SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PMS'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM6_A_9CRA501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	1v6c	ALKALINE SERINE PROTEASE (Pseudoalteromona s sp. AS-11)	5 / 12	ILE A 114 ALA A 113 TRP A 104 VAL A 174 LEU A 130	None None None CA A 505 (-4.5A) PMS A 501 (-4.5A)	0.90A	1fm6A-1v6cA: undetectable	1fm6A-1v6cA: 18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM6_U_9CRU502_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	2gko	SUBTILISIN MICROBIAL SERINE PROTEINASES (Bacillus subtilis)	5 / 12	ALA A 166 ALA A 165 VAL A 233 ILE A 245 HIS A 74	None PMS A 601 ( 3.8A) None PMS A 601 (-4.5A) None	1.02A	1fm6U-2gkoA: undetectable	1fm6U-2gkoA: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RI4_A_SAMA299_0 (MRNA CAPPING ENZYME)	5z6o	PROTEASE (Penicillium cyclopium)	5 / 12	GLY A 209 GLY A 226 ILE A 184 SER A 187 TYR A 206	None PMS A 302 (-3.6A) None None None	1.05A	1ri4A-5z6oA: 2.0	1ri4A-5z6oA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Y4L_B_SVRB301_1 (PHOSPHOLIPASE A2 HOMOLOG 2)	1aur	CARBOXYLESTERASE (Pseudomonas fluorescens)	5 / 12	GLY A 24 GLY A 22 LEU A 20 GLY A 112 PRO A 143	None PMS A 801 ( 3.9A) None None None	1.22A	1y4lA-1aurA: undetectable	1y4lA-1aurA: 17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIM_A_CHDA525_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	1wb8	SUPEROXIDE DISMUTASE [FE] (Sulfolobus solfataricus)	4 / 6	HIS A 33 ASP A 19 TYR A 16 HIS A 37	FE A 212 (-3.3A) None None PMS A 213 (-4.0A)	1.50A	2eimA-1wb8A: undetectable 2eimC-1wb8A: undetectable	2eimA-1wb8A: 16.73 2eimC-1wb8A: 22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_D_SAMD300_0 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	1eq9	CHYMOTRYPSIN (Solenopsis invicta)	6 / 12	GLY A 142 GLY A 196 GLY A 193 THR A 54 LEU A 53 VAL A 31	None None PMS A1201 (-4.0A) None None None	1.34A	2oxtD-1eq9A: undetectable	2oxtD-1eq9A: 20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1eq9	CHYMOTRYPSIN (Solenopsis invicta)	5 / 12	ALA A 190 SER A 195 VAL A 213 GLY A 216 TYR A 228	PMS A1201 (-3.6A) PMS A1201 (-1.5A) None PMS A1201 ( 4.5A) None	0.43A	2p16A-1eq9A: 12.9	2p16A-1eq9A: 34.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2W26_A_RIVA1001_1 (ACTIVATED FACTOR XA HEAVY CHAIN)	1eq9	CHYMOTRYPSIN (Solenopsis invicta)	5 / 12	ALA A 190 SER A 195 VAL A 213 GLY A 216 TYR A 228	PMS A1201 (-3.6A) PMS A1201 (-1.5A) None PMS A1201 ( 4.5A) None	0.37A	2w26A-1eq9A: 11.8	2w26A-1eq9A: 34.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YVL_D_SAMD603_0 (HYPOTHETICAL PROTEIN)	2gko	MICROBIAL SERINE PROTEINASES SUBTILISIN (Bacillus subtilis)	5 / 12	GLY A 230 ALA A 232 ALA A 165 VAL A 188 VAL A 75	None None PMS A 601 ( 3.8A) None None	1.16A	2yvlD-2gkoA: 2.2	2yvlD-2gkoA: 17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BOG_C_DHIC8_0 (6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN)	1s2n	EXTRACELLULAR SUBTILISIN-LIKE SERINE PROTEINASE (Vibrio sp. PA-44)	3 / 3	SER A 220 GLY A 156 GLY A 130	PMS A1284 (-2.1A) PMS