SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PLM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.36A 1a52A-2dt8A:
undetectable		 1a52A-2dt8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.37A 1a52B-2dt8A:
undetectable		 1a52B-2dt8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 7 LEU A 135
THR A 174
TRP A 138
TYR A  76
 None
None
None
PLM  A 563 (-4.5A)
 1.23A 1afsA-3ib3A:
undetectable		 1afsA-3ib3A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 7 LEU A 135
THR A 174
TRP A 138
TYR A  76
 None
None
None
PLM  A 563 (-4.5A)
 1.23A 1afsB-3ib3A:
undetectable		 1afsB-3ib3A:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  37
PRO A  39
THR A  54
ARG A 127
TYR A 129
 SO4  A 903 (-3.6A)
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 1.25A 1cbrA-3nr3A:
19.0		 1cbrA-3nr3A:
36.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  17
PRO A  39
THR A  54
ARG A 127
TYR A 129
 None
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.86A 1cbrA-3nr3A:
19.0		 1cbrA-3nr3A:
36.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		5 / 12 PRO A  38
THR A  53
LEU A 115
ARG A 126
TYR A 128
 PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.2A)
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
 0.67A 1cbrA-5b29A:
19.3		 1cbrA-5b29A:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  37
PRO A  39
THR A  54
ARG A 127
TYR A 129
 SO4  A 903 (-3.6A)
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 1.25A 1cbrB-3nr3A:
19.0		 1cbrB-3nr3A:
36.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  17
PRO A  39
THR A  54
ARG A 127
TYR A 129
 None
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.86A 1cbrB-3nr3A:
19.0		 1cbrB-3nr3A:
36.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		5 / 12 PRO A  38
THR A  53
LEU A 115
ARG A 126
TYR A 128
 PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.2A)
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
 0.67A 1cbrB-5b29A:
19.3		 1cbrB-5b29A:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  17
PRO A  39
THR A  54
ARG A 127
TYR A 129
 None
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.85A 1cbsA-3nr3A:
18.9		 1cbsA-3nr3A:
35.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		5 / 12 PRO A  38
THR A  53
LEU A 115
ARG A 126
TYR A 128
 PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.2A)
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
 0.75A 1cbsA-5b29A:
19.2		 1cbsA-5b29A:
42.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  91
ILE A 263
GLY A 272
ALA A 271
LEU A 169
 PLM  A 702 ( 4.5A)
PLM  A 702 (-4.4A)
None
PLM  A 702 ( 4.7A)
None
 0.98A 1cqeA-1pzxA:
undetectable		 1cqeA-1pzxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  91
ILE A 263
GLY A 272
ALA A 271
LEU A 169
 PLM  A 702 ( 4.5A)
PLM  A 702 (-4.4A)
None
PLM  A 702 ( 4.7A)
None
 0.98A 1cqeB-1pzxA:
undetectable		 1cqeB-1pzxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 12 ILE A 240
PHE A 171
SER A 149
ILE A 146
LEU A 140
 PLM  A 275 ( 4.4A)
None
MLY  A 148 ( 4.2A)
None
None
 1.21A 1dlsA-3eglA:
undetectable		 1dlsA-3eglA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		6 / 12 ILE A 240
LEU A  72
PHE A 171
SER A 149
ILE A 146
LEU A 140
 PLM  A 275 ( 4.4A)
PLM  A 275 ( 4.2A)
None
MLY  A 148 ( 4.2A)
None
None
 1.26A 1drfA-3eglA:
undetectable		 1drfA-3eglA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 PHE A 235
ALA A 133
VAL A 104
TYR A 251
 None
PLM  A 401 (-2.8A)
PLM  A 401 ( 4.7A)
None
 0.81A 1epbB-5oceA:
undetectable		 1epbB-5oceA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  91
ILE A 263
GLY A 272
ALA A 271
LEU A 169
 PLM  A 702 ( 4.5A)
PLM  A 702 (-4.4A)
None
PLM  A 702 ( 4.7A)
None
 1.01A 1eqhA-1pzxA:
undetectable		 1eqhA-1pzxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  91
ILE A 263
GLY A 272
ALA A 271
LEU A 169
 PLM  A 702 ( 4.5A)
PLM  A 702 (-4.4A)
None
PLM  A 702 ( 4.7A)
None
 0.99A 1eqhB-1pzxA:
undetectable		 1eqhB-1pzxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 9 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.42A 1ereA-2dt8A:
undetectable		 1ereA-2dt8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 9 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.42A 1ereB-2dt8A:
undetectable		 1ereB-2dt8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 9 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.41A 1ereD-2dt8A:
undetectable		 1ereD-2dt8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 3u3l TABLYSIN 15
(Tabanus
yao) 		4 / 6 PHE C 188
GLU C 155
LEU C 156
VAL C  50
 None
None
None
PLM  C 233 ( 4.1A)
 1.06A 1hk1A-3u3lC:
undetectable		 1hk1A-3u3lC:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 3u3l TABLYSIN 15
(Tabanus
yao) 		4 / 7 PHE C 188
GLU C 155
LEU C 156
VAL C  50
 None
None
None
PLM  C 233 ( 4.1A)
 1.04A 1hk3A-3u3lC:
undetectable		 1hk3A-3u3lC:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 11 LEU A  66
GLY A 100
ALA A  11
VAL A  25
VAL A   5
 None
PLM  A 275 ( 4.2A)
None
None
None
 0.95A 1hxwB-3eglA:
undetectable		 1hxwB-3eglA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 TRP A  40
ILE A  48
ILE A  88
ALA A 118
THR A 272
 None
None
None
PLM  A 701 ( 4.0A)
None
 1.10A 1jtxA-2dt8A:
undetectable		 1jtxA-2dt8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 11 ILE A  66
GLY A  94
SER A  93
LEU A  88
HIS A  87
 None
None
PLM  A 501 (-2.8A)
None
None
 1.41A 1kyvA-3fysA:
undetectable
1kyvB-3fysA:
undetectable		 1kyvA-3fysA:
21.15
1kyvB-3fysA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7Q_A_BEZA600_0
(COCAINE ESTERASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 TYR A  76
TYR A 170
HIS A 274
LEU A 273
PHE A 213
 PLM  A 563 (-4.5A)
None
None
None
None
 1.40A 1l7qA-3ib3A:
32.5		 1l7qA-3ib3A:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7Q_A_BEZA600_0
(COCAINE ESTERASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 TYR A  76
TYR A 170
TRP A 217
HIS A 274
PHE A 213
 PLM  A 563 (-4.5A)
None
None
None
None
 1.31A 1l7qA-3ib3A:
32.5		 1l7qA-3ib3A:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5dic ODORANT-BINDING
PROTEIN
(Phormia
regina) 		5 / 12 GLU A  29
GLY A  49
VAL A  20
PHE A  53
PHE A  16
 None
None
None
PLM  A 201 ( 3.7A)
None
 0.88A 1nw3A-5dicA:
undetectable		 1nw3A-5dicA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		5 / 12 LEU A 149
MET A 152
ILE A 124
ILE A  88
TYR A  98
 None
None
PLM  A 301 ( 4.9A)
None
None
 1.13A 1osvB-5utoA:
undetectable		 1osvB-5utoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		5 / 12 LEU A 149
MET A 152
ILE A 124
ILE A  88
TYR A  98
 None
None
PLM  A 301 ( 4.9A)
None
None
 1.09A 1ot7B-5utoA:
undetectable		 1ot7B-5utoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		6 / 12 LEU A 160
TYR A 280
GLY A 277
TYR A 128
LEU A 120
PHE A 225
 PLM  A 301 ( 4.4A)
None
PLM  A 301 (-3.8A)
None
None
None
 1.40A 1pj7A-5utoA:
undetectable		 1pj7A-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 11 THR A  62
PHE A  89
LEU A 171
PHE A 163
VAL A 271
 PLM  A 702 (-3.7A)
PLM  A 702 ( 4.9A)
None
PLM  A 702 (-3.9A)
None
 1.42A 1q23I-3pl5A:
undetectable		 1q23I-3pl5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 11 THR A  62
