SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PIR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		6 / 12 GLY A 155
GLY A 153
PHE A 167
VAL A 291
ALA A 165
THR A 275
 None
None
PIR  A 400 ( 4.0A)
None
None
None
 1.26A 3dh0B-2masA:
4.7		 3dh0B-2masA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 12 ASP A 242
PRO A  11
ILE A 169
MET A 152
ASP A  10
 PIR  A 400 (-2.5A)
None
None
PIR  A 400 (-3.5A)
CA  A 316 ( 3.1A)
 1.45A 3topA-2masA:
undetectable		 3topA-2masA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE
(Crithidia
fasciculata) 		5 / 8 GLY A 190
GLY A 154
MET A 152
LEU A 129
VAL A 186
 None
None
PIR  A 400 (-3.5A)
None
None
 1.27A 3v1nA-2masA:
4.0		 3v1nA-2masA:
24.84