SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PL3'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		5 / 12 GLU A 358
GLN A 360
GLU A 357
LEU A 361
GLU A  62
 None
None
None
PL3  A1588 ( 4.6A)
None
 1.16A 5nwuA-2uuuA:
undetectable		 5nwuA-2uuuA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		4 / 5 ARG A 447
ARG A 133
GLY A  23
ASN A  22
 PL3  A1588 (-3.4A)
None
None
None
 1.40A 6dwjB-2uuuA:
2.9
6dwjD-2uuuA:
3.2		 6dwjB-2uuuA:
22.58
6dwjD-2uuuA:
22.58