SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PP1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 9 LEU A 730
GLY A 731
VAL A 738
ALA A 756
TYR A 806
ALA A 807
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 ( 3.5A)
PP1  A2012 (-4.6A)
 0.80A 1muoA-5fm2A:
8.5		 1muoA-5fm2A:
24.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 6 LEU A 730
LYS A 758
VAL A 778
ARG A 873
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.1A)
None
SEP  A 909 ( 3.0A)
 1.11A 1opjB-5fm2A:
30.8		 1opjB-5fm2A:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 ALA A 756
LYS A 758
GLU A 775
LEU A 779
LEU A 865
HIS A 872
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
None
None
 0.80A 1uwhB-5fm2A:
27.4		 1uwhB-5fm2A:
30.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 9 LEU A 730
VAL A 738
ALA A 756
ALA A 807
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.61A 1xbbA-5fm2A:
33.4		 1xbbA-5fm2A:
32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 10 LEU A 730
PHE A 735
ALA A 756
ILE A 788
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.0A)
PP1  A2012 (-3.2A)
None
PP1  A2012 (-4.6A)
 0.99A 1yi4A-5fm2A:
24.5		 1yi4A-5fm2A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 11 GLY A 731
VAL A 738
ALA A 756
TYR A 806
ALA A 807
SER A 811
LEU A 881
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 ( 3.5A)
PP1  A2012 ( 4.7A)
PP1  A2012 (-4.6A)
 0.48A 2evaA-5fm2A:
27.6		 2evaA-5fm2A:
27.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
ALA A 756
LYS A 758
LEU A 802
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.47A 2itoA-5fm2A:
33.4		 2itoA-5fm2A:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		11 / 12 LEU A 730
GLY A 731
VAL A 738
LYS A 758
GLU A 775
LEU A 779
LEU A 802
VAL A 804
TYR A 806
ALA A 807
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
None
PP1  A2012 (-4.5A)
None
PP1  A2012 ( 3.5A)
PP1  A2012 (-4.6A)
 0.51A 2ivuA-5fm2A:
40.3		 2ivuA-5fm2A:
87.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
GLY A 731
ALA A 756
LYS A 758
VAL A 804
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.74A 3c7qA-5fm2A:
32.2		 3c7qA-5fm2A:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 10 LEU A 730
VAL A 738
ALA A 756
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.66A 3g0fB-5fm2A:
32.0		 3g0fB-5fm2A:
42.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.63A 3g5dB-5fm2A:
33.1		 3g5dB-5fm2A:
31.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 VAL A 738
ALA A 756
GLU A 775
LEU A 779
ILE A 788
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
None
None
 1.10A 3gp0A-5fm2A:
21.3		 3gp0A-5fm2A:
24.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
ALA A 756
LYS A 758
TYR A 806
GLY A 810
LEU A 881
SER A 891
 PP1  A2012 (-4.6A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.64A 3k54A-5fm2A:
31.8		 3k54A-5fm2A:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 GLY A 731
VAL A 738
ALA A 756
ILE A 788
TYR A 806
SER A 811
LEU A 881
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
None
PP1  A2012 ( 4.7A)
PP1  A2012 (-4.6A)
 0.64A 3lxnA-5fm2A:
31.2		 3lxnA-5fm2A:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 LEU A 730
GLY A 731
VAL A 738
ALA A 756
LYS A 758
ILE A 788
TYR A 806
SER A 811
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
None
PP1  A2012 ( 4.7A)
 0.68A 3lxnA-5fm2A:
31.2		 3lxnA-5fm2A:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 9 ALA A 756
LYS A 758
GLY A 810
LEU A 881
SER A 891
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.51A 3miyB-5fm2A:
31.7		 3miyB-5fm2A:
32.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.61A 3octA-5fm2A:
31.4		 3octA-5fm2A:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 GLY A 731
VAL A 738
ALA A 756
LYS A 758
ILE A 788
LEU A 881
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.6A)
 0.83A 3ohtA-5fm2A:
16.6		 3ohtA-5fm2A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 GLY A 731
VAL A 738
ALA A 756
LYS A 758
LEU A 779
ILE A 788
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
None
 0.57A 3ohtA-5fm2A:
16.6		 3ohtA-5fm2A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 GLY A 731
VAL A 738
ALA A 756
LEU A 779
ILE A 788
GLY A 810
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
None
PTR  A 809 (-2.4A)
 0.85A 3ohtB-5fm2A:
16.5		 3ohtB-5fm2A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 GLY A 731
VAL A 738
ALA A 756
LYS A 758
LEU A 779
ILE A 788
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
None
 0.59A 3ohtB-5fm2A:
16.5		 3ohtB-5fm2A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 VAL A 738
