SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PP6'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		4 / 8 THR A 131
ASN A 130
ASP A  77
GLY A 123
 None
None
PP6  A 327 (-3.5A)
None
 0.98A 1bu5B-2wedA:
undetectable		 1bu5B-2wedA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		4 / 4 GLY A 292
ASP A 222
GLY A 210
THR A 216
 None
None
None
PP6  A 327 (-3.6A)
 0.96A 1hxbB-2wedA:
7.8		 1hxbB-2wedA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		5 / 9 LEU A 157
ASP A 300
ILE A 211
GLY A  35
VAL A 155
 None
None
None
PP6  A 327 (-4.0A)
None
 0.99A 2avoA-2wedA:
7.4		 2avoA-2wedA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		6 / 12 ASP A  33
GLY A  35
SER A  36
TYR A  75
ASP A 213
GLY A 215
 PP6  A 327 ( 2.7A)
PP6  A 327 (-4.0A)
PP6  A 327 ( 4.0A)
PP6  A 327 (-3.8A)
PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
 0.38A 2v0zC-2wedA:
38.3		 2v0zC-2wedA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		5 / 12 ASP A 213
GLY A 215
PHE A 295
LEU A 121
ASP A  33
 PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
None
None
PP6  A 327 ( 2.7A)
 1.20A 3d91A-2wedA:
38.2		 3d91A-2wedA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		4 / 4 GLY A 292
ASP A 222
GLY A 210
THR A 216
 None
None
None
PP6  A 327 (-3.6A)
 0.94A 3k4vC-2wedA:
7.9		 3k4vC-2wedA:
14.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		6 / 10 ILE A  73
TYR A  75
LEU A 121
THR A 131
ILE A 211
ILE A 293
 None
PP6  A 327 (-3.8A)
None
None
None
None
 0.88A 3prsA-2wedA:
47.9		 3prsA-2wedA:
54.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		6 / 10 ILE A  73
TYR A  75
LEU A 121
THR A 131
ILE A 211
THR A 217
 None
PP6  A 327 (-3.8A)
None
None
None
PP6  A 327 (-4.5A)
 0.40A 3prsA-2wedA:
47.9		 3prsA-2wedA:
54.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		5 / 12 ASP A  14
ASP A  33
GLY A  35
PHE A 190
ASP A 213
 None
PP6  A 327 ( 2.7A)
PP6  A 327 (-4.0A)
PP6  A 327 ( 4.8A)
PP6  A 327 ( 2.5A)
 1.14A 3prsA-2wedA:
47.9		 3prsA-2wedA:
54.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		8 / 12 ASP A  33
GLY A  35
GLY A  76
ASP A  77
ASP A 115
PHE A 190
ASP A 213
THR A 216
 PP6  A 327 ( 2.7A)
PP6  A 327 (-4.0A)
PP6  A 327 (-3.5A)
PP6  A 327 (-3.5A)
None
PP6  A 327 ( 4.8A)
PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
 0.42A 3prsA-2wedA:
47.9		 3prsA-2wedA:
54.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		8 / 12 ASP A  33
GLY A  35
GLY A  76
ASP A 115
PHE A 190
ASP A 213
THR A 216
ILE A 297
 PP6  A 327 ( 2.7A)
PP6  A 327 (-4.0A)
PP6  A 327 (-3.5A)
None
PP6  A 327 ( 4.8A)
PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
PP6  A 327 (-4.2A)
 0.47A 3prsA-2wedA:
47.9		 3prsA-2wedA:
54.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		8 / 12 ASP A  33
GLY A  76
PHE A 112
LEU A 121
PHE A 190
ILE A 211
THR A 216
ILE A 297
