SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PPK'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1P7L_C_SAMC685_0 (S-ADENOSYLMETHIONINESYNTHETASE) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 7 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.26A | 1p7lC-5a1iA:57.1 | 1p7lC-5a1iA:54.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1P7L_C_SAMC885_1 (S-ADENOSYLMETHIONINESYNTHETASE) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 7 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.26A | 1p7lD-5a1iA:57.2 | 1p7lD-5a1iA:54.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1RG9_A_SAMA385_0 (S-ADENOSYLMETHIONINESYNTHETASE) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 7 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.29A | 1rg9A-5a1iA:57.2 | 1rg9A-5a1iA:54.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1RG9_B_SAMB485_1 (S-ADENOSYLMETHIONINESYNTHETASE) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 7 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.29A | 1rg9B-5a1iA:57.2 | 1rg9B-5a1iA:54.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1RG9_C_SAMC585_0 (S-ADENOSYLMETHIONINESYNTHETASE) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 7 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.31A | 1rg9C-5a1iA:57.1 | 1rg9C-5a1iA:54.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1RG9_C_SAMC685_1 (S-ADENOSYLMETHIONINESYNTHETASE) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 7 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.30A | 1rg9D-5a1iA:57.2 | 1rg9D-5a1iA:54.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2OBV_A_SAMA501_0 (S-ADENOSYLMETHIONINESYNTHETASE ISOFORMTYPE-1) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 8 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.20A | 2obvA-5a1iA:64.9 | 2obvA-5a1iA:85.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2P02_A_SAMA2_0 (S-ADENOSYLMETHIONINESYNTHETASE ISOFORMTYPE-2) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 8 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.11A | 2p02A-5a1iA:66.8 | 2p02A-5a1iA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4K0B_B_SAMB504_1 (S-ADENOSYLMETHIONINESYNTHASE) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 5 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A) K A 403 ( 3.0A) | 0.32A | 4k0bB-5a1iA:27.0 | 4k0bB-5a1iA:24.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4KTT_A_SAMA405_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 8 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.28A | 4kttA-5a1iA:56.3 | 4kttA-5a1iA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4KTT_C_SAMC404_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 8 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.23A | 4kttC-5a1iA:56.1 | 4kttC-5a1iA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4KTV_A_ADNA403_1 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 8 / 12 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.66A | 4ktvA-5a1iA:55.94ktvB-5a1iA:61.7 | 4ktvA-5a1iA:100.004ktvB-5a1iA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4KTV_C_ADNC403_1 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 7 / 11 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.46A | 4ktvC-5a1iA:55.64ktvD-5a1iA:62.0 | 4ktvC-5a1iA:100.004ktvD-5a1iA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L7I_B_SAMB501_1 (S-ADENOSYLMETHIONINESYNTHASE) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 5 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A) K A 403 ( 3.0A) | 0.33A | 4l7iB-5a1iA:26.4 | 4l7iB-5a1iA:24.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4NDN_A_SAMA407_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 8 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.21A | 4ndnA-5a1iA:56.7 | 4ndnA-5a1iA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4NDN_C_SAMC405_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 7 / 7 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.17A | 4ndnC-5a1iA:56.6 | 4ndnC-5a1iA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ODJ_A_SAMA500_0 (S-ADENOSYLMETHIONINESYNTHASE) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 7 / 7 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.25A | 4odjA-5a1iA:60.2 | 4odjA-5a1iA:56.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5A1I_A_SAMA405_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 7 / 7 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.01A | 5a1iA-5a1iA:68.5 | 5a1iA-5a1iA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5T8S_B_SAMB402_1 (S-ADENOSYLMETHIONINESYNTHASE) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 7 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.19A | 5t8sB-5a1iA:54.9 | 5t8sB-5a1iA:56.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6FBN_B_SAMB401_1 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 8 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.23A | 6fbnB-5a1iA:54.6 | 6fbnB-5a1iA:99.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6FBO_A_ADNA406_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 8 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.09A | 6fboA-5a1iA:66.2 | 6fboA-5a1iA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6FBP_B_ADNB404_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 8 / 12 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.19A | 6fbpA-5a1iA:63.46fbpB-5a1iA:56.7 | 6fbpA-5a1iA:100.006fbpB-5a1iA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6FCB_A_SAMA405_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 8 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.26A | 6fcbA-5a1iA:64.1 | 6fcbA-5a1iA:99.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6FCD_A_ADNA405_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 8 / 8 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 206SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 ( 3.9A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.07A | 6fcdA-5a1iA:65.7 | 6fcdA-5a1iA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6G6R_A_SAMA406_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) |
5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homosapiens) | 7 / 7 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.04A | 6g6rA-5a1iA:66.9 | 6g6rA-5a1iA:100.00 |