SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'POA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4i3u ALDEHYDE
DEHYDROGENASE (NAD+)
(Sinorhizobium
meliloti) 		5 / 9 THR A 292
GLY A 445
GLY A 436
LEU A 414
GLY A 454
 POA  A 500 (-3.0A)
POA  A 500 ( 4.9A)
None
None
None
 1.20A 1jhoA-4i3uA:
undetectable		 1jhoA-4i3uA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4i3u ALDEHYDE
DEHYDROGENASE (NAD+)
(Sinorhizobium
meliloti) 		5 / 9 THR A 292
GLY A 445
GLY A 436
LEU A 414
GLY A 454
 POA  A 500 (-3.0A)
POA  A 500 ( 4.9A)
None
None
None
 1.22A 1l5lA-4i3uA:
undetectable		 1l5lA-4i3uA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4i3u ALDEHYDE
DEHYDROGENASE (NAD+)
(Sinorhizobium
meliloti) 		5 / 9 THR A 292
GLY A 445
GLY A 436
LEU A 414
GLY A 454
 POA  A 500 (-3.0A)
POA  A 500 ( 4.9A)
None
None
None
 1.21A 1l5mA-4i3uA:
undetectable		 1l5mA-4i3uA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 1m32 2-AMINOETHYLPHOSPHON
ATE-PYRUVATE
AMINOTRANSFERASE
(Salmonella
enterica) 		4 / 8 VAL A  69
ARG A 339
GLU A 141
ASP A 167
 None
POA  A4601 (-3.4A)
None
PLP  A4401 (-2.9A)
 1.30A 1s3zA-1m32A:
undetectable
1s3zB-1m32A:
undetectable		 1s3zA-1m32A:
18.13
1s3zB-1m32A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4i3u ALDEHYDE
DEHYDROGENASE (NAD+)
(Sinorhizobium
meliloti) 		5 / 12 ALA A 470
PRO A 156
ASN A 158
ARG A 108
VAL A 112
 None
None
POA  A 500 (-3.5A)
POA  A 500 (-2.6A)
None
 1.28A 1u72A-4i3uA:
undetectable		 1u72A-4i3uA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4i3u ALDEHYDE
DEHYDROGENASE (NAD+)
(Sinorhizobium
meliloti) 		3 / 3 ARG A 108
GLU A 442
TYR A 104
 POA  A 500 (-2.6A)
None
None
 0.98A 4r29D-4i3uA:
undetectable		 4r29D-4i3uA:
18.39