SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PLX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
(Homo
sapiens) 		3 / 3 LEU g  62
TYR g  63
GLN g  60
 PLX  g 203 (-3.9A)
PLX  g 203 (-3.9A)
None
 0.74A 2wekA-5xtcg:
undetectable		 2wekA-5xtcg:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		5 / 12 PHE g  67
GLY g  37
ALA i 331
THR i 334
ILE i 209
 PLX  g 203 (-4.3A)
None
None
CDL  i 401 ( 4.3A)
PLX  g 201 ( 4.6A)
 1.20A 3ld6A-5xtcg:
undetectable		 3ld6A-5xtcg:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 7 ILE U  31
LEU U  28
GLY U  26
GLY U  27
 None
None
PLX  U 101 (-3.4A)
PLX  U 101 ( 4.7A)
 0.87A 5a06B-5xtcU:
undetectable		 5a06B-5xtcU:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		4 / 6 ILE i 209
TYR i 208
PHE i 216
THR i 119
 PLX  g 201 ( 4.6A)
None
None
None
 0.96A 5g08A-5xtci:
undetectable		 5g08A-5xtci:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		3 / 3 THR i 132
THR i 333
LEU i 218
 PLX  g 201 (-4.0A)
None
None
 0.65A 5m66D-5xtci:
undetectable		 5m66D-5xtci:
19.45