 PP6  A 327 ( 2.7A)
PP6  A 327 (-3.5A)
PP6  A 327 ( 4.9A)
None
PP6  A 327 ( 4.8A)
None
PP6  A 327 (-3.6A)
PP6  A 327 (-4.2A)
 0.37A 3pwwA-2wedA:
48.0		 3pwwA-2wedA:
54.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		8 / 8 GLY A  35
SER A  36
ILE A  73
TYR A  75
ASP A  77
SER A  79
ASP A 213
THR A 217
 PP6  A 327 (-4.0A)
PP6  A 327 ( 4.0A)
None
PP6  A 327 (-3.8A)
PP6  A 327 (-3.5A)
PP6  A 327 (-3.4A)
PP6  A 327 ( 2.5A)
PP6  A 327 (-4.5A)
 0.29A 3pwwA-2wedA:
48.0		 3pwwA-2wedA:
54.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		6 / 12 ASP A  33
GLY A  35
GLY A  76
ASP A 213
THR A 216
ILE A 297
 PP6  A 327 ( 2.7A)
PP6  A 327 (-4.0A)
PP6  A 327 (-3.5A)
PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
PP6  A 327 (-4.2A)
 0.39A 3q70A-2wedA:
10.6		 3q70A-2wedA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		5 / 12 ILE A 211
ASP A 213
GLY A 215
GLY A  76
ASP A  33
 None
PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
PP6  A 327 (-3.5A)
PP6  A 327 ( 2.7A)
 0.64A 3q70A-2wedA:
10.6		 3q70A-2wedA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		5 / 12 ILE A 211
ASP A 213
GLY A 215
ILE A 293
ASP A  33
 None
PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
None
PP6  A 327 ( 2.7A)
 0.65A 3q70A-2wedA:
10.6		 3q70A-2wedA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		4 / 6 SER A  36
ILE A  73
TYR A  75
ASP A 115
 PP6  A 327 ( 4.0A)
None
PP6  A 327 (-3.8A)
None
 0.88A 3q70A-2wedA:
10.6		 3q70A-2wedA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		4 / 6 SER A  36
ILE A  73
TYR A  75
THR A 217
 PP6  A 327 ( 4.0A)
None
PP6  A 327 (-3.8A)
PP6  A 327 (-4.5A)
 0.23A 3q70A-2wedA:
10.6		 3q70A-2wedA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		8 / 12 ASP A  33
GLY A  35
ILE A  73
GLY A  76
ASP A  77
SER A  79
ASP A 213
ILE A 297
 PP6  A 327 ( 2.7A)
PP6  A 327 (-4.0A)
None
PP6  A 327 (-3.5A)
PP6  A 327 (-3.5A)
PP6  A 327 (-3.4A)
PP6  A 327 ( 2.5A)
PP6  A 327 (-4.2A)
 0.47A 3tneA-2wedA:
35.7		 3tneA-2wedA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		7 / 12 ASP A  33
GLY A  35
ILE A  73
GLY A  76
ASP A 115
ASP A 213
ILE A 297
 PP6  A 327 ( 2.7A)
PP6  A 327 (-4.0A)
None
PP6  A 327 (-3.5A)
None
PP6  A 327 ( 2.5A)
PP6  A 327 (-4.2A)
 0.90A 3tneA-2wedA:
35.7		 3tneA-2wedA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		5 / 12 ILE A 211
ASP A 213
GLY A 215
GLY A  76
ASP A  33
 None
PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
PP6  A 327 (-3.5A)
PP6  A 327 ( 2.7A)
 0.81A 3tneA-2wedA:
35.7		 3tneA-2wedA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		4 / 6 SER A  36
TYR A  75
THR A 216
THR A 217
 PP6  A 327 ( 4.0A)
PP6  A 327 (-3.8A)
PP6  A 327 (-3.6A)
PP6  A 327 (-4.5A)
 0.25A 3tneA-2wedA:
35.7		 3tneA-2wedA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		8 / 12 ASP A  33
GLY A  35
ILE A  73
