k8cB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.00A 4k8kA-1d6nA:
undetectable		 4k8kA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.01A 4k8kB-1d6nA:
undetectable		 4k8kB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.00A 4kahA-1d6nA:
undetectable		 4kahA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.98A 4kahB-1d6nA:
undetectable		 4kahB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.99A 4kalA-1d6nA:
undetectable		 4kalA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.98A 4kalB-1d6nA:
undetectable		 4kalB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.01A 4kanA-1d6nA:
undetectable		 4kanA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.00A 4kanB-1d6nA:
undetectable		 4kanB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.98A 4kbeA-1d6nA:
undetectable		 4kbeA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.99A 4kbeB-1d6nA:
undetectable		 4kbeB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.99A 4lbgA-1d6nA:
undetectable		 4lbgA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 1.00A 4lbgB-1d6nA:
undetectable		 4lbgB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.99A 4lcaA-1d6nA:
undetectable		 4lcaA-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		5 / 12 ASP A 134
GLY A  70
GLY A  69
ILE A 135
GLU A 196
 PRP  A 312 ( 2.9A)
PRP  A 312 (-3.1A)
PRP  A 312 (-4.3A)
PPO  A 300 ( 4.5A)
None
 0.98A 4lcaB-1d6nA:
undetectable		 4lcaB-1d6nA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Homo
sapiens) 		4 / 4 ASP A 193
GLY A  70
ASP A 134
ASP A 137
 None
PRP  A 312 (-3.1A)
PRP  A 312 ( 2.9A)
PPO  A 300 ( 3.9A)
 1.13A 5e72A-1d6nA:
undetectable		 5e72A-1d6nA:
23.15