SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'POP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.82A 1a7yA-2wgrA:
undetectable		 1a7yA-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF
(Saccharomyces
cerevisiae) 		4 / 8 GLY B 475
GLY B 524
LEU B 297
ASP B 245
 POP  B 999 (-3.1A)
POP  B 999 (-2.9A)
None
None
 0.85A 1aegA-1ox4B:
undetectable		 1aegA-1ox4B:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		5 / 9 GLU A 144
PRO A 116
ALA A 117
ILE A 118
THR A 142
 None
None
None
None
POP  A 404 ( 4.3A)
 1.21A 1aj6A-3qtyA:
undetectable		 1aj6A-3qtyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 11 ILE A 187
ILE A  34
LEU A 166
PRO A 165
ILE A  40
 None
None
None
None
POP  A4001 (-4.9A)
 1.07A 1dg5A-3fiuA:
undetectable		 1dg5A-3fiuA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 HIS A 225
GLY A 227
GLY A 484
ASP A 486
HIS A 513
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.6A)
 0.80A 1ffyA-3kflA:
21.6		 1ffyA-3kflA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 HIS A 228
GLY A 227
GLY A 484
ASP A 486
HIS A 513
 POP  A 802 ( 3.8A)
ME8  A 801 (-3.4A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.6A)
 1.05A 1ffyA-3kflA:
21.6		 1ffyA-3kflA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ub6 PHOSPHATE-BINDING
PROTEIN
(Xanthomonas
citri) 		3 / 3 GLN A 148
ILE A 134
HIS A 143
 POP  A 401 ( 4.5A)
None
None
 0.71A 1fm9A-5ub6A:
undetectable		 1fm9A-5ub6A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.17A 1gtfJ-2jgrA:
undetectable
1gtfK-2jgrA:
undetectable		 1gtfJ-2jgrA:
14.23
1gtfK-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.34A 1gtfP-3rykA:
1.2
1gtfQ-3rykA:
2.3		 1gtfP-3rykA:
18.40
1gtfQ-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2jgr YEGS
(Escherichia
coli) 		5 / 11 GLY A  68
ALA A  63
ILE A  70
GLY A  13
THR A  40
 POP  A1300 (-3.1A)
None
None
None
None
 1.14A 1gtfQ-2jgrA:
undetectable
1gtfR-2jgrA:
undetectable		 1gtfQ-2jgrA:
14.23
1gtfR-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2jgr YEGS
(Escherichia
coli) 		5 / 9 GLY A  68
ALA A  63
ILE A  70
GLY A  13
THR A  40
 POP  A1300 (-3.1A)
None
None
None
None
 1.12A 1gtfR-2jgrA:
undetectable
1gtfS-2jgrA:
undetectable		 1gtfR-2jgrA:
14.23
1gtfS-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 1gtfT-3rykA:
2.2
1gtfU-3rykA:
2.2		 1gtfT-3rykA:
18.40
1gtfU-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 11 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.32A 1gtfU-3rykA:
2.2
1gtfV-3rykA:
1.2		 1gtfU-3rykA:
18.40
1gtfV-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.30A 1gtfL-3rykA:
2.2
1gtfV-3rykA:
1.2		 1gtfL-3rykA:
18.40
1gtfV-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 9 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.37A 1gtnG-3rykA:
1.3
1gtnH-3rykA:
2.3		 1gtnG-3rykA:
18.40
1gtnH-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 1gtnN-3rykA:
3.0
1gtnO-3rykA:
1.1		 1gtnN-3rykA:
18.40
1gtnO-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 9 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 1gtnS-3rykA:
2.3
1gtnT-3rykA:
3.1		 1gtnS-3rykA:
18.40
1gtnT-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 153
PRO A 151
THR A 152
 None
POP  A1170 (-4.4A)
None
 0.82A 1i3wE-2wgrA:
undetectable		 1i3wE-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.86A 1i3wE-2wgrA:
undetectable		 1i3wE-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.79A 1i3wF-2wgrA:
undetectable		 1i3wF-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 153
PRO A 151
THR A 152
 None
POP  A1170 (-4.4A)
None
 0.87A 1i3wG-2wgrA:
undetectable		 1i3wG-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.86A 1i3wG-2wgrA:
undetectable		 1i3wG-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2qor GUANYLATE KINASE
(Plasmodium
vivax) 		5 / 11 VAL A  15
GLY A  16
LEU A  20
GLY A  11
GLU A 181
 POP  A 198 (-3.8A)
POP  A 198 (-3.3A)
None
None
None
 0.90A 1iolA-2qorA:
3.3		 1iolA-2qorA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ub6 PHOSPHATE-BINDING
PROTEIN
(Xanthomonas
citri) 		3 / 3 GLN A 148
ILE A 134
HIS A 143
 POP  A 401 ( 4.5A)
None
None
 0.73A 1k74A-5ub6A:
undetectable		 1k74A-5ub6A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 153
PRO A 151
THR A 152
 None
POP  A1170 (-4.4A)
None
 0.83A 1mnvD-2wgrA:
undetectable		 1mnvD-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.76A 1mnvD-2wgrA:
undetectable		 1mnvD-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 153
PRO A 151
THR A 152
 None
POP  A1170 (-4.4A)
None
 0.83A 1ovfB-2wgrA:
undetectable		 1ovfB-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		7 / 11 HIS A 225
GLY A 227
HIS A 228
GLY A 484
ASP A 486
ILE A 487
HIS A 513
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.0A)
ME8  A 801 (-4.6A)
 0.66A 1pg2A-3kflA:
35.5		 1pg2A-3kflA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 155
GLY A 149
VAL A 190
SER A 132
ILE A  65
 POP  A1155 (-1.5A)
None
None
None
None
 1.10A 1pk9C-1ocmA:
undetectable		 1pk9C-1ocmA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.79A 1qfiA-2wgrA:
undetectable		 1qfiA-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		6 / 12 HIS A 225
GLY A 227
HIS A 228
GLY A 484
ASP A 486
HIS A 513
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.6A)
 0.83A 1qu2A-3kflA:
21.7		 1qu2A-3kflA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 HIS A 228
GLY A 227
GLY A 484
ASP A 486
HIS A 513
 POP  A 802 ( 3.8A)
ME8  A 801 (-3.4A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.6A)
 1.05A 1qu2A-3kflA:
21.7		 1qu2A-3kflA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 HIS A 225
GLY A 227
HIS A 228
ASP A 486
HIS A 513
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.6A)
 1.04A 1qu3A-3kflA:
16.0		 1qu3A-3kflA:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		8 / 11 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 DMA  A 300 (-3.7A)
None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.39A 1rqjA-3p41A:
36.5		 1rqjA-3p41A:
50.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		8 / 11 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 DMA  A 300 (-3.7A)
None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.37A 1rqjB-3p41A:
36.2		 1rqjB-3p41A:
50.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 11 SER A  79
LEU A  80
LYS A 180
THR A 181
GLN A 219
 DMA  A 300 (-3.7A)
None
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
 0.96A 1rqjB-3p41A:
36.2		 1rqjB-3p41A:
50.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 152
THR A 153
PRO A 151
 None
None
POP  A1170 (-4.4A)
 0.84A 1unjF-2wgrA:
undetectable		 1unjF-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 11 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 1utdM-3rykA:
2.2
1utdN-3rykA:
2.3		 1utdM-3rykA:
18.40
1utdN-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 1utdN-3rykA:
2.3
1utdO-3rykA:
2.2		 1utdN-3rykA:
18.40
1utdO-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_R_TRPR81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 1utdR-3rykA:
2.2
1utdS-3rykA:
2.2		 1utdR-3rykA:
18.40
1utdS-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 11 GLY A  68
ALA A  63
ILE A  70
GLY A  13
THR A  40
 POP  A1300 (-3.1A)
None
None
None
None
 1.14A 1utdS-2jgrA:
undetectable
1utdT-2jgrA:
undetectable		 1utdS-2jgrA:
14.23
1utdT-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  68
ALA A  63
ILE A  70
GLY A  13
THR A  40
 POP  A1300 (-3.1A)
None
None
None
None
 1.13A 1utdU-2jgrA:
undetectable
1utdV-2jgrA:
undetectable		 1utdU-2jgrA:
14.23
1utdV-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.94A 1v7zA-1yqeA:
2.6		 1v7zA-1yqeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.94A 1v7zB-1yqeA:
2.6		 1v7zB-1yqeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.95A 1v7zC-1yqeA:
2.6		 1v7zC-1yqeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.95A 1v7zD-1yqeA:
2.6		 1v7zD-1yqeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.96A 1v7zE-1yqeA:
2.5		 1v7zE-1yqeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.94A 1v7zF-1yqeA:
2.6		 1v7zF-1yqeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 4 GLY A  81
SER A  78
ILE A  84
HIS A  76
 None
None
None
POP  A3000 (-3.8A)
 1.14A 1yajJ-1yqeA:
2.1		 1yajJ-1yqeA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 11 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.52A 1yhlA-3p41A:
24.4		 1yhlA-3p41A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 11 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.53A 1yq7A-3p41A:
23.3		 1yq7A-3p41A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.49A 1yv5A-3p41A:
23.4		 1yv5A-3p41A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.56A 1zw5A-3p41A:
23.9		 1zw5A-3p41A:
28.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A8T_A_ADNA252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		8 / 9 HIS A  37
ARG A  63
GLY A  72
THR A 122
ILE A 178
ASN A 180
SER A 181
GLN A 184
 POP  A1307 (-4.1A)
POP  A1307 (-3.3A)
MN  A 300 (-4.6A)
None
None
None
None
None
 1.02A 2a8tA-2a8qA:
34.0		 2a8tA-2a8qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A8T_A_ADNA252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		9 / 9 HIS A  37
ARG A  63
GLY A  73
PHE A  74
THR A 122
ILE A 178
ASN A 180
SER A 181
GLN A 184
 POP  A1307 (-4.1A)
POP  A1307 (-3.3A)
POP  A1307 (-3.2A)
POP  A1307 (-4.1A)
None
None
None
None
None
 0.38A 2a8tA-2a8qA:
34.0		 2a8tA-2a8qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		8 / 8 HIS A  37
GLY A  69
PHE A  74
THR A 122
ILE A 178
ASN A 180
SER A 181
GLN A 184
 POP  A1307 (-4.1A)
None
POP  A1307 (-4.1A)
None
None
None
None
None
 0.44A 2a8tB-2a8qA:
33.3		 2a8tB-2a8qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1g67 THIAMIN PHOSPHATE
SYNTHASE
(Bacillus
subtilis) 		5 / 11 VAL A 184
ALA A 130
ILE A 108
ALA A 145
ASP A 112
 None
POP  A2003 (-3.5A)
None
None
MG  A2007 ( 2.6A)
 1.08A 2admB-1g67A:
undetectable		 2admB-1g67A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 393
GLY A 237
VAL A 384
ILE A 337
GLY A 335
 None
POP  A 526 (-3.4A)
None
None
None
 0.82A 2avvD-1gpmA:
undetectable		 2avvD-1gpmA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.53A 2e91A-3p41A:
19.5		 2e91A-3p41A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.72A 2e91B-3p41A:
18.4		 2e91B-3p41A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 9 ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
POP  A 301 ( 2.4A)
None
 0.45A 2f89F-3p41A:
24.5		 2f89F-3p41A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 11 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.54A 2f8cF-3p41A:
24.3		 2f8cF-3p41A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 11 LEU A  80
GLN A 157
LYS A 180
THR A 181
GLN A 219
 None
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
 0.96A 2f8cF-3p41A:
24.3		 2f8cF-3p41A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.51A 2f8zF-3p41A:
24.5		 2f8zF-3p41A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 10 LEU A  80
GLN A 157
LYS A 180
THR A 181
GLN A 219
 None
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
 0.96A 2f8zF-3p41A:
24.5		 2f8zF-3p41A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 12 LEU A  80
ARG A  94
GLN A 157
LYS A 180
THR A 181
GLN A 219
 None
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
 1.07A 2f94F-3p41A:
24.0		 2f94F-3p41A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 12 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.75A 2f94F-3p41A:
24.0		 2f94F-3p41A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.51A 2f9kF-3p41A:
24.1		 2f9kF-3p41A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 10 LEU A  80
GLN A 157
LYS A 180
THR A 181
GLN A 219
 None
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
 0.97A 2f9kF-3p41A:
24.1		 2f9kF-3p41A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		6 / 12 LEU A 268
GLY A  91
ILE A  61
GLY A  75
ILE A  74
VAL A  50
 None
None
None
None
POP  A 509 ( 4.6A)
None
 1.48A 2nnkB-4dwqA:
undetectable		 2nnkB-4dwqA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 9 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.47A 2o1oA-3p41A:
22.8		 2o1oA-3p41A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.63A 2o1oB-3p41A:
23.5		 2o1oB-3p41A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 393
GLY A 237
VAL A 384
ILE A 337
GLY A 335
 None
POP  A 526 (-3.4A)
None
None
None
 0.89A 2o4lB-1gpmA:
undetectable		 2o4lB-1gpmA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.71A 2q58A-3p41A:
23.1		 2q58A-3p41A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.63A 2q58B-3p41A:
23.1		 2q58B-3p41A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 393
GLY A 237
VAL A 384
ILE A 337
GLY A 335
 None
POP  A 526 (-3.4A)
None
None
None
 0.84A 2q63A-1gpmA:
undetectable		 2q63A-1gpmA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 393
GLY A 237
VAL A 384
ILE A 337
GLY A 335
 None
POP  A 526 (-3.4A)
None
None
None
