SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PLR'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)
3gzd SELENOCYSTEINE LYASE
(Homo
sapiens)
5 / 12 THR C  96
GLY C  98
ASP C 233
LEU C 248
VAL C 245
None
PLR  C 500 ( 4.5A)
PLR  C 500 (-2.7A)
None
None
1.07A 1r30A-3gzdC:
undetectable
1r30A-3gzdC:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)
4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Homo
sapiens)
4 / 7 THR A 144
VAL A 257
GLY A 256
ASP A 283
PLR  A1001 (-3.6A)
None
None
None
0.87A 2a1mA-4zdlA:
undetectable
2a1mA-4zdlA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)
5vye L-THREONINE ALDOLASE
(Pseudomonas
putida)
5 / 8 GLY A 213
GLY A  64
THR A  65
ALA A  66
ALA A  67
None
PLR  A 401 (-2.8A)
PLR  A 401 (-3.8A)
None
None
0.64A 2ej3A-5vyeA:
undetectable
2ej3A-5vyeA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)
5vye L-THREONINE ALDOLASE
(Pseudomonas
putida)
5 / 10 GLY A 213
GLY A  64
THR A  65
ALA A  66
ALA A  67
None
PLR  A 401 (-2.8A)
PLR  A 401 (-3.8A)
None
None
0.67A 2ej3B-5vyeA:
undetectable
2ej3B-5vyeA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
5 / 11 GLY A 135
ASP A 693
THR A 676
GLY A 677
GLN A 665
PLR  A 940 ( 3.8A)
None
PLR  A 940 (-4.5A)
PLR  A 940 (-3.8A)
PLR  A 940 ( 4.4A)
1.47A 2hmaA-2gj4A:
undetectable
2hmaA-2gj4A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
5 / 8 GLY A 675
THR A 676
GLU A 672
GLY A 694
ALA A 695
PLR  A 940 (-3.3A)
PLR  A 940 (-4.5A)
PLR  A 940 ( 4.5A)
None
None
1.09A 3aruA-2gj4A:
2.2
3aruA-2gj4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)
5vye L-THREONINE ALDOLASE
(Pseudomonas
putida)
5 / 12 GLY A 291
ALA A 181
ASP A 174
ASP A  11
GLY A 175
None
None
PLR  A 401 (-2.6A)
None
None
1.31A 3jzjA-5vyeA:
undetectable
3jzjA-5vyeA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5vye L-THREONINE ALDOLASE
(Pseudomonas
putida)
3 / 3 ALA A 289
ARG A 177
LYS A 207
None
PLR  A 401 (-3.9A)
PLR  A 401 (-2.3A)
0.93A 3kp3B-5vyeA:
undetectable
3kp3B-5vyeA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
3 / 3 GLU A 672
GLU A 382
ASN A 284
PLR  A 940 ( 4.5A)
None
None
0.88A 3lp9B-2gj4A:
undetectable
3lp9D-2gj4A:
undetectable
3lp9B-2gj4A:
14.09
3lp9D-2gj4A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)
3gzd SELENOCYSTEINE LYASE
(Homo
sapiens)
4 / 5 ILE C 148
HIS C 231
VAL C 106
ASN C 103
None
None
None
PLR  C 500 ( 4.6A)
0.92A 3nneA-3gzdC:
0.0
3nneA-3gzdC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)
3gzd SELENOCYSTEINE LYASE
(Homo
sapiens)
4 / 6 ILE C 148
HIS C 231
VAL C 106
ASN C 103
None
None
None
PLR  C 500 ( 4.6A)
1.03A 3nneG-3gzdC:
undetectable
3nneG-3gzdC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)
3gzd SELENOCYSTEINE LYASE
(Homo
sapiens)
5 / 11 PHE C 260
ALA C 235
THR C 232
VAL C 243
VAL C 245
None
PLR  C 500 (-3.5A)
None
None
None
1.07A 3tmzA-3gzdC:
undetectable
3tmzA-3gzdC:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Homo
sapiens)
4 / 4 SER A 174
ASP A 283
ASP A 321
ALA A 143
PLR  A1001 (-2.7A)
None
None
PLR  A1001 (-3.0A)
1.32A 3uj6A-4zdlA:
3.4
3uj6A-4zdlA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
5 / 11 GLY A 135
ARG A 138
ALA A 141
GLY A 132
LEU A 198
PLR  A 940 ( 3.8A)
None
None
None
None
1.06A 4kt0A-2gj4A:
undetectable
4kt0J-2gj4A:
undetectable
4kt0A-2gj4A:
22.56
4kt0J-2gj4A:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3gzd SELENOCYSTEINE LYASE
(Homo
sapiens)
4 / 4 GLY C  98
LEU C 279
PHE C 292
ILE C  94
PLR  C 500 ( 4.5A)
None
None
None
0.95A 4xv2A-3gzdC:
undetectable
4xv2A-3gzdC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3gzd SELENOCYSTEINE LYASE
(Homo
sapiens)
4 / 4 GLY C  99
LEU C 279
PHE C 292
ILE C  94
PLR  C 500 (-3.6A)
None
None
None
0.92A 4xv2A-3gzdC:
undetectable
