SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PMP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2fnu AMINOTRANSFERASE
(Helicobacter
pylori) 		4 / 7 TYR A 316
HIS A 157
THR A  79
ASN A 108
 UD1  A 902 ( 4.5A)
PMP  A 901 (-3.9A)
None
None
 1.30A 1afsA-2fnuA:
undetectable		 1afsA-2fnuA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2fnu AMINOTRANSFERASE
(Helicobacter
pylori) 		4 / 7 TYR A 316
HIS A 157
THR A  79
ASN A 108
 UD1  A 902 ( 4.5A)
PMP  A 901 (-3.9A)
None
None
 1.29A 1afsB-2fnuA:
undetectable		 1afsB-2fnuA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 5ghf AMINOTRANSFERASE
CLASS-III
(Ochrobactrum
anthropi) 		4 / 6 ASN A 167
HIS A 180
ALA A 159
GLY A 153
 None
None
None
PMP  A 501 ( 3.7A)
 1.14A 1c8lA-5ghfA:
undetectable		 1c8lA-5ghfA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 TYR A 239
LEU A 237
SER A 227
HIS A 126
LEU A 102
 None
None
PMP  A 401 (-2.6A)
None
None
 1.18A 1fmlA-3cq5A:
undetectable		 1fmlA-3cq5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 TYR A 239
LEU A 237
SER A 227
HIS A 126
LEU A 102
 None
None
PMP  A 401 (-2.6A)
None
None
 1.18A 1fmlB-3cq5A:
undetectable		 1fmlB-3cq5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		6 / 12 GLY A  59
ALA A  62
ASP A  61
ILE A  54
ILE A 196
ILE A 195
 PMP  A 377 (-3.5A)
None
None
None
None
None
 1.42A 1hshA-3uwcA:
undetectable		 1hshA-3uwcA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 12 ALA A 154
ASP A 153
GLY A 150
ILE A 241
ILE A 129
 None
None
PMP  A 501 ( 3.9A)
None
None
 0.93A 1hshC-2epjA:
undetectable		 1hshC-2epjA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 8 SER A 241
ASN A 242
GLY A 102
GLY A 110
 None
None
PMP  A 409 (-3.6A)
None
 0.85A 1jr1B-4rkcA:
undetectable		 1jr1B-4rkcA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 10 GLY A  97
LEU A 129
GLN A 103
THR A 225
GLY A 238
 PMP  A 401 (-3.6A)
None
None
PMP  A 401 (-3.2A)
PMP  A 401 ( 4.5A)
 1.38A 1kvlA-3cq5A:
undetectable		 1kvlA-3cq5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  84
LEU A 112
GLN A 116
THR A 214
GLY A 227
 PMP  A 402 (-3.4A)
GOL  A 403 (-4.9A)
GOL  A 403 (-4.0A)
PMP  A 402 (-3.3A)
PMP  A 402 ( 4.6A)
 1.12A 1kvlA-4r5zA:
undetectable		 1kvlA-4r5zA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 2fnu AMINOTRANSFERASE
(Helicobacter
pylori) 		5 / 10 LEU A  45
ALA A  56
ALA A 192
VAL A  47
ASP A 129
 None
PMP  A 901 (-3.3A)
None
None
None
 1.11A 1rlbE-2fnuA:
undetectable		 1rlbE-2fnuA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 8 ASP A 163
ALA A 165
GLY A 199
GLY A 200
ALA A  98
 PMP  A1416 (-2.8A)
PMP  A1416 (-3.5A)
None
None
None
 0.97A 1sguA-2c81A:
undetectable		 1sguA-2c81A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 8 ASP A 163
ALA A 165
GLY A 200
ILE A 202
ALA A  98
 PMP  A1416 (-2.8A)
PMP  A1416 (-3.5A)
None
None
None
 1.30A 1sguA-2c81A:
undetectable		 1sguA-2c81A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 8 ASP A 163
GLY A 199
GLY A 200
ILE A 201
ALA A  73
 PMP  A1416 (-2.8A)
None
None
None
None
 1.18A 1sguA-2c81A:
undetectable		 1sguA-2c81A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 8 TYR A  95
ARG A  97
GLY A 255
THR A 256
ALA A 257
 None
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
 0.36A 2a1hA-2ej0A:
30.3
2a1hB-2ej0A:
30.2		 2a1hA-2ej0A:
27.85
2a1hB-2ej0A:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 8 TYR A  95
ARG A  97
GLY A 255
THR A 256
ALA A 257
 None