 0.87A 2qakA-1gpmA:
undetectable		 2qakA-1gpmA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		5 / 12 LEU A 116
LEU A  66
ARG A 111
GLN A  13
LEU A 197
 None
None
POP  A 230 (-3.8A)
None
None
 1.29A 2qd4B-2pnyA:
undetectable		 2qd4B-2pnyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
 0.39A 2qisA-3p41A:
23.9		 2qisA-3p41A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1g67 THIAMIN PHOSPHATE
SYNTHASE
(Bacillus
subtilis) 		5 / 8 ARG A  59
ILE A 186
ASP A 203
LEU A  26
GLY A 204
 POP  A2003 ( 3.9A)
ICP  A2001 ( 3.7A)
None
None
None
 1.49A 2tsrB-1g67A:
undetectable		 2tsrB-1g67A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 12 THR A 165
ALA A 147
ALA A  38
THR A 118
GLY A 130
 None
None
None
None
POP  A1155 ( 4.9A)
 1.03A 2ve3A-1ocmA:
0.0		 2ve3A-1ocmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 12 THR A 165
ALA A 147
ALA A  38
THR A 118
GLY A 130
 None
None
None
None
POP  A1155 ( 4.9A)
 1.01A 2ve3B-1ocmA:
undetectable		 2ve3B-1ocmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1g29 MALTOSE TRANSPORT
PROTEIN MALK
(Thermococcus
litoralis) 		5 / 12 GLY 1  41
LEU 1   6
VAL 1   4
ALA 1  18
GLY 1  51
 POP  1 501 (-3.1A)
None
None
None
None
 0.97A 2vmyA-1g291:
undetectable		 2vmyA-1g291:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A  44
LEU A   9
VAL A   7
ALA A  21
GLY A  54
 POP  A1293 (-3.1A)
None
None
None
None
 1.01A 2vmyA-2d62A:
undetectable		 2vmyA-2d62A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLY A  99
HIS A 139
ILE A 144
ALA A  96
 None
POP  A3000 (-4.3A)
None
None
 0.93A 2x0pA-1yqeA:
undetectable		 2x0pA-1yqeA:
19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		7 / 11 HIS A 225
GLY A 227
HIS A 228
GLY A 484
ASP A 486
ILE A 487
HIS A 513
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.0A)
ME8  A 801 (-4.6A)
 0.52A 2x1lA-3kflA:
45.3		 2x1lA-3kflA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		7 / 12 HIS A 225
GLY A 227
HIS A 228
GLY A 484
ASP A 486
ILE A 487
HIS A 513
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.0A)
ME8  A 801 (-4.6A)
 0.50A 2x1lB-3kflA:
43.3		 2x1lB-3kflA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		7 / 11 HIS A 225
GLY A 227
HIS A 228
GLY A 484
ASP A 486
ILE A 487
HIS A 513
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
ME8  A 801 (-3.2A)
ME8  A 801 ( 2.6A)
ME8  A 801 (-4.0A)
ME8  A 801 (-4.6A)
 0.50A 2x1lC-3kflA:
43.0		 2x1lC-3kflA:
41.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5ub6 PHOSPHATE-BINDING
PROTEIN
(Xanthomonas
citri) 		4 / 7 GLY A 300
THR A 153
GLN A 104
LEU A 297
 None
POP  A 401 (-4.2A)
None
None
 1.03A 2xrhA-5ub6A:
undetectable		 2xrhA-5ub6A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		4 / 5 ARG A 111
ALA A 114
ASP A 164
GLU A 167
 POP  A 230 (-3.8A)
None
None
POP  A 230 ( 4.3A)
 1.15A 2xrzA-2pnyA:
undetectable		 2xrzA-2pnyA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 GLU A 175
ARG A 194
GLU A 253
TYR A 172
 MG  A 700 ( 3.9A)
POP  A 703 (-2.8A)
MG  A 700 ( 4.9A)
None
 0.97A 2zt7A-3lg5A:
undetectable		 2zt7A-3lg5A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2qor GUANYLATE KINASE
(Plasmodium
vivax) 		5 / 12 ILE A 131
ASN A 172
GLY A  14
GLY A  16
LEU A 136
 None
None
POP  A 198 (-3.3A)
POP  A 198 (-3.3A)
None
 1.16A 2zw9A-2qorA:
undetectable		 2zw9A-2qorA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.94A 3a6jC-1yqeA:
2.6		 3a6jC-1yqeA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		5 / 9 LEU A 112
ILE A 118
GLY A 117
SER A  86
GLU A 167
 None
None
None
POP  A 230 ( 2.7A)
POP  A 230 ( 4.3A)
 1.14A 3ai9X-2pnyA:
undetectable		 3ai9X-2pnyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2jgr YEGS
(Escherichia
coli) 		4 / 8 GLY A  66
GLU A  72
ILE A  90
ALA A 100
 POP  A1300 (-3.5A)
None
None
None
 0.95A 3aodA-2jgrA:
undetectable		 3aodA-2jgrA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 10 ALA A  45
GLY A  39
ILE A 187
ALA A  58
ILE A  34
 None
POP  A4001 (-3.3A)
None
None
None
 1.00A 3ekwA-3fiuA:
undetectable		 3ekwA-3fiuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.58A 3ez3A-3p41A:
23.8		 3ez3A-3p41A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.50A 3ez3B-3p41A:
23.3		 3ez3B-3p41A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.59A 3ez3C-3p41A:
23.8		 3ez3C-3p41A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.52A 3ez3D-3p41A:
23.5		 3ez3D-3p41A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5cux ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		4 / 8 ASP A 323
ASP A 328
TRP A 364
TYR A 270
 POP  A 802 (-2.8A)
None
None
None
 1.27A 3havA-5cuxA:
undetectable		 3havA-5cuxA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 10 ARG A  94
GLN A 157
LYS A 180
THR A 181
GLN A 219
 DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
 1.02A 3ibaA-3p41A:
24.3		 3ibaA-3p41A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 10 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.48A 3ibaA-3p41A:
24.3		 3ibaA-3p41A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 ILE A 337
SER A 341
LYS A 340
GLY A 339
LEU A 320
 None
None
POP  A 377 (-2.9A)
None
None
 1.13A 3ik6B-3orqA:
undetectable
3ik6E-3orqA:
undetectable		 3ik6B-3orqA:
21.17
3ik6E-3orqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 10 LEU A 320
ILE A 337
SER A 341
LYS A 340
GLY A 339
 None
None
None
POP  A 377 (-2.9A)
None
 1.18A 3ik6B-3orqA:
undetectable
3ik6E-3orqA:
undetectable		 3ik6B-3orqA:
21.17
3ik6E-3orqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 ILE A 337
SER A 341
LYS A 340
GLY A 339
LEU A 320
 None
None
POP  A 377 (-2.9A)
None
None
 1.19A 3iluB-3orqA:
undetectable
3iluE-3orqA:
undetectable		 3iluB-3orqA:
21.17
3iluE-3orqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.59A 3ldwA-3p41A:
23.7		 3ldwA-3p41A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.53A 3ldwB-3p41A:
23.3		 3ldwB-3p41A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.59A 3ldwC-3p41A:
23.4		 3ldwC-3p41A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.54A 3ldwD-3p41A:
23.1		 3ldwD-3p41A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		5 / 12 ASP A 112
GLU A 144
PRO A 116
ILE A 118
THR A 142
 None
None
None
None
POP  A 404 ( 4.3A)
 1.37A 3lpsA-3qtyA:
undetectable		 3lpsA-3qtyA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 11 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.52A 3n45F-3p41A:
24.1		 3n45F-3p41A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.53A 3n46F-3p41A:
24.2		 3n46F-3p41A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5cux ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		3 / 3 LYS A 237
ARG A 259
ASP A 291
 POP  A 802 (-3.1A)
PO4  A 805 (-3.7A)
None
 1.45A 3o7wA-5cuxA:
undetectable		 3o7wA-5cuxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5cux ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		3 / 3 LYS A 237
ARG A 259
ASP A 328
 POP  A 802 (-3.1A)
PO4  A 805 (-3.7A)
None
 1.35A 3o7wA-5cuxA:
undetectable		 3o7wA-5cuxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 2qor GUANYLATE KINASE
(Plasmodium
vivax) 		4 / 5 LEU A 132
ARG A 139
LEU A 154
PRO A  12
 None
POP  A 198 (-2.8A)
None
None
 1.17A 3onnA-2qorA:
undetectable		 3onnA-2qorA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		3 / 3 LYS A 402
SER A 340
GLN A 317
 POP  A 602 (-2.7A)
None
None
 1.32A 3si7A-1vkoA:
undetectable		 3si7A-1vkoA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1g29 MALTOSE TRANSPORT
PROTEIN MALK
(Thermococcus
litoralis) 		3 / 3 GLY 1  39
GLY 1  41
THR 1  43
 POP  1 501 (-3.2A)
POP  1 501 (-3.1A)
POP  1 501 ( 4.1A)
 0.44A 3si7B-1g291:
15.6		 3si7B-1g291:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 GLY A  42
GLY A  44
THR A  46
 POP  A1293 (-3.2A)
POP  A1293 (-3.1A)
POP  A1293 (-3.9A)
 0.46A 3si7B-2d62A:
15.4		 3si7B-2d62A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		4 / 6 GLU A 205
PRO A 192
TRP A 233
GLU A 203
 None
POP  A4001 (-3.7A)
None
None
 1.49A 4a7tA-3fiuA:
0.0		 4a7tA-3fiuA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		4 / 6 GLU A 205
PRO A 192
TRP A 233
GLU A 203
 None
POP  A4001 (-3.7A)
None
None
 1.49A 4a7uA-3fiuA:
0.0		 4a7uA-3fiuA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		4 / 8 ILE A 227
ASP A 220
ILE A 221
GLY A  33
 None
None
None
POP  A1240 (-3.3A)
 0.82A 4ac9C-2w0mA:
2.4		 4ac9C-2w0mA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 ASP A 114
GLU A 130
HIS A 111
HIS A 133
 POP  A 701 ( 4.8A)
None
NAD  A 601 (-4.3A)
NAD  A 601 (-4.3A)
 1.30A 4aq7A-2qjoA:
undetectable		 4aq7A-2qjoA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 SER A 401
GLN A  46
THR A  43
ARG A 350
HIS A  67
 None
None
None
None
POP  A 509 (-3.7A)
 1.45A 4c49D-4dwqA:
undetectable		 4c49D-4dwqA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 11 HIS A 364
SER A 335
GLU A 337
LEU A 416
LEU A 340
 EDO  A 811 (-4.4A)
POP  A 802 ( 4.2A)
None
EDO  A 814 ( 4.4A)
None
 1.47A 4foxC-3kflA:
undetectable		 4foxC-3kflA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 2wgr GLUTATHIONE
PEROXIDASE
(Schistosoma
mansoni) 		3 / 3 THR A 153
PRO A 151
THR A 152
 None
POP  A1170 (-4.4A)
None
 0.88A 4hivD-2wgrA:
undetectable		 4hivD-2wgrA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 VAL A 187
GLY A 154
LYS A 189
 None
None
POP  A 500 (-2.9A)
 0.62A 4k50A-2x4dA:
undetectable		 4k50A-2x4dA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 VAL A 187
GLY A 154
LYS A 189
 None
None
POP  A 500 (-2.9A)
 0.72A 4k50E-2x4dA:
undetectable		 4k50E-2x4dA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 VAL A 187
GLY A 154
LYS A 189
 None
None
POP  A 500 (-2.9A)
 0.61A 4k50I-2x4dA:
undetectable		 4k50I-2x4dA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 8 ARG A 262
PHE A 274
GLY A 423
ARG A 480
 LAD  A 601 ( 2.6A)
LAD  A 601 (-3.4A)
LAD  A 601 ( 3.7A)
POP  A 602 ( 2.4A)
 0.43A 4k87A-1e1tA:
10.8		 4k87A-1e1tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
 0.37A 4kfaA-3p41A:
23.6		 4kfaA-3p41A:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.47A 4kpdA-3p41A:
24.3		 4kpdA-3p41A:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
POP  A 301 ( 2.4A)
None
 0.51A 4kpjA-3p41A:
23.6		 4kpjA-3p41A:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.49A 4kq5A-3p41A:
23.6		 4kq5A-3p41A:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.48A 4kqsA-3p41A:
24.5		 4kqsA-3p41A:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 12 ILE A 187
ILE A  34
LEU A 166
PRO A 165
ILE A  40
 None
None
None
None
POP  A4001 (-4.9A)
 1.01A 4m2xA-3fiuA:
undetectable		 4m2xA-3fiuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 12 ILE A 187
ILE A  34
LEU A 166
PRO A 165
ILE A  40
 None
None
None
None
POP  A4001 (-4.9A)
 1.03A 4m2xC-3fiuA:
undetectable		 4m2xC-3fiuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 12 ILE A 187
ILE A  34
LEU A 166
PRO A 165
ILE A  40
 None
None
None
None
POP  A4001 (-4.9A)
 1.01A 4m2xE-3fiuA:
undetectable		 4m2xE-3fiuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Francisella
tularensis) 		5 / 12 ILE A 187
ILE A  34
LEU A 166
PRO A 165
ILE A  40
 None
None
None
None
POP  A4001 (-4.9A)
 1.04A 4m2xG-3fiuA:
undetectable		 4m2xG-3fiuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.51A 4nkeA-3p41A:
24.0		 4nkeA-3p41A:
28.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 9 LEU A  80
ARG A  94
LYS A 180
THR A 181
GLN A 219
 None
DMA  A 300 (-2.9A)
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
 0.95A 4nkfA-3p41A:
23.9		 4nkfA-3p41A:
28.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
POP  A 301 ( 2.4A)
None
 0.58A 4nkfA-3p41A:
23.9		 4nkfA-3p41A:
28.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.50A 4nuaA-3p41A:
24.0		 4nuaA-3p41A:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
POP  A 301 ( 2.4A)
None
 0.56A 4oguA-3p41A:
23.8		 4oguA-3p41A:
28.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 9 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.55A 4p0vA-3p41A:
24.3		 4p0vA-3p41A:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 11 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.55A 4p0wA-3p41A:
24.2		 4p0wA-3p41A:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5cux ACIDOCALCISOMAL
PYROPHOSPHATASE
(Trypanosoma
cruzi) 		3 / 3 PRO A 274
VAL A 313
HIS A 336
 None
None
POP  A 801 ( 4.8A)
 0.82A 4pevC-5cuxA:
undetectable		 4pevC-5cuxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
 0.39A 4q23A-3p41A:
23.6		 4q23A-3p41A:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.36A 4qvmV-1ocmA:
undetectable
4qvmb-1ocmA:
undetectable		 4qvmV-1ocmA:
19.76
4qvmb-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.36A 4qvmH-1ocmA:
undetectable
4qvmN-1ocmA:
undetectable		 4qvmH-1ocmA:
19.76
4qvmN-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.36A 4qvpV-1ocmA:
undetectable
4qvpb-1ocmA:
undetectable		 4qvpV-1ocmA:
19.76
4qvpb-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.35A 4qvpH-1ocmA:
undetectable