PHE A  89
LEU A 171
PHE A 163
VAL A 271
 PLM  A 702 (-3.7A)
PLM  A 702 ( 4.9A)
None
PLM  A 702 (-3.9A)
None
 1.44A 1q23J-3pl5A:
undetectable		 1q23J-3pl5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 11 THR A  62
PHE A  89
LEU A 171
PHE A 163
VAL A 271
 PLM  A 702 (-3.7A)
PLM  A 702 ( 4.9A)
None
PLM  A 702 (-3.9A)
None
 1.41A 1q23L-3pl5A:
undetectable		 1q23L-3pl5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.42A 1qkuA-2dt8A:
undetectable		 1qkuA-2dt8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.43A 1qkuB-2dt8A:
undetectable		 1qkuB-2dt8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.42A 1qkuC-2dt8A:
undetectable		 1qkuC-2dt8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE
(Chlamydia
trachomatis) 		5 / 12 GLY A 262
GLY A 280
ALA A 264
ASP A 224
GLN A 278
 PLM  A1349 ( 4.2A)
PLM  A1349 (-3.7A)
PLM  A1349 (-3.2A)
None
None
 1.14A 1ri4A-2iu8A:
undetectable		 1ri4A-2iu8A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4dol AT1G53520
(Arabidopsis
thaliana) 		5 / 10 LEU A 190
ALA A 116
ALA A 120
LEU A 136
PHE A 194
 None
PLM  A 301 (-3.5A)
PLM  A 301 ( 3.7A)
None
None
 1.20A 1rlbE-4dolA:
undetectable		 1rlbE-4dolA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		4 / 6 ALA A  11
LEU A  99
ILE A  68
SER A   9
 None
PLM  A 275 ( 4.6A)
None
None
 1.07A 1sbrA-3eglA:
undetectable
1sbrB-3eglA:
undetectable		 1sbrA-3eglA:
22.46
1sbrB-3eglA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		4 / 6 ALA A 122
LEU A 121
ILE A 232
SER A 119
 None
None
PLM  A 501 (-4.0A)
PLM  A 501 ( 4.7A)
 0.94A 1sbrA-3fysA:
undetectable
1sbrB-3fysA:
undetectable		 1sbrA-3fysA:
20.39
1sbrB-3fysA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3o2y PROSTAGLANDIN-H2
D-ISOMERASE
(Homo
sapiens) 		4 / 6 PHE A  39
VAL A  69
LEU A  79
PHE A  34
 None
None
PLM  A 201 (-4.8A)
None
 1.00A 1wrlB-3o2yA:
undetectable		 1wrlB-3o2yA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4dol AT1G53520
(Arabidopsis
thaliana) 		5 / 11 PHE A 143
PHE A 113
ILE A 154
LEU A 117
PHE A 139
 None
PLM  A 301 (-4.8A)
PLM  A 301 (-4.4A)
PLM  A 301 ( 4.7A)
None
 1.08A 1z11B-4dolA:
undetectable		 1z11B-4dolA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 5ncc FATTY ACID
PHOTODECARBOXYLASE
(Chlorella
variabilis) 		3 / 3 TRP A 479
THR A 131
TYR A 466
 PLM  A 702 ( 4.6A)
None
PLM  A 702 (-4.2A)
 1.07A 2a3aA-5nccA:
undetectable		 2a3aA-5nccA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 5ncc FATTY ACID
PHOTODECARBOXYLASE
(Chlorella
variabilis) 		3 / 3 TRP A 479
THR A 131
TYR A 466
 PLM  A 702 ( 4.6A)
None
PLM  A 702 (-4.2A)
 1.11A 2a3aB-5nccA:
undetectable		 2a3aB-5nccA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 5ncc FATTY ACID
PHOTODECARBOXYLASE
(Chlorella
variabilis) 		3 / 3 TRP A 479
THR A 131
TYR A 466
 PLM  A 702 ( 4.6A)
None
PLM  A 702 (-4.2A)
 1.10A 2a3bA-5nccA:
undetectable		 2a3bA-5nccA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A 189
LEU A 122
LEU A 197
LEU A 234
 None
PLM  A 401 ( 4.1A)
None
None
 1.01A 2ab2A-5oceA:
undetectable		 2ab2A-5oceA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1o8v FATTY ACID BINDING
PROTEIN HOMOLOG
(Echinococcus
granulosus) 		3 / 3 ASP A  17
VAL A  25
PRO A  76
 None
None
PLM  A1136 (-4.6A)
 0.78A 2avvA-1o8vA:
undetectable		 2avvA-1o8vA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  91
ILE A 263
GLY A 272
ALA A 271
LEU A 169
 PLM  A 702 ( 4.5A)
PLM  A 702 (-4.4A)
None
PLM  A 702 ( 4.7A)
None
 0.99A 2aylB-1pzxA:
undetectable		 2aylB-1pzxA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 3bdq STEROL CARRIER
PROTEIN 2-LIKE 2
(Aedes
aegypti) 		4 / 8 VAL A  51
LEU A  49
VAL A  17
VAL A 104
 None
None
PLM  A 300 ( 4.9A)
PLM  A 300 ( 4.9A)
 0.91A 2bdmA-3bdqA:
undetectable		 2bdmA-3bdqA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1ev1 ECHOVIRUS 1
(Enterovirus
B) 		4 / 8 LEU 1 219
TYR 1 146
ILE 1 119
ILE 1  95
 None
PLM  1   0 (-3.7A)
None
PLM  1   0 ( 4.6A)
 0.75A 2bu8A-1ev11:
undetectable		 2bu8A-1ev11:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		5 / 12 VAL A  25
THR A  53
LEU A 115
ARG A 126
TYR A 128
 None
PLM  A 200 ( 4.2A)
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
 0.80A 2cbrA-5b29A:
19.3		 2cbrA-5b29A:
40.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 5fuk MROUPO
(Marasmius
rotula) 		4 / 6 ALA A  59
ILE A 153
GLU A 157
PHE A 160
 PLM  A1237 (-3.5A)
RNP  A1238 ( 4.2A)
HEM  A1235 ( 3.4A)
PLM  A1237 ( 4.0A)
 0.41A 2cizA-5fukA:
26.8		 2cizA-5fukA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		4 / 7 SER A 122
LEU A 246
PHE A 162
THR A 276
 PLM  A 501 (-3.7A)
None
PLM  A 501 (-3.7A)
None
 0.97A 2f78A-1vpvA:
undetectable		 2f78A-1vpvA:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  17
PRO A  39
THR A  54
ARG A 127
TYR A 129
 None
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.88A 2fr3A-3nr3A:
19.1		 2fr3A-3nr3A:
35.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		5 / 12 PRO A  38
THR A  53
LEU A 115
ARG A 126
TYR A 128
 PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.2A)
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
 0.81A 2fr3A-5b29A:
19.3		 2fr3A-5b29A:
42.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		5 / 12 PHE A 279
ASP A 282
VAL A 283
ALA A 384
PHE A 383
 None
None
None
None
PLM  A 513 (-3.7A)
 1.32A 2g70A-5lgdA:
undetectable		 2g70A-5lgdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5ca6 PORCINE ROTAVIRUS
TFR-41 VP8*
(Rotavirus
A) 		4 / 7 TYR A 189
GLY A 187
THR A 176
TYR A 165
 PLM  A 307 (-3.2A)
None
None
None
 0.76A 2g70A-5ca6A:
undetectable		 2g70A-5ca6A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		5 / 12 PHE A 279
ASP A 282
VAL A 283
ALA A 384
PHE A 383
 None
None
None
None
PLM  A 513 (-3.7A)
 1.35A 2g70B-5lgdA:
undetectable		 2g70B-5lgdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5ca6 PORCINE ROTAVIRUS
TFR-41 VP8*
(Rotavirus
A) 		4 / 7 TYR A 189
GLY A 187
THR A 176
TYR A 165
 PLM  A 307 (-3.2A)
None
None
None
 0.77A 2g70B-5ca6A:
undetectable		 2g70B-5ca6A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		5 / 12 PHE A 279
ASP A 282
VAL A 283
ALA A 384
PHE A 383
 None
None
None
None
PLM  A 513 (-3.7A)
 1.41A 2g72A-5lgdA:
undetectable		 2g72A-5lgdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 3epy ACYL-COA-BINDING
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 5 ASP A  23
LEU A  26
LYS A  27
ARG A  20
 None
PLM  A 101 ( 4.2A)
None
None
 1.21A 2gj5A-3epyA:
undetectable		 2gj5A-3epyA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11
(Mycobacterium
tuberculosis) 		4 / 6 SER A 138
PRO A 341
SER A 312
VAL A 106
 PLM  A 400 (-2.9A)
PLM  A 400 ( 4.5A)
PLM  A 400 (-2.5A)
None
 1.17A 2hdnI-4jatA:
undetectable
2hdnJ-4jatA:
undetectable
2hdnL-4jatA:
undetectable		 2hdnI-4jatA:
7.83
2hdnJ-4jatA:
21.83
2hdnL-4jatA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11
(Mycobacterium
tuberculosis) 		4 / 6 SER A 312
VAL A 106
SER A 138
PRO A 341
 PLM  A 400 (-2.5A)
None
PLM  A 400 (-2.9A)
PLM  A 400 ( 4.5A)
 1.20A 2hdnJ-4jatA:
undetectable
2hdnK-4jatA:
undetectable
2hdnL-4jatA:
undetectable		 2hdnJ-4jatA:
21.83
2hdnK-4jatA:
7.83
