SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PKZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 5dv5 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
alginolyticus) 		4 / 6 ASP A 185
TYR A 219
PHE A 232
TYR A 233
 PKZ  A 301 ( 4.3A)
PKZ  A 301 (-3.7A)
None
None
 1.47A 5e2iA-5dv5A:
undetectable		 5e2iA-5dv5A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_C_PFLC407_1
(PROTON-GATED ION
CHANNEL)		 5dv5 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
alginolyticus) 		5 / 9 TYR A 184
ILE A 148
VAL A 157
THR A 180
ILE A 177
 PKZ  A 302 (-4.1A)
None
PKZ  A 302 ( 4.2A)
None
None
 1.40A 5mvnC-5dv5A:
undetectable		 5mvnC-5dv5A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5dv5 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
alginolyticus) 		5 / 10 TYR A 184
ILE A 148
VAL A 157
THR A 180
ILE A 177
 PKZ  A 302 (-4.1A)
None
PKZ  A 302 ( 4.2A)
None
None
 1.40A 5mvnD-5dv5A:
undetectable		 5mvnD-5dv5A:
17.41