4qvpN-1ocmA:
undetectable		 4qvpH-1ocmA:
19.76
4qvpN-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.36A 4qvqV-1ocmA:
undetectable
4qvqb-1ocmA:
undetectable		 4qvqV-1ocmA:
19.76
4qvqb-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.36A 4qvqH-1ocmA:
undetectable
4qvqN-1ocmA:
undetectable		 4qvqH-1ocmA:
19.76
4qvqN-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 10 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.35A 4qvvV-1ocmA:
undetectable
4qvvb-1ocmA:
undetectable		 4qvvV-1ocmA:
19.76
4qvvb-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 10 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.36A 4qvvH-1ocmA:
0.0
4qvvN-1ocmA:
undetectable		 4qvvH-1ocmA:
19.76
4qvvN-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.35A 4qvwV-1ocmA:
undetectable
4qvwb-1ocmA:
undetectable		 4qvwV-1ocmA:
19.76
4qvwb-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.35A 4qvwH-1ocmA:
undetectable
4qvwN-1ocmA:
undetectable		 4qvwH-1ocmA:
19.76
4qvwN-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.33A 4qvyV-1ocmA:
0.0
4qvyb-1ocmA:
undetectable		 4qvyV-1ocmA:
19.76
4qvyb-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.34A 4qvyH-1ocmA:
0.0
4qvyN-1ocmA:
undetectable		 4qvyH-1ocmA:
19.76
4qvyN-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.35A 4qw0V-1ocmA:
undetectable
4qw0b-1ocmA:
undetectable		 4qw0V-1ocmA:
19.76
4qw0b-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.36A 4qw0H-1ocmA:
undetectable
4qw0N-1ocmA:
undetectable		 4qw0H-1ocmA:
19.76
4qw0N-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.36A 4qw1H-1ocmA:
undetectable
4qw1N-1ocmA:
undetectable		 4qw1H-1ocmA:
19.76
4qw1N-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.37A 4qw3V-1ocmA:
undetectable
4qw3b-1ocmA:
undetectable		 4qw3V-1ocmA:
19.76
4qw3b-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.37A 4qw3H-1ocmA:
undetectable
4qw3N-1ocmA:
undetectable		 4qw3H-1ocmA:
19.76
4qw3N-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 10 LEU A  80
ARG A  94
LYS A 180
THR A 181
GLN A 219
 None
DMA  A 300 (-2.9A)
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
 0.96A 4rxdA-3p41A:
23.8		 4rxdA-3p41A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.49A 4rxdA-3p41A:
23.8		 4rxdA-3p41A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		6 / 10 LEU A  80
ARG A  94
GLN A 157
LYS A 180
THR A 181
GLN A 219
 None
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
 0.93A 4rxdB-3p41A:
24.0		 4rxdB-3p41A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.48A 4rxdB-3p41A:
24.0		 4rxdB-3p41A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 10 LEU A  80
ARG A  94
LYS A 180
THR A 181
GLN A 219
 None
DMA  A 300 (-2.9A)
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
 0.95A 4rxdC-3p41A:
24.1		 4rxdC-3p41A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.48A 4rxdC-3p41A:
24.1		 4rxdC-3p41A:
27.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		8 / 8 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
MET A 153
GLN A 157
LYS A 180
 DMA  A 300 (-3.7A)
None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 ( 4.3A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
 0.63A 4umjA-3p41A:
43.4		 4umjA-3p41A:
76.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		9 / 9 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
MET A 153
GLN A 157
LYS A 180
THR A 181
 DMA  A 300 (-3.7A)
None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 ( 4.3A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.40A 4umjB-3p41A:
43.8		 4umjB-3p41A:
76.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		5 / 11 ASP A 112
GLU A 144
PRO A 116
ILE A 118
THR A 142
 None
None
None
None
POP  A 404 ( 4.3A)
 1.23A 4urnB-3qtyA:
undetectable		 4urnB-3qtyA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		5 / 11 ASP A 112
GLU A 144
PRO A 116
ILE A 118
THR A 142
 None
None
None
None
POP  A 404 ( 4.3A)
 1.26A 4urnC-3qtyA:
undetectable		 4urnC-3qtyA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE
(Francisella
tularensis) 		3 / 3 MET A  23
ASP A 107
PHE A  88
 POP  A 404 ( 3.9A)
POP  A 404 (-2.6A)
None
 1.01A 4xeyA-3qtyA:
undetectable		 4xeyA-3qtyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 7 ILE A  84
HIS A  76
GLY A  81
LYS A  79
 None
POP  A3000 (-3.8A)
None
None
 0.86A 4z69A-1yqeA:
undetectable		 4z69A-1yqeA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 9 TYR A 183
THR A 152
GLY A 130
THR A 356
LEU A 300
 None
POP  A1155 (-4.5A)
POP  A1155 ( 4.9A)
None
None
 1.33A 4ze0A-1ocmA:
undetectable		 4ze0A-1ocmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 12 LEU A  80
ARG A  94
LYS A 180
THR A 181
GLN A 219
 None
DMA  A 300 (-2.9A)
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
 0.98A 5cg5A-3p41A:
23.4		 5cg5A-3p41A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 12 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.47A 5cg5A-3p41A:
23.4		 5cg5A-3p41A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		7 / 12 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.45A 5cg6A-3p41A:
24.0		 5cg6A-3p41A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 9 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.34A 5cz7V-1ocmA:
0.0
5cz7b-1ocmA:
undetectable		 5cz7V-1ocmA:
19.76
5cz7b-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.35A 5cz7H-1ocmA:
undetectable
5cz7N-1ocmA:
undetectable		 5cz7H-1ocmA:
19.76
5cz7N-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.35A 5d0xV-1ocmA:
undetectable
5d0xb-1ocmA:
undetectable		 5d0xV-1ocmA:
19.76
5d0xb-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.36A 5d0xH-1ocmA:
undetectable
5d0xN-1ocmA:
undetectable		 5d0xH-1ocmA:
19.76
5d0xN-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		7 / 9 ASP A  99
ARG A 194
ASN A 240
SER A 244
GLU A 248
ARG A 338
TYR A 339
 MG  A 701 (-2.5A)
POP  A 703 (-2.8A)
MG  A 702 (-2.6A)
MG  A 702 ( 2.3A)
MG  A 702 ( 2.6A)
POP  A 703 (-4.0A)
POP  A 703 ( 4.4A)
 0.72A 5dz2A-3lg5A:
36.0		 5dz2A-3lg5A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_B_212B404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		7 / 9 ASP A  99
ARG A 194
ASN A 240
SER A 244
GLU A 248
ARG A 338
TYR A 339
 MG  A 701 (-2.5A)
POP  A 703 (-2.8A)
MG  A 702 (-2.6A)
MG  A 702 ( 2.3A)
MG  A 702 ( 2.6A)
POP  A 703 (-4.0A)
POP  A 703 ( 4.4A)
 0.67A 5dz2B-3lg5A:
35.9		 5dz2B-3lg5A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.36A 5eeuG-3rykA:
1.2
5eeuH-3rykA:
1.2		 5eeuG-3rykA:
18.40
5eeuH-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.35A 5eeuN-3rykA:
1.2
5eeuO-3rykA:
1.2		 5eeuN-3rykA:
18.40
5eeuO-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5eeuP-3rykA:
1.1
5eeuQ-3rykA:
1.2		 5eeuP-3rykA:
18.40
5eeuQ-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5eeuR-3rykA:
1.2
5eeuS-3rykA:
1.1		 5eeuR-3rykA:
18.40
5eeuS-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5eeuS-3rykA:
1.1
5eeuT-3rykA:
1.1		 5eeuS-3rykA:
18.40
5eeuT-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5eeuT-3rykA:
1.1
5eeuU-3rykA:
1.2		 5eeuT-3rykA:
18.40
5eeuU-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.30A 5eeuU-3rykA:
1.2
5eeuV-3rykA:
1.2		 5eeuU-3rykA:
18.40
5eeuV-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.16A 5eevA-2jgrA:
3.0
5eevB-2jgrA:
undetectable		 5eevA-2jgrA:
14.23
5eevB-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.36A 5eevG-3rykA:
1.2
5eevH-3rykA:
1.2		 5eevG-3rykA:
18.40
5eevH-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.35A 5eevN-3rykA:
1.2
5eevO-3rykA:
1.2		 5eevN-3rykA:
18.40
5eevO-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5eevP-3rykA:
1.1
5eevQ-3rykA:
1.2		 5eevP-3rykA:
18.40
5eevQ-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5eevR-3rykA:
1.2
5eevS-3rykA:
1.1		 5eevR-3rykA:
18.40
5eevS-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5eevS-3rykA:
1.1
5eevT-3rykA:
1.1		 5eevS-3rykA:
18.40
5eevT-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5eevT-3rykA:
1.1
5eevU-3rykA:
1.2		 5eevT-3rykA:
18.40
5eevU-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.30A 5eevU-3rykA:
1.2
5eevV-3rykA:
1.2		 5eevU-3rykA:
18.40
5eevV-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.15A 5eewA-2jgrA:
1.4
5eewB-2jgrA:
undetectable		 5eewA-2jgrA:
14.23
5eewB-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.36A 5eewG-3rykA:
1.2
5eewH-3rykA:
1.2		 5eewG-3rykA:
18.40
5eewH-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.35A 5eewN-3rykA:
1.2
5eewO-3rykA:
1.2		 5eewN-3rykA:
18.40
5eewO-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5eewP-3rykA:
1.1
5eewQ-3rykA:
1.1		 5eewP-3rykA:
18.40
5eewQ-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.30A 5eewR-3rykA:
1.2
5eewS-3rykA:
1.1		 5eewR-3rykA:
18.40
5eewS-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5eewS-3rykA:
1.1
5eewT-3rykA:
1.2		 5eewS-3rykA:
18.40
5eewT-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5eewT-3rykA:
1.2
5eewU-3rykA:
1.2		 5eewT-3rykA:
18.40
5eewU-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.30A 5eewU-3rykA:
1.2
5eewV-3rykA:
1.2		 5eewU-3rykA:
18.40
5eewV-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.16A 5eexA-2jgrA:
1.4
5eexB-2jgrA:
undetectable		 5eexA-2jgrA:
14.23
5eexB-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.36A 5eexG-3rykA:
1.2
5eexH-3rykA:
1.2		 5eexG-3rykA:
18.40
5eexH-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 11 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.35A 5eexI-3rykA:
1.2
5eexJ-3rykA:
1.1		 5eexI-3rykA:
18.40
5eexJ-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5eexA-3rykA:
1.1
5eexK-3rykA:
1.2		 5eexA-3rykA:
18.40
5eexK-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.34A 5eexN-3rykA:
1.2
5eexO-3rykA:
1.2		 5eexN-3rykA:
18.40
5eexO-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5eexP-3rykA:
1.1
5eexQ-3rykA:
1.1		 5eexP-3rykA:
18.40
5eexQ-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5eexR-3rykA:
1.2
5eexS-3rykA:
1.1		 5eexR-3rykA:
18.40
5eexS-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5eexS-3rykA:
1.1
5eexT-3rykA:
1.2		 5eexS-3rykA:
18.40
5eexT-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5eexT-3rykA:
1.2
5eexU-3rykA:
1.2		 5eexT-3rykA:
18.40
5eexU-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.30A 5eexU-3rykA:
1.2
5eexV-3rykA:
1.2		 5eexU-3rykA:
18.40
5eexV-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.15A 5eeyA-2jgrA:
3.0
5eeyB-2jgrA:
1.3		 5eeyA-2jgrA:
14.23
5eeyB-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.36A 5eeyG-3rykA:
1.2
5eeyH-3rykA:
1.2		 5eeyG-3rykA:
18.40
5eeyH-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 11 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.35A 5eeyI-3rykA:
1.2
5eeyJ-3rykA:
1.1		 5eeyI-3rykA:
18.40
5eeyJ-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.35A 5eeyN-3rykA:
1.2
5eeyO-3rykA:
1.1		 5eeyN-3rykA:
18.40
5eeyO-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5eeyP-3rykA:
1.1
5eeyQ-3rykA:
1.1		 5eeyP-3rykA:
18.40
5eeyQ-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5eeyR-3rykA:
1.2
5eeyS-3rykA:
1.2		 5eeyR-3rykA:
18.40
5eeyS-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5eeyS-3rykA:
1.2
5eeyT-3rykA:
1.2		 5eeyS-3rykA:
18.40
5eeyT-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5eeyT-3rykA:
1.2
5eeyU-3rykA:
1.2		 5eeyT-3rykA:
18.40
5eeyU-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.30A 5eeyU-3rykA:
1.2
5eeyV-3rykA:
1.2		 5eeyU-3rykA:
18.40
5eeyV-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.15A 5eezA-2jgrA:
undetectable
5eezB-2jgrA:
undetectable		 5eezA-2jgrA:
14.23
5eezB-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.36A 5eezG-3rykA:
1.2
5eezH-3rykA:
1.2		 5eezG-3rykA:
18.40
5eezH-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 11 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.35A 5eezI-3rykA:
1.2
5eezJ-3rykA:
1.1		 5eezI-3rykA:
18.40
5eezJ-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.34A 5eezN-3rykA:
1.2
5eezO-3rykA:
1.1		 5eezN-3rykA:
18.40
5eezO-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5eezP-3rykA:
1.1
5eezQ-3rykA:
1.2		 5eezP-3rykA:
18.40
5eezQ-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.30A 5eezR-3rykA:
1.2
5eezS-3rykA:
1.1		 5eezR-3rykA:
18.40
5eezS-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5eezS-3rykA:
1.1
5eezT-3rykA:
1.1		 5eezS-3rykA:
18.40
5eezT-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5eezT-3rykA:
1.1
5eezU-3rykA:
1.2		 5eezT-3rykA:
18.40
5eezU-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.30A 5eezU-3rykA:
1.2
5eezV-3rykA:
1.2		 5eezU-3rykA:
18.40
5eezV-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.15A 5ef0A-2jgrA:
undetectable
5ef0B-2jgrA:
1.2		 5ef0A-2jgrA:
14.23
5ef0B-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.36A 5ef0G-3rykA:
1.2
5ef0H-3rykA:
1.2		 5ef0G-3rykA:
18.40
5ef0H-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 11 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.35A 5ef0I-3rykA:
1.2
5ef0J-3rykA:
1.1		 5ef0I-3rykA:
18.40
5ef0J-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5ef0A-3rykA:
1.1
5ef0K-3rykA:
1.2		 5ef0A-3rykA:
18.40
5ef0K-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.34A 5ef0N-3rykA:
1.2
5ef0O-3rykA:
1.1		 5ef0N-3rykA:
18.40
5ef0O-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5ef0P-3rykA:
1.1
5ef0Q-3rykA:
1.2		 5ef0P-3rykA:
18.40
5ef0Q-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5ef0R-3rykA:
1.2
5ef0S-3rykA:
1.2		 5ef0R-3rykA:
18.40
5ef0S-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5ef0S-3rykA:
1.2
5ef0T-3rykA:
1.1		 5ef0S-3rykA:
18.40
5ef0T-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5ef0T-3rykA:
1.1
5ef0U-3rykA:
1.2		 5ef0T-3rykA:
18.40
5ef0U-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.30A 5ef0U-3rykA:
1.2
5ef0V-3rykA:
1.2		 5ef0U-3rykA:
18.40
5ef0V-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.15A 5ef1A-2jgrA:
1.4
5ef1B-2jgrA:
undetectable		 5ef1A-2jgrA:
14.23
5ef1B-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.36A 5ef1G-3rykA:
1.2
5ef1H-3rykA:
1.2		 5ef1G-3rykA:
18.40
5ef1H-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 11 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.35A 5ef1I-3rykA:
1.2
5ef1J-3rykA:
1.1		 5ef1I-3rykA:
18.40
5ef1J-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.35A 5ef1N-3rykA:
1.2
5ef1O-3rykA:
1.2		 5ef1N-3rykA:
18.40
5ef1O-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5ef1P-3rykA:
1.1
5ef1Q-3rykA:
1.2		 5ef1P-3rykA:
18.40
5ef1Q-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.30A 5ef1R-3rykA:
1.2
5ef1S-3rykA:
1.1		 5ef1R-3rykA:
18.40
5ef1S-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5ef1S-3rykA:
1.1
5ef1T-3rykA:
1.1		 5ef1S-3rykA:
18.40
5ef1T-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5ef1T-3rykA:
1.1
5ef1U-3rykA:
1.2		 5ef1T-3rykA:
18.40
5ef1U-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.30A 5ef1U-3rykA:
1.2
5ef1V-3rykA:
1.2		 5ef1U-3rykA:
18.40
5ef1V-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.15A 5ef2A-2jgrA:
3.0
5ef2B-2jgrA:
undetectable		 5ef2A-2jgrA:
14.23
5ef2B-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.36A 5ef2G-3rykA:
1.2
5ef2H-3rykA:
1.2		 5ef2G-3rykA:
18.40
5ef2H-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 11 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.35A 5ef2I-3rykA:
1.2
5ef2J-3rykA:
1.1		 5ef2I-3rykA:
18.40
5ef2J-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.34A 5ef2N-3rykA:
1.2
5ef2O-3rykA:
1.2		 5ef2N-3rykA:
18.40
5ef2O-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5ef2P-3rykA:
1.1
5ef2Q-3rykA:
1.2		 5ef2P-3rykA:
18.40
5ef2Q-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5ef2R-3rykA:
1.2
5ef2S-3rykA:
1.1		 5ef2R-3rykA:
18.40
5ef2S-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5ef2S-3rykA:
1.1
5ef2T-3rykA:
1.1		 5ef2S-3rykA:
18.40
5ef2T-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5ef2T-3rykA:
1.1
5ef2U-3rykA:
1.2		 5ef2T-3rykA:
18.40
5ef2U-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.30A 5ef2U-3rykA:
1.2
5ef2V-3rykA:
1.2		 5ef2U-3rykA:
18.40
5ef2V-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2jgr YEGS
(Escherichia
coli) 		5 / 10 GLY A  13
THR A  40
GLY A  68
ALA A  63
ILE A  70
 None
None
POP  A1300 (-3.1A)
None
None
 1.15A 5ef3A-2jgrA:
undetectable
5ef3B-2jgrA:
undetectable		 5ef3A-2jgrA:
14.23
5ef3B-2jgrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.36A 5ef3G-3rykA:
1.2
5ef3H-3rykA:
1.2		 5ef3G-3rykA:
18.40
5ef3H-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 11 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.35A 5ef3I-3rykA:
1.2
5ef3J-3rykA:
1.1		 5ef3I-3rykA:
18.40
5ef3J-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5ef3A-3rykA:
1.1
5ef3K-3rykA:
1.2		 5ef3A-3rykA:
18.40
5ef3K-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.34A 5ef3N-3rykA:
1.2
5ef3O-3rykA:
1.2		 5ef3N-3rykA:
18.40
5ef3O-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5ef3P-3rykA:
1.2
5ef3Q-3rykA:
1.2		 5ef3P-3rykA:
18.40
5ef3Q-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5ef3R-3rykA:
1.2
5ef3S-3rykA:
1.1		 5ef3R-3rykA:
18.40
5ef3S-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.37A 5ef3S-3rykA:
1.1
5ef3T-3rykA:
1.2		 5ef3S-3rykA:
18.40
5ef3T-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.31A 5ef3T-3rykA:
1.2
5ef3U-3rykA:
1.2		 5ef3T-3rykA:
18.40
5ef3U-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Bacillus
anthracis) 		5 / 10 GLY A  60
HIS A  62
HIS A 119
ILE A  58
SER A  50
 None
POP  A 182 ( 4.5A)
None
None
None
 1.30A 5ef3U-3rykA:
1.2
5ef3V-3rykA:
1.2		 5ef3U-3rykA:
18.40
5ef3V-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		8 / 10 ASP A  99
ARG A 194
ASN A 240
SER A 244
LYS A 247
GLU A 248
ARG A 338
TYR A 339
 MG  A 701 (-2.5A)
POP  A 703 (-2.8A)
MG  A 702 (-2.6A)
MG  A 702 ( 2.3A)
POP  A 703 (-2.8A)
MG  A 702 ( 2.6A)
POP  A 703 (-4.0A)
POP  A 703 ( 4.4A)
 0.57A 5ermA-3lg5A:
6.1		 5ermA-3lg5A:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_B_210B704_1
(FUSICOCCADIENE
SYNTHASE)		 3lg5 EPI-ISOZIZAENE
SYNTHASE
(Streptomyces
coelicolor) 		8 / 9 ASP A  99
ARG A 194
ASN A 240
SER A 244
LYS A 247
GLU A 248
ARG A 338
TYR A 339
 MG  A 701 (-2.5A)
POP  A 703 (-2.8A)
MG  A 702 (-2.6A)
MG  A 702 ( 2.3A)
POP  A 703 (-2.8A)
MG  A 702 ( 2.6A)
POP  A 703 (-4.0A)
POP  A 703 ( 4.4A)
 0.56A 5ermB-3lg5A:
23.1		 5ermB-3lg5A:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 9 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
POP  A 301 ( 2.4A)
 0.66A 5eroA-3p41A:
21.8		 5eroA-3p41A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 10 ASP A  83
ASP A  84
ASP A  89
ARG A  94
LYS A 180
 MG  A 297 (-2.5A)
None
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
POP  A 301 ( 2.4A)
 0.75A 5eroC-3p41A:
21.9		 5eroC-3p41A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 HIS A 225
GLY A 227
HIS A 228
VAL A 442
ASP A 486
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
None
ME8  A 801 ( 2.6A)
 0.96A 5hg0B-3kflA:
7.5		 5hg0B-3kflA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 HIS A 225
GLY A 227
HIS A 228
VAL A 442
GLY A 484
 POP  A 802 ( 4.0A)
ME8  A 801 (-3.4A)
POP  A 802 ( 3.8A)
None
ME8  A 801 (-3.2A)
 0.67A 5hg0B-3kflA:
7.5		 5hg0B-3kflA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME
([Candida]
glabrata) 		4 / 6 LYS A 146
ASP A  95
GLY A  92
ASP A  76