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
 0.29A 2a1hA-2ej0A:
30.3
2a1hB-2ej0A:
30.2		 2a1hA-2ej0A:
27.85
2a1hB-2ej0A:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 2fnu AMINOTRANSFERASE
(Helicobacter
pylori) 		5 / 12 LEU A 152
ALA A 172
LEU A 200
MET A 204
THR A  87
 None
None
None
None
PMP  A 901 (-4.6A)
 1.29A 2aa6A-2fnuA:
undetectable		 2aa6A-2fnuA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		4 / 5 GLY A 118
PRO A  64
VAL A 269
ILE A 270
 PMP  A 431 (-3.6A)
None
None
None
 1.00A 2aoiA-3bs8A:
undetectable		 2aoiA-3bs8A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 10 TYR A  95
ARG A  97
GLY A 255
THR A 256
ALA A 257
 None
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
 0.21A 2coiA-2ej0A:
30.7
2coiB-2ej0A:
31.1		 2coiA-2ej0A:
28.14
2coiB-2ej0A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 10 TYR A  95
ARG A  97
GLY A 255
THR A 256
ALA A 257
 None
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
 0.26A 2coiA-2ej0A:
30.7
2coiB-2ej0A:
31.1		 2coiA-2ej0A:
28.14
2coiB-2ej0A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		6 / 11 PHE A  36
TYR A  95
ARG A  97
GLY A 255
THR A 256
ALA A 257
 None
None
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
 0.34A 2cojA-2ej0A:
30.5
2cojB-2ej0A:
30.8		 2cojA-2ej0A:
28.14
2cojB-2ej0A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 9 TYR A  95
ARG A  97
GLY A 255
THR A 256
ALA A 257
 None
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
 0.25A 2cojA-2ej0A:
30.5
2cojB-2ej0A:
30.8		 2cojA-2ej0A:
28.14
2cojB-2ej0A:
28.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		8 / 8 TYR A  95
ARG A  97
GLY A 196
GLU A 197
GLY A 255
THR A 256
ALA A 257
ALA A 258
 None
None
PMP  A3413 (-3.7A)
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
None
 0.29A 2ej3A-2ej0A:
49.5		 2ej3A-2ej0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		10 / 10 PHE A  36
TYR A  95
ARG A  97
TYR A 164
GLY A 196
GLU A 197
GLY A 255
THR A 256
ALA A 257
ALA A 258
 None
None
None
PMP  A3413 (-4.4A)
PMP  A3413 (-3.7A)
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
None
 0.24A 2ej3B-2ej0A:
48.4		 2ej3B-2ej0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		8 / 8 TYR A  95
ARG A  97
GLY A 196
GLU A 197
GLY A 255
THR A 256
ALA A 257
ALA A 258
 None
None
PMP  A3413 (-3.7A)
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
None
 0.30A 2ej3C-2ej0A:
48.7		 2ej3C-2ej0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 GLY A 107
GLY A 109
ALA A 242
THR A 215
ALA A 216
 PMP  A 409 (-3.7A)
None
None
None
PMP  A 409 ( 3.7A)
 1.05A 2gluB-2zc0A:
undetectable		 2gluB-2zc0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		4 / 5 ILE A 272
PRO A  67
PHE A 407
VAL A 246
 None
None
None
PMP  A 501 ( 4.5A)
 1.23A 2hjhB-2epjA:
0.3		 2hjhB-2epjA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 GLY A 243
ALA A 242
ASP A 214
ILE A 105
VAL A 268
 None
None
PMP  A 409 (-2.7A)
None
None
 0.95A 2ieoA-2zc0A:
undetectable		 2ieoA-2zc0A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 PHE A 113
ALA A 275
SER A 116
GLY A 269
GLY A 265
 None
None
PMP  A1001 (-3.7A)
None
None
 1.15A 2igtB-2e7uA:
3.0		 2igtB-2e7uA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 8 ALA A 192
GLU A 193
LEU A 141
VAL A 263
ILE A 271
 None
PMP  A3413 (-3.3A)
None
None
None
 1.45A 2uxpA-2ej0A:
undetectable		 2uxpA-2ej0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 7 TYR A 251
TYR A 214
CYH A 180
CYH A 181
 None
PMP  A 409 ( 4.5A)
