SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PP2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		4 / 8 LEU A 501
VAL A 544
CYH A 542
GLY A 495
 None
None
None
PP2  A   1 ( 4.2A)
 1.02A 1jlfA-3sxsA:
undetectable
1jlfB-3sxsA:
undetectable		 1jlfA-3sxsA:
18.35
1jlfB-3sxsA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 9 LEU A 423
GLY A 424
VAL A 431
ALA A 443
TYR A 491
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.70A 1muoA-3sxsA:
8.8		 1muoA-3sxsA:
24.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
THR A 489
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 (-4.6A)
 0.66A 1opjA-3sxsA:
31.0		 1opjA-3sxsA:
41.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		5 / 12 VAL A 431
ALA A 443
THR A 489
LEU A 527
HIS A 534
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.3A)
None
None
 0.47A 1uwjA-3sxsA:
26.7		 1uwjA-3sxsA:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		5 / 12 VAL A 431
ALA A 443
THR A 489
LEU A 527
HIS A 534
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.3A)
None
None
 0.47A 1uwjB-3sxsA:
8.0		 1uwjB-3sxsA:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		5 / 9 LEU A 423
VAL A 431
ALA A 443
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.38A 1xbbA-3sxsA:
33.2		 1xbbA-3sxsA:
37.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 ALA A 443
THR A 489
GLY A 495
CYH A 496
LEU A 498
ARG A 502
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
None
None
PP2  A   1 (-4.6A)
 0.81A 1xkkA-3sxsA:
24.7		 1xkkA-3sxsA:
29.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 11 GLY A 424
GLY A 426
VAL A 431
ALA A 443
TYR A 491
LEU A 543
 PP2  A   1 ( 4.1A)
PP2  A   1 ( 4.8A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.52A 2evaA-3sxsA:
27.8		 2evaA-3sxsA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 LEU A 423
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.48A 2gqgA-3sxsA:
35.0		 2gqgA-3sxsA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.42A 2gqgB-3sxsA:
35.4		 2gqgB-3sxsA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 VAL A 431
ALA A 443
MET A 464
ILE A 487
THR A 489
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 (-4.6A)
 0.76A 2hyyD-3sxsA:
32.1		 2hyyD-3sxsA:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 LEU A 423
ALA A 443
LYS A 445
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.64A 2itoA-3sxsA:
30.8		 2itoA-3sxsA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 LEU A 423
ALA A 443
MET A 464
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.75A 2itoA-3sxsA:
30.8		 2itoA-3sxsA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 LEU A 423
GLY A 424
VAL A 431
ALA A 443
MET A 464
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.73A 2ityA-3sxsA:
30.7		 2ityA-3sxsA:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 LEU A 423
VAL A 431
ALA A 443
LYS A 445
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.70A 2itzA-3sxsA:
30.6		 2itzA-3sxsA:
30.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.72A 2itzA-3sxsA:
30.6		 2itzA-3sxsA:
30.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 VAL A 431
ALA A 443
MET A 464
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.72A 2oiqA-3sxsA:
31.5		 2oiqA-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
TYR A 491
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.83A 2pl0A-3sxsA:
30.6		 2pl0A-3sxsA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 ALA A 443
LYS A 445
ILE A 487
THR A 489
TYR A 491
LEU A 543
SER A 553
 PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.78A 2y6oA-3sxsA:
31.9		 2y6oA-3sxsA:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LYS A 421
ALA A 443
MET A 464
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
SER A 553
 None
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.55A 2y6oA-3sxsA:
31.9		 2y6oA-3sxsA:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 ALA A 443
LYS A 445
VAL A 473
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.73A 2zvaA-3sxsA:
34.3		 2zvaA-3sxsA:
43.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 LEU A 423
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.53A 2zvaA-3sxsA:
34.3		 2zvaA-3sxsA:
43.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 10 LEU A 423
ALA A 443
LYS A 445
VAL A 473
