SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PID'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		3 / 3 ALA M 238
VAL M 241
TRP M 186
 None
PID  M 624 (-4.2A)
PID  M 624 ( 3.6A)
 0.93A 1av2A-1pprM:
undetectable
1av2B-1pprM:
undetectable		 1av2A-1pprM:
7.10
1av2B-1pprM:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		3 / 3 TRP M 186
ALA M 238
VAL M 241
 PID  M 624 ( 3.6A)
None
PID  M 624 (-4.2A)
 0.94A 1av2C-1pprM:
undetectable
1av2D-1pprM:
undetectable		 1av2C-1pprM:
7.10
1av2D-1pprM:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		3 / 3 ALA M 238
VAL M 241
TRP M 186
 None
PID  M 624 (-4.2A)
PID  M 624 ( 3.6A)
 0.96A 1gmkA-1pprM:
undetectable
1gmkB-1pprM:
undetectable		 1gmkA-1pprM:
7.10
1gmkB-1pprM:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		3 / 3 ALA M 238
VAL M 241
TRP M 186
 None
PID  M 624 (-4.2A)
PID  M 624 ( 3.6A)
 0.95A 1gmkC-1pprM:
undetectable
1gmkD-1pprM:
undetectable		 1gmkC-1pprM:
7.10
1gmkD-1pprM:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		4 / 8 GLY M  71
ILE M  73
ILE M 207
ILE M 211
 None
PID  M 614 (-4.4A)
PID  M 612 (-4.1A)
CLA  M 601 (-4.1A)
 0.72A 1hshD-1pprM:
undetectable		 1hshD-1pprM:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		3 / 3 TRP M 186
ALA M 238
VAL M 241
 PID  M 624 ( 3.6A)
None
PID  M 624 (-4.2A)
 0.90A 1w5uA-1pprM:
undetectable
1w5uB-1pprM:
undetectable		 1w5uA-1pprM:
7.10
1w5uB-1pprM:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		4 / 5 LEU M  58
ALA M  91
LEU M  92
MET M  50
 None
None
PID  M 614 (-4.5A)
PID  M 613 ( 4.0A)
 1.25A 2oaxA-1pprM:
0.9		 2oaxA-1pprM:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3iiu PERIDININ-CHLOROPHYL
L A-BINDING PROTEIN
1, CHLOROPLASTIC
(Amphidinium
carterae) 		4 / 5 LEU M  58
ALA M  91
LEU M  92
MET M  50
 None
None
CLA  M 601 ( 4.3A)
PID  M 613 ( 3.8A)
 1.25A 2oaxA-3iiuM:
undetectable		 2oaxA-3iiuM:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		3 / 3 TRP M 186
ALA M 238
VAL M 241
 PID  M 624 ( 3.6A)
None
PID  M 624 (-4.2A)
 0.97A 3l8lC-1pprM:
undetectable
3l8lD-1pprM:
undetectable		 3l8lC-1pprM:
7.10
3l8lD-1pprM:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 3iiu PERIDININ-CHLOROPHYL
L A-BINDING PROTEIN
1, CHLOROPLASTIC
(Amphidinium
carterae) 		3 / 3 SER M 112
TYR M 108
PRO M  32
 J7Z  M 615 (-3.6A)
PID  M 613 ( 3.4A)
J7Z  M 615 ( 4.5A)
 0.90A 4k8cA-3iiuM:
undetectable		 4k8cA-3iiuM:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3iiu PERIDININ-CHLOROPHYL
L A-BINDING PROTEIN
1, CHLOROPLASTIC
(Amphidinium
carterae) 		3 / 3 SER M 112
TYR M 108
PRO M  32
 J7Z  M 615 (-3.6A)
PID  M 613 ( 3.4A)
J7Z  M 615 ( 4.5A)
 0.89A 4kahA-3iiuM:
undetectable		 4kahA-3iiuM:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3iiu PERIDININ-CHLOROPHYL
L A-BINDING PROTEIN
1, CHLOROPLASTIC
(Amphidinium
carterae) 		3 / 3 SER M 112
TYR M 108
PRO M  32
 J7Z  M 615 (-3.6A)
PID  M 613 ( 3.4A)
J7Z  M 615 ( 4.5A)
 0.89A 4kahB-3iiuM:
undetectable		 4kahB-3iiuM:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3iiu PERIDININ-CHLOROPHYL
L A-BINDING PROTEIN
1, CHLOROPLASTIC
(Amphidinium
carterae) 		3 / 3 SER M 112
TYR M 108
PRO M  32
 J7Z  M 615 (-3.6A)
PID  M 613 ( 3.4A)
