SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'POL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 4 GLY A 525
ASP A 522
GLY A 518
THR A 502
 POL  A 707 (-3.7A)
POL  A 707 ( 4.7A)
None
None
 1.01A 1hxbB-4uzsA:
undetectable		 1hxbB-4uzsA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wsb GALACTITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 TYR A 159
ILE A  23
GLY A 143
SER A 162
GLY A 190
 POL  A1255 (-3.8A)
NAD  A 500 (-3.9A)
None
None
POL  A1256 (-4.7A)
 0.97A 1kiaA-2wsbA:
8.1		 1kiaA-2wsbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wsb GALACTITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 TYR A 159
GLY A 147
ALA A 161
SER A 162
TYR A 191
 POL  A1255 (-3.8A)
None
None
None
POL  A1256 (-4.0A)
 1.38A 1kiaD-2wsbA:
6.4		 1kiaD-2wsbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wsb GALACTITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 TYR A 159
ILE A  23
GLY A 143
SER A 162
GLY A 190
 POL  A1255 (-3.8A)
NAD  A 500 (-3.9A)
None
None
POL  A1256 (-4.7A)
 0.99A 1nbhB-2wsbA:
7.9		 1nbhB-2wsbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wsb GALACTITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 TYR A 159
ILE A  23
GLY A 143
SER A 162
GLY A 190
 POL  A1255 (-3.8A)
NAD  A 500 (-3.9A)
None
None
POL  A1256 (-4.7A)
 1.01A 1nbiA-2wsbA:
7.9		 1nbiA-2wsbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wsb GALACTITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 TYR A 159
ILE A  23
GLY A 143
SER A 162
GLY A 190
 POL  A1255 (-3.8A)
NAD  A 500 (-3.9A)
None
None
POL  A1256 (-4.7A)
 1.00A 1nbiB-2wsbA:
7.9		 1nbiB-2wsbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		4 / 4 ASP H 189
ASP H 186
ASP H 146
GLY H 223
 0Z7  H 501 (-2.3A)
None
None
POL  H 509 ( 4.0A)
 1.36A 2igtC-4ylqH:
undetectable		 2igtC-4ylqH:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 4 GLY A 525
ASP A 522
GLY A 518
THR A 502
 POL  A 707 (-3.7A)
POL  A 707 ( 4.7A)
None
None
 0.99A 3k4vC-4uzsA:
undetectable		 3k4vC-4uzsA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 THR A 561
SER A 562
ARG A 527
 None
POL  A 707 (-3.1A)
None
 0.83A 3phnA-4uzsA:
undetectable		 3phnA-4uzsA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 ILE A  77
LEU A  80
GLY A  54
ALA A  90
VAL A 153
 POL  A 706 ( 4.1A)
None
None
None
None
 0.88A 3rukB-4uzsA:
undetectable		 3rukB-4uzsA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		3 / 3 PRO A 517
TYR A 599
GLY A 525
 None
None
POL  A 707 (-3.7A)
 0.68A 4g2zA-4uzsA:
undetectable		 4g2zA-4uzsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		5 / 12 ILE A  77
LEU A  80
GLY A  54
ALA A  90
VAL A 153
 POL  A 706 ( 4.1A)
None
None
None
None
 0.88A 4nkvB-4uzsA:
undetectable		 4nkvB-4uzsA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 2wsb GALACTITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 6 ILE A 149
THR A 252
HIS A 167
TYR A 159
 None
None
None
POL  A1255 (-3.8A)
 1.02A 4qwpA-2wsbA:
undetectable		 4qwpA-2wsbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 ARG A 487
SER A 483
GLY A 525
THR A 561
 None
None
POL  A 707 (-3.7A)
None
 0.98A 5btaA-4uzsA:
undetectable
5btaC-4uzsA:
undetectable
5btaD-4uzsA:
undetectable		 5btaA-4uzsA:
22.16
5btaC-4uzsA:
22.16
5btaD-4uzsA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 SER A 483
GLY A 525
THR A 561
ARG A 487
 None
POL  A 707 (-3.7A)
None
None
 0.96A 5btaA-4uzsA:
undetectable
5btaB-4uzsA:
undetectable
5btaC-4uzsA:
undetectable		 5btaA-4uzsA:
22.16
5btaB-4uzsA:
17.92
5btaC-4uzsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 ARG A 487
SER A 483
GLY A 525
THR A 561
 None
None
POL  A 707 (-3.7A)
None
 0.88A 5btcA-4uzsA:
undetectable
5btcC-4uzsA:
undetectable
5btcD-4uzsA:
undetectable		 5btcA-4uzsA:
22.16
5btcC-4uzsA:
22.16
5btcD-4uzsA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 6 SER A 483
GLY A 525
THR A 561
ARG A 487
 None
POL  A 707 (-3.7A)
None
None
 0.91A 5btcA-4uzsA:
undetectable
5btcB-4uzsA:
undetectable
5btcC-4uzsA:
undetectable		 5btcA-4uzsA:
22.16
5btcB-4uzsA:
17.92
5btcC-4uzsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4uzs BETA-GALACTOSIDASE
(Bifidobacterium
bifidum) 		4 / 7 SER A 483
GLY A 525
THR A 561
ARG A 487
 None
POL  A 707 (-3.7A)
None
None
 0.92A 5btfA-4uzsA:
undetectable
5btfB-4uzsA:
undetectable
5btfC-4uzsA:
undetectable		 5btfA-4uzsA:
22.16
5btfB-4uzsA:
17.92
5btfC-4uzsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 2wsb GALACTITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 5 GLY A  18
ASP A  42
ARG A  43
MET A 200
 NAD  A 500 (-3.3A)
NAD  A 500 (-2.8A)
NAD  A 500 (-3.4A)
POL  A1255 ( 4.5A)
 1.47A 5gwkA-2wsbA:
1.5		 5gwkA-2wsbA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 2wsb GALACTITOL
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 8 SER A 146
MET A 160
TYR A 159
MET A 196
 POL  A1256 (-2.6A)
None
POL  A1255 (-3.8A)
NAD  A 500 (-3.7A)
 1.46A 5wqpA-2wsbA:
22.8		 5wqpA-2wsbA:
27.14