SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PHY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		5 / 10 SER B  20
GLY B 311
GLU B  15
GLY B 100
GLU B 104
 None
PHY  B 355 (-3.3A)
None
None
PHY  B 355 ( 4.6A)
 0.85A 1mehA-1e4eB:
undetectable		 1mehA-1e4eB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		5 / 11 GLY B  12
SER B 102
GLY B 100
HIS B  99
PHE B 312
 None
None
None
PHY  B 355 ( 3.8A)
None
 1.25A 2hmaA-1e4eB:
undetectable		 2hmaA-1e4eB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		3 / 3 PRO A 317
ASN A 318
ARG A 301
 None
MG  A 783 ( 3.3A)
PHY  A 782 (-3.0A)
 0.97A 2qeuB-1ehiA:
undetectable		 2qeuB-1ehiA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gB-1ehiA:
undetectable		 3j6gB-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gD-1ehiA:
undetectable		 3j6gD-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gF-1ehiA:
undetectable		 3j6gF-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gH-1ehiA:
undetectable		 3j6gH-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gJ-1ehiA:
undetectable		 3j6gJ-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gL-1ehiA:
undetectable		 3j6gL-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gN-1ehiA:
undetectable		 3j6gN-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gP-1ehiA:
undetectable		 3j6gP-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gR-1ehiA:
undetectable		 3j6gR-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		4 / 5 ASP B  18
GLU B  60
THR B  44
SER B 177
 None
None
None
PHY  B 355 ( 3.6A)
 1.45A 3p2kC-1e4eB:
undetectable		 3p2kC-1e4eB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		5 / 11 GLY B  12
SER B 102
GLY B 311
ASN B 307
MET B 131
 None
None
PHY  B 355 (-3.3A)
MG  B 360 ( 2.4A)
None
 1.35A 3v3nD-1e4eB:
3.1		 3v3nD-1e4eB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		4 / 6 ARG B 290
ASP B 292
LEU B 309
SER B  23
 PHY  B 355 (-3.2A)
PHY  B 355 ( 4.7A)
None
None
 1.03A 4ot2A-1e4eB:
1.0		 4ot2A-1e4eB:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		4 / 6 TYR A 255
LYS A 260
GLY A 322
SER A 327
 None
PHY  A 782 ( 2.6A)
PHY  A 782 (-3.5A)
PHY  A 782 (-2.6A)
 0.77A 5bphA-1ehiA:
36.2		 5bphA-1ehiA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		4 / 6 TYR A 255
LYS A 260
GLY A 322
SER A 327
 None
PHY  A 782 ( 2.6A)
PHY  A 782 (-3.5A)
PHY  A 782 (-2.6A)
 0.72A 5bphD-1ehiA:
35.2		 5bphD-1ehiA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.22A 5m5cE-1ehiA:
undetectable		 5m5cE-1ehiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 12 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.02A 6b0lB-1ehiA:
0.0		 6b0lB-1ehiA:
13.24