2hdnL-4jatA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A 230
TYR A 141
ASN A 192
LEU A 110
 None
None
None
PLM  A 401 ( 4.4A)
 1.18A 2hzqA-5oceA:
undetectable		 2hzqA-5oceA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 5ncc FATTY ACID
PHOTODECARBOXYLASE
(Chlorella
variabilis) 		4 / 6 HIS A 233
PHE A 237
ARG A 451
GLY A 435
 None
None
PLM  A 702 (-4.1A)
None
 1.49A 2i30A-5nccA:
undetectable		 2i30A-5nccA:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 2nnj CYTOCHROME P450 2C8
(Homo
sapiens) 		9 / 12 SER A 100
ILE A 102
ILE A 106
ASN A 204
LEU A 208
ASN A 209
ASN A 217
VAL A 237
VAL A 296
 None
PLM  A 502 ( 4.1A)
PLM  A 502 (-4.6A)
None
225  A 501 ( 4.3A)
None
None
None
None
 0.59A 2nnhA-2nnjA:
62.3		 2nnhA-2nnjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 2nnj CYTOCHROME P450 2C8
(Homo
sapiens) 		9 / 12 SER A 100
ILE A 102
SER A 103
ILE A 106
ASN A 204
ASN A 209
ASN A 217
VAL A 237
VAL A 296
 None
PLM  A 502 ( 4.1A)
225  A 501 ( 4.0A)
PLM  A 502 (-4.6A)
None
None
None
None
None
 0.64A 2nnhA-2nnjA:
62.3		 2nnhA-2nnjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 2nnj CYTOCHROME P450 2C8
(Homo
sapiens) 		7 / 12 SER A 100
ILE A 102
SER A 103
ILE A 106
ASN A 217
VAL A 237
ARG A 241
 None
PLM  A 502 ( 4.1A)
225  A 501 ( 4.0A)
PLM  A 502 (-4.6A)
None
None
None
 1.49A 2nnhA-2nnjA:
62.3		 2nnhA-2nnjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 2nnj CYTOCHROME P450 2C8
(Homo
sapiens) 		7 / 10 SER A 100
ILE A 102
ASN A 204
ASN A 209
ASN A 217
VAL A 296
ILE A 476
 None
PLM  A 502 ( 4.1A)
None
None
None
None
225  A 501 ( 3.9A)
 0.64A 2nnhB-2nnjA:
61.9		 2nnhB-2nnjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 2nnj CYTOCHROME P450 2C8
(Homo
sapiens) 		8 / 10 SER A 100
ILE A 102
ILE A 106
ASN A 204
LEU A 208
ASN A 209
ASN A 217
VAL A 296
 None
PLM  A 502 ( 4.1A)
PLM  A 502 (-4.6A)
None
225  A 501 ( 4.3A)
None
None
None
 0.60A 2nnhB-2nnjA:
61.9		 2nnhB-2nnjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2nnj CYTOCHROME P450 2C8
(Homo
sapiens) 		8 / 8 ILE A 102
ILE A 106
ILE A 113
ARG A 200
ILE A 213
ASN A 236
VAL A 237
ALA A 292
 PLM  A 502 ( 4.1A)
PLM  A 502 (-4.6A)
225  A 501 ( 4.3A)
None
None
None
None
None
 0.66A 2nniA-2nnjA:
63.1		 2nniA-2nnjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 105
GLU A  73
LEU A  24
TYR A  20
ALA A  76
 PLM  A 901 ( 4.5A)
None
None
None
PLM  A 901 ( 4.0A)
 1.22A 2noaA-3nr3A:
undetectable		 2noaA-3nr3A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 8 TRP A 196
MET A 172
ALA A 194
LEU A 197
 None
PLM  A 700 (-4.1A)
None
None
 1.02A 2o01A-2z6vA:
undetectable		 2o01A-2z6vA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 12 ILE A 232
LEU A 121
PHE A 125
ALA A 229
ALA A 230
 PLM  A 501 (-4.0A)
None
None
None
None
 0.96A 2oc8A-3fysA:
undetectable		 2oc8A-3fysA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		3 / 3 PHE A 637
PHE A 608
PHE A 605
 None
None
PLM  A1009 ( 4.6A)
 0.88A 2od9A-5mkfA:
undetectable		 2od9A-5mkfA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 7 TYR A 278
HIS A 153
TYR A 228
TYR A 276
 None
GOL  A 601 (-3.5A)
None
PLM  A 701 (-4.6A)
 1.10A 2ombC-2dt8A:
undetectable
2ombD-2dt8A:
undetectable		 2ombC-2dt8A:
21.99
2ombD-2dt8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		3 / 3 ASP A  80
ASN A  52
THR A  60
 None
None
PLM  A1001 ( 4.6A)
 0.59A 2pymB-3aynA:
undetectable		 2pymB-3aynA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4ww3 RHODOPSIN
(Todarodes
pacificus) 		3 / 3 ASP A  80
ASN A  52
THR A  60
 None
None
PLM  A 402 ( 4.2A)
 0.60A 2pymB-4ww3A:
undetectable		 2pymB-4ww3A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		3 / 3 ASP A  80
ASN A  52
THR A  60
 None
None
PLM  A1001 ( 4.6A)
 0.63A 2q63B-3aynA:
undetectable		 2q63B-3aynA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 1ev1 ECHOVIRUS 1
(Enterovirus
B) 		4 / 6 LEU 1 219
TYR 1 146
ILE 1 119
ILE 1  95
 None
PLM  1   0 (-3.7A)
None
PLM  1   0 ( 4.6A)
 0.70A 2q8hA-1ev11:
undetectable		 2q8hA-1ev11:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		3 / 3 GLY A  40
ASP A  43
SER A  83
 PLM  A 430 ( 3.8A)
None
None
 0.73A 2qhfA-1eh5A:
0.0		 2qhfA-1eh5A:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1o8v FATTY ACID BINDING
PROTEIN HOMOLOG
(Echinococcus
granulosus) 		6 / 12 PHE A  16
VAL A  25
SER A  54
ASP A  77
ARG A  79
ARG A 127
 PLM  A1136 (-4.7A)
None
PLM  A1136 ( 4.9A)
PLM  A1136 (-3.8A)
PLM  A1136 (-4.6A)
PLM  A1136 (-4.4A)
 1.16A 2qm9A-1o8vA:
23.5		 2qm9A-1o8vA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1o8v FATTY ACID BINDING
PROTEIN HOMOLOG
(Echinococcus
granulosus) 		9 / 12 PHE A  16
VAL A  25
SER A  54
SER A  56
THR A  61
ASP A  77
ARG A  79
ARG A 127
TYR A 129
 PLM  A1136 (-4.7A)
None
PLM  A1136 ( 4.9A)
PLM  A1136 ( 3.8A)
None
PLM  A1136 (-3.8A)
PLM  A1136 (-4.6A)
PLM  A1136 (-4.4A)
PLM  A1136 (-4.6A)
 0.54A 2qm9A-1o8vA:
23.5		 2qm9A-1o8vA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		10 / 12 PHE A  17
VAL A  26
SER A  56
THR A  61
ALA A  76
ASP A  77
ARG A  79
CYH A 118
ARG A 127
TYR A 129
 None
None
PLM  A 901 (-3.7A)
None
PLM  A 901 ( 4.0A)
PLM  A 901 (-4.0A)
None
PLM  A 901 ( 3.8A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.56A 2qm9A-3nr3A:
25.3		 2qm9A-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		8 / 12 PHE A  17
VAL A  26
SER A  56
THR A  61
ALA A  76
ASP A  77
CYH A 125
TYR A 129
 None
None
PLM  A 901 (-3.7A)
None
PLM  A 901 ( 4.0A)
PLM  A 901 (-4.0A)
None
PLM  A 901 (-4.6A)
 1.32A 2qm9A-3nr3A:
25.3		 2qm9A-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		9 / 12 VAL A  25
ALA A  33
SER A  55
THR A  60
ALA A  75
ASP A  76
ARG A  78
ARG A 126
TYR A 128
 None
PLM  A 200 ( 3.7A)
PLM  A 200 ( 4.1A)
PLM  A 200 ( 4.8A)
PLM  A 200 ( 4.0A)
PLM  A 200 ( 4.3A)
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
 0.68A 2qm9A-5b29A:
24.7		 2qm9A-5b29A:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		6 / 12 VAL A  25
SER A  55
ALA A  75
ASP A  76
CYH A 124
TYR A 128
 None
PLM  A 200 ( 4.1A)
PLM  A 200 ( 4.0A)
PLM  A 200 ( 4.3A)
None
PLM  A 200 (-4.8A)
 1.26A 2qm9A-5b29A:
24.7		 2qm9A-5b29A:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		4 / 4 TYR A  20
MET A  21
PRO A  39
ILE A 105
 None
PLM  A 901 (-3.7A)
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.5A)
 0.54A 2qm9A-3nr3A:
25.3		 2qm9A-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1o8v FATTY ACID BINDING
PROTEIN HOMOLOG
(Echinococcus
granulosus) 		5 / 12 PHE A  16
VAL A  25
SER A  54
ARG A  79
ARG A 127
 PLM  A1136 (-4.7A)
None
PLM  A1136 ( 4.9A)
PLM  A1136 (-4.6A)
PLM  A1136 (-4.4A)
 1.13A 2qm9B-1o8vA:
24.2		 2qm9B-1o8vA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1o8v FATTY ACID BINDING
PROTEIN HOMOLOG
(Echinococcus
granulosus) 		8 / 12 PHE A  16
VAL A  25
SER A  54
SER A  56
THR A  61
ARG A  79
ARG A 127
TYR A 129
 PLM  A1136 (-4.7A)
None
PLM  A1136 ( 4.9A)
PLM  A1136 ( 3.8A)
None
PLM  A1136 (-4.6A)
PLM  A1136 (-4.4A)
PLM  A1136 (-4.6A)
 0.58A 2qm9B-1o8vA:
24.2		 2qm9B-1o8vA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1o8v FATTY ACID BINDING
PROTEIN HOMOLOG
(Echinococcus
granulosus) 		8 / 12 PHE A  16
VAL A  25
