SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PMV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		4 / 6 TYR A  11
GLY A 146
ASP A 144
ASN A 145
 PMV  A 400 (-4.0A)
PMV  A 400 (-3.4A)
None
None
 1.26A 2g72A-3gonA:
undetectable		 2g72A-3gonA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		3 / 3 ASN A 145
TYR A  16
SER A 147
 None
PMV  A 400 (-3.6A)
PMV  A 400 (-2.7A)
 0.86A 2gvcB-3gonA:
undetectable		 2gvcB-3gonA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		3 / 3 ASN A 145
TYR A  16
SER A 147
 None
PMV  A 400 (-3.6A)
PMV  A 400 (-2.7A)
 0.81A 2gvcE-3gonA:
undetectable		 2gvcE-3gonA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		4 / 8 TYR A  11
ILE A  18
LEU A 139
PHE A 132
 PMV  A 400 (-4.0A)
PMV  A 400 (-4.6A)
None
None
 0.83A 2vctA-3gonA:
undetectable		 2vctA-3gonA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		4 / 8 TYR A  11
ILE A  18
LEU A 139
PHE A 132
 PMV  A 400 (-4.0A)
PMV  A 400 (-4.6A)
None
None
 0.86A 2vctC-3gonA:
undetectable		 2vctC-3gonA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		4 / 5 TYR A  11
GLY A 146
ASP A 144
VAL A 115
 PMV  A 400 (-4.0A)
PMV  A 400 (-3.4A)
None
None
 0.80A 4nkvD-3gonA:
undetectable		 4nkvD-3gonA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3gon PHOSPHOMEVALONATE
KINASE
(Streptococcus
pneumoniae) 		4 / 5 ILE A  18
LEU A  19
ASP A 150
GLU A  15
 PMV  A 400 (-4.6A)
PMV  A 400 ( 4.8A)
None
None
 0.90A 4nkxB-3gonA:
undetectable		 4nkxB-3gonA:
23.71