A1284 (-3.5A) PMS A1284 (-3.3A)	0.57A	3bogA-1s2nA: undetectable 3bogC-1s2nA: undetectable	3bogA-1s2nA: undetectable 3bogC-1s2nA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BOG_C_DHIC8_0 (6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN)	1v6c	ALKALINE SERINE PROTEASE (Pseudoalteromona s sp. AS-11)	3 / 3	SER A 369 GLY A 158 GLY A 131	PMS A 501 (-1.5A) PMS A 501 ( 4.6A) PMS A 501 (-4.3A)	0.49A	3bogA-1v6cA: undetectable 3bogC-1v6cA: undetectable	3bogA-1v6cA: undetectable 3bogC-1v6cA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D2T_B_1FLB500_1 (TRANSTHYRETIN)	1eq9	CHYMOTRYPSIN (Solenopsis invicta)	4 / 6	ALA A 44 SER A 195 THR A 54 VAL A 106	None PMS A1201 (-1.5A) None None	1.01A	3d2tB-1eq9A: 0.0	3d2tB-1eq9A: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DCJ_A_THHA401_0 (PROBABLE 5'-PHOSPHORIBOSYLGLY CINAMIDE FORMYLTRANSFERASE PURN)	4dzt	AQUALYSIN-1 (Thermus aquaticus)	5 / 12	ILE A 204 LEU A 218 THR A 82 THR A 77 PRO A 7	None PMS A 301 ( 4.3A) None None None	1.13A	3dcjA-4dztA: 2.9 3dcjB-4dztA: 3.1	3dcjA-4dztA: 24.29 3dcjB-4dztA: 24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KEE_C_30BC500_1 (GENOME POLYPROTEIN)	5z6o	PROTEASE (Penicillium cyclopium)	5 / 12	GLY A 236 VAL A 203 SER A 160 ALA A 162 ALA A 163	None None None PMS A 302 (-3.6A) None	1.06A	3keeC-5z6oA: undetectable	3keeC-5z6oA: 17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_A_CELA682_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2gko	SUBTILISIN MICROBIAL SERINE PROTEINASES (Bacillus subtilis)	5 / 12	ALA A 165 VAL A 75 GLY A 77 ALA A 76 LEU A 98	PMS A 601 ( 3.8A) None None None None	0.96A	3ln1A-2gkoA: undetectable	3ln1A-2gkoA: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_B_CELB682_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2gko	SUBTILISIN MICROBIAL SERINE PROTEINASES (Bacillus subtilis)	5 / 12	ALA A 165 VAL A 75 GLY A 77 ALA A 76 LEU A 98	PMS A 601 ( 3.8A) None None None None	0.95A	3ln1B-2gkoA: undetectable	3ln1B-2gkoA: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_C_CELC682_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2gko	SUBTILISIN MICROBIAL SERINE PROTEINASES (Bacillus subtilis)	5 / 12	ALA A 165 VAL A 75 GLY A 77 ALA A 76 LEU A 98	PMS A 601 ( 3.8A) None None None None	0.96A	3ln1C-2gkoA: undetectable	3ln1C-2gkoA: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_D_CELD682_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2gko	SUBTILISIN MICROBIAL SERINE PROTEINASES (Bacillus subtilis)	5 / 12	ALA A 165 VAL A 75 GLY A 77 ALA A 76 LEU A 98	PMS A 601 ( 3.8A) None None None None	0.94A	3ln1D-2gkoA: 0.7	3ln1D-2gkoA: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S8P_B_SAMB500_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1)	2gko	MICROBIAL SERINE PROTEINASES SUBTILISIN (Bacillus subtilis)	3 / 3	HIS A 71 SER A 252 ASN A 168	PMS A 601 (-3.1A) None PMS A 601 (-3.0A)	0.87A	3s8pB-2gkoA: undetectable	3s8pB-2gkoA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A99_D_MIYD392_1 (TETX2 PROTEIN)	1eq9	CHYMOTRYPSIN (Solenopsis invicta)	4 / 5	HIS A 57 