None
None
 1.34A 2xytD-4rkcA:
undetectable		 2xytD-4rkcA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 7 TYR A 251
TYR A 214
CYH A 180
CYH A 181
 None
PMP  A 409 ( 4.5A)
None
None
 1.26A 2xytG-4rkcA:
undetectable		 2xytG-4rkcA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 7 TYR A 251
TYR A 214
CYH A 180
CYH A 181
 None
PMP  A 409 ( 4.5A)
None
None
 1.24A 2xytH-4rkcA:
undetectable		 2xytH-4rkcA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 SER A  38
PHE A 336
ASN A 381
ASN A 186
TYR A 132
 None
None
None
PMP  A 409 (-3.7A)
PMP  A 409 (-3.7A)
 1.44A 2y00A-2zc0A:
undetectable		 2y00A-2zc0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_A_68HA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 11 SER A  38
PHE A 336
ASN A 381
ASN A 186
TYR A 132
 None
None
None
PMP  A 409 (-3.7A)
PMP  A 409 (-3.7A)
 1.41A 2y04A-2zc0A:
undetectable		 2y04A-2zc0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 GLY A 243
ALA A 242
ASP A 214
ILE A 105
VAL A 268
 None
None
PMP  A 409 (-2.7A)
None
None
 1.00A 2z54A-2zc0A:
undetectable		 2z54A-2zc0A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 VAL A  93
GLY A 227
ARG A 213
LEU A  66
 None
PMP  A 402 ( 4.6A)
None
None
 0.94A 3bjwE-4r5zA:
undetectable		 3bjwE-4r5zA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5wml -
(-) 		3 / 3 GLY A 167
GLY A 303
GLY A 316
 PMP  A 501 (-3.4A)
None
None
 0.38A 3bogD-5wmlA:
undetectable		 3bogD-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ghf AMINOTRANSFERASE
CLASS-III
(Ochrobactrum
anthropi) 		4 / 6 ASN A 167
HIS A 180
ALA A 159
GLY A 153
 None
None
None
PMP  A 501 ( 3.7A)
 1.16A 3ddsA-5ghfA:
undetectable		 3ddsA-5ghfA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 9 ALA A 278
GLY A 118
PRO A  64
VAL A 269
ILE A 270
 None
PMP  A 431 (-3.6A)
None
None
None
 1.19A 3em4B-3bs8A:
undetectable		 3em4B-3bs8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 5ghf AMINOTRANSFERASE
CLASS-III
(Ochrobactrum
anthropi) 		5 / 12 GLY A 272
GLY A 263
GLU A 225
VAL A 125
ILE A 256
 None
None
PMP  A 501 (-3.9A)
None
None
 1.01A 3embA-5ghfA:
undetectable		 3embA-5ghfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 THR A 220
THR A 254
LEU A 283
ILE A 207
TYR A  42
 PMP  A3413 (-3.5A)
None
None
None
None
 1.39A 3gwxB-2ej0A:
undetectable		 3gwxB-2ej0A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5ghf AMINOTRANSFERASE
CLASS-III
(Ochrobactrum
anthropi) 		5 / 12 LEU A 294
ILE A 296
SER A 286
LEU A 289
SER A 290
 None
None
PMP  A 501 ( 4.3A)
None
None
 1.28A 3gyqA-5ghfA:
undetectable
3gyqB-5ghfA:
undetectable		 3gyqA-5ghfA:
22.39
3gyqB-5ghfA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		6 / 12 GLY A 103
ASN A 242
GLY A  70
ALA A  69
GLY A 257
LEU A 258
 PMP  A 409 (-3.4A)
None
None
None
None
None
 1.43A 3hs6B-4rkcA:
undetectable		 3hs6B-4rkcA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 ASP A 197
PHE A 166
SER A 124
 PMP  A 401 (-2.7A)
None
SO4  A 402 ( 3.7A)
 0.69A 3i5uB-3cq5A:
4.9		 3i5uB-3cq5A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		4 / 4 GLY A  76
VAL A 102
GLY A 106
THR A 108
 None
None
PMP  A 409 (-2.8A)
PMP  A 409 (-3.6A)
 0.93A 3ib2A-2zc0A:
undetectable		 3ib2A-2zc0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		3 / 3 SER A 116
GLY A 117
THR A 118
 PMP  A1001 (-3.7A)
PMP  A1001 (-3.5A)
PMP  A1001 (-3.6A)
 0.14A 3k9wA-2e7uA:
undetectable		 3k9wA-2e7uA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		3 / 3 SER A 120