SER A  54
SER A  56
THR A  61
ILE A 105
ARG A 127
TYR A 129
 PLM  A1136 (-4.7A)
None
PLM  A1136 ( 4.9A)
PLM  A1136 ( 3.8A)
None
None
PLM  A1136 (-4.4A)
PLM  A1136 (-4.6A)
 0.65A 2qm9B-1o8vA:
24.2		 2qm9B-1o8vA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		11 / 12 PHE A  17
TYR A  20
VAL A  26
SER A  56
THR A  61
ALA A  76
ARG A  79
ILE A 105
CYH A 118
ARG A 127
TYR A 129
 None
None
None
PLM  A 901 (-3.7A)
None
PLM  A 901 ( 4.0A)
None
PLM  A 901 ( 4.5A)
PLM  A 901 ( 3.8A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.63A 2qm9B-3nr3A:
25.6		 2qm9B-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		7 / 12 PHE A  17
VAL A  26
SER A  56
ALA A  76
CYH A 125
ARG A 127
TYR A 129
 None
None
PLM  A 901 (-3.7A)
PLM  A 901 ( 4.0A)
None
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 1.49A 2qm9B-3nr3A:
25.6		 2qm9B-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 TYR A  20
VAL A  26
THR A  54
ARG A  79
ILE A 105
 None
None
PLM  A 901 ( 4.6A)
None
PLM  A 901 ( 4.5A)
 1.22A 2qm9B-3nr3A:
25.6		 2qm9B-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		8 / 12 TYR A  19
VAL A  25
SER A  55
THR A  60
ALA A  75
ARG A  78
ARG A 126
TYR A 128
 None
None
PLM  A 200 ( 4.1A)
PLM  A 200 ( 4.8A)
PLM  A 200 ( 4.0A)
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
 0.51A 2qm9B-5b29A:
25.3		 2qm9B-5b29A:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		5 / 12 VAL A  25
SER A  55
ALA A  75
CYH A 124
TYR A 128
 None
PLM  A 200 ( 4.1A)
PLM  A 200 ( 4.0A)
None
PLM  A 200 (-4.8A)
 1.23A 2qm9B-5b29A:
25.3		 2qm9B-5b29A:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1o8v FATTY ACID BINDING
PROTEIN HOMOLOG
(Echinococcus
granulosus) 		4 / 4 MET A  20
PRO A  38
ASP A  77
ARG A 107
 PLM  A1136 (-3.5A)
None
PLM  A1136 (-3.8A)
PLM  A1136 (-3.9A)
 0.48A 2qm9B-1o8vA:
24.2		 2qm9B-1o8vA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		4 / 4 MET A  21
PRO A  39
ASP A  77
ARG A 107
 PLM  A 901 (-3.7A)
SO4  A 903 ( 4.8A)
PLM  A 901 (-4.0A)
PLM  A 901 (-3.7A)
 0.41A 2qm9B-3nr3A:
25.6		 2qm9B-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		4 / 4 MET A  20
PRO A  38
ASP A  76
ARG A 106
 PLM  A 200 ( 4.0A)
PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.3A)
None
 0.54A 2qm9B-5b29A:
25.3		 2qm9B-5b29A:
62.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5mkf POLYCYSTIN-2
(Homo
sapiens) 		3 / 3 PHE A 637
PHE A 608
PHE A 605
 None
None
PLM  A1009 ( 4.6A)
 0.88A 2qqgA-5mkfA:
undetectable		 2qqgA-5mkfA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 4xcp NEMATODE FATTY ACID
RETINOID BINDING
PROTEIN
(Necator
americanus) 		4 / 4 LYS A  62
LEU A  59
ALA A  61
LEU A  52
 None
None
None
PLM  A 202 ( 4.2A)
 1.35A 2roxA-4xcpA:
undetectable		 2roxA-4xcpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 169
PHE A 161
ILE A 200
GLY A 172
 None
PLM  A 702 ( 4.2A)
None
None
 0.85A 2v0mC-1pzxA:
undetectable		 2v0mC-1pzxA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 9 LEU A 339
LEU A 321
ALA A 220
LEU A 233
ALA A 232
 PLM  A 402 ( 4.9A)
None
PLM  A 402 ( 4.0A)
PLM  A 402 ( 4.3A)
PLM  A 402 ( 4.0A)
 1.21A 2vcvD-1m66A:
undetectable		 2vcvD-1m66A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 9 LEU A 339
LEU A 321
ALA A 220
LEU A 233
ALA A 232
 PLM  A 402 ( 4.9A)
None
PLM  A 402 ( 4.0A)
PLM  A 402 ( 4.3A)
PLM  A 402 ( 4.0A)
 1.19A 2vcvE-1m66A:
undetectable		 2vcvE-1m66A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A  91
ALA A 271
ALA A 277
PHE A 279
 PLM  A 702 ( 4.5A)
PLM  A 702 ( 4.7A)
PLM  A 702 (-3.1A)
None
 0.97A 2vcvG-1pzxA:
undetectable		 2vcvG-1pzxA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 9 LEU A 339
LEU A 321
ALA A 220
LEU A 233
ALA A 232
 PLM  A 402 ( 4.9A)
None
PLM  A 402 ( 4.0A)
PLM  A 402 ( 4.3A)
PLM  A 402 ( 4.0A)
 1.19A 2vcvH-1m66A:
undetectable		 2vcvH-1m66A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 9 LEU A 339
LEU A 321
ALA A 220
LEU A 233
ALA A 232
 PLM  A 402 ( 4.9A)
None
PLM  A 402 ( 4.0A)
PLM  A 402 ( 4.3A)
PLM  A 402 ( 4.0A)
 1.20A 2vcvI-1m66A:
undetectable		 2vcvI-1m66A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 9 PHE A 161
LEU A  91
ALA A 271
ALA A 277
PHE A 279
 PLM  A 702 ( 4.2A)
PLM  A 702 ( 4.5A)
PLM  A 702 ( 4.7A)
PLM  A 702 (-3.1A)
None
 1.24A 2vcvI-1pzxA:
undetectable		 2vcvI-1pzxA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5d1w RV3249C
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 168
ALA A 202
PHE A  97
PHE A 101
 None
None
None
PLM  A 301 (-4.8A)
 0.92A 2vcvL-5d1wA:
2.3		 2vcvL-5d1wA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 2nnj CYTOCHROME P450 2C8
(Homo
sapiens) 		11 / 12 ILE A 106
THR A 107
ASN A 204
PHE A 205
LEU A 208
ASN A 209
VAL A 237
VAL A 296
GLU A 300
THR A 301
ILE A 476
 PLM  A 502 (-4.6A)
None
None
None
225  A 501 ( 4.3A)
None
None
None
None
HEM  A 500 ( 3.7A)
225  A 501 ( 3.9A)
 0.60A 2vn0A-2nnjA:
63.3		 2vn0A-2nnjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		4 / 8 ILE A 268
PHE A 162
VAL A 176
LEU A 170
 PLM  A 501 ( 4.5A)
PLM  A 501 (-3.7A)
None
None
 0.90A 2w98B-1vpvA:
undetectable		 2w98B-1vpvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		3 / 3 GLY A 236
TYR A 235
SER A 267
 None
PLM  A 301 (-4.7A)
None
 0.73A 2xatA-5azbA:
0.8		 2xatA-5azbA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		4 / 7 TYR A  19
LEU A 104
THR A  53
ASP A  76
 None
None
PLM  A 200 ( 4.2A)
PLM  A 200 ( 4.3A)
 1.01A 2zaxA-5b29A:
undetectable		 2zaxA-5b29A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 12 ILE A 281
GLY A 234
GLY A 123
ASP A  12
LEU A 247
 None
None
PLM  A 501 (-4.0A)
None
None
 1.22A 2zw9A-1vpvA:
2.1		 2zw9A-1vpvA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4kvl FATTY ACID
ALPHA-OXIDASE
(Oryza
sativa) 		4 / 8 ILE A 313
ASN A 332
ARG A 559
TYR A 334
 None
PLM  A 702 ( 3.6A)
PLM  A 702 (-2.9A)
None
 1.02A 2zw9B-4kvlA:
undetectable		 2zw9B-4kvlA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		4 / 8 VAL A  30
GLY A 264
TYR A  12
HIS A 270
 None
None
None
PLM  A 301 (-3.5A)
 0.93A 3af0A-5utoA:
undetectable		 3af0A-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 1o8v FATTY ACID BINDING
PROTEIN HOMOLOG
(Echinococcus
granulosus) 		4 / 7 VAL A  81
SER A  83
HIS A  94
THR A  75
 None
None
CSO  A  63 ( 4.8A)
PLM  A1136 ( 4.9A)
 0.79A 3arrA-1o8vA:
undetectable		 3arrA-1o8vA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 GLY A 372
LEU A 306
SER A 327
SER A 303
ALA A 304
 None
None
PLM  A 601 (-3.6A)
None
None
 1.25A 3d91A-4n03A:
undetectable		 3d91A-4n03A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 GLY A 372
THR A 297
LEU A 306
SER A 327
ALA A 304
 None
PLM  A 601 ( 4.8A)
None
PLM  A 601 (-3.6A)
None
 1.17A 3d91A-4n03A:
undetectable		 3d91A-4n03A:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens) 		5 / 12 CYH A 139
GLN A 145
LEU A 179
ARG A 186
LEU A 196
 None
PLM  A 328 ( 4.8A)
PLM  A 328 ( 4.6A)
PLM  A 328 (-3.3A)
PLM  A 328 (-3.7A)
 0.78A 3fc6C-1lv2A:
23.9		 3fc6C-1lv2A:
39.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3r1o ODORANT BINDING
PROTEIN, ANTENNAL
(Anopheles
gambiae) 		5 / 10 LEU A 124
VAL A 107
ILE A  57
LEU A  72
PHE A  54
 PLM  A 128 (-4.9A)