SER A 195 SER A 214 VAL A 213	PMS A1201 ( 4.6A) PMS A1201 (-1.5A) None None	1.38A	4a99D-1eq9A: undetectable	4a99D-1eq9A: 22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DRJ_A_RAPA201_2 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4 SERINE/THREONINE-PRO TEIN KINASE MTOR)	2gko	SUBTILISIN MICROBIAL SERINE PROTEINASES (Bacillus subtilis)	4 / 8	LEU A 139 SER A 249 THR A 73 ASP A 67	None PMS A 601 (-1.7A) None None	1.08A	4drjB-2gkoA: undetectable	4drjB-2gkoA: 12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEU_D_KAND301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	3iox	AGI/II (Streptococcus mutans)	4 / 8	ASP A 760 ASP A 554 ASP A 555 ASN A 699	PMS A 900 (-3.6A) None None CA A 903 (-3.1A)	1.09A	4feuD-3ioxA: undetectable	4feuD-3ioxA: 16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FO4_A_MOAA502_1 (INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE)	2gko	SUBTILISIN MICROBIAL SERINE PROTEINASES (Bacillus subtilis)	4 / 8	SER A 175 SER A 207 THR A 248 GLY A 140	None None PMS A 601 (-4.7A) None	0.90A	4fo4A-2gkoA: undetectable	4fo4A-2gkoA: 24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FO4_B_MOAB502_1 (INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE)	2gko	SUBTILISIN MICROBIAL SERINE PROTEINASES (Bacillus subtilis)	4 / 8	SER A 175 SER A 207 THR A 248 GLY A 140	None None PMS A 601 (-4.7A) None	0.84A	4fo4B-2gkoA: undetectable	4fo4B-2gkoA: 24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KOE_F_TR6F101_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B E-SITE DNA2)	5z6o	PROTEASE (Penicillium cyclopium)	4 / 6	SER A 228 GLY A 101 ASP A 103 GLY A 106	PMS A 302 (-1.5A) None None None	1.00A	4koeA-5z6oA: undetectable 4koeB-5z6oA: undetectable 4koeC-5z6oA: 2.2	4koeA-5z6oA: 10.25 4koeB-5z6oA: 10.25 4koeC-5z6oA: 13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PWJ_B_30ZB201_1 (TRANSTHYRETIN)	1s2n	EXTRACELLULAR SUBTILISIN-LIKE SERINE PROTEINASE (Vibrio sp. PA-44)	4 / 7	LEU A 129 THR A 175 ALA A 154 THR A 219	None None PMS A1284 ( 3.8A) PMS A1284 (-4.6A)	1.04A	4pwjB-1s2nA: undetectable	4pwjB-1s2nA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QWU_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5z6o	PROTEASE (Penicillium cyclopium)	5 / 9	ALA A 162 ALA A 231 GLY A 139 GLY A 138 ASP A 42	PMS A 302 (-3.6A) None None PMS A 302 (-3.7A) PMS A 302 ( 3.9A)	1.19A	4qwuK-5z6oA: undetectable 4qwuL-5z6oA: undetectable	4qwuK-5z6oA: 19.21 4qwuL-5z6oA: 20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XP1_A_LDPA708_1 (DOPAMINE TRANSPORTER, ISOFORM B)	4dzt	AQUALYSIN-1 (Thermus aquaticus)	5 / 10	ASP A 138 ALA A 154 VAL A 153 SER A 166 GLY A 130	None PMS A 301 (-3.6A) None None None	1.42A	4xp1A-4dztA: undetectable	4xp1A-4dztA: 20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YO9_B_ACTB401_0 (3C-LIKE PROTEINASE)	4z9a	LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE (Homo sapiens)	3 / 3	ARG A 58 ASP A 56 TYR A 131	None None PMS A 304 ( 4.6A)	0.81A	4yo9B-4z9aA: undetectable	4yo9B-4z9aA: 