SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PMK'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7A_B_PFLB4001_1 (SERUM ALBUMIN)	4ono	BETA-2-MICROGLOBULIN /T-CELL SURFACE GLYCOPROTEIN CD1C/T-CELL SURFACE GLYCOPROTEIN CD1B CHIMERIC PROTEIN (Homo sapiens)	5 / 9	LEU A 178 ILE A 162 PHE A 125 LEU A 289 GLY A 145	None PMK A 401 ( 3.3A) PMK A 401 ( 4.2A) None PMK A 401 (-3.1A)	1.06A	1e7aB-4onoA: undetectable	1e7aB-4onoA: 20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TBF_A_VIAA501_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4ono	BETA-2-MICROGLOBULIN /T-CELL SURFACE GLYCOPROTEIN CD1C/T-CELL SURFACE GLYCOPROTEIN CD1B CHIMERIC PROTEIN (Homo sapiens)	5 / 9	LEU A 178 VAL A 127 ALA A 215 LEU A 277 PHE A 285	None PMK A 401 (-3.0A) PMK A 401 (-2.7A) PMK A 401 ( 3.8A) PMK A 401 ( 3.6A)	1.25A	1tbfA-4onoA: undetectable	1tbfA-4onoA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BXO_B_SAMB238_0 (N,N-DIMETHYLTRANSFER ASE)	4ono	BETA-2-MICROGLOBULIN /T-CELL SURFACE GLYCOPROTEIN CD1C/T-CELL SURFACE GLYCOPROTEIN CD1B CHIMERIC PROTEIN (Homo sapiens)	5 / 12	GLY A 145 LEU A 54 SER A 55 ARG A 140 PHE A 185	PMK A 401 (-3.1A) None None None PMK A 401 (-3.7A)	1.24A	3bxoB-4onoA: undetectable	3bxoB-4onoA: 21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TZF_B_08DB280_1 (7,8-DIHYDROPTEROATE SYNTHASE)	4ono	BETA-2-MICROGLOBULIN /T-CELL SURFACE GLYCOPROTEIN CD1C/T-CELL SURFACE GLYCOPROTEIN CD1B CHIMERIC PROTEIN (Homo sapiens)	4 / 8	PHE A 125 THR A 281 GLY A 171 PHE A 173	PMK A 401 ( 4.2A) CL A 402 (-3.6A) None None	0.95A	3tzfB-4onoA: undetectable	3tzfB-4onoA: 22.19

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E7A_B_PFLB4001_1","SERUM ALBUMIN","4ono","BETA-2-MICROGLOBULIN\/T-CELL SURFACE GLYCOPROTEIN CD1C\/T-CELL SURFACE GLYCOPROTEIN CD1B CHIMERIC PROTEIN","Homo sapiens",5,"LEU A 178;ILE A 162;PHE A 125;LEU A 289;GLY A 145","None;PMK A 401 ( 3.3A);PMK A 401 ( 4.2A);None;PMK A 401 (-3.1A)","1.06A","1e7aB-4onoA:undetectable",null],["1TBF_A_VIAA501_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4ono","BETA-2-MICROGLOBULIN\/T-CELL SURFACE GLYCOPROTEIN CD1C\/T-CELL SURFACE GLYCOPROTEIN CD1B CHIMERIC PROTEIN","Homo sapiens",5,"LEU A 178;VAL A 127;ALA A 215;LEU A 277;PHE A 285","None;PMK A 401 (-3.0A);PMK A 401 (-2.7A);PMK A 401 ( 3.8A);PMK A 401 ( 3.6A)","1.25A","1tbfA-4onoA:undetectable","1e7aB-4onoA:20.07"],["3BXO_B_SAMB238_0","N,N-DIMETHYLTRANSFERASE","4ono","BETA-2-MICROGLOBULIN\/T-CELL SURFACE GLYCOPROTEIN CD1C\/T-CELL SURFACE GLYCOPROTEIN CD1B CHIMERIC PROTEIN","Homo sapiens",5,"GLY A 145;LEU A  54;SER A  55;ARG A 140;PHE A 185","PMK A 401 (-3.1A);None;None;None;PMK A 401 (-3.7A)","1.24A","3bxoB-4onoA:undetectable","1tbfA-4onoA:20.28"],["3TZF_B_08DB280_1","7,8-DIHYDROPTEROATE SYNTHASE","4ono","BETA-2-MICROGLOBULIN\/T-CELL SURFACE GLYCOPROTEIN CD1C\/T-CELL SURFACE GLYCOPROTEIN CD1B CHIMERIC PROTEIN","Homo sapiens",4,"PHE A 125;THR A 281;GLY A 171;PHE A 173","PMK A 401 ( 4.2A); CL A 402 (-3.6A);None;None","0.95A","3tzfB-4onoA:undetectable","3bxoB-4onoA:21.86"]]