 POP  A 543 (-2.9A)
MG  A 544 ( 2.6A)
POP  A 543 (-2.9A)
MG  A 544 ( 3.2A)
 1.30A 5hp1A-3nm1A:
undetectable		 5hp1A-3nm1A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME
([Candida]
glabrata) 		4 / 6 LYS A 146
ASP A  95
GLY A  92
ASP A  76
 POP  A 543 (-2.9A)
MG  A 544 ( 2.6A)
POP  A 543 (-2.9A)
MG  A 544 ( 3.2A)
 1.31A 5hp1C-3nm1A:
undetectable		 5hp1C-3nm1A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 155
GLY A 149
VAL A 190
SER A 132
ILE A  65
 POP  A1155 (-1.5A)
None
None
None
None
 1.11A 5i3cC-1ocmA:
undetectable		 5i3cC-1ocmA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.37A 5l5fV-1ocmA:
0.0
5l5fb-1ocmA:
0.0		 5l5fV-1ocmA:
19.76
5l5fb-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.38A 5l5fH-1ocmA:
0.0
5l5fN-1ocmA:
undetectable		 5l5fH-1ocmA:
19.76
5l5fN-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		5 / 11 SER A 127
THR A 108
THR A 107
THR A 106
ARG A 158
 None
None
None
None
POP  A1155 (-3.1A)
 1.40A 5l66V-1ocmA:
undetectable
5l66b-1ocmA:
undetectable		 5l66V-1ocmA:
19.76
5l66b-1ocmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME
([Candida]
glabrata) 		5 / 12 ILE A  73
LEU A  41
SER A 114
GLY A 112
GLY A 136
 None
None
POP  A 543 ( 3.0A)
None
IFP  A 542 (-3.1A)
 1.06A 5nnaA-3nm1A:
undetectable		 5nnaA-3nm1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME
([Candida]
glabrata) 		5 / 12 ILE A  73
LEU A  41
SER A 114
GLY A 112
GLY A 136
 None
None
POP  A 543 ( 3.0A)
None
IFP  A 542 (-3.1A)
 1.05A 5nnaB-3nm1A:
undetectable		 5nnaB-3nm1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME
([Candida]
glabrata) 		5 / 12 ILE A  73
LEU A  41
SER A 114
GLY A 112
GLY A 136
 None
None
POP  A 543 ( 3.0A)
None
IFP  A 542 (-3.1A)
 1.02A 5nnaC-3nm1A:
undetectable		 5nnaC-3nm1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME
([Candida]
glabrata) 		5 / 12 ILE A  73
LEU A  41
SER A 114
GLY A 112
GLY A 136
 None
None
POP  A 543 ( 3.0A)
None
IFP  A 542 (-3.1A)
 1.02A 5nnaD-3nm1A:
undetectable		 5nnaD-3nm1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 2w0m SSO2452
(Sulfolobus
solfataricus) 		4 / 7 ARG A  68
THR A  37
ILE A  38
LEU A  41
 None
POP  A1240 (-3.6A)
POP  A1240 (-4.1A)
None
 0.93A 5te8A-2w0mA:
undetectable		 5te8A-2w0mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 LYS A 189
PRO A 190
LYS A 155
 POP  A 500 (-2.9A)
None
None
 1.18A 5y9yA-2x4dA:
undetectable		 5y9yA-2x4dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2col BIFUNCTIONAL
HEMOLYSIN-ADENYLATE
CYCLASE
(Bordetella
pertussis) 		5 / 12 GLY A 143
LYS A  65
SER A  66
ASP A  99
ALA A  96
 None
POP  A 893 (-2.4A)
None
None
None
 0.96A 5zvgA-2colA:
undetectable		 5zvgA-2colA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2col BIFUNCTIONAL
HEMOLYSIN-ADENYLATE
CYCLASE
(Bordetella
pertussis) 		5 / 12 GLY A 143
LYS A  65
SER A  66
ASP A  99
ALA A  96
 None
POP  A 893 (-2.4A)
None
None
None
 0.96A 5zvgB-2colA:
undetectable		 5zvgB-2colA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		8 / 10 ARG A 262
GLU A 264
HIS A 270
PHE A 274
GLU A 421
GLY A 477
ARG A 480
ILE A 491
 LAD  A 601 ( 2.6A)
LAD  A 601 (-4.0A)
POP  A 602 (-4.0A)
LAD  A 601 (-3.4A)
MG  A 603 (-2.7A)
LAD  A 601 (-3.4A)
POP  A 602 ( 2.4A)
None
 0.40A 6bniA-1e1tA:
46.9		 6bniA-1e1tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		8 / 10 ASN A 260
ARG A 262
GLU A 264
HIS A 270
PHE A 274
GLY A 477
ARG A 480
ILE A 491
 None
LAD  A 601 ( 2.6A)
LAD  A 601 (-4.0A)
POP  A 602 (-4.0A)
LAD  A 601 (-3.4A)
LAD  A 601 (-3.4A)
POP  A 602 ( 2.4A)
None
 0.42A 6bniA-1e1tA:
46.9		 6bniA-1e1tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		8 / 10 ARG A 262
GLU A 264
HIS A 270
PHE A 274
GLU A 421
GLY A 477
ARG A 480
ILE A 491
 LAD  A 601 ( 2.6A)
LAD  A 601 (-4.0A)
POP  A 602 (-4.0A)
LAD  A 601 (-3.4A)
MG  A 603 (-2.7A)
LAD  A 601 (-3.4A)
POP  A 602 ( 2.4A)
None
 0.37A 6bniB-1e1tA:
46.6		 6bniB-1e1tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		8 / 10 ASN A 260
ARG A 262
GLU A 264
HIS A 270
PHE A 274
GLY A 477
ARG A 480
ILE A 491
 None
LAD  A 601 ( 2.6A)
LAD  A 601 (-4.0A)
POP  A 602 (-4.0A)
LAD  A 601 (-3.4A)
LAD  A 601 (-3.4A)
POP  A 602 ( 2.4A)
None
 0.41A 6bniB-1e1tA:
46.6		 6bniB-1e1tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 393
GLY A 237
VAL A 384
ILE A 337
GLY A 335
 None
POP  A 526 (-3.4A)
None
None
None
 0.85A 6dilB-1gpmA:
undetectable		 6dilB-1gpmA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1ocm MALONAMIDASE E2
(Bradyrhizobium
japonicum) 		4 / 6 ARG A 113
PRO A 274
GLN A 277
ARG A 363
 POP  A1155 (-4.0A)
None
POP  A1155 ( 4.7A)
None
 1.45A 6ef6A-1ocmA:
0.0		 6ef6A-1ocmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 HIS A  67
GLN A  46
THR A  43
ASN A 330
HIS A 404
 POP  A 509 (-3.7A)
None
None
MLI  A 503 (-4.1A)
5GP  A 501 (-3.0A)
 1.49A 6exiC-4dwqA:
undetectable		 6exiC-4dwqA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 7 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
 0.93A 6g31A-3p41A:
21.7		 6g31A-3p41A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 5 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
 1.11A 6g31C-3p41A:
21.6		 6g31C-3p41A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3p41 GERANYLTRANSTRANSFER
ASE
(Pseudomonas
protegens) 		5 / 7 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
 0.66A 6g31G-3p41A:
20.8		 6g31G-3p41A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3kfl METHIONYL-TRNA
SYNTHETASE
(Leishmania
major) 		5 / 12 ASN A 221
ILE A 487
TYR A 450
THR A 253
PHE A 284
 POP  A 802 (-3.3A)
ME8  A 801 (-4.0A)
ME8  A 801 (-4.7A)
None
None
 1.46A 6j20A-3kflA:
undetectable		 6j20A-3kflA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 GLY A  12
HIS A  21
SER A 138
SER A 139
 NAD  A 601 (-3.3A)
NAD  A 601 (-4.5A)
POP  A 701 (-2.9A)
POP  A 701 (-3.9A)
 0.56A 6jmjA-2qjoA:
14.5		 6jmjA-2qjoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		5 / 7 GLY A  12
PHE A  14
HIS A  21
SER A 138
SER A 139
 NAD  A 601 (-3.3A)
NAD  A 601 (-4.8A)
NAD  A 601 (-4.5A)
POP  A 701 (-2.9A)
POP  A 701 (-3.9A)
 0.59A 6jnhA-2qjoA:
14.3		 6jnhA-2qjoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLY A  12
HIS A  21
SER A 138
SER A 139
 NAD  A 601 (-3.3A)
NAD  A 601 (-4.5A)
POP  A 701 (-2.9A)
POP  A 701 (-3.9A)
 0.62A 6jogA-2qjoA:
14.8		 6jogA-2qjoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 ASP A 168
SER A  25
SER A  19
 None
None
POP  A 500 ( 3.9A)
 0.83A 6mxtA-2x4dA:
undetectable		 6mxtA-2x4dA:
21.11