SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PIN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE
(Escherichia
coli) 		4 / 5 SER A 368
SER A 394
PHE A 254
PHE A 436
 PIN  A 506 ( 3.8A)
None
None
None
 1.42A 1oipA-1ecgA:
undetectable		 1oipA-1ecgA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE
(Escherichia
coli) 		4 / 8 ILE A 429
GLY A 372
LEU A 415
PHE A 436
 None
PIN  A 506 ( 3.4A)
None
None
 0.72A 2vctA-1ecgA:
0.0		 2vctA-1ecgA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5jk6 PHENYLALANINE-4-HYDR
OXYLASE
(Dictyostelium
discoideum) 		3 / 3 ASP A 392
ARG A 388
ALA A 391
 None
PIN  A 501 (-3.1A)
None
 0.78A 3mbgC-5jk6A:
undetectable		 3mbgC-5jk6A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE
(Escherichia
coli) 		4 / 6 ILE A 407
PHE A 461
TYR A 258
VAL A 365
 None
None
PIN  A 506 ( 4.0A)
None
 1.24A 4a97I-1ecgA:
0.0		 4a97I-1ecgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJH_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU A 209
ASP A 263
GLU A 303
VAL A  22
ASP A 214
 None
None
PIN  A 506 (-4.7A)
None
None
 1.27A 4njhA-1ecgA:
2.2		 4njhA-1ecgA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU A 209
ASP A 263
GLU A 303
VAL A  22
ASP A 214
 None
None
PIN  A 506 (-4.7A)
None
None
 1.25A 4njkA-1ecgA:
2.2		 4njkA-1ecgA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU A 209
ASP A 263
GLU A 303
VAL A  22
ASP A 214
 None
None
PIN  A 506 (-4.7A)
None
None
 1.25A 4njkB-1ecgA:
2.2		 4njkB-1ecgA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE
(Escherichia
coli) 		3 / 3 SER A 368
SER A 394
PHE A 254
 PIN  A 506 ( 3.8A)
None
None
 0.88A 5mugA-1ecgA:
undetectable		 5mugA-1ecgA:
18.97