J7Z  M 615 ( 4.5A)
 0.89A 4kanA-3iiuM:
undetectable		 4kanA-3iiuM:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3iiu PERIDININ-CHLOROPHYL
L A-BINDING PROTEIN
1, CHLOROPLASTIC
(Amphidinium
carterae) 		3 / 3 SER M 112
TYR M 108
PRO M  32
 J7Z  M 615 (-3.6A)
PID  M 613 ( 3.4A)
J7Z  M 615 ( 4.5A)
 0.88A 4kanB-3iiuM:
undetectable		 4kanB-3iiuM:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3iiu PERIDININ-CHLOROPHYL
L A-BINDING PROTEIN
1, CHLOROPLASTIC
(Amphidinium
carterae) 		3 / 3 SER M 112
TYR M 108
PRO M  32
 J7Z  M 615 (-3.6A)
PID  M 613 ( 3.4A)
J7Z  M 615 ( 4.5A)
 0.89A 4kbeA-3iiuM:
undetectable		 4kbeA-3iiuM:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3iiu PERIDININ-CHLOROPHYL
L A-BINDING PROTEIN
1, CHLOROPLASTIC
(Amphidinium
carterae) 		3 / 3 SER M 112
TYR M 108
PRO M  32
 J7Z  M 615 (-3.6A)
PID  M 613 ( 3.4A)
J7Z  M 615 ( 4.5A)
 0.90A 4kbeB-3iiuM:
undetectable		 4kbeB-3iiuM:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		4 / 4 ILE M  73
SER M  72
ASP M 208
ASP M 268
 PID  M 614 (-4.4A)
None
None
None
 1.24A 4krhB-1pprM:
undetectable		 4krhB-1pprM:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3iiu PERIDININ-CHLOROPHYL
L A-BINDING PROTEIN
1, CHLOROPLASTIC
(Amphidinium
carterae) 		3 / 3 SER M 112
TYR M 108
PRO M  32
 J7Z  M 615 (-3.6A)
PID  M 613 ( 3.4A)
J7Z  M 615 ( 4.5A)
 0.89A 4lbgA-3iiuM:
undetectable		 4lbgA-3iiuM:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3iiu PERIDININ-CHLOROPHYL
L A-BINDING PROTEIN
1, CHLOROPLASTIC
(Amphidinium
carterae) 		3 / 3 SER M 112
TYR M 108
PRO M  32
 J7Z  M 615 (-3.6A)
PID  M 613 ( 3.4A)
J7Z  M 615 ( 4.5A)
 0.88A 4lbgB-3iiuM:
undetectable		 4lbgB-3iiuM:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2c9e PERIDININ-CHLOROPHYL
L A PROTEIN
(Amphidinium
carterae) 		3 / 3 LYS A 143
ASN A  94
ASP A 140
 DGD  A1332 (-3.6A)
PID  A1331 (-3.9A)
DGD  A1332 ( 4.7A)
 0.57A 4o1eA-2c9eA:
undetectable		 4o1eA-2c9eA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2c9e PERIDININ-CHLOROPHYL
L A PROTEIN
(Amphidinium
carterae) 		4 / 8 ALA A  45
GLY A 198
LEU A 257
LEU A 252
 PID  A1335 (-3.6A)
None
PID  A1335 (-4.2A)
None
 0.78A 4po0A-2c9eA:
undetectable		 4po0A-2c9eA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2c9e PERIDININ-CHLOROPHYL
L A PROTEIN
(Amphidinium
carterae) 		5 / 8 ALA A 104
ALA A 102
ILE A 101
ALA A  65
LEU A  97
 None
None
PID  A1331 (-4.1A)
None
PID  A1331 ( 4.4A)
 1.32A 4v1fA-2c9eA:
undetectable
4v1fB-2c9eA:
undetectable		 4v1fA-2c9eA:
15.29
4v1fB-2c9eA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 2c9e PERIDININ-CHLOROPHYL
L A PROTEIN
(Amphidinium
carterae) 		5 / 12 PHE A 109
ALA A 110
PHE A  21
ALA A  30
THR A 114
 PID  A1330 ( 3.5A)
PID  A1331 ( 3.8A)
PID  A1329 (-4.1A)
PID  A1329 (-3.9A)
None
 1.23A 5tl8A-2c9eA:
undetectable		 5tl8A-2c9eA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		3 / 3 TYR M 247
ALA M 253
LEU M 254
 None
None
PID  M 624 (-4.4A)
 0.63A 6ag0C-1pprM:
undetectable		 6ag0C-1pprM:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		4 / 7 ASP M  86
ASN M  89
ALA M  90
LEU M  10
 None
PID  M 614 (-4.0A)
None
CLA  M 601 ( 4.9A)
 0.96A 6ci6A-1pprM:
1.7		 6ci6A-1pprM:
11.39