SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'POG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens) 		4 / 8 LEU A 716
LEU A 644
LEU A 709
THR A 746
 None
None
None
POG  A 834 ( 4.5A)
 0.89A 1dvtA-3t6aA:
undetectable
1dvtB-3t6aA:
undetectable		 1dvtA-3t6aA:
16.22
1dvtB-3t6aA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 1woz 177AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(ST1454)
(Sulfurisphaera
tokodaii) 		5 / 11 LEU A  31
ASP A  32
LEU A  68
SER A  69
ILE A  64
 POG  A 201 ( 4.7A)
POG  A 201 ( 4.6A)
None
None
None
 1.18A 3ko0A-1wozA:
1.3
3ko0B-1wozA:
0.9
3ko0I-1wozA:
1.0
3ko0J-1wozA:
0.9		 3ko0A-1wozA:
20.57
3ko0B-1wozA:
20.57
3ko0I-1wozA:
20.57
3ko0J-1wozA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 1woz 177AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(ST1454)
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  68
SER A  69
ILE A  64
LEU A  31
ASP A  32
 None
None
None
POG  A 201 ( 4.7A)
POG  A 201 ( 4.6A)
 1.10A 3ko0K-1wozA:
0.9
3ko0L-1wozA:
1.4
3ko0S-1wozA:
0.9
3ko0T-1wozA:
undetectable		 3ko0K-1wozA:
20.57
3ko0L-1wozA:
20.57
3ko0S-1wozA:
20.57
3ko0T-1wozA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 1woz 177AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(ST1454)
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  31
ASP A  32
LEU A  68
SER A  69
ILE A  64
 POG  A 201 ( 4.7A)
POG  A 201 ( 4.6A)
None
None
None
 1.16A 3ko0K-1wozA:
0.9
3ko0L-1wozA:
undetectable
3ko0M-1wozA:
0.8
3ko0N-1wozA:
undetectable		 3ko0K-1wozA:
20.57
3ko0L-1wozA:
20.57
3ko0M-1wozA:
20.57
3ko0N-1wozA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 1woz 177AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(ST1454)
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  68
SER A  69
ILE A  64
LEU A  31
ASP A  32
 None
None
None
POG  A 201 ( 4.7A)
POG  A 201 ( 4.6A)
 1.10A 3ko0M-1wozA:
0.8
3ko0N-1wozA:
undetectable
3ko0O-1wozA:
undetectable
3ko0P-1wozA:
undetectable		 3ko0M-1wozA:
20.57
3ko0N-1wozA:
20.57
3ko0O-1wozA:
20.57
3ko0P-1wozA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 1woz 177AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(ST1454)
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  31
ASP A  32
LEU A  68
SER A  69
ILE A  64
 POG  A 201 ( 4.7A)
POG  A 201 ( 4.6A)
None
None
None
 1.07A 3ko0M-1wozA:
0.8
3ko0N-1wozA:
undetectable
3ko0O-1wozA:
undetectable
3ko0P-1wozA:
undetectable		 3ko0M-1wozA:
20.57
3ko0N-1wozA:
20.57
3ko0O-1wozA:
20.57
3ko0P-1wozA:
20.57