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.72A 3aoxA-3sxsA:
24.9		 3aoxA-3sxsA:
33.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		5 / 10 LEU A 423
LYS A 445
VAL A 473
ILE A 487
VAL A 552
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
None
 0.90A 3cs9A-3sxsA:
25.9		 3cs9A-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		5 / 10 LEU A 423
VAL A 431
VAL A 473
ILE A 487
VAL A 552
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
None
 0.46A 3cs9A-3sxsA:
25.9		 3cs9A-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 ALA A 443
MET A 464
LEU A 472
THR A 489
GLY A 495
HIS A 534
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
PP2  A   1 (-4.6A)
 0.44A 3cs9A-3sxsA:
25.9		 3cs9A-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 ALA A 443
MET A 464
LEU A 472
THR A 489
GLY A 495
HIS A 534
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
 0.41A 3cs9B-3sxsA:
31.9		 3cs9B-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 9 LEU A 423
VAL A 431
LYS A 445
VAL A 473
ILE A 487
PHE A 532
VAL A 552
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
None
None
 0.84A 3cs9B-3sxsA:
31.9		 3cs9B-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 9 LEU A 423
VAL A 431
VAL A 473
ILE A 487
PHE A 532
LEU A 543
VAL A 552
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
None
PP2  A   1 (-4.6A)
None
 0.60A 3cs9B-3sxsA:
31.9		 3cs9B-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		5 / 12 ALA A 443
MET A 464
LEU A 472
THR A 489
HIS A 534
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
None
 0.47A 3cs9C-3sxsA:
31.8		 3cs9C-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		5 / 9 LEU A 423
LYS A 445
VAL A 473
ILE A 487
VAL A 552
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
None
 0.93A 3cs9C-3sxsA:
31.8		 3cs9C-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		5 / 9 LEU A 423
VAL A 431
VAL A 473
ILE A 487
VAL A 552
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
None
 0.50A 3cs9C-3sxsA:
31.8		 3cs9C-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 ALA A 443
MET A 464
LEU A 472
THR A 489
GLY A 495
HIS A 534
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
 0.40A 3cs9D-3sxsA:
30.9		 3cs9D-3sxsA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 LEU A 423
GLY A 424
VAL A 431
ALA A 443
VAL A 473
TYR A 491
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.46A 3fupB-3sxsA:
31.0		 3fupB-3sxsA:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 11 LEU A 423
VAL A 431
ALA A 443
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.68A 3g0eA-3sxsA:
28.5		 3g0eA-3sxsA:
34.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 11 LEU A 423
VAL A 431
ALA A 443
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.76A 3g0fA-3sxsA:
24.6		 3g0fA-3sxsA:
34.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 10 LEU A 423
VAL A 431
ALA A 443
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.66A 3g0fB-3sxsA:
29.9		 3g0fB-3sxsA:
34.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		10 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.48A 3g5dA-3sxsA:
32.7		 3g5dA-3sxsA:
43.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.53A 3g5dB-3sxsA:
32.9		 3g5dB-3sxsA:
43.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 VAL A 431
ALA A 443
LYS A 445
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.69A 3g5dB-3sxsA:
32.9		 3g5dB-3sxsA:
43.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
THR A 489
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 (-4.6A)
 0.60A 3gvuA-3sxsA:
31.8		 3gvuA-3sxsA:
40.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 ALA A 443
MET A 464
LEU A 472
VAL A 473
HIS A 534
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
None
None
PP2  A   1 (-4.6A)
 0.65A 3ik3A-3sxsA:
31.6		 3ik3A-3sxsA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 ALA A 443
MET A 464
LEU A 472
VAL A 473
HIS A 534
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
None
None
PP2  A   1 (-4.6A)
 0.68A 3ik3B-3sxsA:
31.3		 3ik3B-3sxsA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		10 / 12 LEU A 423
ALA A 443
LYS A 445
VAL A 473
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
SER A 553
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.75A 3k54A-3sxsA:
33.2		 3k54A-3sxsA:
62.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		10 / 12 LEU A 423