GLY A 121
THR A 122
 PMP  A 501 ( 3.8A)
PMP  A 501 ( 3.3A)
PMP  A 501 ( 3.5A)
 0.18A 3k9wA-2epjA:
undetectable		 3k9wA-2epjA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		3 / 3 SER A 117
GLY A 118
THR A 119
 PMP  A 431 ( 3.8A)
PMP  A 431 (-3.6A)
PMP  A 431 (-3.4A)
 0.15A 3k9wA-3bs8A:
undetectable		 3k9wA-3bs8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		3 / 3 SER A1122
GLY A1123
THR A1124
 PMP  A5000 (-3.8A)
PMP  A5000 (-3.3A)
PMP  A5000 (-3.5A)
 0.12A 3k9wA-3fq8A:
undetectable		 3k9wA-3fq8A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5hdm GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 ILE A 229
PHE A 245
ASP A 246
GLU A 213
 None
None
PMP  A 500 (-2.8A)
PMP  A 500 (-3.8A)
 1.16A 3kp6A-5hdmA:
undetectable
3kp6B-5hdmA:
undetectable		 3kp6A-5hdmA:
18.30
3kp6B-5hdmA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 10 THR A 122
GLY A 149
GLU A 120
LEU A 152
LEU A 153
 PMP  A 431 ( 4.4A)
None
None
None
None
 1.16A 3kvrA-3bs8A:
undetectable		 3kvrA-3bs8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 12 LEU A 250
ILE A 201
GLY A  66
ALA A  69
LEU A  72
 None
None
PMP  A1416 (-3.7A)
None
None
 1.25A 3n8xA-2c81A:
undetectable		 3n8xA-2c81A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 9 THR A 122
GLY A 149
GLU A 120
LEU A 152
LEU A 153
 PMP  A 431 ( 4.4A)
None
None
None
None
 1.14A 3nbqA-3bs8A:
undetectable		 3nbqA-3bs8A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		6 / 11 GLY A 243
ALA A 242
ASP A 214
ILE A 105
VAL A 268
ILE A 258
 None
None
PMP  A 409 (-2.7A)
None
None
None
 1.49A 3ndxB-2zc0A:
undetectable		 3ndxB-2zc0A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 5hdm GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		6 / 9 LEU A 242
GLY A 286
ASP A 246
ILE A 211
GLY A 130
ILE A 244
 None
None
PMP  A 500 (-2.8A)
None
None
None
 1.24A 3nu4B-5hdmA:
undetectable		 3nu4B-5hdmA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 6 VAL A 115
SER A 112
TYR A 138
GLY A 140
 None
PLP  A1261 ( 2.6A)
PMP  A1271 (-4.2A)
PLP  A1261 ( 3.9A)
 1.13A 3tj7C-1szsA:
0.0
3tj7D-1szsA:
0.0		 3tj7C-1szsA:
20.66
3tj7D-1szsA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE
(Bacillus
circulans) 		3 / 3 GLN A 166
PHE A 140
TYR A 342
 PMP  A1416 (-3.7A)
None
None
 1.00A 3ucjB-2c81A:
undetectable		 3ucjB-2c81A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE
(Bacillus
circulans) 		3 / 3 GLN A 166
PHE A 140
TYR A 342
 PMP  A1416 (-3.7A)
None
None
 1.01A 3ucjA-2c81A:
undetectable		 3ucjA-2c81A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5wml -
(-) 		5 / 12 ILE A 274
ILE A 237
VAL A 186
LEU A 235
VAL A 179
 PMP  A 501 ( 4.7A)
None
None
None
None
 1.17A 3w68C-5wmlA:
undetectable		 3w68C-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 227
GLY A  82
VAL A 248
PHE A 215
ALA A 229
 PMP  A 402 ( 4.6A)
None
None
None
None
 1.15A 4a6dA-4r5zA:
undetectable		 4a6dA-4r5zA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_A_CVDA1359_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 SER A  38
PHE A 336
ASN A 381
ASN A 186
TYR A 132
 None
None
None
PMP  A 409 (-3.7A)
PMP  A 409 (-3.7A)
 1.34A 4amjA-2zc0A:
undetectable		 4amjA-2zc0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 SER A  38
PHE A 336
ASN A 381
ASN A 186
TYR A 132
 None
None
None
PMP  A 409 (-3.7A)
PMP  A 409 (-3.7A)
 1.36A 4amjB-2zc0A:
undetectable		 4amjB-2zc0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 GLU A 206
TYR A 215
