SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PLR'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1R30_A_SAMA501_0 (BIOTIN SYNTHASE) |
3gzd | SELENOCYSTEINE LYASE (Homosapiens) | 5 / 12 | THR C 96GLY C 98ASP C 233LEU C 248VAL C 245 | NonePLR C 500 ( 4.5A)PLR C 500 (-2.7A)NoneNone | 1.07A | 1r30A-3gzdC:undetectable | 1r30A-3gzdC:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2A1M_A_CAMA1422_0 (CYTOCHROME P450-CAM) |
4zdl | O-PHOSPHOSERYL-TRNA(SEC) SELENIUMTRANSFERASE (Homosapiens) | 4 / 7 | THR A 144VAL A 257GLY A 256ASP A 283 | PLR A1001 (-3.6A)NoneNoneNone | 0.87A | 2a1mA-4zdlA:undetectable | 2a1mA-4zdlA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2EJ3_A_GBNA2414_1 (BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE) |
5vye | L-THREONINE ALDOLASE (Pseudomonasputida) | 5 / 8 | GLY A 213GLY A 64THR A 65ALA A 66ALA A 67 | NonePLR A 401 (-2.8A)PLR A 401 (-3.8A)NoneNone | 0.64A | 2ej3A-5vyeA:undetectable | 2ej3A-5vyeA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2EJ3_B_GBNB914_1 (BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE) |
5vye | L-THREONINE ALDOLASE (Pseudomonasputida) | 5 / 10 | GLY A 213GLY A 64THR A 65ALA A 66ALA A 67 | NonePLR A 401 (-2.8A)PLR A 401 (-3.8A)NoneNone | 0.67A | 2ej3B-5vyeA:undetectable | 2ej3B-5vyeA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2HMA_A_SAMA375_0 (PROBABLE TRNA(5-METHYLAMINOMETHYL-2-THIOURIDYLATE)-METHYLTRANSFERASE) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 5 / 11 | GLY A 135ASP A 693THR A 676GLY A 677GLN A 665 | PLR A 940 ( 3.8A)NonePLR A 940 (-4.5A)PLR A 940 (-3.8A)PLR A 940 ( 4.4A) | 1.47A | 2hmaA-2gj4A:undetectable | 2hmaA-2gj4A:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ARU_A_PNXA607_1 (CHITINASE A) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 5 / 8 | GLY A 675THR A 676GLU A 672GLY A 694ALA A 695 | PLR A 940 (-3.3A)PLR A 940 (-4.5A)PLR A 940 ( 4.5A)NoneNone | 1.09A | 3aruA-2gj4A:2.2 | 3aruA-2gj4A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3JZJ_A_ACRA405_1 (ACARBOSE/MALTOSEBINDING PROTEIN GACH) |
5vye | L-THREONINE ALDOLASE (Pseudomonasputida) | 5 / 12 | GLY A 291ALA A 181ASP A 174ASP A 11GLY A 175 | NoneNonePLR A 401 (-2.6A)NoneNone | 1.31A | 3jzjA-5vyeA:undetectable | 3jzjA-5vyeA:11.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3KP3_B_AICB2002_1 (TRANSCRIPTIONALREGULATOR TCAR) |
5vye | L-THREONINE ALDOLASE (Pseudomonasputida) | 3 / 3 | ALA A 289ARG A 177LYS A 207 | NonePLR A 401 (-3.9A)PLR A 401 (-2.3A) | 0.93A | 3kp3B-5vyeA:undetectable | 3kp3B-5vyeA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3LP9_D_SPMD230_1 (LS-24) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 3 / 3 | GLU A 672GLU A 382ASN A 284 | PLR A 940 ( 4.5A)NoneNone | 0.88A | 3lp9B-2gj4A:undetectable3lp9D-2gj4A:undetectable | 3lp9B-2gj4A:14.093lp9D-2gj4A:14.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NNE_A_ACTA601_0 (CHOLINE OXIDASE) |
3gzd | SELENOCYSTEINE LYASE (Homosapiens) | 4 / 5 | ILE C 148HIS C 231VAL C 106ASN C 103 | NoneNoneNonePLR C 500 ( 4.6A) | 0.92A | 3nneA-3gzdC:0.0 | 3nneA-3gzdC:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NNE_G_ACTG601_0 (CHOLINE OXIDASE) |
3gzd | SELENOCYSTEINE LYASE (Homosapiens) | 4 / 6 | ILE C 148HIS C 231VAL C 106ASN C 103 | NoneNoneNonePLR C 500 ( 4.6A) | 1.03A | 3nneG-3gzdC:undetectable | 3nneG-3gzdC:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TMZ_A_06XA503_1 (CYTOCHROME P450 2B4) |