GLY A  76
ASP A  77
SER A  79
ASP A 213
ILE A 297
 PP6  A 327 ( 2.7A)
PP6  A 327 (-4.0A)
None
PP6  A 327 (-3.5A)
PP6  A 327 (-3.5A)
PP6  A 327 (-3.4A)
PP6  A 327 ( 2.5A)
PP6  A 327 (-4.2A)
 0.51A 3tneB-2wedA:
35.8		 3tneB-2wedA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		8 / 12 ASP A  33
GLY A  35
ILE A  73
GLY A  76
SER A  79
ASP A 115
ASP A 213
ILE A 297
 PP6  A 327 ( 2.7A)
PP6  A 327 (-4.0A)
None
PP6  A 327 (-3.5A)
PP6  A 327 (-3.4A)
None
PP6  A 327 ( 2.5A)
PP6  A 327 (-4.2A)
 0.90A 3tneB-2wedA:
35.8		 3tneB-2wedA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		5 / 12 ILE A 211
ASP A 213
GLY A 215
GLY A  76
ASP A  33
 None
PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
PP6  A 327 (-3.5A)
PP6  A 327 ( 2.7A)
 0.77A 3tneB-2wedA:
35.8		 3tneB-2wedA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		4 / 7 SER A  36
TYR A  75
THR A 216
THR A 217
 PP6  A 327 ( 4.0A)
PP6  A 327 (-3.8A)
PP6  A 327 (-3.6A)
PP6  A 327 (-4.5A)
 0.30A 3tneB-2wedA:
35.8		 3tneB-2wedA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		5 / 12 SER A  79
ALA A  37
ASP A  33
ILE A 297
GLY A  78
 PP6  A 327 (-3.4A)
None
PP6  A 327 ( 2.7A)
PP6  A 327 (-4.2A)
None
 1.44A 4iilA-2wedA:
undetectable		 4iilA-2wedA:
23.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y4J_A_LNRA412_1
(ENDOTHIAPEPSIN)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		7 / 9 ASP A  33
TYR A  75
ASP A  77
SER A  79
PHE A 112
ASP A 115
LEU A 121
 PP6  A 327 ( 2.7A)
PP6  A 327 (-3.8A)
PP6  A 327 (-3.5A)
PP6  A 327 (-3.4A)
PP6  A 327 ( 4.9A)
None
None
 0.43A 4y4jA-2wedA:
47.9		 4y4jA-2wedA:
54.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y4J_A_LNRA412_1
(ENDOTHIAPEPSIN)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		7 / 9 ASP A  33
TYR A  75
ASP A  77
SER A  79
SER A 109
PHE A 112
LEU A 121
 PP6  A 327 ( 2.7A)
PP6  A 327 (-3.8A)
PP6  A 327 (-3.5A)
PP6  A 327 (-3.4A)
None
PP6  A 327 ( 4.9A)
None
 1.42A 4y4jA-2wedA:
47.9		 4y4jA-2wedA:
54.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		4 / 6 PHE A  32
SER A  36
LEU A 121
LEU A  30
 None
PP6  A 327 ( 4.0A)
None
None
 1.33A 5dzke-2wedA:
undetectable
5dzks-2wedA:
undetectable		 5dzke-2wedA:
18.24
5dzks-2wedA:
0.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		5 / 10 ILE A 297
VAL A 184
LEU A 317
PRO A 315
LEU A 221
 PP6  A 327 (-4.2A)
None
None
None
None
 1.19A 5ienB-2wedA:
undetectable		 5ienB-2wedA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		4 / 6 PHE A 126
LEU A 124
TRP A 191
GLY A  35
 None
None
None
PP6  A 327 (-4.0A)
 0.89A 5o4yA-2wedA:
undetectable		 5o4yA-2wedA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 2wed PENICILLOPEPSIN
(Penicillium
janthinellum) 		4 / 6 PHE A 126
LEU A 124
TRP A 191
GLY A  35
 None
None
None
PP6  A 327 (-4.0A)
 1.07A 5o4yF-2wedA:
undetectable		 5o4yF-2wedA:
10.13