17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z53_F_TR6F101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A E-SITE DNA)	5z6o	PROTEASE (Penicillium cyclopium)	4 / 6	GLY A 101 ASP A 103 GLY A 106 SER A 228	None None None PMS A 302 (-1.5A)	1.02A	4z53A-5z6oA: undetectable 4z53B-5z6oA: undetectable	4z53A-5z6oA: 7.24 4z53B-5z6oA: 7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BOJ_B_4TXB201_1 (TRANSTHYRETIN)	1s2n	EXTRACELLULAR SUBTILISIN-LIKE SERINE PROTEINASE (Vibrio sp. PA-44)	4 / 7	LEU A 129 THR A 175 ALA A 154 THR A 219	None None PMS A1284 ( 3.8A) PMS A1284 (-4.6A)	1.01A	5bojB-1s2nA: undetectable	5bojB-1s2nA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CPR_B_SAMB402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1)	2gko	MICROBIAL SERINE PROTEINASES SUBTILISIN (Bacillus subtilis)	3 / 3	HIS A 71 SER A 252 ASN A 168	PMS A 601 (-3.1A) None PMS A 601 (-3.0A)	0.90A	5cprB-2gkoA: undetectable	5cprB-2gkoA: 22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESK_A_1YNA701_2 (LANOSTEROL 14-ALPHA DEMETHYLASE)	1s2n	EXTRACELLULAR SUBTILISIN-LIKE SERINE PROTEINASE (Vibrio sp. PA-44)	4 / 4	ALA A 207 PRO A 224 LEU A 129 HIS A 70	None None None PMS A1284 (-4.1A)	1.29A	5eskA-1s2nA: undetectable	5eskA-1s2nA: 20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESK_A_1YNA701_2 (LANOSTEROL 14-ALPHA DEMETHYLASE)	4dzt	AQUALYSIN-1 (Thermus aquaticus)	4 / 4	ALA A 207 PRO A 226 LEU A 129 HIS A 70	None None None PMS A 301 (-4.2A)	1.18A	5eskA-4dztA: undetectable	5eskA-4dztA: 20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JW1_A_CELA602_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2gko	SUBTILISIN MICROBIAL SERINE PROTEINASES (Bacillus subtilis)	5 / 12	ALA A 165 VAL A 75 GLY A 77 ALA A 76 LEU A 98	PMS A 601 ( 3.8A) None None None None	0.98A	5jw1A-2gkoA: undetectable	5jw1A-2gkoA: 20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KIR_A_RCXA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2gko	SUBTILISIN MICROBIAL SERINE PROTEINASES (Bacillus subtilis)	5 / 12	ALA A 165 VAL A 75 GLY A 77 ALA A 76 LEU A 98	PMS A 601 ( 3.8A) None None None None	0.92A	5kirA-2gkoA: undetectable	5kirA-2gkoA: 20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KIR_B_RCXB601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2gko	SUBTILISIN MICROBIAL SERINE PROTEINASES (Bacillus subtilis)	5 / 12	ALA A 165 VAL A 75 GLY A 77 ALA A 76 LEU A 98	PMS A 601 ( 3.8A) None None None None	0.92A	5kirB-2gkoA: undetectable	5kirB-2gkoA: 20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UAN_A_9CRA503_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	1v6c	ALKALINE SERINE PROTEASE (Pseudoalteromona s sp. AS-11)	5 / 12	ILE A 114 ALA A 113 TRP A 104 VAL A 174 LEU A 130	None None None CA A 505 (-4.5A) PMS A 501 (-4.5A)	1.02A	5uanA-1v6cA: undetectable	5uanA-1v6cA: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W4Z_B_RBFB502_1 (RIBOFLAVIN LYASE)	2gko	SUBTILISIN MICROBIAL SERINE PROTEINASES (Bacillus subtilis)	5 / 12	SER A 227 ALA A 165 GLY A 247 GLY A 290 ALA A 293	None PMS A 601 ( 3.8A) PMS A 601 ( 3.8A) None None	0.91A	5w4zB-2gkoA: 0.8	