3gzd | SELENOCYSTEINE LYASE (Homosapiens) | 5 / 11 | PHE C 260ALA C 235THR C 232VAL C 243VAL C 245 | NonePLR C 500 (-3.5A)NoneNoneNone | 1.07A | 3tmzA-3gzdC:undetectable | 3tmzA-3gzdC:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UJ6_A_SAMA300_1 (PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE) |
4zdl | O-PHOSPHOSERYL-TRNA(SEC) SELENIUMTRANSFERASE (Homosapiens) | 4 / 4 | SER A 174ASP A 283ASP A 321ALA A 143 | PLR A1001 (-2.7A)NoneNonePLR A1001 (-3.0A) | 1.32A | 3uj6A-4zdlA:3.4 | 3uj6A-4zdlA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KT0_A_PQNA2001_1 (PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1PHOTOSYSTEM IREACTION CENTERSUBUNIT IX) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 5 / 11 | GLY A 135ARG A 138ALA A 141GLY A 132LEU A 198 | PLR A 940 ( 3.8A)NoneNoneNoneNone | 1.06A | 4kt0A-2gj4A:undetectable4kt0J-2gj4A:undetectable | 4kt0A-2gj4A:22.564kt0J-2gj4A:4.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XV2_A_P06A801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3gzd | SELENOCYSTEINE LYASE (Homosapiens) | 4 / 4 | GLY C 98LEU C 279PHE C 292ILE C 94 | PLR C 500 ( 4.5A)NoneNoneNone | 0.95A | 4xv2A-3gzdC:undetectable | 4xv2A-3gzdC:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XV2_A_P06A801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
3gzd | SELENOCYSTEINE LYASE (Homosapiens) | 4 / 4 | GLY C 99LEU C 279PHE C 292ILE C 94 | PLR C 500 (-3.6A)NoneNoneNone | 0.92A | 4xv2A-3gzdC:undetectable | 4xv2A-3gzdC:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5C0O_H_SAMH301_0 (TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASETRMI) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 5 / 12 | ALA A 140GLY A 132GLY A 137GLY A 135LEU A 131 | NoneNoneNonePLR A 940 ( 3.8A)None | 0.80A | 5c0oH-2gj4A:undetectable | 5c0oH-2gj4A:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5DB5_A_CYSA503_0 (CYSTEINE DESULFURASE) |
3gzd | SELENOCYSTEINE LYASE (Homosapiens) | 5 / 8 | ALA C 38HIS C 145ASN C 198LYS C 259ARG C 415 | NO3 C 600 (-3.6A)PLR C 500 (-3.7A)NO3 C 600 (-3.5A)PLR C 500 (-1.3A)NO3 C 600 (-3.1A) | 0.63A | 5db5A-3gzdC:40.15db5B-3gzdC:40.0 | 5db5A-3gzdC:27.625db5B-3gzdC:27.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HFJ_A_SAMA301_0 (ADENINE SPECIFIC DNAMETHYLTRANSFERASE(DPNA)) |
4zdl | O-PHOSPHOSERYL-TRNA(SEC) SELENIUMTRANSFERASE (Homosapiens) | 5 / 12 | ASP A 283PRO A 289GLY A 292THR A 144SER A 317 | NoneNoneNonePLR A1001 (-3.6A)None | 1.28A | 5hfjA-4zdlA:3.2 | 5hfjA-4zdlA:17.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KBW_A_RBFA201_1 (RIBOFLAVINTRANSPORTER RIBU) |
5vye | L-THREONINE ALDOLASE (Pseudomonasputida) | 5 / 12 | GLU A 147ASP A 174GLY A 175ALA A 183ASN A 265 | PLR A 401 ( 4.0A)PLR A 401 (-2.6A)NoneNoneNone | 1.36A | 5kbwA-5vyeA:undetectable | 5kbwA-5vyeA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5O96_C_SAMC501_0 (RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE E) |
2cfb | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE (Synechococcuselongatus) | 4 / 7 | GLY A 260GLY A 101LEU A 257ALA A 290 | NonePLR A1412 (-3.3A)NoneNone | 0.75A | 5o96C-2cfbA:undetectable | 5o96C-2cfbA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5UUN_A_ACTA305_0 (GLUTATHIONES-TRANSFERASE-LIKEPROTEIN) |
