SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PPE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		4 / 4 SER A 111
GLY A 268
HIS A 189
ASP A 199
 None
None
PPE  A 411 ( 4.6A)
None
 1.29A 2oxtC-1akcA:
2.5		 2oxtC-1akcA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 TYR A 187
TYR A 299
ILE A 272
SER A 295
 PPE  A 413 (-4.4A)
None
None
None
 1.11A 2xz5B-1geyA:
0.0
2xz5E-1geyA:
0.0		 2xz5B-1geyA:
20.00
2xz5E-1geyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 ILE A 272
SER A 295
TYR A 187
TYR A 299
 None
None
PPE  A 413 (-4.4A)
None
 1.09A 2xz5D-1geyA:
0.0
2xz5E-1geyA:
0.0		 2xz5D-1geyA:
20.00
2xz5E-1geyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 ALA A  84
TYR A 113
GLY A  87
ILE A  88
 PPE  A 413 (-3.7A)
None
None
None
 0.88A 2zm9A-1geyA:
0.0		 2zm9A-1geyA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 PRO A 328
LEU A 330
ARG A 335
 None
None
PPE  A 413 (-3.3A)
 0.84A 3aqiA-1geyA:
undetectable		 3aqiA-1geyA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		5 / 12 ARG A 386
GLY A  36
LEU A 337
SER A 332
ALA A 390
 PPE  A 411 ( 2.7A)
None
None
None
None
 1.08A 3kkzB-1akcA:
2.9		 3kkzB-1akcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		4 / 4 GLY A  38
GLY A  36
THR A  21
LEU A  18
 PPE  A 411 ( 3.8A)
None
None
None
 0.89A 3si7C-1akcA:
1.1
3si7D-1akcA:
1.0		 3si7C-1akcA:
22.93
3si7D-1akcA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A  79
GLU A  86
GLY A  83
CYH A 223
ALA A  84
 None
None
PPE  A 413 (-3.4A)
None
PPE  A 413 (-3.7A)
 1.25A 4pclB-1geyA:
3.6		 4pclB-1geyA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 ALA A 186
THR A 226
GLY A 224
GLY A  83
ALA A  84
 PPE  A 413 (-3.6A)
None
PPE  A 413 ( 4.9A)
PPE  A 413 (-3.4A)
PPE  A 413 (-3.7A)
 0.96A 4qvpK-1geyA:
undetectable
4qvpL-1geyA:
undetectable		 4qvpK-1geyA:
19.50
4qvpL-1geyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 ALA A 186
THR A 226
GLY A 224
GLY A  83
ALA A  84
 PPE  A 413 (-3.6A)
None
PPE  A 413 ( 4.9A)
PPE  A 413 (-3.4A)
PPE  A 413 (-3.7A)
 0.96A 4qvpY-1geyA:
undetectable
4qvpZ-1geyA:
undetectable		 4qvpY-1geyA:
19.50
4qvpZ-1geyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 ALA A  36
ARG A  82
GLY A  83
GLU A  86
 PPE  A 413 (-3.7A)
None
PPE  A 413 (-3.4A)
None
 0.78A 5bs8A-1geyA:
1.3
5bs8C-1geyA:
1.3
5bs8D-1geyA:
1.0		 5bs8A-1geyA:
24.36
5bs8C-1geyA:
24.36
5bs8D-1geyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 ALA A  36
ARG A  82
GLY A  83
GLU A  86
 PPE  A 413 (-3.7A)
None
PPE  A 413 (-3.4A)
None
 0.90A 5btgA-1geyA:
1.3
5btgC-1geyA:
1.3
5btgD-1geyA:
undetectable		 5btgA-1geyA:
24.36
5btgC-1geyA:
24.36
5btgD-1geyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 VAL A 249
SER A 213
MET A 265
 None
PPE  A 413 (-2.8A)
None
 0.77A 5ikqA-1geyA:
0.0		 5ikqA-1geyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		5 / 12 LEU A 400
PHE A 360
GLY A  36
TYR A 263
HIS A 258
 None
None
None
None
PPE  A 411 (-4.9A)
 1.26A 5y2tA-1akcA:
undetectable		 5y2tA-1akcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		3 / 3 SER A 253
SER A 111
ALA A 257
 None
None
PPE  A 411 ( 3.8A)
 0.68A 6dwnC-1akcA:
0.0		 6dwnC-1akcA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		5 / 8 GLY A 261
VAL A 323
GLY A 268
SER A 255
ALA A 224
 None
None
None
PPE  A 411 ( 3.0A)
PPE  A 411 ( 3.6A)
 1.25A 6hu9H-1akcA:
0.0
6hu9e-1akcA:
0.4		 6hu9H-1akcA:
11.84
6hu9e-1akcA:
15.56