ALA A 756
GLU A 775
LEU A 779
ILE A 788
LEU A 865
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
None
None
None
 1.01A 3rgfA-5fm2A:
7.6		 3rgfA-5fm2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 VAL A 738
ALA A 756
GLU A 775
LEU A 779
ILE A 788
TYR A 806
LEU A 865
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
None
None
None
 0.78A 3rgfA-5fm2A:
7.6		 3rgfA-5fm2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 VAL A 738
ALA A 756
LEU A 779
ILE A 788
ALA A 807
LEU A 865
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
None
PP1  A2012 ( 3.5A)
None
None
 0.68A 3rgfA-5fm2A:
7.6		 3rgfA-5fm2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 VAL A 738
ALA A 756
LEU A 779
ILE A 788
TYR A 806
ALA A 807
LEU A 865
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
None
None
PP1  A2012 ( 3.5A)
None
 0.86A 3rgfA-5fm2A:
7.6		 3rgfA-5fm2A:
22.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
TYR A 806
GLY A 810
LEU A 881
SER A 891
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.73A 3sxrB-5fm2A:
31.5		 3sxrB-5fm2A:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
GLY A 731
ALA A 756
GLU A 775
LEU A 779
VAL A 804
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
PP1  A2012 (-4.5A)
 0.99A 3wzdA-5fm2A:
32.7		 3wzdA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
GLY A 731
ALA A 756
LEU A 779
VAL A 804
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
 0.80A 3wzdA-5fm2A:
32.7		 3wzdA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
GLY A 731
ALA A 756
VAL A 804
GLY A 810
PHE A 893
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
 0.96A 3wzdA-5fm2A:
32.7		 3wzdA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
GLU A 775
LEU A 779
VAL A 804
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
PP1  A2012 (-4.5A)
 0.47A 3wzdA-5fm2A:
32.7		 3wzdA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
 0.63A 3wzdA-5fm2A:
32.7		 3wzdA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
VAL A 804
GLY A 810
PHE A 893
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
 0.85A 3wzdA-5fm2A:
32.7		 3wzdA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
LEU A 779
VAL A 804
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PP1  A2012 (-4.5A)
 0.60A 3wzeA-5fm2A:
33.1		 3wzeA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
LEU A 779
VAL A 804
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
 0.53A 3wzeA-5fm2A:
33.1		 3wzeA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
LEU A 865
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
None
 0.70A 3wzeA-5fm2A:
33.1		 3wzeA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 VAL A 738
ALA A 756
LYS A 758
LEU A 779
VAL A 804
GLY A 810
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
 0.68A 3wzeA-5fm2A:
33.1		 3wzeA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
VAL A 804
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.66A 4ag8A-5fm2A:
32.9		 4ag8A-5fm2A:
41.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
LEU A 779
VAL A 804
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PP1  A2012 (-4.5A)
 0.64A 4agcA-5fm2A:
32.4		 4agcA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
LEU A 779
VAL A 804
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
 0.65A 4agcA-5fm2A:
32.4		 4agcA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
VAL A 804
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.61A 4agcA-5fm2A:
32.4		 4agcA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 11 LEU A 730
ALA A 756
VAL A 804
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.52A 4agdA-5fm2A:
32.3		 4agdA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 LEU A 730
VAL A 738
ALA A 756
GLU A 775
LEU A 779
VAL A 804
LEU A 865
HIS A 872
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
PP1  A2012 (-4.5A)
None
None
 0.99A 4asdA-5fm2A:
32.5		 4asdA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 LEU A 730
VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
LEU A 865
HIS A 872
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
None
 0.81A 4asdA-5fm2A:
32.5		 4asdA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
LEU A 779
VAL A 804
HIS A 872
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PP1  A2012 (-4.5A)
None
 0.96A 4asdA-5fm2A:
32.5		 4asdA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
LEU A 779
VAL A 804
GLY A 810
HIS A 872
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
 0.78A 4asdA-5fm2A:
32.5		 4asdA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		10 / 10 LEU A 730
GLY A 731
GLY A 733
