SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PPG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1c7o CYSTALYSIN
(Treponema
denticola) 		3 / 3 GLU A 343
ASP A 355
TYR A 124
 None
PPG  A1500 ( 4.0A)
None
 0.69A 2yvlB-1c7oA:
3.5		 2yvlB-1c7oA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1c7o CYSTALYSIN
(Treponema
denticola) 		3 / 3 ASN A 132
PHE A 127
TYR A 123
 None
None
PPG  A1500 (-3.6A)
 0.87A 4u15A-1c7oA:
0.0		 4u15A-1c7oA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1c7o CYSTALYSIN
(Treponema
denticola) 		5 / 12 ASP A 203
LEU A  17
ASP A  40
SER A 248
PRO A 100
 PPG  A1500 (-3.0A)
PPG  A1500 (-3.5A)
None
PPG  A1500 ( 3.9A)
None
 1.38A 5hnzB-1c7oA:
3.1		 5hnzB-1c7oA:
21.01