PLM  A 128 ( 4.7A)
PLM  A 128 ( 4.5A)
None
PLM  A 128 ( 4.9A)
 1.18A 3fl9F-3r1oA:
undetectable		 3fl9F-3r1oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		4 / 7 TYR A  19
LEU A 104
THR A  53
ASP A  76
 None
None
PLM  A 200 ( 4.2A)
PLM  A 200 ( 4.3A)
 1.04A 3fwgB-5b29A:
undetectable		 3fwgB-5b29A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 9 VAL A  25
ALA A  11
THR A  75
SER A  73
ILE A  26
 None
None
None
PLM  A 275 (-2.6A)
None
 1.35A 3hbbB-3eglA:
2.1		 3hbbB-3eglA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		5 / 9 ALA A 122
VAL A 267
ILE A 198
LEU A 168
ILE A  94
 PLM  A 301 ( 4.5A)
PLM  A 301 (-4.3A)
None
None
PLM  A 301 (-4.2A)
 1.29A 3jw3B-5utoA:
undetectable		 3jw3B-5utoA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 6bms PALMITOYLTRANSFERASE
(Danio
rerio) 		4 / 7 TYR A  59
LEU A 214
PHE A 207
VAL A 203
 None
LMT  A1003 (-4.4A)
PLM  A1006 (-4.1A)
PLM  A1006 (-4.7A)
 1.14A 3jwqC-6bmsA:
undetectable		 3jwqC-6bmsA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		4 / 4 ARG A 107
ASP A  19
GLY A 122
THR A 103
 PLM  A 901 (-3.7A)
SO4  A 904 (-3.7A)
None
None
 1.05A 3k4vB-3nr3A:
undetectable		 3k4vB-3nr3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2nnj CYTOCHROME P450 2C8
(Homo
sapiens) 		5 / 9 PHE A 226
TRP A 212
VAL A 233
ASN A 231
GLY A 228
 PLM  A 502 (-3.9A)
None
None
None
None
 1.21A 3km6B-2nnjA:
undetectable		 3km6B-2nnjA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3ocj PUTATIVE EXPORTED
PROTEIN
(Bordetella
parapertussis) 		5 / 10 GLY A  54
GLU A  85
LEU A  57
LEU A  58
ILE A 258
 PLM  A 305 (-3.5A)
None
None
None
None
 1.31A 3kvrA-3ocjA:
undetectable		 3kvrA-3ocjA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3ocj PUTATIVE EXPORTED
PROTEIN
(Bordetella
parapertussis) 		5 / 10 GLY A  54
GLU A  85
LEU A  57
LEU A  58
ILE A 258
 PLM  A 305 (-3.5A)
None
None
None
None
 1.32A 3kvrB-3ocjA:
undetectable		 3kvrB-3ocjA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4a2n ISOPRENYLCYSTEINE
CARBOXYL
METHYLTRANSFERASE
(Methanosarcina
acetivorans) 		4 / 6 LEU B 107
GLU B  42
PRO B  39
ARG B 163
 None
None
None
PLM  B1194 ( 4.6A)
 1.25A 3ltwA-4a2nB:
undetectable		 3ltwA-4a2nB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 11 ILE A 281
ALA A 124
ILE A 261
LEU A 247
VAL A 232
 None
PLM  A 501 (-4.4A)
None
None
None
 1.13A 3n0hA-1vpvA:
undetectable		 3n0hA-1vpvA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  91
ILE A 263
GLY A 272
ALA A 271
LEU A 169
 PLM  A 702 ( 4.5A)
PLM  A 702 (-4.4A)
None
PLM  A 702 ( 4.7A)
None
 1.04A 3n8xB-1pzxA:
0.0		 3n8xB-1pzxA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		3 / 3 VAL A 122
VAL A  96
SER A  93
 None
None
PLM  A 701 (-2.5A)
 0.71A 3n8xB-2dt8A:
undetectable		 3n8xB-2dt8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3ocj PUTATIVE EXPORTED
PROTEIN
(Bordetella
parapertussis) 		5 / 9 GLY A  54
GLU A  85
LEU A  57
LEU A  58
ILE A 258
 PLM  A 305 (-3.5A)
None
None
None
None
 1.31A 3nbqA-3ocjA:
undetectable		 3nbqA-3ocjA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4kvl FATTY ACID
ALPHA-OXIDASE
(Oryza
sativa) 		5 / 12 PHE A 379
PHE A 272
ILE A 593
ALA A 433
ILE A 146
 PLM  A 702 ( 4.7A)
None
None
None
None
 1.07A 3nxuA-4kvlA:
undetectable		 3nxuA-4kvlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4kvl FATTY ACID
ALPHA-OXIDASE
(Oryza
sativa) 		5 / 12 PHE A 379
PHE A 272
ILE A 593
ALA A 433
ILE A 146
 PLM  A 702 ( 4.7A)
None
None
None
None
 1.10A 3nxuB-4kvlA:
undetectable		 3nxuB-4kvlA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1mdc INSECT FATTY ACID
BINDING PROTEIN
(Manduca
sexta) 		5 / 12 PHE A  15
PRO A  37
VAL A 114
ARG A 127
TYR A 129
 None
None
PLM  A 133 (-4.8A)
PLM  A 133 (-3.8A)
PLM  A 133 (-4.7A)
 0.69A 3p6gA-1mdcA:
19.0		 3p6gA-1mdcA:
31.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1mdc INSECT FATTY ACID
BINDING PROTEIN
(Manduca
sexta) 		5 / 12 PRO A  37
ASP A  77
VAL A 114
ARG A 127
TYR A 129
 None
PLM  A 133 ( 4.4A)
PLM  A 133 (-4.8A)
PLM  A 133 (-3.8A)
PLM  A 133 (-4.7A)
 1.13A 3p6gA-1mdcA:
19.0		 3p6gA-1mdcA:
31.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1o8v FATTY ACID BINDING
PROTEIN HOMOLOG
(Echinococcus
granulosus) 		10 / 12 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  77
ARG A  79
ILE A 105
ARG A 107
ARG A 127
TYR A 129
 PLM  A1136 (-4.7A)
PLM  A1136 (-3.5A)
None
None
PLM  A1136 (-3.8A)
PLM  A1136 (-4.6A)
None
PLM  A1136 (-3.9A)
PLM  A1136 (-4.4A)
PLM  A1136 (-4.6A)
 0.55A 3p6gA-1o8vA:
23.7		 3p6gA-1o8vA:
41.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1o8v FATTY ACID BINDING
PROTEIN HOMOLOG
(Echinococcus
granulosus) 		7 / 12 PHE A  16
MET A  20
VAL A  25
PRO A  38
CYH A 125
ARG A 127
TYR A 129
 PLM  A1136 (-4.7A)
PLM  A1136 (-3.5A)
None
None
None
PLM  A1136 (-4.4A)
PLM  A1136 (-4.6A)
 1.24A 3p6gA-1o8vA:
23.7		 3p6gA-1o8vA:
41.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		11 / 12 PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ILE A 105
ARG A 107
CYH A 118
ARG A 127
TYR A 129
 None
PLM  A 901 (-3.7A)
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-4.0A)
None
PLM  A 901 ( 4.5A)
PLM  A 901 (-3.7A)
PLM  A 901 ( 3.8A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.58A 3p6gA-3nr3A:
25.2		 3p6gA-3nr3A:
58.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		8 / 12 PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
CYH A 125
ARG A 127
TYR A 129
 None
PLM  A 901 (-3.7A)
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-4.0A)
None
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 1.17A 3p6gA-3nr3A:
25.2		 3p6gA-3nr3A:
58.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		8 / 12 MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ARG A 106
ARG A 126
TYR A 128
 PLM  A 200 ( 4.0A)
None
PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.3A)
None
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
 0.60A 3p6gA-5b29A:
24.5		 3p6gA-5b29A:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		7 / 12 MET A  20
VAL A  25
PRO A  38
ASP A  76
CYH A 124
ARG A 126
TYR A 128
 PLM  A 200 ( 4.0A)
None
PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.3A)
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
 1.14A 3p6gA-5b29A:
24.5		 3p6gA-5b29A:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1mdc INSECT FATTY ACID
BINDING PROTEIN
(Manduca
sexta) 		4 / 7 PHE A  15
VAL A 114
ARG A 127
TYR A 129
 None
PLM  A 133 (-4.8A)
PLM  A 133 (-3.8A)
PLM  A 133 (-4.7A)
 0.76A 3p6hA-1mdcA:
19.0		 3p6hA-1mdcA:
31.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1o8v FATTY ACID BINDING
PROTEIN HOMOLOG
(Echinococcus
granulosus) 		6 / 7 PHE A  16
MET A  20
ASP A  77
ILE A 105
ARG A 127
TYR A 129
 PLM  A1136 (-4.7A)
PLM  A1136 (-3.5A)
PLM  A1136 (-3.8A)
None
PLM  A1136 (-4.4A)
PLM  A1136 (-4.6A)
 0.58A 3p6hA-1o8vA:
23.7		 3p6hA-1o8vA:
41.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		6 / 7 PHE A  17
MET A  21
ASP A  77
ILE A 105
ARG A 127
TYR A 129
 None
PLM  A 901 (-3.7A)
PLM  A 901 (-4.0A)
PLM  A 901 ( 4.5A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.51A 3p6hA-3nr3A:
25.3		 3p6hA-3nr3A:
58.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		4 / 7 MET A  20
ASP A  76
ARG A 126
TYR A 128
 PLM  A 200 ( 4.0A)
PLM  A 200 ( 4.3A)
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
 0.44A 3p6hA-5b29A:
24.3		 3p6hA-5b29A:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 THR A  58
GLY A 328
ASP A 326
LEU A 325
LEU A 312
 None
PLM  A 601 ( 4.0A)
None
None
None
 1.16A 3q87B-4n03A:
2.8		 3q87B-4n03A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 6bms PALMITOYLTRANSFERASE
(Danio
rerio) 		4 / 7 VAL A  19
TYR A  59
PHE A 207
LEU A 211
 PLM  A1006 ( 4.9A)
None
PLM  A1006 (-4.1A)
None
 0.99A 3qeoB-6bmsA:
undetectable		 3qeoB-6bmsA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 12 VAL A 161
ALA A 273
GLY A 272
ALA A 263
HIS A 268
 None
None
None
None
PLM  A 501 (-3.8A)
 1.00A 3qxyA-3fysA:
undetectable		 3qxyA-3fysA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 12 ILE A 281
ALA A 124
ILE A 261
LEU A 247
VAL A 232
 None
PLM  A 501 (-4.4A)
None
None
None
 1.11A 3s3vA-1vpvA:
undetectable		 3s3vA-1vpvA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens) 		5 / 12 LEU A 222
GLY A 182
ALA A 183
VAL A 138
ILE A 297
 None
None
PLM  A 328 ( 3.9A)
None
None
 0.87A 3s54A-1lv2A:
undetectable		 3s54A-1lv2A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		4 / 4 LEU A 155
GLY A 154
GLY A 152
THR A 207
 None
None
PLM  A1278 ( 4.2A)
None
 0.69A 3si7A-2w3yA:
undetectable		 3si7A-2w3yA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		3 / 3 GLY A 154
GLY A 152
THR A 207
 None
PLM  A1278 ( 4.2A)
None
 0.44A 3si7B-2w3yA:
undetectable		 3si7B-2w3yA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5d1w RV3249C
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 149
ALA A 202
THR A 160
LEU A  90
 PLM  A 301 ( 3.9A)
None
None
None
 1.01A 3t3zA-5d1wA:
undetectable		 3t3zA-5d1wA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 2ksi STEROL CARRIER
PROTEIN 2
(Aedes
aegypti) 		4 / 6 GLN A  25
PHE A 105
PRO A 104
LEU A 102
 None
PLM  A 200 (-3.0A)
None
PLM  A 200 (-2.8A)
 1.09A 3tgvB-2ksiA:
undetectable		 3tgvB-2ksiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 2ksi STEROL CARRIER
PROTEIN 2
(Aedes
aegypti) 		4 / 6 GLN A  25
PHE A 105
PRO A 104
LEU A 102
 None
PLM  A 200 (-3.0A)
None
PLM  A 200 (-2.8A)
 1.11A 3tgvD-2ksiA:
undetectable		 3tgvD-2ksiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 10 THR A  62
PHE A  89
LEU A 171
PHE A 163
VAL A 271
 PLM  A 702 (-3.7A)
PLM  A 702 ( 4.9A)
None
PLM  A 702 (-3.9A)
None
 1.43A 3u9fE-3pl5A:
undetectable		 3u9fE-3pl5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 12 THR A  62
PHE A  89
LEU A 171
PHE A 163
VAL A 271
 PLM  A 702 (-3.7A)
PLM  A 702 ( 4.9A)
None
PLM  A 702 (-3.9A)
None
 1.42A 3u9fH-3pl5A:
undetectable
3u9fI-3pl5A:
undetectable		 3u9fH-3pl5A:
18.95
3u9fI-3pl5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1mdc INSECT FATTY ACID
BINDING PROTEIN
(Manduca
sexta) 		5 / 7 ILE A  73
GLY A  74
PHE A  18
PHE A  15
LEU A  19
 PLM  A 133 ( 4.9A)
PLM  A 133 ( 4.1A)
None
None
None
 1.11A 3v7pA-1mdcA:
undetectable		 3v7pA-1mdcA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3ocj PUTATIVE EXPORTED
PROTEIN
(Bordetella
parapertussis) 		5 / 11 GLY A 125
ASP A 147
ASP A 149
ASP A 175
ASN A 191
 None
None
None
None
PLM  A 305 ( 4.3A)
 0.73A 3v8vB-3ocjA:
13.1		 3v8vB-3ocjA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT
(Geobacillus
kaustophilus) 		4 / 6 LEU A  95
ILE A  76
TYR A 162
ASN A 163
 None
None
PLM  A 404 (-4.3A)
None
 0.95A 4a9kA-6f6eA:
undetectable		 4a9kA-6f6eA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 5jnq PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE
([Clostridium]
bolteae) 		5 / 12 ILE A 257
ALA A 189
ILE A 194
PHE A 191
LEU A 322
 None
None
PLM  A 402 ( 4.6A)
None
None
 1.09A 4cd2A-5jnqA:
undetectable		 4cd2A-5jnqA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		5 / 11 ALA A 126
LEU A 148
PHE A 144
PHE A 219
VAL A 221
 None
PLM  A1278 (-4.2A)
None
PLM  A1278 ( 3.7A)
None
 1.46A 4claA-2w3yA:
undetectable		 4claA-2w3yA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		4 / 6 LEU A 416
LEU A 387
ILE A 271
THR A 369
 None
PLM  A 513 ( 4.4A)
PLM  A 513 ( 4.6A)
PLM  A 513 (-3.9A)
 0.91A 4do3B-5lgdA:
undetectable		 4do3B-5lgdA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		4 / 8 GLY A 152
PHE A 198
ILE A 205
PHE A 219
 PLM  A1278 ( 4.2A)
None
None
PLM  A1278 ( 3.7A)
 0.95A 4fglD-2w3yA:
undetectable		 4fglD-2w3yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		4 / 7 GLY A 152
PHE A 198
ILE A 205
PHE A 219
 PLM  A1278 ( 4.2A)
None
None
PLM  A1278 ( 3.7A)
 0.88A 4fglC-2w3yA:
undetectable		 4fglC-2w3yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 12 GLY A 104
GLY A 100
LEU A  13
PRO A  14
VAL A  17
 None
PLM  A 275 ( 4.2A)
None
None
None
 0.96A 4gc9A-3eglA:
undetectable		 4gc9A-3eglA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1mdc INSECT FATTY ACID
BINDING PROTEIN
(Manduca
sexta) 		5 / 12 ARG A 127
GLY A  56
GLY A  55
GLY A  54
VAL A  72
 PLM  A 133 (-3.8A)
None
None
None
None
 1.00A 4htfB-1mdcA:
undetectable		 4htfB-1mdcA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 12 ILE A 125
VAL A 272
ASP A  12
ILE A 268
ARG A  42
 None
None
None
PLM  A 501 ( 4.5A)
None
 1.15A 4i41A-1vpvA:
undetectable		 4i41A-1vpvA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5gp9 TRANSCRIPTIONAL
REGULATOR (TETR/ACRR
FAMILY)
(Bacillus
halodurans) 		4 / 7 THR A 166
LEU A 124
LYS A 119
GLN A  60
 None
PLM  A 203 ( 4.7A)
None
None
 1.01A 4ib4A-5gp9A:
undetectable		 4ib4A-5gp9A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 10 TYR A 198
TYR A 166
ASN A 331
LEU A 125
LEU A  67
 PLM  A 601 (-3.9A)
PLM  A 601 (-4.5A)
PLM  A 601 ( 4.6A)
PLM  A 601 ( 4.3A)
PLM  A 601 ( 3.8A)
 1.32A 4jq4B-4n03A:
undetectable		 4jq4B-4n03A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 12 GLN A 123
LEU A 121
ILE A 232
LEU A 269
CYH A 120
 None
None
PLM  A 501 (-4.0A)
PLM  A 501 ( 4.6A)
PLM  A 501 ( 3.9A)
 1.46A 4k38A-3fysA:
undetectable
4k38D-3fysA:
undetectable		 4k38A-3fysA:
22.14
4k38D-3fysA:
6.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens) 		5 / 12 GLN A 145
LEU A 179
ARG A 186
LEU A 196
VAL A 218
 PLM  A 328 ( 4.8A)
PLM  A 328 ( 4.6A)
PLM  A 328 (-3.3A)
PLM  A 328 (-3.7A)
None
 0.71A 4k6iA-1lv2A:
27.9		 4k6iA-1lv2A:
40.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		 3fys PROTEIN DEGV
(Bacillus
subtilis) 		5 / 10 TYR A 260
CYH A 120
ALA A 122
GLN A 123
GLY A 262
 None
PLM  A 501 ( 3.9A)
None
None
None
 1.43A 4lb9A-3fysA:
0.0		 4lb9A-3fysA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5ncc FATTY ACID
PHOTODECARBOXYLASE
(Chlorella
variabilis) 		5 / 12 GLY A 482
GLY A 455
LYS A 394
ALA A 388
GLU A 545
 None
PLM  A 702 ( 4.2A)
None
None
None
 1.00A 4lg1B-5nccA:
undetectable		 4lg1B-5nccA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		3 / 3 ASP A 233
TRP A 186
SER A 115
 None
None
PLM  A 430 (-1.2A)
 0.85A 4lrhA-1eh5A:
0.0		 4lrhA-1eh5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		4 / 8 GLN A  96
PHE A  71
THR A  54
THR A  61
 None
None
PLM  A 901 ( 4.6A)
None
 0.87A 4n16A-3nr3A:
undetectable		 4n16A-3nr3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		4 / 8 GLN A  95
PHE A  70
THR A  53
THR A  60
 None
None
PLM  A 200 ( 4.2A)
PLM  A 200 ( 4.8A)
 0.85A 4n16A-5b29A:
undetectable		 4n16A-5b29A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		4 / 4 HIS A 270
ALA A 268
VAL A 267
GLU A  40
 PLM  A 301 (-3.5A)
None
PLM  A 301 (-4.3A)
None
 1.48A 4n6pA-5utoA:
undetectable		 4n6pA-5utoA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		4 / 8 LYS A 127
ALA A 126
GLY A 122
LEU A 148
 None
None
None
PLM  A1278 (-4.2A)
 0.86A 4po0A-2w3yA:
undetectable		 4po0A-2w3yA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		3 / 3 ILE A 264
ASP A  39
ARG A 170
 PLM  A 701 ( 4.5A)
None
PLM  A 701 (-4.1A)
 0.83A 4pstA-2dt8A:
undetectable		 4pstA-2dt8A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE
(Chlamydia
trachomatis) 		4 / 8 ILE A 285
GLY A 280
MET A 293
ILE A 263
 None
PLM  A1349 (-3.7A)
None
None
 0.83A 4qogA-2iu8A:
undetectable
4qogB-2iu8A:
undetectable		 4qogA-2iu8A:
19.54
4qogB-2iu8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		4 / 6 GLY A 152
PHE A 198
ILE A 205
PHE A 219
 PLM  A1278 ( 4.2A)
None
None
PLM  A1278 ( 3.7A)
 1.01A 4qogA-2w3yA:
undetectable
4qogB-2w3yA:
undetectable		 4qogA-2w3yA:
21.58
4qogB-2w3yA:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		5 / 12 MET A  20
ALA A  33
THR A  53
LEU A 115
LEU A 117
 PLM  A 200 ( 4.0A)
PLM  A 200 ( 3.7A)
PLM  A 200 ( 4.2A)
None
None
 0.75A 4qzuC-5b29A:
21.1		 4qzuC-5b29A:
40.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ww3 RHODOPSIN
(Todarodes
pacificus) 		4 / 5 ILE A 314
PHE A  72
SER A 316
ASP A  80
 None
None
PLM  A 403 (-3.1A)
None
 1.37A 4rzvB-4ww3A:
2.0		 4rzvB-4ww3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT
(Geobacillus
kaustophilus) 		4 / 6 TYR A 162
ASN A 163
GLU A 102
PHE A  94
 PLM  A 404 (-4.3A)
None
FE2  A 401 (-2.5A)
None
 1.47A 4twdG-6f6eA:
0.6
4twdH-6f6eA:
1.3		 4twdG-6f6eA:
11.37
4twdH-6f6eA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 12 ASN A 237
ASP A 238
ALA A 234
PHE A 279
ARG A 211
 None
None
PLM  A 702 ( 4.9A)
None
None
 1.08A 4u8yB-3pl5A:
undetectable		 4u8yB-3pl5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens) 		4 / 7 ALA A 133
LEU A 196
LEU A 195
ILE A 132
 None
PLM  A 328 (-3.7A)
None
None
 0.74A 4ubsA-1lv2A:
undetectable		 4ubsA-1lv2A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4ntb LEUKOTRIENE C4
SYNTHASE
(Mus
musculus) 		4 / 6 LEU A  84
LEU A  18
VAL A  14
PHE A  88
 None
PLM  A 206 (-4.0A)
None
None
 1.23A 4uswA-4ntbA:
undetectable		 4uswA-4ntbA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens) 		4 / 7 ASN A 390
PRO A 412
PHE A  68
PHE A 201
 None
None
None
PLM  A 512 (-4.9A)
 1.49A 4v32A-5lgdA:
undetectable		 4v32A-5lgdA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4xcp NEMATODE FATTY ACID
RETINOID BINDING
PROTEIN
(Necator
americanus) 		4 / 7 TYR A 100
VAL A  36
ILE A  49
LEU A  25
 PLM  A 201 (-4.5A)
None
PLM  A 202 ( 4.5A)
None
 1.09A 4xo7B-4xcpA:
undetectable		 4xo7B-4xcpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 11 GLY A 232
SER A 123
ALA A 122
ILE A 267
ILE A 160
 None
PLM  A 702 (-3.7A)
PLM  A 702 ( 4.0A)
PLM  A 702 ( 4.4A)
None
 1.14A 4xumB-1pzxA:
undetectable		 4xumB-1pzxA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 11 GLY A 280
SER A 122
ILE A 268
LEU A 193
ILE A 161
 PLM  A 501 (-3.8A)
PLM  A 501 (-3.7A)
PLM  A 501 ( 4.5A)
None
None
 1.17A 4xumB-1vpvA:
undetectable		 4xumB-1vpvA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		4 / 4 LEU A 170
ILE A 268
HIS A 271
VAL A 272
 None
PLM  A 501 ( 4.5A)
PLM  A 501 (-3.6A)
None
 0.93A 4xyzA-1vpvA:
undetectable		 4xyzA-1vpvA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 4 LEU A 171
ILE A 267
HIS A 270
VAL A 271
 None
PLM  A 702 ( 4.7A)
PLM  A 702 (-3.6A)
None
 1.07A 4xyzA-3pl5A:
0.2		 4xyzA-3pl5A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3r1o ODORANT BINDING
PROTEIN, ANTENNAL
(Anopheles
gambiae) 		4 / 6 ILE A 118
HIS A  18
ILE A  50
VAL A 107
 None
None
PLM  A 128 ( 4.9A)
PLM  A 128 ( 4.7A)
 0.96A 4zj8A-3r1oA:
undetectable		 4zj8A-3r1oA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		4 / 8 ALA A 208
VAL A 238
ALA A 102
GLY A 100
 None
None
None
PLM  A 275 ( 4.2A)
 0.55A 4zjzA-3eglA:
4.6		 4zjzA-3eglA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A 277
ILE A 276
PHE A 161
ALA A 236
ASP A 262
 PLM  A 702 (-3.1A)
None
PLM  A 702 ( 4.2A)
None
None
 1.18A 5ajqB-1pzxA:
undetectable		 5ajqB-1pzxA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ocj PUTATIVE EXPORTED
PROTEIN
(Bordetella
parapertussis) 		3 / 3 THR A  68
HIS A 172
LEU A 153
 PLM  A 305 ( 4.5A)
None
None
 0.78A 5axdA-3ocjA:
5.2		 5axdA-3ocjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		4 / 6 SER A  34
ASP A  76
ARG A  78
GLY A  24
 None
PLM  A 200 ( 4.3A)
None
None
 1.03A 5cdqA-5b29A:
undetectable
5cdqC-5b29A:
undetectable
5cdqD-5b29A:
undetectable		 5cdqA-5b29A:
17.05
5cdqC-5b29A:
17.05
5cdqD-5b29A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 268
ALA A 266
SER A 261
PHE A 279
CYH A 121
 None
PLM  A 702 ( 4.6A)
None
None
None
 1.49A 5cprB-1pzxA:
undetectable		 5cprB-1pzxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 12 SER A  91
LEU A  28
THR A  10
ALA A 124
TYR A  86
 None
PLM  A 702 (-4.9A)
None
PLM  A 702 (-3.6A)
None
 1.48A 5dsgB-3pl5A:
undetectable		 5dsgB-3pl5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11
(Mycobacterium
tuberculosis) 		4 / 6 SER A 138
HIS A 277
MET A 228
LEU A 187
 PLM  A 400 (-2.9A)
None
PLM  A 400 ( 4.8A)
None
 1.33A 5dzke-4jatA:
undetectable
5dzks-4jatA:
undetectable		 5dzke-4jatA:
24.58
5dzks-4jatA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 4 LEU A 125
ILE A  71
PRO A  66
LEU A  60
 PLM  A 601 ( 4.3A)
None
None
None
 1.23A 5eb3A-4n03A:
7.7		 5eb3A-4n03A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 10 THR A  96
ALA A 106
GLY A 100
ALA A 105
HIS A  67
 None
None
PLM  A 275 ( 4.2A)
None
None
 1.20A 5eeuF-3eglA:
undetectable
5eeuG-3eglA:
undetectable		 5eeuF-3eglA:
13.98
5eeuG-3eglA:
13.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		6 / 12 PHE A  17
TYR A  20
VAL A  26
PRO A  39
ILE A  52
SER A  56
 None
None
None
SO4  A 903 ( 4.8A)
None
PLM  A 901 (-3.7A)
 0.62A 5hbsA-3nr3A:
19.8		 5hbsA-3nr3A:
34.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens) 		6 / 12 TYR A  19
VAL A  25
ALA A  33
PRO A  38
SER A  55
LEU A 115
 None
None
PLM  A 200 ( 3.7A)
PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.1A)
None
 0.83A 5hbsA-5b29A:
20.5		 5hbsA-5b29A:
34.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 8 TYR A 198
PHE A 194
VAL A  63
ILE A 295
 PLM  A 601 (-3.9A)
None
None
None
 0.85A 5hw8H-4n03A:
undetectable		 5hw8H-4n03A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		5 / 12 LEU A 168
PHE A 263
GLU A  40
THR A  10
ALA A 122
 None
PLM  A 301 ( 4.8A)
None
None
PLM  A 301 ( 4.5A)
 1.23A 5ieoA-5utoA:
undetectable		 5ieoA-5utoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 8 ILE A 271
MET A 278
ILE A 213
TYR A 235
 PGT  A 311 ( 4.1A)
PGT  A 307 (-4.0A)
None
PLM  A 301 (-4.7A)
 0.87A 5ieoA-5azbA:
undetectable		 5ieoA-5azbA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 6bms PALMITOYLTRANSFERASE
(Danio
rerio) 		4 / 5 HIS A 142
LEU A 137
TYR A 155
PHE A 158
 ZN  A1002 ( 3.1A)
None
None
PLM  A1006 (-4.7A)
 1.42A 5igjA-6bmsA:
2.0		 5igjA-6bmsA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ev1 ECHOVIRUS 1
(Enterovirus
B) 		4 / 4 ASN 1 214
ILE 1 259
TYR 1 258
PHE 3 237
 PLM  1   0 (-3.5A)
None
None
None
 1.20A 5igvA-1ev11:
0.0		 5igvA-1ev11:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		3 / 3 GLY A 117
GLY A 118
GLN A 142
 None
None
PLM  A 430 (-3.8A)
 0.46A 5imsA-1eh5A:
2.7		 5imsA-1eh5A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 6aq3 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 3
(Naegleria
fowleri) 		5 / 12 LEU A 147
ILE A 143
GLY A  52
TYR A  27
ILE A 139
 None
None
None
PLM  A 201 ( 4.5A)
PLM  A 201 ( 4.2A)
 1.19A 5j7wC-6aq3A:
undetectable		 5j7wC-6aq3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4kvl FATTY ACID
ALPHA-OXIDASE
(Oryza
sativa) 		5 / 11 ILE A 551
ARG A 559
ALA A 556
VAL A 485
LEU A 533
 None
PLM  A 702 (-2.9A)
PLM  A 702 (-3.4A)
None
None
 1.08A 5ji0A-4kvlA:
undetectable		 5ji0A-4kvlA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		4 / 5 ILE A 233
LEU A 191
HIS A 270
VAL A 267
 PLM  A 301 (-4.1A)
None
PLM  A 301 (-3.5A)
PLM  A 301 (-4.3A)
 1.19A 5jmnB-5utoA:
undetectable		 5jmnB-5utoA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4dol AT1G53520
(Arabidopsis
thaliana) 		5 / 12 ALA A 120
LEU A 117
ALA A 116
PHE A 113
THR A 112
 PLM  A 301 ( 3.7A)
PLM  A 301 ( 4.7A)
PLM  A 301 (-3.5A)
PLM  A 301 (-4.8A)
None
 0.97A 5k9dA-4dolA:
undetectable		 5k9dA-4dolA:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  17
TYR A  20
PRO A  39
SER A  56
PHE A  58
 None
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-3.7A)
None
 0.97A 5ljbA-3nr3A:
19.8		 5ljbA-3nr3A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  17
TYR A  20
PRO A  39
SER A  56
PHE A  58
 None
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-3.7A)
None
 0.96A 5ljcA-3nr3A:
19.9		 5ljcA-3nr3A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1o8v FATTY ACID BINDING
PROTEIN HOMOLOG
(Echinococcus
granulosus) 		5 / 12 PHE A  16
PRO A  38
LEU A  40
SER A  56
PHE A  58
 PLM  A1136 (-4.7A)
None
None
PLM  A1136 ( 3.8A)
PLM  A1136 ( 4.9A)
 1.09A 5ljeA-1o8vA:
19.9		 5ljeA-1o8vA:
32.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		4 / 7 GLN A  96
PHE A  71
THR A  54
THR A  61
 None
None
PLM  A 901 ( 4.6A)
None
 0.91A 5m78A-3nr3A:
undetectable		 5m78A-3nr3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1pzx HYPOTHETICAL PROTEIN
APC36103
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 263
GLY A 268
HIS A 270
PHE A 161
ILE A 233
 PLM  A 702 (-4.4A)
None
PLM  A 702 (-3.5A)
PLM  A 702 ( 4.2A)
None
 1.10A 5n0tA-1pzxA:
undetectable		 5n0tA-1pzxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4kvl FATTY ACID
ALPHA-OXIDASE
(Oryza
sativa) 		5 / 11 LEU A 336
GLY A 354
GLY A 350
LEU A  50
ALA A 331
 PLM  A 702 ( 4.7A)
None
PLM  A 704 ( 3.2A)
PLM  A 702 ( 4.1A)
PLM  A 702 (-3.6A)
 0.98A 5o96G-4kvlA:
undetectable		 5o96G-4kvlA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens) 		5 / 12 ILE A 305
VAL A 138
LEU A 324
LEU A 179
LEU A 146
 PLM  A 328 (-4.5A)
None
None
PLM  A 328 ( 4.6A)
None
 1.26A 5tiwA-1lv2A:
undetectable		 5tiwA-1lv2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_B_SALB504_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 6 SER A 233
HIS A 295
PHE A 198
GLN A 291
 None
PLM  A 700 (-3.8A)
None
PLM  A 700 (-3.1A)
 1.48A 5u6nB-2z6vA:
undetectable		 5u6nB-2z6vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 7 ARG A 176
LEU A 263
THR A 161
THR A  39
 PLM  A 702 (-3.9A)
PLM  A 702 ( 4.8A)
PLM  A 702 ( 4.8A)
None
 1.03A 5vc0A-3pl5A:
undetectable		 5vc0A-3pl5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3bks STEROL CARRIER
PROTEIN-2 LIKE-3
(Aedes
aegypti) 		3 / 3 ARG A  21
PHE A  26
LEU A  16
 None
None
PLM  A 400 ( 4.3A)
 0.79A 5x1bC-3bksA:
undetectable		 5x1bC-3bksA:
16.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2nnj CYTOCHROME P450 2C8
(Homo
sapiens) 		4 / 5 GLY A 228
THR A 229
ASN A 231
LYS A 232
 None
PLM  A 502 (-3.9A)
None
None
 0.78A 5x23A-2nnjA:
58.2		 5x23A-2nnjA:
78.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2nnj CYTOCHROME P450 2C8
(Homo
sapiens) 		4 / 5 PRO A 227
GLY A 228
THR A 229
LYS A 232
 None
None
PLM  A 502 (-3.9A)
None
 0.43A 5x23A-2nnjA:
58.2		 5x23A-2nnjA:
78.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2nnj CYTOCHROME P450 2C8
(Homo
sapiens) 		6 / 6 PHE A 226
PRO A 227
GLY A 228
THR A 229
ASN A 231
LYS A 232
 PLM  A 502 (-3.9A)
None
None
PLM  A 502 (-3.9A)
None
None
 0.74A 5x24A-2nnjA:
57.6		 5x24A-2nnjA:
78.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 7 ASN A 273
ASP A 169
ASP A 167
GLY A 205
 PLM  A 601 ( 3.8A)
None
None
None
 1.01A 5x7pA-4n03A:
undetectable		 5x7pA-4n03A:
16.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2nnj CYTOCHROME P450 2C8
(Homo
sapiens) 		6 / 6 PRO A 227
GLY A 228
THR A 229
ASN A 231
LYS A 232
LYS A 235
 None
None
PLM  A 502 (-3.9A)
None
None
None
 0.59A 5xxiA-2nnjA:
58.3		 5xxiA-2nnjA:
78.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3egl DEGV FAMILY PROTEIN
(Corynebacterium
glutamicum) 		5 / 12 LEU A 163
ILE A 152
ILE A  68
LEU A  99
MET A 169
 None
None
None
PLM  A 275 ( 4.6A)
None
 1.02A 5y2tB-3eglA:
undetectable		 5y2tB-3eglA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 5 HIS A 191
SER A 247
TYR A 198
GLY A 199
 None
None
PLM  A 601 (-3.9A)
None
 1.31A 5yodH-4n03A:
undetectable		 5yodH-4n03A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4kvl FATTY ACID
ALPHA-OXIDASE
(Oryza
sativa) 		5 / 12 ILE A 551
ARG A 559
ALA A 556
VAL A 485
LEU A 533
 None
PLM  A 702 (-2.9A)
PLM  A 702 (-3.4A)
None
None
 1.03A 5z12C-4kvlA:
undetectable		 5z12C-4kvlA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 2w3y VIRULENCE FACTOR
(Pectobacterium
carotovorum) 		5 / 12 VAL A  71
LEU A 155
PHE A 198
THR A 196
GLY A 195
 None
None
None
PLM  A1278 ( 4.8A)
None
 1.05A 6brdA-2w3yA:
undetectable		 6brdA-2w3yA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11
(Mycobacterium
tuberculosis) 		5 / 9 PRO A 341
GLY A 229
SER A 312
LEU A 245
LEU A 187
 PLM  A 400 ( 4.5A)
None
PLM  A 400 (-2.5A)
None
None
 1.49A 6dm0A-4jatA:
undetectable
6dm0D-4jatA:
undetectable		 6dm0A-4jatA:
11.01
6dm0D-4jatA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6aq3 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 3
(Naegleria
fowleri) 		4 / 6 GLY A  56
LEU A  59
VAL A 173
PHE A  89
 None
None
None
PLM  A 201 ( 4.9A)
 0.92A 6h7lA-6aq3A:
undetectable		 6h7lA-6aq3A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6aq3 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 3
(Naegleria
fowleri) 		4 / 6 GLY A  56
LEU A  59
VAL A 173
PHE A  89
 None
None
None
PLM  A 201 ( 4.9A)
 0.92A 6h7lB-6aq3A:
undetectable		 6h7lB-6aq3A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 12 LEU A 220
ILE A 281
GLY A 278
PHE A 279
ALA A 121
 None
None
PLM  A 501 ( 4.5A)
None
PLM  A 501 ( 4.1A)
 1.42A 6qyaB-1vpvA:
undetectable		 6qyaB-1vpvA:
21.78