SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PLG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.66A 1dfoA-5xmrA:
53.7		 1dfoA-5xmrA:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.66A 1dfoB-5xmrA:
56.4		 1dfoB-5xmrA:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.66A 1dfoC-5xmrA:
56.3		 1dfoC-5xmrA:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.66A 1dfoD-5xmrA:
53.8		 1dfoD-5xmrA:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.65A 1eqbA-5xmrA:
53.6		 1eqbA-5xmrA:
40.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 8 HIS A 142
HIS A 217
LYS A 248
ARG A 374
 PLG  A 500 (-3.4A)
PLG  A 500 (-3.8A)
PLG  A 500 (-2.7A)
PLG  A 500 ( 4.0A)
 1.12A 1eqbA-2bwpA:
28.5
1eqbB-2bwpA:
28.6		 1eqbA-2bwpA:
23.80
1eqbB-2bwpA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 8 SER A 189
HIS A 217
LYS A 248
ARG A 374
 PLG  A 500 (-3.6A)
PLG  A 500 (-3.8A)
PLG  A 500 (-2.7A)
PLG  A 500 ( 4.0A)
 1.19A 1eqbA-2bwpA:
28.5
1eqbB-2bwpA:
28.6		 1eqbA-2bwpA:
23.80
1eqbB-2bwpA:
23.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		5 / 8 SER A  34
HIS A 129
HIS A 211
LYS A 237
ARG A 371
 PLG  A 501 (-2.4A)
PLG  A 501 ( 3.5A)
PLG  A 501 (-3.8A)
PLG  A 501 (-3.4A)
PLG  A 501 (-3.1A)
 0.25A 1eqbA-5xmrA:
53.6
1eqbB-5xmrA:
56.1		 1eqbA-5xmrA:
40.55
1eqbB-5xmrA:
40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.65A 1eqbB-5xmrA:
56.1		 1eqbB-5xmrA:
40.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 8 HIS A 142
HIS A 217
LYS A 248
ARG A 374
 PLG  A 500 (-3.4A)
PLG  A 500 (-3.8A)
PLG  A 500 (-2.7A)
PLG  A 500 ( 4.0A)
 1.12A 1eqbA-2bwpA:
28.5
1eqbB-2bwpA:
28.6		 1eqbA-2bwpA:
23.80
1eqbB-2bwpA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 8 SER A 189
HIS A 217
LYS A 248
ARG A 374
 PLG  A 500 (-3.6A)
PLG  A 500 (-3.8A)
PLG  A 500 (-2.7A)
PLG  A 500 ( 4.0A)
 1.19A 1eqbA-2bwpA:
28.5
1eqbB-2bwpA:
28.6		 1eqbA-2bwpA:
23.80
1eqbB-2bwpA:
23.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		5 / 8 SER A  34
HIS A 129
HIS A 211
LYS A 237
ARG A 371
 PLG  A 501 (-2.4A)
PLG  A 501 ( 3.5A)
PLG  A 501 (-3.8A)
PLG  A 501 (-3.4A)
PLG  A 501 (-3.1A)
 0.25A 1eqbA-5xmrA:
53.6
1eqbB-5xmrA:
56.1		 1eqbA-5xmrA:
40.55
1eqbB-5xmrA:
40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.65A 1eqbC-5xmrA:
56.1		 1eqbC-5xmrA:
40.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 8 HIS A 142
HIS A 217
LYS A 248
ARG A 374
 PLG  A 500 (-3.4A)
PLG  A 500 (-3.8A)
PLG  A 500 (-2.7A)
PLG  A 500 ( 4.0A)
 1.12A 1eqbC-2bwpA:
28.5
1eqbD-2bwpA:
28.1		 1eqbC-2bwpA:
23.80
1eqbD-2bwpA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 8 SER A 189
HIS A 217
LYS A 248
ARG A 374
 PLG  A 500 (-3.6A)
PLG  A 500 (-3.8A)
PLG  A 500 (-2.7A)
PLG  A 500 ( 4.0A)
 1.19A 1eqbC-2bwpA:
28.5
1eqbD-2bwpA:
28.1		 1eqbC-2bwpA:
23.80
1eqbD-2bwpA:
23.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		5 / 8 SER A  34
HIS A 129
HIS A 211
LYS A 237
ARG A 371
 PLG  A 501 (-2.4A)
PLG  A 501 ( 3.5A)
PLG  A 501 (-3.8A)
PLG  A 501 (-3.4A)
PLG  A 501 (-3.1A)
 0.25A 1eqbC-5xmrA:
56.1
1eqbD-5xmrA:
56.8		 1eqbC-5xmrA:
40.55
1eqbD-5xmrA:
40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.65A 1eqbD-5xmrA:
56.8		 1eqbD-5xmrA:
40.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 8 HIS A 142
HIS A 217
LYS A 248
ARG A 374
 PLG  A 500 (-3.4A)
PLG  A 500 (-3.8A)
PLG  A 500 (-2.7A)
PLG  A 500 ( 4.0A)