ARG A 349
GLY A 391
 PMP  A1271 ( 3.9A)
None
None
None
 1.07A 4fgzA-1szsA:
undetectable		 4fgzA-1szsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 GLY A 156
ASN A 198
GLU A 193
MET A  69
 None
PMP  A3413 ( 3.7A)
PMP  A3413 (-3.3A)
None
 1.28A 4g0vB-2ej0A:
undetectable		 4g0vB-2ej0A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		5 / 12 ASP A 211
ILE A 207
LEU A 176
HIS A 133
TRP A 130
 PMP  A 409 (-2.7A)
None
None
PMP  A 409 ( 4.7A)
PMP  A 409 ( 3.6A)
 1.19A 4j03A-4rkcA:
2.2		 4j03A-4rkcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 PHE A 309
TYR A 200
THR A 174
VAL A 335
 None
PMP  A 401 (-4.3A)
None
None
 1.10A 4l4dA-3cq5A:
undetectable		 4l4dA-3cq5A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 PHE A 309
TYR A 200
THR A 174
VAL A 335
 None
PMP  A 401 (-4.3A)
None
None
 1.12A 4l4eA-3cq5A:
undetectable		 4l4eA-3cq5A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 PHE A 309
TYR A 200
THR A 174
VAL A 335
 None
PMP  A 401 (-4.3A)
None
None
 1.12A 4l4fA-3cq5A:
undetectable		 4l4fA-3cq5A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 9 ALA A 278
GLY A 118
PRO A  64
VAL A 269
ILE A 270
 None
PMP  A 431 (-3.6A)
None
None
None
 1.24A 4ll3B-3bs8A:
undetectable		 4ll3B-3bs8A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3bwn L-TRYPTOPHAN
AMINOTRANSFERASE
(Arabidopsis
thaliana) 		4 / 5 TYR A 199
THR A  89
LEU A 230
THR A 164
 None
None
None
PMP  A1001 (-3.5A)
 1.41A 4mbsB-3bwnA:
undetectable		 4mbsB-3bwnA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 9 VAL A 268
ALA A 281
GLY A 150
SER A 120
GLY A 270
 None
None
PMP  A 501 ( 3.9A)
PMP  A 501 ( 3.8A)
None
 1.31A 4mmbA-2epjA:
undetectable		 4mmbA-2epjA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 9 VAL A 268
ALA A 281
GLY A 150
SER A 120
GLY A 270
 None
None
PMP  A 501 ( 3.9A)
PMP  A 501 ( 3.8A)
None
 1.39A 4mmeA-2epjA:
undetectable		 4mmeA-2epjA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 9 VAL A 268
ALA A 281
GLY A 150
SER A 120
GLY A 270
 None
None
PMP  A 501 ( 3.9A)
PMP  A 501 ( 3.8A)
None
 1.35A 4mmeB-2epjA:
undetectable		 4mmeB-2epjA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 9 VAL A 268
ALA A 281
GLY A 150
SER A 120
GLY A 270
 None
None
PMP  A 501 ( 3.9A)
PMP  A 501 ( 3.8A)
None
 1.29A 4mmfA-2epjA:
undetectable		 4mmfA-2epjA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		5 / 9 VAL A 268
ALA A 281
GLY A 150
SER A 120
GLY A 270
 None
None
PMP  A 501 ( 3.9A)
PMP  A 501 ( 3.8A)
None
 1.26A 4mmfB-2epjA:
undetectable		 4mmfB-2epjA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 10 SER A 117
THR A 122
SER A 124
TYR A 279
GLY A 147
 PMP  A 431 ( 3.8A)
PMP  A 431 ( 4.4A)
None
None
PMP  A 431 ( 3.7A)
 1.33A 4qb9C-3bs8A:
0.0		 4qb9C-3bs8A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 10 SER A 117
THR A 122
SER A 124
TYR A 279
TYR A 145
 PMP  A 431 ( 3.8A)
PMP  A 431 ( 4.4A)
None
None
None
 1.45A 4qb9C-3bs8A:
0.0		 4qb9C-3bs8A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 SER A 116
THR A 121
SER A 123
TYR A 277
GLY A 146
 PMP  A1001 (-3.7A)
PMP  A1001 ( 4.8A)
None
None
PMP  A1001 ( 4.1A)
 1.16A 4qb9E-2e7uA:
undetectable		 4qb9E-2e7uA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		5 / 12 SER A 116
THR A 121
SER A 123
TYR A 277
TYR A 144
 PMP  A1001 (-3.7A)
PMP  A1001 ( 4.8A)
None
None
PMP  A1001 (-4.6A)
 1.46A 4qb9E-2e7uA:
undetectable		 4qb9E-2e7uA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 SER A 117