VAL A 738
ALA A 756
VAL A 804
TYR A 806
ALA A 807
SER A 811
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
None
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
None
PP1  A2012 ( 3.5A)
PP1  A2012 ( 4.7A)
PP1  A2012 (-4.6A)
 0.52A 4ckjA-5fm2A:
40.5		 4ckjA-5fm2A:
87.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 12 LEU A 730
GLY A 731
VAL A 738
ALA A 756
LYS A 758
LEU A 802
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.60A 4i22A-5fm2A:
28.7		 4i22A-5fm2A:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 GLY A 731
VAL A 738
ALA A 756
LYS A 758
LEU A 790
LEU A 802
LEU A 881
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
None
PP1  A2012 (-4.6A)
 0.61A 4ifgA-5fm2A:
21.4		 4ifgA-5fm2A:
23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
 0.48A 4mxoA-5fm2A:
33.3		 4mxoA-5fm2A:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.72A 4mxxB-5fm2A:
30.9		 4mxxB-5fm2A:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
GLU A 775
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.63A 4mxyB-5fm2A:
33.3		 4mxyB-5fm2A:
31.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
GLU A 775
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.63A 4mxzB-5fm2A:
33.3		 4mxzB-5fm2A:
31.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 11 LEU A 730
GLY A 731
VAL A 738
ALA A 756
LYS A 758
ASN A 879
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.6A)
 0.84A 4o0sA-5fm2A:
27.5		 4o0sA-5fm2A:
23.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 ALA A 756
GLU A 775
VAL A 804
LEU A 865
ARG A 873
 PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
PP1  A2012 (-4.5A)
None
SEP  A 909 ( 3.0A)
 1.01A 4qrcA-5fm2A:
34.7		 4qrcA-5fm2A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 ALA A 756
VAL A 804
ALA A 807
HIS A 872
LEU A 881
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
None
PP1  A2012 (-4.6A)
 0.50A 4tyjA-5fm2A:
34.6		 4tyjA-5fm2A:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		8 / 11 LEU A 730
GLY A 733
VAL A 738
ALA A 756
TYR A 806
GLY A 810
ASN A 879
LEU A 881
 PP1  A2012 (-4.6A)
None
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PTR  A 809 (-2.4A)
None
PP1  A2012 (-4.6A)
 0.62A 4u5jA-5fm2A:
34.5		 4u5jA-5fm2A:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 9 LEU A 730
VAL A 738
ALA A 756
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.52A 4u5jB-5fm2A:
33.4		 4u5jB-5fm2A:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 ALA A 756
VAL A 804
LEU A 865
HIS A 872
LEU A 881
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
None
None
PP1  A2012 (-4.6A)
 0.46A 4uxqA-5fm2A:
34.8		 4uxqA-5fm2A:
48.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 7 VAL A 738
ILE A 788
ALA A 807
ARG A 873
ILE A 890
 PP1  A2012 (-4.4A)
None
PP1  A2012 ( 3.5A)
SEP  A 909 ( 3.0A)
None
 1.24A 4uxqA-5fm2A:
34.8		 4uxqA-5fm2A:
48.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 ALA A 756
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
None
None
 0.61A 4v01A-5fm2A:
33.7		 4v01A-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 9 LEU A 730
VAL A 738
ILE A 788
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
None
None
SEP  A 909 ( 3.0A)
PP1  A2012 (-4.6A)
None
 0.94A 4v01A-5fm2A:
33.7		 4v01A-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 9 LEU A 730
VAL A 738
LYS A 758
ILE A 788
TYR A 806
ARG A 873
ILE A 890
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-4.1A)
None
None
SEP  A 909 ( 3.0A)
None
 1.08A 4v01A-5fm2A:
33.7		 4v01A-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 ALA A 756
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
None
None
 0.62A 4v01B-5fm2A:
34.1		 4v01B-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 9 LEU A 730
VAL A 738
LYS A 758
ILE A 788
TYR A 806
ARG A 873
ILE A 890
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-4.1A)
None
None
SEP  A 909 ( 3.0A)
None
 0.86A 4v01B-5fm2A:
34.1		 4v01B-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 9 LEU A 730
VAL A 738
LYS A 758
ILE A 788
TYR A 806
LEU A 881
ILE A 890
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-4.1A)
None
None
PP1  A2012 (-4.6A)
None
 0.68A 4v01B-5fm2A:
34.1		 4v01B-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 VAL A 738
ALA A 756
GLU A 775
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
None
None
 0.90A 4v04A-5fm2A:
33.7		 4v04A-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 8 ILE A 788
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 None
None
SEP  A 909 ( 3.0A)
PP1  A2012 (-4.6A)
None
 1.33A 4v04A-5fm2A:
33.7		 4v04A-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 10 LEU A 730
VAL A 738
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
None
SEP  A 909 ( 3.0A)
PP1  A2012 (-4.6A)
None
 1.17A 4v04B-5fm2A:
34.0		 4v04B-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 ALA A 756
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
None
None
 0.73A 4v04B-5fm2A:
34.0		 4v04B-5fm2A:
51.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 8 LEU A 730
ALA A 756
LEU A 881
SER A 891
 PP1  A2012 (-4.6A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.68A 4wboB-5fm2A:
23.5		 4wboB-5fm2A:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
ALA A 756
LYS A 758
LEU A 802
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.49A 4wkqA-5fm2A:
33.2		 4wkqA-5fm2A:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 ALA A 756
LYS A 758
GLU A 775
LEU A 779
LEU A 865
HIS A 872
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
None
None
 0.75A 5hi2A-5fm2A:
27.4		 5hi2A-5fm2A:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 ALA A 756
GLU A 775
ILE A 788
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.55A 5i9xA-5fm2A:
31.8		 5i9xA-5fm2A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 ALA A 756
ILE A 788
TYR A 806
GLY A 810
LEU A 881
SER A 891
 PP1  A2012 (-3.2A)
None
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.67A 5i9xA-5fm2A:
31.8		 5i9xA-5fm2A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLU A 818
LEU A 881
SER A 891
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 ( 4.7A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.76A 5i9yA-5fm2A:
25.1		 5i9yA-5fm2A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLY A 810
LEU A 881
SER A 891
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
PP1  A2012 (-3.1A)
 0.60A 5i9yA-5fm2A:
25.1		 5i9yA-5fm2A:
32.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 7 GLY A 731
GLY A 733
VAL A 738
LYS A 758
 PP1  A2012 ( 3.9A)
None
PP1  A2012 (-4.4A)
PP1  A2012 (-4.1A)
 0.47A 5izjA-5fm2A:
24.1		 5izjA-5fm2A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 7 GLY A 731
GLY A 733
VAL A 738
LYS A 758
 PP1  A2012 ( 3.9A)
None
PP1  A2012 (-4.4A)
PP1  A2012 (-4.1A)
 0.44A 5j5xA-5fm2A:
24.4		 5j5xA-5fm2A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 11 LEU A 730
GLY A 731
VAL A 738
ALA A 756
TYR A 806
ALA A 807
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 ( 3.5A)
PP1  A2012 (-4.6A)
 0.59A 5lvnA-5fm2A:
26.9		 5lvnA-5fm2A:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 GLY A 731
VAL A 738
ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLY A 810
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
 0.64A 5mafA-5fm2A:
26.3		 5mafA-5fm2A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
GLY A 731
VAL A 738
ALA A 756
LYS A 758
LEU A 802
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.6A)
 0.51A 5yu9A-5fm2A:
28.6		 5yu9A-5fm2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 GLY A 731
VAL A 738
ALA A 756
LYS A 758
LEU A 802
LEU A 881
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.6A)
 0.52A 5yu9B-5fm2A:
29.0		 5yu9B-5fm2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 VAL A 738
ALA A 756
LYS A 758
LEU A 802
GLY A 810
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
 0.55A 5yu9C-5fm2A:
28.3		 5yu9C-5fm2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
GLY A 731
ALA A 756
VAL A 804
TYR A 806
ALA A 807
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
None
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
 0.75A 5zv2A-5fm2A:
34.7		 5zv2A-5fm2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
GLU A 775
VAL A 804
TYR A 806
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
PP1  A2012 (-4.5A)
None
 0.54A 5zv2A-5fm2A:
34.7		 5zv2A-5fm2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		7 / 12 LEU A 730
VAL A 738
ALA A 756
VAL A 804
TYR A 806
ALA A 807
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
None
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
 0.58A 5zv2A-5fm2A:
34.7		 5zv2A-5fm2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
VAL A 804
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
PP1  A2012 (-4.5A)
 0.44A 5zv2B-5fm2A:
34.1		 5zv2B-5fm2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
LYS A 758
VAL A 804
ALA A 807
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
 0.56A 5zv2B-5fm2A:
34.1		 5zv2B-5fm2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		6 / 12 LEU A 730
VAL A 738
ALA A 756
VAL A 804
ALA A 807
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
 0.63A 5zv2B-5fm2A:
34.1		 5zv2B-5fm2A:
13.76