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
SER A 553
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.62A 3k54A-3sxsA:
33.2		 3k54A-3sxsA:
62.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 VAL A 431
ALA A 443
MET A 464
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.74A 3k5vA-3sxsA:
31.0		 3k5vA-3sxsA:
41.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 LEU A 423
GLY A 424
VAL A 431
ALA A 443
VAL A 473
TYR A 491
CYH A 496
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 ( 4.9A)
None
PP2  A   1 (-4.6A)
 0.83A 3lxkA-3sxsA:
31.5		 3lxkA-3sxsA:
31.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
THR A 489
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 (-4.6A)
 0.77A 3ms9A-3sxsA:
31.7		 3ms9A-3sxsA:
41.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.81A 3ms9B-3sxsA:
31.8		 3ms9B-3sxsA:
41.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
THR A 489
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 (-4.6A)
 0.80A 3mssA-3sxsA:
31.8		 3mssA-3sxsA:
41.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
THR A 489
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 (-4.6A)
 0.81A 3mssC-3sxsA:
31.8		 3mssC-3sxsA:
41.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 LEU A 423
ALA A 443
MET A 464
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.78A 3mssD-3sxsA:
31.8		 3mssD-3sxsA:
41.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 LEU A 423
ALA A 443
LYS A 445
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.64A 3octA-3sxsA:
34.6		 3octA-3sxsA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 LEU A 423
ALA A 443
LYS A 445
VAL A 473
THR A 489
TYR A 491
SER A 553
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-3.5A)
 0.69A 3octA-3sxsA:
34.6		 3octA-3sxsA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.64A 3octA-3sxsA:
34.6		 3octA-3sxsA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
THR A 489
TYR A 491
SER A 553
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-3.5A)
 0.75A 3octA-3sxsA:
34.6		 3octA-3sxsA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 ALA A 443
MET A 464
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.54A 3oezA-3sxsA:
31.3		 3oezA-3sxsA:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 VAL A 431
ALA A 443
MET A 464
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.69A 3oezA-3sxsA:
31.3		 3oezA-3sxsA:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 ALA A 443
LYS A 445
MET A 464
ILE A 487
THR A 489
TYR A 491
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.71A 3oezB-3sxsA:
31.8		 3oezB-3sxsA:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 VAL A 431
ALA A 443
MET A 464
ILE A 487
THR A 489
TYR A 491
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.45A 3oezB-3sxsA:
31.8		 3oezB-3sxsA:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 ALA A 443
MET A 464
LEU A 472
VAL A 473
THR A 489
GLY A 495
HIS A 534
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
 0.44A 3oxzA-3sxsA:
31.5		 3oxzA-3sxsA:
42.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
THR A 489
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 (-4.6A)
 0.66A 3pyyB-3sxsA:
31.3		 3pyyB-3sxsA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.59A 3qlgA-3sxsA:
25.5		 3qlgA-3sxsA:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.54A 3qlgB-3sxsA:
26.1		 3qlgB-3sxsA:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		12 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
TYR A 491
ILE A 492
GLY A 495
LEU A 543
SER A 553
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.1A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.38A 3sxrA-3sxsA:
42.4		 3sxrA-3sxsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		12 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
THR A 489
TYR A 491
ILE A 492
GLY A 495
LEU A 543
SER A 553
PHE A 555
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.1A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
PP2  A   1 ( 4.6A)
 0.51A 3sxrB-3sxsA:
42.3		 3sxrB-3sxsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 LEU A 423
ALA A 443
LYS A 445
VAL A 473
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.60A 3ue4A-3sxsA:
34.8		 3ue4A-3sxsA:
41.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.54A 3ue4B-3sxsA:
34.6		 3ue4B-3sxsA:
41.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		5 / 11 LEU A 423
ALA A 443
VAL A 473
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
None
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.47A 4agdA-3sxsA:
29.0		 4agdA-3sxsA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 11 LEU A 423
GLY A 424
GLY A 426
VAL A 431
ALA A 443
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 ( 4.8A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.53A 4ckiA-3sxsA:
33.6		 4ckiA-3sxsA:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 10 LEU A 423
GLY A 424
VAL A 431
ALA A 443
TYR A 491
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.39A 4ckjA-3sxsA:
33.0		 4ckjA-3sxsA:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 VAL A 431
ALA A 443
MET A 464
VAL A 473
THR A 489
TYR A 491
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.59A 4csvA-3sxsA:
32.3		 4csvA-3sxsA:
52.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 LEU A 423
VAL A 431
ALA A 443
LYS A 445
THR A 489
GLY A 495
CYH A 496
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
PP2  A   1 (-4.6A)
 0.54A 4hjoA-3sxsA:
30.7		 4hjoA-3sxsA:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
TYR A 491
GLY A 495
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
 0.73A 4mxoA-3sxsA:
32.8		 4mxoA-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 VAL A 431
ALA A 443
LYS A 445
MET A 464
VAL A 473
ILE A 487
THR A 489
TYR A 491
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
 0.89A 4mxoA-3sxsA:
32.8		 4mxoA-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
VAL A 431
ALA A 443
VAL A 473
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.64A 4mxoB-3sxsA:
32.6		 4mxoB-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
ALA A 443
LYS A 445
MET A 464
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.87A 4mxxA-3sxsA:
32.8		 4mxxA-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
ALA A 443
LYS A 445
MET A 464
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.86A 4mxxA-3sxsA:
32.8		 4mxxA-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
VAL A 431
ALA A 443
LYS A 445
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.71A 4mxxB-3sxsA:
31.8		 4mxxB-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
VAL A 431
ALA A 443
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
PHE A 555
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 ( 4.6A)
 0.65A 4mxxB-3sxsA:
31.8		 4mxxB-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 LEU A 423
VAL A 431
ALA A 443
VAL A 473
ILE A 487
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 (-3.6A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.64A 4mxyA-3sxsA:
33.2		 4mxyA-3sxsA:
42.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 LEU A 423
VAL A 431
ALA A 443
VAL A 473
ILE A 487
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 (-3.6A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.64A 4mxzA-3sxsA:
33.2		 4mxzA-3sxsA:
42.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 11 LEU A 423
GLY A 424
VAL A 431
ALA A 443
LYS A 445
ASN A 541
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-4.6A)
 0.79A 4o0sA-3sxsA:
27.1		 4o0sA-3sxsA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		4 / 6 VAL A 431
ALA A 443
LYS A 445
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-4.6A)
 0.51A 4o0uA-3sxsA:
8.8		 4o0uA-3sxsA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		5 / 6 LEU A 423
GLY A 424
VAL A 431
ALA A 443
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.6A)
 0.54A 4o0wA-3sxsA:
26.3		 4o0wA-3sxsA:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 LEU A 423
VAL A 431
LYS A 445
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.62A 4otwA-3sxsA:
29.4		 4otwA-3sxsA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 9 LEU A 423
VAL A 431
ALA A 443
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.53A 4u5jB-3sxsA:
33.6		 4u5jB-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 11 LEU A 423
ALA A 443
LYS A 445
THR A 489
GLY A 495
ASN A 541
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
 0.84A 4wa9A-3sxsA:
30.9		 4wa9A-3sxsA:
41.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 11 LEU A 423
ALA A 443
THR A 489
GLY A 495
ASN A 541