THR A 122
SER A 124
TYR A 279
GLY A 147
 PMP  A 431 ( 3.8A)
PMP  A 431 ( 4.4A)
None
None
PMP  A 431 ( 3.7A)
 1.18A 4qb9E-3bs8A:
undetectable		 4qb9E-3bs8A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 SER A 117
THR A 122
SER A 124
TYR A 279
TYR A 145
 PMP  A 431 ( 3.8A)
PMP  A 431 ( 4.4A)
None
None
None
 1.45A 4qb9E-3bs8A:
undetectable		 4qb9E-3bs8A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5ghf AMINOTRANSFERASE
CLASS-III
(Ochrobactrum
anthropi) 		4 / 7 GLU A 225
ARG A 375
GLY A 232
GLY A 229
 PMP  A 501 (-3.9A)
None
None
None
 0.82A 4rdxA-5ghfA:
undetectable		 4rdxA-5ghfA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 TYR A 290
THR A 244
GLY A 250
ALA A 287
HIS A 300
 None
PMP  A 409 (-2.8A)
None
None
None
 1.06A 4rvgA-2zc0A:
4.2		 4rvgA-2zc0A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 THR A 135
LEU A 137
ALA A 138
LEU A 142
GLY A 106
 None
IMD  A 410 (-4.6A)
None
None
PMP  A 409 (-2.8A)
 0.96A 4xi3C-2zc0A:
undetectable		 4xi3C-2zc0A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 GLY A 281
ILE A 175
GLY A 149
THR A 119
THR A 264
 None
None
None
PMP  A 431 (-3.4A)
None
 1.05A 4zdyA-3bs8A:
undetectable		 4zdyA-3bs8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 GLY A 281
ILE A 175
GLY A 149
THR A 119
THR A 264
 None
None
None
PMP  A 431 (-3.4A)
None
 1.15A 4ze2A-3bs8A:
undetectable		 4ze2A-3bs8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		5 / 12 ILE A 101
TYR A 283
GLY A 102
GLY A 257
LEU A 275
 None
None
PMP  A 409 (-3.6A)
None
None
 1.11A 5eqbA-4rkcA:
2.5		 5eqbA-4rkcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 GLY A 281
ILE A 175
GLY A 149
THR A 119
THR A 264
 None
None
None
PMP  A 431 (-3.4A)
None
 1.11A 5eskA-3bs8A:
undetectable		 5eskA-3bs8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 GLY A 281
ILE A 175
GLY A 149
THR A 119
THR A 264
 None
None
None
PMP  A 431 (-3.4A)
None
 1.04A 5eslA-3bs8A:
undetectable		 5eslA-3bs8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 12 ALA A  48
THR A  68
GLY A 200
SER A 187
SER A 255
 None
None
None
PMP  A1416 (-2.5A)
None
 1.17A 5hfjB-2c81A:
undetectable		 5hfjB-2c81A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 12 ALA A  48
THR A  68
GLY A 200
SER A 187
SER A 255
 None
None
None
PMP  A1416 (-2.5A)
None
 1.26A 5hfjF-2c81A:
undetectable		 5hfjF-2c81A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A 247
THR A 210
PHE A 109
ALA A 108
SER A  98
 None
None
None
None
PMP  A 401 (-3.3A)
 1.31A 5iwuA-3cq5A:
undetectable		 5iwuA-3cq5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wml -
(-) 		5 / 12 TYR A 275
GLY A 167
ALA A 168
SER A 171
LEU A 172
 PMP  A 501 (-4.3A)
PMP  A 501 (-3.4A)
PMP  A 501 (-3.6A)
None
None
 1.08A 5jvzA-5wmlA:
undetectable		 5jvzA-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wml -
(-) 		5 / 12 TYR A 275
GLY A 167
ALA A 168
SER A 171
LEU A 172
 PMP  A 501 (-4.3A)
PMP  A 501 (-3.4A)
PMP  A 501 (-3.6A)
None
None
 1.09A 5jvzB-5wmlA:
undetectable		 5jvzB-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wml -
(-) 		5 / 12 ALA A 350
GLY A 167
ALA A 168
SER A 171
LEU A 172
 None
PMP  A 501 (-3.4A)
PMP  A 501 (-3.6A)
None
None
 0.95A 5kirB-5wmlA:
undetectable		 5kirB-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 8 SER A 241
HIS A 178
VAL A 125
SER A 126
 None
PMP  A 409 ( 4.6A)
None
None
 1.03A 5m8rB-4rkcA:
undetectable		 5m8rB-4rkcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE
(Psychrobacter
sp.