4xv2A-3gzdC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
5 / 12 ALA A 140
GLY A 132
GLY A 137
GLY A 135
LEU A 131
None
None
None
PLR  A 940 ( 3.8A)
None
0.80A 5c0oH-2gj4A:
undetectable
5c0oH-2gj4A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)
3gzd SELENOCYSTEINE LYASE
(Homo
sapiens)
5 / 8 ALA C  38
HIS C 145
ASN C 198
LYS C 259
ARG C 415
NO3  C 600 (-3.6A)
PLR  C 500 (-3.7A)
NO3  C 600 (-3.5A)
PLR  C 500 (-1.3A)
NO3  C 600 (-3.1A)
0.63A 5db5A-3gzdC:
40.1
5db5B-3gzdC:
40.0
5db5A-3gzdC:
27.62
5db5B-3gzdC:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Homo
sapiens)
5 / 12 ASP A 283
PRO A 289
GLY A 292
THR A 144
SER A 317
None
None
None
PLR  A1001 (-3.6A)
None
1.28A 5hfjA-4zdlA:
3.2
5hfjA-4zdlA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)
5vye L-THREONINE ALDOLASE
(Pseudomonas
putida)
5 / 12 GLU A 147
ASP A 174
GLY A 175
ALA A 183
ASN A 265
PLR  A 401 ( 4.0A)
PLR  A 401 (-2.6A)
None
None
None
1.36A 5kbwA-5vyeA:
undetectable
5kbwA-5vyeA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus)
4 / 7 GLY A 260
GLY A 101
LEU A 257
ALA A 290
None
PLR  A1412 (-3.3A)
None
None
0.75A 5o96C-2cfbA:
undetectable
5o96C-2cfbA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
5vye L-THREONINE ALDOLASE
(Pseudomonas
putida)
3 / 3 THR A 143
MET A 173
HIS A 172
PLR  A 401 ( 3.3A)
None
None
1.03A 5uunA-5vyeA:
undetectable
5uunA-5vyeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
7 / 10 GLY A 135
HIS A 377
VAL A 455
ASN A 484
LYS A 574
GLU A 672
GLY A 675
PLR  A 940 ( 3.8A)
None
None
None
PLR  A 940 (-2.8A)
PLR  A 940 ( 4.5A)
PLR  A 940 (-3.3A)
0.70A 5vncC-2gj4A:
18.0
5vncC-2gj4A:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
6 / 12 GLY A 134
GLY A 135
ASP A 339
VAL A 455
ASN A 484
GLY A 675
PLR  A 940 (-3.6A)
PLR  A 940 ( 3.8A)
None
None
None
PLR  A 940 (-3.3A)
0.69A 6gneA-2gj4A:
22.8
6gneA-2gj4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
7 / 12 GLU A  88
GLY A 134
GLY A 135
ASP A 339
VAL A 455
ASN A 484
GLY A 675
None
PLR  A 940 (-3.6A)
PLR  A 940 ( 3.8A)
None
None
None
PLR  A 940 (-3.3A)
0.78A 6gneB-2gj4A:
22.8
6gneB-2gj4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
5 / 12 ASP A 339
HIS A 341
ASN A 484
GLU A 672
GLY A 675
None
None
None
PLR  A 940 ( 4.5A)
PLR  A 940 (-3.3A)
0.77A 6gnfA-2gj4A:
21.6
6gnfA-2gj4A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
5 / 12 ASP A 339
HIS A 341
ASN A 484
GLU A 672
GLY A 675
None
None
None
PLR  A 940 ( 4.5A)
PLR  A 940 (-3.3A)
0.76A 6gnfC-2gj4A:
21.9
6gnfC-2gj4A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
5 / 12 GLY A 134
LEU A 136
ASP A 339
HIS A 341
ASN A 484
PLR  A 940 (-3.6A)
None
None
None
None
0.88A 6gngA-2gj4A:
21.8
6gngA-2gj4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
6 / 12 GLU A  88
GLY A 135
HIS A 377
VAL A 455
GLU A 672
GLY A 675
None
PLR  A 940 ( 3.8A)
None
None
PLR  A 940 ( 4.5A)
PLR  A 940 (-3.3A)
0.72A 6gngA-2gj4A:
21.8
6gngA-2gj4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
5 / 12 GLU A  88
GLY A 134
GLY A 135
GLY A 612
ASN A 284
None
PLR  A 940 (-3.6A)
PLR  A 940 ( 3.8A)
None
None
1.03A 6gngB-2gj4A:
21.8
6gngB-2gj4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
6 / 12 GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
ASN A 284
None
PLR  A 940 (-3.6A)
PLR  A 940 ( 3.8A)
None
None
None
1.12A 6gngB-2gj4A:
21.8
6gngB-2gj4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
5 / 12 GLU A  88
GLY A 134
LEU A 136
HIS A 341
ASN A 284
None
PLR  A 940 (-3.6A)
None
None
None
1.07A 6gngB-2gj4A:
21.8
6gngB-2gj4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus)
5 / 10 GLY A 135
ARG A 138
ALA A 141
GLY A 132
LEU A 198
PLR  A 940 ( 3.8A)
None
None
None
None
1.05A 6hqbA-2gj4A:
undetectable
6hqbJ-2gj4A:
undetectable
6hqbA-2gj4A:
6.92
6hqbJ-2gj4A:
4.56