5vye | L-THREONINE ALDOLASE (Pseudomonasputida) | 3 / 3 | THR A 143MET A 173HIS A 172 | PLR A 401 ( 3.3A)NoneNone | 1.03A | 5uunA-5vyeA:undetectable | 5uunA-5vyeA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VNC_C_GCSC801_1 (GLYCOGEN [STARCH]SYNTHASE ISOFORM 2) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 7 / 10 | GLY A 135HIS A 377VAL A 455ASN A 484LYS A 574GLU A 672GLY A 675 | PLR A 940 ( 3.8A)NoneNoneNonePLR A 940 (-2.8A)PLR A 940 ( 4.5A)PLR A 940 (-3.3A) | 0.70A | 5vncC-2gj4A:18.0 | 5vncC-2gj4A:6.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GNE_A_ACRA602_1 (-) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 6 / 12 | GLY A 134GLY A 135ASP A 339VAL A 455ASN A 484GLY A 675 | PLR A 940 (-3.6A)PLR A 940 ( 3.8A)NoneNoneNonePLR A 940 (-3.3A) | 0.69A | 6gneA-2gj4A:22.8 | 6gneA-2gj4A:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GNE_B_ACRB602_1 (-) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 7 / 12 | GLU A 88GLY A 134GLY A 135ASP A 339VAL A 455ASN A 484GLY A 675 | NonePLR A 940 (-3.6A)PLR A 940 ( 3.8A)NoneNoneNonePLR A 940 (-3.3A) | 0.78A | 6gneB-2gj4A:22.8 | 6gneB-2gj4A:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GNF_A_QPSA602_1 (-) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 5 / 12 | ASP A 339HIS A 341ASN A 484GLU A 672GLY A 675 | NoneNoneNonePLR A 940 ( 4.5A)PLR A 940 (-3.3A) | 0.77A | 6gnfA-2gj4A:21.6 | 6gnfA-2gj4A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GNF_C_QPSC602_2 (-) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 5 / 12 | ASP A 339HIS A 341ASN A 484GLU A 672GLY A 675 | NoneNoneNonePLR A 940 ( 4.5A)PLR A 940 (-3.3A) | 0.76A | 6gnfC-2gj4A:21.9 | 6gnfC-2gj4A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GNG_A_QPSA601_1 (-) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 5 / 12 | GLY A 134LEU A 136ASP A 339HIS A 341ASN A 484 | PLR A 940 (-3.6A)NoneNoneNoneNone | 0.88A | 6gngA-2gj4A:21.8 | 6gngA-2gj4A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GNG_A_QPSA601_2 (-) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 6 / 12 | GLU A 88GLY A 135HIS A 377VAL A 455GLU A 672GLY A 675 | NonePLR A 940 ( 3.8A)NoneNonePLR A 940 ( 4.5A)PLR A 940 (-3.3A) | 0.72A | 6gngA-2gj4A:21.8 | 6gngA-2gj4A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GNG_B_QPSB601_2 (-) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 5 / 12 | GLU A 88GLY A 134GLY A 135GLY A 612ASN A 284 | NonePLR A 940 (-3.6A)PLR A 940 ( 3.8A)NoneNone | 1.03A | 6gngB-2gj4A:21.8 | 6gngB-2gj4A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GNG_B_QPSB601_2 (-) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 6 / 12 | GLU A 88GLY A 134GLY A 135LEU A 136HIS A 341ASN A 284 | NonePLR A 940 (-3.6A)PLR A 940 ( 3.8A)NoneNoneNone | 1.12A | 6gngB-2gj4A:21.8 | 6gngB-2gj4A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GNG_B_QPSB601_2 (-) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 5 / 12 | GLU A 88GLY A 134LEU A 136HIS A 341ASN A 284 | NonePLR A 940 (-3.6A)NoneNoneNone | 1.07A | 6gngB-2gj4A:21.8 | 6gngB-2gj4A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HQB_A_PQNA2001_0 (PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1PHOTOSYSTEM IREACTION CENTERSUBUNIT IX) |
2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) | 5 / 10 | GLY A 135ARG A 138ALA A 141GLY A 132LEU A 198 | PLR A 940 ( 3.8A)NoneNoneNoneNone | 1.05A | 6hqbA-2gj4A:undetectable6hqbJ-2gj4A:undetectable | 6hqbA-2gj4A:6.926hqbJ-2gj4A:4.56 |