 1.12A 1eqbC-2bwpA:
28.5
1eqbD-2bwpA:
28.1		 1eqbC-2bwpA:
23.80
1eqbD-2bwpA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 8 SER A 189
HIS A 217
LYS A 248
ARG A 374
 PLG  A 500 (-3.6A)
PLG  A 500 (-3.8A)
PLG  A 500 (-2.7A)
PLG  A 500 ( 4.0A)
 1.19A 1eqbC-2bwpA:
28.5
1eqbD-2bwpA:
28.1		 1eqbC-2bwpA:
23.80
1eqbD-2bwpA:
23.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		5 / 8 SER A  34
HIS A 129
HIS A 211
LYS A 237
ARG A 371
 PLG  A 501 (-2.4A)
PLG  A 501 ( 3.5A)
PLG  A 501 (-3.8A)
PLG  A 501 (-3.4A)
PLG  A 501 (-3.1A)
 0.25A 1eqbC-5xmrA:
56.1
1eqbD-5xmrA:
56.8		 1eqbC-5xmrA:
40.55
1eqbD-5xmrA:
40.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 SER B 134
VAL B  78
TYR B  76
GLU B 136
GLY B 167
 None
None
None
PLG  B 401 (-3.5A)
None
 1.34A 1i9jH-3wlxB:
undetectable
1i9jL-3wlxB:
undetectable		 1i9jH-3wlxB:
20.59
1i9jL-3wlxB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 THR B 311
ALA B 256
ARG B 248
GLY B 198
SER B   6
 None
None
None
None
PLG  B 401 (-2.9A)
 1.15A 2f162-3wlxB:
undetectable		 2f162-3wlxB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 THR B 192
ALA B  82
ALA B  61
GLY B  58
THR B  59
 None
None
None
PLG  B 401 (-3.5A)
PLG  B 401 (-3.7A)
 1.18A 2f16H-3wlxB:
undetectable
2f16I-3wlxB:
undetectable		 2f16H-3wlxB:
21.39
2f16I-3wlxB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 THR B 311
ALA B 256
ARG B 248
GLY B 198
SER B   6
 None
None
None
None
PLG  B 401 (-2.9A)
 1.15A 2f16N-3wlxB:
undetectable		 2f16N-3wlxB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 THR B 192
ALA B  82
ALA B  61
GLY B  58
THR B  59
 None
None
None
PLG  B 401 (-3.5A)
PLG  B 401 (-3.7A)
 1.18A 2f16V-3wlxB:
undetectable
2f16W-3wlxB:
undetectable		 2f16V-3wlxB:
21.39
2f16W-3wlxB:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.73A 2vmyB-5xmrA:
57.3		 2vmyB-5xmrA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 7 HIS A 142
HIS A 217
LYS A 248
ARG A 374
 PLG  A 500 (-3.4A)
PLG  A 500 (-3.8A)
PLG  A 500 (-2.7A)
PLG  A 500 ( 4.0A)
 1.11A 2vmyA-2bwpA:
28.7
2vmyB-2bwpA:
28.0		 2vmyA-2bwpA:
26.77
2vmyB-2bwpA:
26.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		5 / 7 SER A  34
HIS A 129
HIS A 211
LYS A 237
ARG A 371
 PLG  A 501 (-2.4A)
PLG  A 501 ( 3.5A)
PLG  A 501 (-3.8A)
PLG  A 501 (-3.4A)
PLG  A 501 (-3.1A)
 0.40A 2vmyA-5xmrA:
57.2
2vmyB-5xmrA:
57.3		 2vmyA-5xmrA:
41.94
2vmyB-5xmrA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 8 HIS A 142
HIS A 217
LYS A 248
ARG A 374
 PLG  A 500 (-3.4A)
PLG  A 500 (-3.8A)
PLG  A 500 (-2.7A)
PLG  A 500 ( 4.0A)
 1.17A 2vmyA-2bwpA:
28.7
2vmyB-2bwpA:
27.9		 2vmyA-2bwpA:
26.77
2vmyB-2bwpA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 8 SER A 189
HIS A 217
LYS A 248
ARG A 374
 PLG  A 500 (-3.6A)
PLG  A 500 (-3.8A)
PLG  A 500 (-2.7A)
PLG  A 500 ( 4.0A)
 1.27A 2vmyA-2bwpA:
28.7
2vmyB-2bwpA:
27.9		 2vmyA-2bwpA:
26.77
2vmyB-2bwpA:
26.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		5 / 8 SER A  34
HIS A 129
HIS A 211
LYS A 237
ARG A 371
 PLG  A 501 (-2.4A)
PLG  A 501 ( 3.5A)
PLG  A 501 (-3.8A)
PLG  A 501 (-3.4A)
PLG  A 501 (-3.1A)
 0.30A 2vmyA-5xmrA:
57.2
2vmyB-5xmrA:
57.3		 2vmyA-5xmrA:
41.94
2vmyB-5xmrA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		5 / 12 TYR A 212
ILE A 100
GLY A 244
ALA A 247
ILE A 257
 None
None
None
PLG  A 500 ( 4.0A)
None
 0.85A 3jayA-2bwpA:
3.4		 3jayA-2bwpA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		3 / 3 SER A  59
GLY A  60
THR A  61
 PLG  A 401 (-3.6A)
PLG  A 401 (-3.2A)
PLG  A 401 (-3.8A)
 0.19A 3k9wA-3wgcA:
undetectable		 3k9wA-3wgcA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 THR B 311
ALA B 256
ARG B 248
GLY B 198
SER B   6
 None
None
None
None
PLG  B 401 (-2.9A)
 1.18A 3mg0N-3wlxB:
undetectable		 3mg0N-3wlxB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		4 / 4 GLU B  88
ASP B 166
ARG B 308
THR B 192
 None
PLG  B 401 (-2.7A)
PLG  B 401 (-3.3A)
None
 1.47A 4ej1A-3wlxB:
1.6		 4ej1A-3wlxB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		4 / 8 ASP A 168
ASP A   9
CYH A 196
GLU A 138
 PLG  A 401 (-2.9A)
None
PLG  A 401 ( 4.2A)
PLG  A 401 ( 4.0A)
 1.16A 4fewF-3wgcA:
undetectable		 4fewF-3wgcA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		4 / 8 ASP A 168
ASP A   9
CYH A 196
GLU A 138
 PLG  A 401 (-2.9A)
None
PLG  A 401 ( 4.2A)
PLG  A 401 ( 4.0A)
 1.13A 4gkhD-3wgcA:
undetectable		 4gkhD-3wgcA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		4 / 8 HIS A 129
ASP A 208
ALA A 104
SER A 210
 PLG  A 501 ( 3.5A)
PLG  A 501 (-3.1A)
None
PLG  A 501 (-3.5A)
 1.02A 4k0bB-5xmrA:
undetectable		 4k0bB-5xmrA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		4 / 8 HIS A 129
ASP A 208
ALA A 104
SER A 210
 PLG  A 501 ( 3.5A)
PLG  A 501 (-3.1A)
None
PLG  A 501 (-3.5A)
 1.01A 4l7iB-5xmrA:
undetectable		 4l7iB-5xmrA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		4 / 8 HIS A 129
ARG A 371
HIS A 236
THR A 234
 PLG  A 501 ( 3.5A)
PLG  A 501 (-3.1A)
PLG  A 501 (-4.1A)
PLG  A 501 ( 4.7A)
 1.31A 5db5A-5xmrA:
29.3
5db5B-5xmrA:
28.1		 5db5A-5xmrA:
21.82
5db5B-5xmrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 5 ASN A 162
ASP A 138
ASN A 141
ASP A 214
 None
None
None
PLG  A 500 (-3.1A)
 1.44A 5vooA-2bwpA:
undetectable		 5vooA-2bwpA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 5 ASN A 162
ASP A 138
ASN A 141
ASP A 214
 None
None
None
PLG  A 500 (-3.1A)
 1.44A 5vooC-2bwpA:
undetectable		 5vooC-2bwpA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 5 ASN A 162
ASP A 138
ASN A 141
ASP A 214
 None
None
None
PLG  A 500 (-3.1A)
 1.45A 5vooE-2bwpA:
undetectable		 5vooE-2bwpA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2bwp 5-AMINOLEVULINATE
SYNTHASE
(Rhodobacter
capsulatus) 		4 / 7 LEU A  57
ASP A  55
TYR A 250
HIS A 142
 None
None
None
PLG  A 500 (-3.4A)
 1.18A 5w97C-2bwpA:
undetectable
5w97a-2bwpA:
undetectable
5w97c-2bwpA:
undetectable		 5w97C-2bwpA:
18.25
5w97a-2bwpA:
23.30
5w97c-2bwpA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		5 / 12 VAL A  38
GLY A 227
VAL A 226
THR A  61
GLY A  60
 None
None
None
PLG  A 401 (-3.8A)
PLG  A 401 (-3.2A)
 1.17A 6brdC-3wgcA:
undetectable		 6brdC-3wgcA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 LEU B  55
SER B  47
LYS B  49
ILE B 170
ASP B 166
 None
None
None
None
PLG  B 401 (-2.7A)
 1.36A 6bxnA-3wlxB:
3.3		 6bxnA-3wlxB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		5 / 11 GLY A  60
SER A 194
ALA A 219
ALA A  67
HIS A 166
 PLG  A 401 (-3.2A)
None
None
None
None
 1.10A 6qgbA-3wgcA:
undetectable		 6qgbA-3wgcA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		5 / 11 GLY A  60
SER A 194
ALA A 219
ALA A  67
HIS A 166
 PLG  A 401 (-3.2A)
None
None
None
None
 1.09A 6qgbE-3wgcA:
undetectable		 6qgbE-3wgcA:
21.96