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
PP2  A   1 (-4.6A)
 0.54A 4wa9A-3sxsA:
30.9		 4wa9A-3sxsA:
41.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		10 / 12 LEU A 423
VAL A 431
ALA A 443
LYS A 445
MET A 464
VAL A 473
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.60A 4xeyA-3sxsA:
27.4		 4xeyA-3sxsA:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
VAL A 431
ALA A 443
LYS A 445
VAL A 473
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.50A 4xeyB-3sxsA:
34.0		 4xeyB-3sxsA:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.57A 4xeyB-3sxsA:
34.0		 4xeyB-3sxsA:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 LEU A 423
ALA A 443
MET A 464
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.58A 4xliA-3sxsA:
34.1		 4xliA-3sxsA:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		9 / 12 LEU A 423
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.57A 4xliB-3sxsA:
34.7		 4xliB-3sxsA:
42.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		4 / 4 GLY A 426
VAL A 431
PHE A 475
ILE A 487
 PP2  A   1 ( 4.8A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.6A)
 0.47A 4xv2B-3sxsA:
28.2		 4xv2B-3sxsA:
29.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 10 LEU A 423
VAL A 431
ALA A 443
LYS A 445
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.45A 5aacA-3sxsA:
31.3		 5aacA-3sxsA:
34.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.71A 5bvwA-3sxsA:
21.9		 5bvwA-3sxsA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 LEU A 423
VAL A 431
ALA A 443
LYS A 445
THR A 489
GLY A 495
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
 0.69A 5h2uA-3sxsA:
32.0		 5h2uA-3sxsA:
43.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 LEU A 423
VAL A 431
ALA A 443
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.57A 5h2uA-3sxsA:
32.0		 5h2uA-3sxsA:
43.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 LEU A 423
VAL A 431
ALA A 443
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.62A 5h2uB-3sxsA:
32.4		 5h2uB-3sxsA:
43.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 LEU A 423
VAL A 431
ALA A 443
LYS A 445
ILE A 487
THR A 489
GLY A 495
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
 0.82A 5h2uB-3sxsA:
32.4		 5h2uB-3sxsA:
43.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 LEU A 423
ALA A 443
LYS A 445
ILE A 487
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.6A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.65A 5h2uC-3sxsA:
32.1		 5h2uC-3sxsA:
43.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 LEU A 423
ALA A 443
LYS A 445
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.63A 5h2uC-3sxsA:
32.1		 5h2uC-3sxsA:
43.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 LEU A 423
VAL A 431
ALA A 443
ILE A 487
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.6A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.52A 5h2uD-3sxsA:
32.2		 5h2uD-3sxsA:
43.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		5 / 12 VAL A 431
ALA A 443
ILE A 487
THR A 489
TYR A 491
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
 0.45A 5hesA-3sxsA:
10.4		 5hesA-3sxsA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 VAL A 431
ALA A 443
LYS A 445
ILE A 487
THR A 489
TYR A 491
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
 0.73A 5hesB-3sxsA:
26.4		 5hesB-3sxsA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 GLY A 426
VAL A 431
ALA A 443
LYS A 445
ILE A 487
THR A 489
 PP2  A   1 ( 4.8A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
 0.63A 5hieA-3sxsA:
26.4		 5hieA-3sxsA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 GLY A 426
VAL A 431
ALA A 443
LYS A 445
ILE A 487
THR A 489
 PP2  A   1 ( 4.8A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
 0.63A 5hieB-3sxsA:
26.4		 5hieB-3sxsA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 GLY A 424
GLY A 426
VAL A 431
ALA A 443
LYS A 445
THR A 489
 PP2  A   1 ( 4.1A)
PP2  A   1 ( 4.8A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.3A)
 0.69A 5hieC-3sxsA:
26.8		 5hieC-3sxsA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 GLY A 426
VAL A 431
ALA A 443
LYS A 445
ILE A 487
THR A 489
 PP2  A   1 ( 4.8A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
 0.64A 5hieD-3sxsA:
26.6		 5hieD-3sxsA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 ALA A 443