5w4zB-2gkoA: 12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z12_C_9CRC501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	1v6c	ALKALINE SERINE PROTEASE (Pseudoalteromona s sp. AS-11)	5 / 12	ILE A 114 ALA A 113 TRP A 104 VAL A 174 LEU A 130	None None None CA A 505 (-4.5A) PMS A 501 (-4.5A)	0.94A	5z12C-1v6cA: undetectable	5z12C-1v6cA: 10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BKL_G_EU7G101_0 (MATRIX PROTEIN 2)	3iox	AGI/II (Streptococcus mutans)	5 / 9	ALA A 696 GLY A 772 ALA A 732 SER A 722 GLY A 724	PMS A 900 ( 4.8A) None None None None	1.07A	6bklE-3ioxA: undetectable 6bklF-3ioxA: undetectable 6bklG-3ioxA: undetectable 6bklH-3ioxA: undetectable	6bklE-3ioxA: 3.67 6bklF-3ioxA: 3.67 6bklG-3ioxA: 3.67 6bklH-3ioxA: 3.67

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FM6_A_9CRA501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","1v6c","ALKALINE SERINE PROTEASE","Pseudoalteromonas sp. AS-11",5,"ILE A 114;ALA A 113;TRP A 104;VAL A 174;LEU A 130","None;None;None; CA A 505 (-4.5A);PMS A 501 (-4.5A)","0.90A","1fm6A-1v6cA:undetectable",null],["1FM6_U_9CRU502_1","RETINOIC ACID RECEPTOR RXR-ALPHA","2gko"," SUBTILISIN;MICROBIAL SERINE PROTEINASES","Bacillus subtilis",5,"ALA A 166;ALA A 165;VAL A 233;ILE A 245;HIS A  74","None;PMS A 601 ( 3.8A);None;PMS A 601 (-4.5A);None","1.02A","1fm6U-2gkoA:undetectable","1fm6A-1v6cA:18.78"],["1RI4_A_SAMA299_0","MRNA CAPPING ENZYME","5z6o","PROTEASE","Penicillium cyclopium",5,"GLY A 209;GLY A 226;ILE A 184;SER A 187;TYR A 206","None;PMS A 302 (-3.6A);None;None;None","1.05A","1ri4A-5z6oA:2.0","1fm6U-2gkoA:21.30"],["1Y4L_B_SVRB301_1","PHOSPHOLIPASE A2 HOMOLOG 2;PHOSPHOLIPASE A2 HOMOLOG 2","1aur","CARBOXYLESTERASE","Pseudomonas fluorescens",5,"GLY A  24;GLY A  22;LEU A  20;GLY A 112;PRO A 143","None;PMS A 801 ( 3.9A);None;None;None","1.22A","1y4lA-1aurA:undetectable","1ri4A-5z6oA:undetectable"],["2EIM_A_CHDA525_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3","1wb8","SUPEROXIDE DISMUTASE [FE]","Sulfolobus solfataricus",4,"HIS A  33;ASP A  19;TYR A  16;HIS A  37"," FE A 212 (-3.3A);None;None;PMS A 213 (-4.0A)","1.50A","2eimA-1wb8A:undetectable;2eimC-1wb8A:undetectable","1y4lA-1aurA:17.83"],["2OXT_D_SAMD300_0","NUCLEOSIDE-2'-O-METHYLTRANSFERASE","1eq9","CHYMOTRYPSIN","Solenopsis invicta",6,"GLY A 142;GLY A 196;GLY A 193;THR A  54;LEU A  53;VAL A  31","None;None;PMS A1201 (-4.0A);None;None;None","1.34A","2oxtD-1eq9A:undetectable","2eimA-1wb8A:16.73;2eimC-1wb8A:22.64"],["2P16_A_GG2A298_1","COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR)","1eq9","CHYMOTRYPSIN","Solenopsis invicta",5,"ALA A 190;SER A 195;VAL A 213;GLY A 216;TYR A 228","PMS A1201 (-3.6A);PMS A1201 (-1.5A);None;PMS A1201 ( 4.5A);None","0.43A","2p16A-1eq9A:12.9","2oxtD-1eq9A:20.37"],["2W26_A_RIVA1001_1","ACTIVATED FACTOR XA HEAVY CHAIN","1eq9","CHYMOTRYPSIN","Solenopsis invicta",5,"ALA A 190;SER A 195;VAL A 213;GLY A 216;TYR A 228","PMS A1201 (-3.6A);PMS A1201 (-1.5A);None;PMS A1201 ( 4.5A);None","0.37A","2w26A-1eq9A:11.8","2p16A-1eq9A:34.43"],["2YVL_D_SAMD603_0","HYPOTHETICAL