SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PPI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 10 GLY A  27
SER A  94
PHE A 181
TRP A  28
HIS A 253
 PPI  A 278 ( 3.7A)
PPI  A 278 ( 2.7A)
None
None
PPI  A 278 ( 4.0A)
 1.25A 1a8uA-1a8sA:
42.1		 1a8uA-1a8sA:
45.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A 443
LEU A 504
LEU A 478
LEU A 549
 PPI  A 808 (-4.0A)
None
None
None
 0.69A 1errA-5gsmA:
undetectable		 1errA-5gsmA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 1tu9 HYPOTHETICAL PROTEIN
PA3967
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  51
ALA A  53
LEU A  58
MET A 119
CYH A  15
 PPI  A 302 ( 4.3A)
None
HEM  A 301 (-4.5A)
None
None
 1.25A 2aa6A-1tu9A:
undetectable		 2aa6A-1tu9A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 8 TYR A 298
TYR A 297
TYR A  51
HIS A  77
 None
LAC  A 399 ( 4.1A)
PPI  A 453 ( 4.7A)
None
 1.30A 2ha2A-3kb6A:
undetectable		 2ha2A-3kb6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 8 TYR A 298
TYR A 297
TYR A  51
HIS A  77
 None
LAC  A 399 ( 4.1A)
PPI  A 453 ( 4.7A)
None
 1.38A 2ha2B-3kb6A:
undetectable		 2ha2B-3kb6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		4 / 7 PHE A 292
THR A 420
ILE A 502
GLY A 444
 PPI  A 601 (-3.2A)
None
None
PPI  A 601 ( 3.9A)
 0.91A 2v0mB-4z7eA:
undetectable		 2v0mB-4z7eA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 12 ALA A 576
LEU A 640
GLN A 644
LEU A 533
PHE A 621
 PPI  A 809 (-3.2A)
None
None
None
None
 1.19A 3datA-5gsmA:
undetectable		 3datA-5gsmA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 TYR A 507
ASN A 451
LEU A 464
ASP A 463
 None
None
PPI  A 808 ( 4.7A)
None
 1.40A 3lslG-5gsmA:
undetectable		 3lslG-5gsmA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 1tu9 HYPOTHETICAL PROTEIN
PA3967
(Pseudomonas
aeruginosa) 		5 / 9 PHE A  24
TYR A  25
ALA A  53
LEU A  96
ALA A  99
 PPI  A 302 (-4.8A)
PPI  A 302 ( 4.4A)
None
None
None
 0.65A 3ozvB-1tu9A:
14.0		 3ozvB-1tu9A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A 616
LEU A 619
ILE A 597
VAL A 574
VAL A 588
 None
None
PPI  A 809 ( 4.2A)
None
None
 1.44A 3r9cA-5gsmA:
undetectable		 3r9cA-5gsmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		4 / 5 ALA A 112
GLU A  54
GLU A  26
ALA A  29
 PPI  A 303 ( 3.7A)
FE  A 301 (-2.5A)
FE  A 302 ( 2.1A)
PPI  A 303 ( 3.7A)
 1.30A 3r9tC-5ux2A:
undetectable		 3r9tC-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 12 VAL A 227
HIS A 253
ASP A 224
GLY A  27
SER A  94
 None
PPI  A 278 ( 4.0A)
None
PPI  A 278 ( 3.7A)
PPI  A 278 ( 2.7A)
 0.99A 3sufB-1a8sA:
undetectable		 3sufB-1a8sA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 12 GLY A  96
GLY A  27
LEU A  30
ALA A 101
LEU A 117
 None
PPI  A 278 ( 3.7A)
None
None
None
 1.22A 3vywD-1a8sA:
undetectable		 3vywD-1a8sA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 6 HIS A 253
SER A  94
GLU A  99
ASP A  70
 PPI  A 278 ( 4.0A)
PPI  A 278 ( 2.7A)
None
None
 1.39A 4blvA-1a8sA:
2.1		 4blvA-1a8sA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 LEU A 265
ASP A  52
PHE A  49
SER A  72
THR A   6
 None
None
PPI  A 398 (-4.0A)
LAC  A 399 (-4.3A)
None
 1.12A 4eckB-3kb6A:
2.3		 4eckB-3kb6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 12 GLY A  96
GLY A  27
ILE A 118
SER A 119
ALA A 120
 None
PPI  A 278 ( 3.7A)
None
None
None
 0.94A 4qtuD-1a8sA:
2.7		 4qtuD-1a8sA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.11A 4w5qA-3kb6A:
3.2		 4w5qA-3kb6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.12A 4w5tA-3kb6A:
3.1		 4w5tA-3kb6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 12 PHE A 205
PHE A 200
GLY A 134
LEU A 135
VAL A 139
 None
PPI  A 278 (-3.6A)
None
None
None
 1.12A 4wnwA-1a8sA:
0.0		 4wnwA-1a8sA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 12 PHE A 205
PHE A 200
GLY A 134
LEU A 135
VAL A 139
 None
PPI  A 278 (-3.6A)
None
None
None
 1.09A 4wnwB-1a8sA:
0.0		 4wnwB-1a8sA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.12A 4z4cA-3kb6A:
3.1		 4z4cA-3kb6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.12A 4z4fA-3kb6A:
3.1		 4z4fA-3kb6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 5 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.10A 4z4gA-3kb6A:
3.0		 4z4gA-3kb6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 5 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.07A 4z4hA-3kb6A:
3.1		 4z4hA-3kb6A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 ASP A  76
ALA A 230
THR A 208
TYR A 204
 PPI  A 453 (-3.9A)
NAD  A 400 (-4.6A)
NAD  A 400 (-4.7A)
None
 1.07A 4z4iA-3kb6A:
3.2		 4z4iA-3kb6A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 5 PHE A 200
ARG A 144
ILE A 143
ILE A 197
 PPI  A 278 (-3.6A)
None
None
None
 1.01A 5dzk4-1a8sA:
undetectable
5dzkg-1a8sA:
1.0
5dzkm-1a8sA:
0.2
5dzkn-1a8sA:
0.5		 5dzk4-1a8sA:
0.75
5dzkg-1a8sA:
24.57
5dzkm-1a8sA:
22.89
5dzkn-1a8sA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 6 GLY A  96
THR A  95
SER A  25
HIS A  57
 None
PPI  A 278 (-3.7A)
None
None
 1.07A 5ewuA-1a8sA:
1.1		 5ewuA-1a8sA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 TYR A  51
ASP A 255
HIS A 294
TYR A  96
 PPI  A 453 ( 4.7A)
NAD  A 400 (-4.1A)
LAC  A 399 (-3.9A)
LAC  A 399 ( 4.6A)
 1.09A 5ih0A-3kb6A:
undetectable		 5ih0A-3kb6A:
25.26