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.39A 5i9xA-3sxsA:
31.5		 5i9xA-3sxsA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 ALA A 443
LYS A 445
THR A 489
TYR A 491
GLY A 495
LEU A 543
SER A 553
 PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.74A 5i9yA-3sxsA:
31.4		 5i9yA-3sxsA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 ALA A 443
MET A 464
THR A 489
TYR A 491
GLY A 495
LEU A 543
SER A 553
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.54A 5i9yA-3sxsA:
31.4		 5i9yA-3sxsA:
39.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 11 LEU A 423
GLY A 424
VAL A 431
ALA A 443
VAL A 473
TYR A 491
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.52A 5lvnA-3sxsA:
18.9		 5lvnA-3sxsA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 ALA A 443
MET A 464
LEU A 472
VAL A 473
HIS A 534
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
None
None
PP2  A   1 (-4.6A)
 0.61A 5mo4A-3sxsA:
8.2		 5mo4A-3sxsA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 10 LEU A 423
VAL A 431
ALA A 443
VAL A 473
TYR A 491
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.42A 5n3hA-3sxsA:
17.9		 5n3hA-3sxsA:
25.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		10 / 12 GLY A 426
VAL A 431
ALA A 443
LYS A 445
ILE A 487
THR A 489
GLY A 495
ASN A 499
LEU A 543
SER A 553
 PP2  A   1 ( 4.8A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 0.88A 5p9iA-3sxsA:
34.5		 5p9iA-3sxsA:
63.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 LEU A 433
ALA A 443
MET A 464
VAL A 473
GLY A 495
LEU A 543
 None
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.59A 5te0A-3sxsA:
13.4		 5te0A-3sxsA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		5 / 12 LEU A 423
GLY A 424
VAL A 431
ALA A 443
GLY A 495
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.2A)
 0.60A 5xv7A-3sxsA:
22.4		 5xv7A-3sxsA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 LEU A 423
GLY A 424
VAL A 431
ALA A 443
LYS A 445
CYH A 496
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-4.6A)
 0.81A 5yu9A-3sxsA:
28.9		 5yu9A-3sxsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 GLY A 424
VAL A 431
ALA A 443
LYS A 445
CYH A 496
LEU A 543
 PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-4.6A)
 0.81A 5yu9B-3sxsA:
23.6		 5yu9B-3sxsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		5 / 12 VAL A 431
ALA A 443
LYS A 445
GLY A 495
CYH A 496
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.2A)
None
 0.80A 5yu9C-3sxsA:
28.9		 5yu9C-3sxsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 VAL A 431
ALA A 443
LYS A 445
GLY A 495
CYH A 496
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.2A)
None
PP2  A   1 (-4.6A)
 0.77A 5yu9D-3sxsA:
29.4		 5yu9D-3sxsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		6 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
TYR A 491
GLY A 495
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
 0.72A 5zv2A-3sxsA:
30.5		 5zv2A-3sxsA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 VAL A 431
ALA A 443
MET A 464
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.67A 6bsdA-3sxsA:
29.3		 6bsdA-3sxsA:
16.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 VAL A 431
ALA A 443
LYS A 445
MET A 464
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.92A 6fnmA-3sxsA:
32.6		 6fnmA-3sxsA:
36.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		8 / 12 VAL A 431
ALA A 443
LYS A 445
MET A 464
THR A 489
GLY A 495
LEU A 543
SER A 553
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 1.08A 6fnmA-3sxsA:
32.6		 6fnmA-3sxsA:
36.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 VAL A 431
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 (-4.6A)
 0.68A 6hd4A-3sxsA:
25.0		 6hd4A-3sxsA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 VAL A 431
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 (-4.6A)
 0.66A 6hd4B-3sxsA:
24.9		 6hd4B-3sxsA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 VAL A 431
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 (-4.6A)
 0.66A 6hd6A-3sxsA:
31.0		 6hd6A-3sxsA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens) 		7 / 12 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
THR A 489
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 (-4.6A)
 0.76A 6hd6B-3sxsA:
25.0		 6hd6B-3sxsA:
12.73