B6) 		4 / 8 SER A 241
HIS A 178
VAL A 125
SER A 126
 None
PMP  A 409 ( 4.6A)
None
None
 0.99A 5m8rD-4rkcA:
undetectable		 5m8rD-4rkcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5wml -
(-) 		5 / 12 ILE A 274
GLY A 303
VAL A 164
GLN A 170
TYR A 196
 PMP  A 501 ( 4.7A)
None
None
None
None
 1.17A 5n0xB-5wmlA:
2.9		 5n0xB-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 5wml -
(-) 		5 / 12 LEU A 315
GLY A 167
LYS A 169
LEU A 163
LEU A 318
 None
PMP  A 501 (-3.4A)
GLU  A 502 ( 2.3A)
None
None
 1.26A 5nwvA-5wmlA:
undetectable		 5nwvA-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 10 PRO A1069
GLY A1282
GLY A1123
LEU A1279
ALA A1312
 None
None
PMP  A5000 (-3.3A)
None
None
 0.99A 5o96E-3fq8A:
undetectable
5o96F-3fq8A:
undetectable		 5o96E-3fq8A:
20.37
5o96F-3fq8A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5hdm GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 PRO A  70
GLY A 283
GLY A 124
LEU A 280
ALA A 313
 None
None
PMP  A 500 (-3.2A)
None
None
 1.01A 5o96E-5hdmA:
undetectable
5o96F-5hdmA:
undetectable		 5o96E-5hdmA:
20.31
5o96F-5hdmA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 2fnu AMINOTRANSFERASE
(Helicobacter
pylori) 		3 / 3 LYS A 183
HIS A 157
HIS A 284
 UD1  A 902 ( 3.3A)
PMP  A 901 (-3.9A)
None
 1.40A 5oexA-2fnuA:
undetectable		 5oexA-2fnuA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 2fnu AMINOTRANSFERASE
(Helicobacter
pylori) 		3 / 3 LYS A 183
HIS A 157
HIS A 284
 UD1  A 902 ( 3.3A)
PMP  A 901 (-3.9A)
None
 1.43A 5oexB-2fnuA:
undetectable		 5oexB-2fnuA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 2fnu AMINOTRANSFERASE
(Helicobacter
pylori) 		3 / 3 LYS A 183
HIS A 157
HIS A 284
 UD1  A 902 ( 3.3A)
PMP  A 901 (-3.9A)
None
 1.42A 5oexC-2fnuA:
undetectable		 5oexC-2fnuA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 2fnu AMINOTRANSFERASE
(Helicobacter
pylori) 		3 / 3 LYS A 183
HIS A 157
HIS A 284
 UD1  A 902 ( 3.3A)
PMP  A 901 (-3.9A)
None
 1.36A 5oexD-2fnuA:
undetectable		 5oexD-2fnuA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		3 / 3 GLY A 147
LEU A 152
HIS A 146
 PMP  A 431 ( 3.7A)
None
None
 0.63A 5u63A-3bs8A:
undetectable		 5u63A-3bs8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Thermus
thermophilus) 		3 / 3 GLY A 146
LEU A 151
HIS A 145
 PMP  A1001 ( 4.1A)
None
None
 0.70A 5u63B-2e7uA:
undetectable		 5u63B-2e7uA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		3 / 3 GLY A 147
LEU A 152
HIS A 146
 PMP  A 431 ( 3.7A)
None
None
 0.63A 5u63B-3bs8A:
1.7		 5u63B-3bs8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 SER A 122
THR A 168
PHE A 137
ILE A 164
 None
PMP  A 401 (-3.9A)
None
None
 1.12A 5vkqB-3cq5A:
3.3
5vkqC-3cq5A:
3.3		 5vkqB-3cq5A:
12.49
5vkqC-3cq5A:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 5ghf AMINOTRANSFERASE
CLASS-III
(Ochrobactrum
anthropi) 		5 / 12 GLY A 272
GLY A 263
GLU A 225
VAL A 125
ILE A 256
