SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PKA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		3 / 3 ALA A 110
VAL A 115
TRP A 143
 PKA  A 201 (-2.9A)
None
None
 0.94A 1grmA-2mgyA:
undetectable		 1grmA-2mgyA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		3 / 3 ALA A 110
VAL A 115
TRP A 143
 PKA  A 201 (-2.9A)
None
None
 0.94A 1grmB-2mgyA:
undetectable		 1grmB-2mgyA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		3 / 3 ALA A 110
VAL A 115
TRP A 143
 PKA  A 201 (-2.9A)
None
None
 0.92A 1jnoA-2mgyA:
undetectable		 1jnoA-2mgyA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		3 / 3 ALA A 110
VAL A 115
TRP A 143
 PKA  A 201 (-2.9A)
None
None
 0.92A 1jnoB-2mgyA:
undetectable		 1jnoB-2mgyA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		3 / 3 ALA A 110
VAL A 115
TRP A 143
 PKA  A 201 (-2.9A)
None
None
 0.93A 1jo3A-2mgyA:
undetectable		 1jo3A-2mgyA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		3 / 3 ALA A 110
VAL A 115
TRP A 143
 PKA  A 201 (-2.9A)
None
None
 0.93A 1jo3B-2mgyA:
undetectable		 1jo3B-2mgyA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		3 / 3 ALA A 110
VAL A 115
TRP A 143
 PKA  A 201 (-2.9A)
None
None
 0.93A 1jo4A-2mgyA:
undetectable		 1jo4A-2mgyA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		3 / 3 ALA A 110
VAL A 115
TRP A 143
 PKA  A 201 (-2.9A)
None
None
 0.93A 1jo4B-2mgyA:
undetectable		 1jo4B-2mgyA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		3 / 3 ALA A 110
VAL A 115
TRP A 143
 PKA  A 201 (-2.9A)
None
None
 0.92A 1magA-2mgyA:
undetectable		 1magA-2mgyA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		3 / 3 ALA A 110
VAL A 115
TRP A 143
 PKA  A 201 (-2.9A)
None
None
 0.92A 1magB-2mgyA:
undetectable		 1magB-2mgyA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		3 / 3 ALA A 110
VAL A 115
TRP A 143
 PKA  A 201 (-2.9A)
None
None
 0.94A 1ng8A-2mgyA:
undetectable		 1ng8A-2mgyA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		3 / 3 ALA A 110
VAL A 115
TRP A 143
 PKA  A 201 (-2.9A)
None
None
 0.94A 1ng8B-2mgyA:
undetectable		 1ng8B-2mgyA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		3 / 3 VAL A 115
ASN A 151
TRP A 155
 None
PKA  A 201 ( 4.1A)
None
 0.95A 2y00B-2mgyA:
undetectable		 2y00B-2mgyA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4ryi INTEGRAL MEMBRANE
PROTEIN
(Bacillus
cereus) 		3 / 3 PHE A  55
SER A  21
SER A  22
 PKA  A 201 (-4.9A)
PKA  A 201 ( 4.0A)
PKA  A 201 (-2.9A)
 0.93A 3ufgB-4ryiA:
2.7		 3ufgB-4ryiA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		4 / 7 ALA A  50
VAL A  26
ARG A  27
ARG A  46
 PKA  A 201 ( 4.8A)
PKA  A 201 (-3.6A)
None
None
 1.16A 4ijiH-2mgyA:
undetectable		 4ijiH-2mgyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		3 / 3 ASP A 157
ASN A 151
PHE A 146
 None
PKA  A 201 ( 4.1A)
PKA  A 201 ( 4.6A)
 0.78A 5dsgB-2mgyA:
undetectable		 5dsgB-2mgyA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 2mgy TRANSLOCATOR PROTEIN
(Mus
musculus) 		4 / 5 VAL A 115
THR A 148
ASN A 151
LEU A 112
 None
None
PKA  A 201 ( 4.1A)
None
 1.29A 5m0iB-2mgyA:
2.4		 5m0iB-2mgyA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ryi INTEGRAL MEMBRANE
PROTEIN
(Bacillus
cereus) 		3 / 3 SER A  22
SER A  91
PHE A  55
 PKA  A 201 (-2.9A)
PKA  A 201 (-2.9A)
PKA  A 201 (-4.9A)
 0.93A 5mugA-4ryiA:
undetectable		 5mugA-4ryiA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4ryi INTEGRAL MEMBRANE
PROTEIN
(Bacillus
cereus) 		3 / 3 TYR A 144
SER A 146
TRP A  40
 None
PKA  A 201 ( 4.4A)
None
 1.03A 5n8jB-4ryiA:
undetectable		 5n8jB-4ryiA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4ryi INTEGRAL MEMBRANE
PROTEIN
(Bacillus
cereus) 		3 / 3 TYR A 144
SER A 146
TRP A  40
 None
PKA  A 201 ( 4.4A)
None
 1.01A 5n8jA-4ryiA:
undetectable		 5n8jA-4ryiA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4ryi INTEGRAL MEMBRANE
PROTEIN
(Bacillus
cereus) 		3 / 3 TYR A 144
SER A 146
TRP A  40
 None
PKA  A 201 ( 4.4A)
None
 1.02A 5n8jD-4ryiA:
undetectable		 5n8jD-4ryiA:
18.41