PROTEIN","2gko","MICROBIAL SERINE PROTEINASES; SUBTILISIN","Bacillus subtilis",5,"GLY A 230;ALA A 232;ALA A 165;VAL A 188;VAL A  75","None;None;PMS A 601 ( 3.8A);None;None","1.16A","2yvlD-2gkoA:2.2","2w26A-1eq9A:34.43"],["3BOG_C_DHIC8_0","6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN","1s2n","EXTRACELLULAR SUBTILISIN-LIKE SERINE PROTEINASE","Vibrio sp. PA-44",3,"SER A 220;GLY A 156;GLY A 130","PMS A1284 (-2.1A);PMS A1284 (-3.5A);PMS A1284 (-3.3A)","0.57A","3bogA-1s2nA:undetectable;3bogC-1s2nA:undetectable","2yvlD-2gkoA:17.77"],["3BOG_C_DHIC8_0","6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN","1v6c","ALKALINE SERINE PROTEASE","Pseudoalteromonas sp. AS-11",3,"SER A 369;GLY A 158;GLY A 131","PMS A 501 (-1.5A);PMS A 501 ( 4.6A);PMS A 501 (-4.3A)","0.49A","3bogA-1v6cA:undetectable;3bogC-1v6cA:undetectable","3bogA-1s2nA:undetectable;3bogC-1s2nA:undetectable"],["3D2T_B_1FLB500_1","TRANSTHYRETIN","1eq9","CHYMOTRYPSIN","Solenopsis invicta",4,"ALA A  44;SER A 195;THR A  54;VAL A 106","None;PMS A1201 (-1.5A);None;None","1.01A","3d2tB-1eq9A:0.0","3bogA-1v6cA:undetectable;3bogC-1v6cA:undetectable"],["3DCJ_A_THHA401_0","PROBABLE 5'-PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE PURN","4dzt","AQUALYSIN-1","Thermus aquaticus",5,"ILE A 204;LEU A 218;THR A  82;THR A  77;PRO A   7","None;PMS A 301 ( 4.3A);None;None;None","1.13A","3dcjA-4dztA:2.9;3dcjB-4dztA:3.1","3d2tB-1eq9A:21.15"],["3KEE_C_30BC500_1","GENOME POLYPROTEIN","5z6o","PROTEASE","Penicillium cyclopium",5,"GLY A 236;VAL A 203;SER A 160;ALA A 162;ALA A 163","None;None;None;PMS A 302 (-3.6A);None","1.06A","3keeC-5z6oA:undetectable","3dcjA-4dztA:24.29;3dcjB-4dztA:24.29"],["3LN1_A_CELA682_1","PROSTAGLANDIN G\/H SYNTHASE 2","2gko"," SUBTILISIN;MICROBIAL SERINE PROTEINASES","Bacillus subtilis",5,"ALA A 165;VAL A  75;GLY A  77;ALA A  76;LEU A  98","PMS A 601 ( 3.8A);None;None;None;None","0.96A","3ln1A-2gkoA:undetectable","3keeC-5z6oA:17.37"],["3LN1_B_CELB682_1","PROSTAGLANDIN G\/H SYNTHASE 2","2gko"," SUBTILISIN;MICROBIAL SERINE PROTEINASES","Bacillus subtilis",5,"ALA A 165;VAL A  75;GLY A  77;ALA A  76;LEU A  98","PMS A 601 ( 3.8A);None;None;None;None","0.95A","3ln1B-2gkoA:undetectable","3ln1A-2gkoA:21.28"],["3LN1_C_CELC682_1","PROSTAGLANDIN G\/H SYNTHASE 2","2gko"," SUBTILISIN;MICROBIAL SERINE PROTEINASES","Bacillus subtilis",5,"ALA A 165;VAL A  75;GLY A  77;ALA A  76;LEU A  98","PMS A 601 ( 3.8A);None;None;None;None","0.96A","3ln1C-2gkoA:undetectable","3ln1B-2gkoA:21.28"],["3LN1_D_CELD682_1","PROSTAGLANDIN G\/H SYNTHASE 2","2gko"," SUBTILISIN;MICROBIAL SERINE PROTEINASES","Bacillus subtilis",5,"ALA A 165;VAL A  75;GLY A  77;ALA A  76;LEU A  98","PMS A 601 ( 3.8A);None;None;None;None","0.94A","3ln1D-2gkoA:0.7","3ln1C-2gkoA:21.28"],["3S8P_B_SAMB500_1","HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1","2gko","MICROBIAL SERINE PROTEINASES; SUBTILISIN","Bacillus subtilis",3,"HIS A  71;SER A 252;ASN A 168","PMS A 601 (-3.1A);None;PMS A 601 (-3.0A)","0.87A","3s8pB-2gkoA:undetectable","3ln1D-2gkoA:21.28"],["4A99_D_MIYD392_1","TETX2 