SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PMR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B
(Prochlorococcus
marinus) 		5 / 12 PRO D 204
GLY D 178
SER D 390
ILE D  46
LEU D 177
 None
None
None
PMR  C1414 ( 4.7A)
GOL  D1530 ( 4.6A)
 1.31A 3iv6C-2ynmD:
undetectable		 3iv6C-2ynmD:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B
LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N
(Prochlorococcus
marinus) 		5 / 12 LEU C  80
VAL C  37
HIS D  13
LEU C  70
TYR D  38
 None
None
None
None
PMR  C1414 (-4.6A)
 1.20A 3sp9B-2ynmC:
undetectable		 3sp9B-2ynmC:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N
(Prochlorococcus
marinus) 		5 / 12 PHE C 384
GLY C  18
LEU C  19
VAL C  36
THR C  62
 PMR  C1414 (-4.3A)
None
SF4  C1413 (-4.3A)
None
None
 1.19A 4wnwA-2ynmC:
undetectable		 4wnwA-2ynmC:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N
(Prochlorococcus
marinus) 		5 / 12 LEU C 238
GLU C 297
PRO C 215
GLU C 145
THR C  20
 None
None
None
None
PMR  C1414 (-3.9A)
 1.47A 5xipD-2ynmC:
undetectable		 5xipD-2ynmC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N
(Prochlorococcus
marinus) 		5 / 12 LEU C 238
GLU C 297
PRO C 215
GLU C 145
THR C  20
 None
None
None
None
PMR  C1414 (-3.9A)
 1.45A 5xiqB-2ynmC:
2.9		 5xiqB-2ynmC:
21.98