 None
None
PMP  A 501 (-3.9A)
None
None
 0.91A 5wz1A-5ghfA:
undetectable		 5wz1A-5ghfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 5ghf AMINOTRANSFERASE
CLASS-III
(Ochrobactrum
anthropi) 		5 / 12 GLY A 272
GLY A 263
GLU A 225
VAL A 125
ILE A 256
 None
None
PMP  A 501 (-3.9A)
None
None
 0.92A 5wz1B-5ghfA:
undetectable		 5wz1B-5ghfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 5ghf AMINOTRANSFERASE
CLASS-III
(Ochrobactrum
anthropi) 		5 / 12 GLY A 272
GLY A 263
GLU A 225
VAL A 125
ILE A 256
 None
None
PMP  A 501 (-3.9A)
None
None
 0.90A 5wz1C-5ghfA:
undetectable		 5wz1C-5ghfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 5ghf AMINOTRANSFERASE
CLASS-III
(Ochrobactrum
anthropi) 		5 / 12 GLY A 272
GLY A 263
GLU A 225
VAL A 125
ILE A 256
 None
None
PMP  A 501 (-3.9A)
None
None
 0.91A 5wz1D-5ghfA:
undetectable		 5wz1D-5ghfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 5ghf AMINOTRANSFERASE
CLASS-III
(Ochrobactrum
anthropi) 		5 / 12 GLY A 272
GLY A 263
GLU A 225
VAL A 125
ILE A 256
 None
None
PMP  A 501 (-3.9A)
None
None
 0.91A 5wz1E-5ghfA:
undetectable		 5wz1E-5ghfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 5ghf AMINOTRANSFERASE
CLASS-III
(Ochrobactrum
anthropi) 		5 / 12 GLY A 272
GLY A 263
GLU A 225
VAL A 125
ILE A 256
 None
None
PMP  A 501 (-3.9A)
None
None
 0.92A 5wz1F-5ghfA:
undetectable		 5wz1F-5ghfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 5ghf AMINOTRANSFERASE
CLASS-III
(Ochrobactrum
anthropi) 		5 / 12 GLY A 272
GLY A 263
GLU A 225
VAL A 125
ILE A 256
 None
None
PMP  A 501 (-3.9A)
None
None
 0.89A 5wz1G-5ghfA:
undetectable		 5wz1G-5ghfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 5ghf AMINOTRANSFERASE
CLASS-III
(Ochrobactrum
anthropi) 		5 / 12 GLY A 272
GLY A 263
GLU A 225
VAL A 125
ILE A 256
 None
None
PMP  A 501 (-3.9A)
None
None
 0.91A 5wz1H-5ghfA:
undetectable		 5wz1H-5ghfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Aeropyrum
pernix) 		4 / 5 GLU A 210
HIS A 149
LEU A 156
VAL A 155
 PMP  A 501 ( 3.9A)
None
None
None
 0.96A 6bc9A-2epjA:
undetectable		 6bc9A-2epjA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 VAL A 241
GLY A 244
ALA A 253
GLU A 116
VAL A 204
 PMP  A1271 ( 4.1A)
None
None
None
None
 1.12A 6bqgA-1szsA:
undetectable		 6bqgA-1szsA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 GLY A 281
ILE A 175
GLY A 149
THR A 119
THR A 264
 None
None
None
PMP  A 431 (-3.4A)
None
 1.11A 6e8qA-3bs8A:
undetectable		 6e8qA-3bs8A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 LEU A 113
GLY A 107
GLY A 109
ILE A 255
SER A 246
 None
PMP  A 409 (-3.7A)
None
None
PMP  A 409 (-3.1A)
 1.04A 6ectA-2zc0A:
undetectable		 6ectA-2zc0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE
(Bacillus
circulans) 		4 / 6 ALA A  94
SER A 187
GLY A 200
THR A  63
 PMP  A1416 ( 3.7A)
PMP  A1416 (-2.5A)
None
None
 0.75A 6f8cA-2c81A:
undetectable		 6f8cA-2c81A:
13.50