PROTEIN","1eq9","CHYMOTRYPSIN","Solenopsis invicta",4,"HIS A  57;SER A 195;SER A 214;VAL A 213","PMS A1201 ( 4.6A);PMS A1201 (-1.5A);None;None","1.38A","4a99D-1eq9A:undetectable","3s8pB-2gkoA:21.97"],["4DRJ_A_RAPA201_2","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4;SERINE\/THREONINE-PROTEIN KINASE MTOR","2gko"," SUBTILISIN;MICROBIAL SERINE PROTEINASES","Bacillus subtilis",4,"LEU A 139;SER A 249;THR A  73;ASP A  67","None;PMS A 601 (-1.7A);None;None","1.08A","4drjB-2gkoA:undetectable","4a99D-1eq9A:22.37"],["4FEU_D_KAND301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","3iox","AGI\/II","Streptococcus mutans",4,"ASP A 760;ASP A 554;ASP A 555;ASN A 699","PMS A 900 (-3.6A);None;None; CA A 903 (-3.1A)","1.09A","4feuD-3ioxA:undetectable","4drjB-2gkoA:12.89"],["4FO4_A_MOAA502_1","INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE","2gko"," SUBTILISIN;MICROBIAL SERINE PROTEINASES","Bacillus subtilis",4,"SER A 175;SER A 207;THR A 248;GLY A 140","None;None;PMS A 601 (-4.7A);None","0.90A","4fo4A-2gkoA:undetectable","4feuD-3ioxA:16.57"],["4FO4_B_MOAB502_1","INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE","2gko"," SUBTILISIN;MICROBIAL SERINE PROTEINASES","Bacillus subtilis",4,"SER A 175;SER A 207;THR A 248;GLY A 140","None;None;PMS A 601 (-4.7A);None","0.84A","4fo4B-2gkoA:undetectable","4fo4A-2gkoA:24.02"],["4KOE_F_TR6F101_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B;E-SITE DNA2","5z6o","PROTEASE","Penicillium cyclopium",4,"SER A 228;GLY A 101;ASP A 103;GLY A 106","PMS A 302 (-1.5A);None;None;None","1.00A","4koeA-5z6oA:undetectable;4koeB-5z6oA:undetectable;4koeC-5z6oA:2.2","4fo4B-2gkoA:24.02"],["4PWJ_B_30ZB201_1","TRANSTHYRETIN","1s2n","EXTRACELLULAR SUBTILISIN-LIKE SERINE PROTEINASE","Vibrio sp. PA-44",4,"LEU A 129;THR A 175;ALA A 154;THR A 219","None;None;PMS A1284 ( 3.8A);PMS A1284 (-4.6A)","1.04A","4pwjB-1s2nA:undetectable","4koeA-5z6oA:10.25;4koeB-5z6oA:10.25;4koeC-5z6oA:13.91"],["4QWU_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5z6o","PROTEASE","Penicillium cyclopium",5,"ALA A 162;ALA A 231;GLY A 139;GLY A 138;ASP A  42","PMS A 302 (-3.6A);None;None;PMS A 302 (-3.7A);PMS A 302 ( 3.9A)","1.19A","4qwuK-5z6oA:undetectable;4qwuL-5z6oA:undetectable","4pwjB-1s2nA:19.35"],["4XP1_A_LDPA708_1","DOPAMINE TRANSPORTER, ISOFORM B","4dzt","AQUALYSIN-1","Thermus aquaticus",5,"ASP A 138;ALA A 154;VAL A 153;SER A 166;GLY A 130","None;PMS A 301 (-3.6A);None;None;None","1.42A","4xp1A-4dztA:undetectable","4qwuK-5z6oA:19.21;4qwuL-5z6oA:20.25"],["4YO9_B_ACTB401_0","3C-LIKE PROTEINASE","4z9a","LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE","Homo sapiens",3,"ARG A  58;ASP A  56;TYR A 131","None;None;PMS A 304 ( 4.6A)","0.81A","4yo9B-4z9aA:undetectable","4xp1A-4dztA:20.49"],["4Z53_F_TR6F101_1","DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;E-SITE DNA","5z6o","PROTEASE","Penicillium cyclopium",4,"GLY A 101;ASP A 103;GLY A 106;SER A 228","None;None;None;PMS A 302 (-1.5A)","1.02A","4z53A-5z6oA:undetectable;4z53B-5z6oA:undetectable","4yo9B-4z9aA:17.25"],["5BOJ_B_4TXB201_1","TRANSTHYRETIN","1s2n","EXTRACELLULAR SUBTILISIN-LIKE SERINE PROTEINASE","Vibrio sp. PA-44",4,"LEU A 129;THR A 175;ALA A 154;THR A 219","None;None;PMS A1284 ( 3.8A);PMS A1284 (-4.6A)","1.01A","5bojB-1s2nA:undetectable","4z53A-5z6oA:7.24;4z53B-5z6oA:7.24"],["5CPR_B_SAMB402_1","HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1","2gko","MICROBIAL SERINE PROTEINASES; SUBTILISIN","Bacillus subtilis",3,"HIS A  71;SER A 252;ASN A 168","PMS A 601 (-3.1A);None;PMS A 601 (-3.0A)","0.90A","5cprB-2gkoA:undetectable","5bojB-1s2nA:20.00"],["5ESK_A_1YNA701_2","LANOSTEROL 14-ALPHA DEMETHYLASE","1s2n","EXTRACELLULAR SUBTILISIN-LIKE SERINE PROTEINASE","Vibrio sp. PA-44",4,"ALA A 207;PRO A 224;LEU A 129;HIS A  70","None;None;None;PMS A1284 (-4.1A)","1.29A","5eskA-1s2nA:undetectable","5cprB-2gkoA:22.32"],["5ESK_A_1YNA701_2","LANOSTEROL 14-ALPHA DEMETHYLASE","4dzt","AQUALYSIN-1","Thermus aquaticus",4,"ALA A 207;PRO A 226;LEU A 129;HIS A  70","None;None;None;PMS A 301 (-4.2A)","1.18A","5eskA-4dztA:undetectable","5eskA-1s2nA:20.26"],["5JW1_A_CELA602_1","PROSTAGLANDIN G\/H SYNTHASE 2","2gko"," SUBTILISIN;MICROBIAL SERINE PROTEINASES","Bacillus subtilis",5,"ALA A 165;VAL A  75;GLY A  77;ALA A  76;LEU A  98","PMS A 601 ( 3.8A);None;None;None;None","0.98A","5jw1A-2gkoA:undetectable","5eskA-4dztA:20.24"],["5KIR_A_RCXA601_1","PROSTAGLANDIN G\/H SYNTHASE 2","2gko"," SUBTILISIN;MICROBIAL SERINE PROTEINASES","Bacillus subtilis",5,"ALA A 165;VAL A  75;GLY A  77;ALA A  76;LEU A  98","PMS A 601 ( 3.8A);None;None;None;None","0.92A","5kirA-2gkoA:undetectable","5jw1A-2gkoA:20.35"],["5KIR_B_RCXB601_1","PROSTAGLANDIN G\/H SYNTHASE 2","2gko"," SUBTILISIN;MICROBIAL SERINE PROTEINASES","Bacillus subtilis",5,"ALA A 165;VAL A  75;GLY A  77;ALA A  76;LEU A  98","PMS A 601 ( 3.8A);None;None;None;None","0.92A","5kirB-2gkoA:undetectable","5kirA-2gkoA:20.11"],["5UAN_A_9CRA503_1","RETINOIC ACID RECEPTOR RXR-ALPHA","1v6c","ALKALINE SERINE PROTEASE","Pseudoalteromonas sp. AS-11",5,"ILE A 114;ALA A 113;TRP A 104;VAL A 174;LEU A 130","None;None;None; CA A 505 (-4.5A);PMS A 501 (-4.5A)","1.02A","5uanA-1v6cA:undetectable","5kirB-2gkoA:20.11"],["5W4Z_B_RBFB502_1","RIBOFLAVIN LYASE","2gko"," SUBTILISIN;MICROBIAL SERINE PROTEINASES","Bacillus subtilis",5,"SER A 227;ALA A 165;GLY A 247;GLY A 290;ALA A 293","None;PMS A 601 ( 3.8A);PMS A 601 ( 3.8A);None;None","0.91A","5w4zB-2gkoA:0.8","5uanA-1v6cA:20.17"],["5Z12_C_9CRC501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","1v6c","ALKALINE SERINE PROTEASE","Pseudoalteromonas sp. AS-11",5,"ILE A 114;ALA A 113;TRP A 104;VAL A 174;LEU A 130","None;None;None; CA A 505 (-4.5A);PMS A 501 (-4.5A)","0.94A","5z12C-1v6cA:undetectable","5w4zB-2gkoA:12.76"],["6BKL_G_EU7G101_0","MATRIX PROTEIN 2","3iox","AGI\/II","Streptococcus mutans",5,"ALA A 696;GLY A 772;ALA A 732;SER A 722;GLY A 724","PMS A 900 ( 4.8A);None;None;None;None","1.07A","6bklE-3ioxA:undetectable;6bklF-3ioxA:undetectable;6bklG-3ioxA:undetectable;6bklH-3ioxA:undetectable","5z12C-1v6cA:10.49"]]