SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PIB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.76A 1c9sI-1zsqA:
undetectable
1c9sJ-1zsqA:
undetectable		 1c9sI-1zsqA:
12.02
1c9sJ-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 7 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.73A 1c9sT-1zsqA:
undetectable
1c9sU-1zsqA:
undetectable		 1c9sT-1zsqA:
12.02
1c9sU-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.72A 1c9sU-1zsqA:
undetectable
1c9sV-1zsqA:
undetectable		 1c9sU-1zsqA:
12.02
1c9sV-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 7 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.74A 1gtfL-1zsqA:
undetectable
1gtfM-1zsqA:
undetectable		 1gtfL-1zsqA:
12.02
1gtfM-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.72A 1gtfN-1zsqA:
undetectable
1gtfO-1zsqA:
undetectable		 1gtfN-1zsqA:
12.02
1gtfO-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 7 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.72A 1gtnA-1zsqA:
undetectable
1gtnK-1zsqA:
undetectable		 1gtnA-1zsqA:
12.02
1gtnK-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.74A 1gtnA-1zsqA:
undetectable
1gtnB-1zsqA:
undetectable		 1gtnA-1zsqA:
12.02
1gtnB-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 7 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.78A 1gtnC-1zsqA:
undetectable
1gtnD-1zsqA:
undetectable		 1gtnC-1zsqA:
12.02
1gtnD-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 6 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.75A 1gtnD-1zsqA:
undetectable
1gtnE-1zsqA:
undetectable		 1gtnD-1zsqA:
12.02
1gtnE-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.71A 1gtnE-1zsqA:
undetectable
1gtnF-1zsqA:
undetectable		 1gtnE-1zsqA:
12.02
1gtnF-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 7 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.75A 1gtnF-1zsqA:
undetectable
1gtnG-1zsqA:
undetectable		 1gtnF-1zsqA:
12.02
1gtnG-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.73A 1gtnI-1zsqA:
undetectable
1gtnJ-1zsqA:
undetectable		 1gtnI-1zsqA:
12.02
1gtnJ-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 7 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.74A 1gtnJ-1zsqA:
undetectable
1gtnK-1zsqA:
undetectable		 1gtnJ-1zsqA:
12.02
1gtnK-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.71A 1gtnP-1zsqA:
undetectable
1gtnQ-1zsqA:
undetectable		 1gtnP-1zsqA:
12.02
1gtnQ-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I6V_C_RFPC1640_1
(DNA-DIRECTED RNA
POLYMERASE)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 ARG A 459
HIS A 458
ARG A 463
SER A 477
ILE A 356
 PIB  A3632 ( 4.8A)
EDO  A1878 (-3.9A)
PIB  A3632 ( 3.8A)
None
PIB  A3632 (-3.9A)
 1.30A 1i6vC-1zsqA:
0.2		 1i6vC-1zsqA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.77A 1utdB-1zsqA:
undetectable
1utdC-1zsqA:
undetectable		 1utdB-1zsqA:
12.02
1utdC-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.76A 1utdF-1zsqA:
undetectable
1utdG-1zsqA:
undetectable		 1utdF-1zsqA:
12.02
1utdG-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.77A 1utdI-1zsqA:
undetectable
1utdJ-1zsqA:
undetectable		 1utdI-1zsqA:
12.02
1utdJ-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.75A 1utdJ-1zsqA:
undetectable
1utdK-1zsqA:
undetectable		 1utdJ-1zsqA:
12.02
1utdK-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		3 / 3 SER A 418
ASP A 320
ASP A 422
 PIB  A3632 (-2.5A)
None
PIB  A3632 (-3.6A)
 0.88A 3iv6A-1zsqA:
undetectable		 3iv6A-1zsqA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		3 / 3 SER A 418
ASP A 320
ASP A 422
 PIB  A3632 (-2.5A)
None
PIB  A3632 (-3.6A)
 0.92A 3iv6C-1zsqA:
undetectable		 3iv6C-1zsqA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.71A 5eevL-1zsqA:
undetectable
5eevV-1zsqA:
undetectable		 5eevL-1zsqA:
12.02
5eevV-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.71A 5eewL-1zsqA:
undetectable
5eewV-1zsqA:
undetectable		 5eewL-1zsqA:
12.02
5eewV-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.71A 5eezL-1zsqA:
undetectable
5eezV-1zsqA:
undetectable		 5eezL-1zsqA:
12.02
5eezV-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.71A 5ef1L-1zsqA:
undetectable
5ef1V-1zsqA:
undetectable		 5ef1L-1zsqA:
12.02
5ef1V-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.71A 5ef2L-1zsqA:
undetectable
5ef2V-1zsqA:
undetectable		 5ef2L-1zsqA:
12.02
5ef2V-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.71A 5ef3L-1zsqA:
undetectable
5ef3V-1zsqA:
undetectable		 5ef3L-1zsqA:
12.02
5ef3V-1zsqA:
12.02