SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PIM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		3 / 3 ALA A 184
VAL A 174
TRP A  81
 None
None
PIM  A1408 (-4.6A)
 0.78A 1av2A-1odoA:
undetectable
1av2B-1odoA:
undetectable		 1av2A-1odoA:
14.86
1av2B-1odoA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		3 / 3 TRP A  81
ALA A 184
VAL A 174
 PIM  A1408 (-4.6A)
None
None
 0.61A 1av2C-1odoA:
undetectable
1av2D-1odoA:
undetectable		 1av2C-1odoA:
14.86
1av2D-1odoA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		5 / 12 LEU A 198
LEU A 195
VAL A 194
SER A 241
VAL A 159
 None
None
None
PIM  A1408 (-4.3A)
None
 1.37A 1ie9A-1odoA:
1.2		 1ie9A-1odoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		3 / 3 ALA A 184
VAL A 174
TRP A  81
 None
None
PIM  A1408 (-4.6A)
 0.78A 1w5uA-1odoA:
undetectable
1w5uB-1odoA:
undetectable		 1w5uA-1odoA:
14.86
1w5uB-1odoA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		3 / 3 TRP A  81
ALA A 184
VAL A 174
 PIM  A1408 (-4.6A)
None
None
 0.74A 1w5uA-1odoA:
undetectable
1w5uB-1odoA:
undetectable		 1w5uA-1odoA:
14.86
1w5uB-1odoA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1s1f PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		3 / 3 ALA A 245
GLY A 356
SER A 363
 PIM  A 431 (-3.6A)
None
None
 0.56A 2ivuA-1s1fA:
undetectable		 2ivuA-1s1fA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		3 / 3 ALA A 184
VAL A 174
TRP A  81
 None
None
PIM  A1408 (-4.6A)
 0.65A 2izqA-1odoA:
undetectable
2izqB-1odoA:
undetectable		 2izqA-1odoA:
14.86
2izqB-1odoA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		3 / 3 TRP A  81
ALA A 184
VAL A 174
 PIM  A1408 (-4.6A)
None
None
 0.83A 2izqC-1odoA:
undetectable
2izqD-1odoA:
undetectable		 2izqC-1odoA:
14.86
2izqD-1odoA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		3 / 3 TRP A  81
ALA A 184
VAL A 174
 PIM  A1408 (-4.6A)
None
None
 0.62A 3l8lA-1odoA:
undetectable
3l8lB-1odoA:
undetectable		 3l8lA-1odoA:
14.86
3l8lB-1odoA:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		3 / 3 TRP A  81
ALA A 184
VAL A 174
 PIM  A1408 (-4.6A)
None
None
 0.79A 3l8lC-1odoA:
undetectable
3l8lD-1odoA:
undetectable		 3l8lC-1odoA:
14.86
3l8lD-1odoA:
3.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		5 / 11 PHE A  88
ALA A 242
THR A 246
VAL A 289
LEU A 292
 PIM  A1408 (-3.6A)
HEM  A1407 ( 3.4A)
HEM  A1407 ( 3.1A)
None
HEM  A1407 ( 4.2A)
 0.83A 4j6cA-1odoA:
54.0		 4j6cA-1odoA:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		5 / 12 PHE A  88
ALA A 242
THR A 246
VAL A 289
LEU A 292
 PIM  A1408 (-3.6A)
HEM  A1407 ( 3.4A)
HEM  A1407 ( 3.1A)
None
HEM  A1407 ( 4.2A)
 0.85A 4j6dA-1odoA:
54.2		 4j6dA-1odoA:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		5 / 12 PHE A  88
ALA A 242
THR A 246
VAL A 289
LEU A 292
 PIM  A1408 (-3.6A)
HEM  A1407 ( 3.4A)
HEM  A1407 ( 3.1A)
None
HEM  A1407 ( 4.2A)
 0.87A 4j6dB-1odoA:
54.2		 4j6dB-1odoA:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		5 / 12 PHE A  88
ALA A 242
THR A 246
VAL A 289
LEU A 292
 PIM  A1408 (-3.6A)
HEM  A1407 ( 3.4A)
HEM  A1407 ( 3.1A)
None
HEM  A1407 ( 4.2A)
 0.81A 4jbtA-1odoA:
54.1		 4jbtA-1odoA:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		5 / 11 PHE A  88
ALA A 242
THR A 246
VAL A 289
LEU A 292
 PIM  A1408 (-3.6A)
HEM  A1407 ( 3.4A)
HEM  A1407 ( 3.1A)
None
HEM  A1407 ( 4.2A)
 0.82A 4jbtB-1odoA:
54.2		 4jbtB-1odoA:
40.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		4 / 5 TRP A  81
LEU A  80
VAL A  84
LEU A 237
 PIM  A1408 (-4.6A)
None
None
None
 0.88A 5xooB-1odoA:
0.0		 5xooB-1odoA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1odo PUTATIVE CYTOCHROME
P450 154A1
(Streptomyces
coelicolor) 		5 / 10 PHE A 167
LEU A 170
SER A 241
GLY A 243
ILE A 240
 None
None
PIM  A1408 (-4.3A)
HEM  A1407 ( 4.4A)
None
 1.25A 6ebpB-1odoA:
undetectable		 6ebpB-1odoA:
10.40