SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PHT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		3 / 3 GLU A 195
HIS A 171
HIS A 193
 PHT  A 302 ( 3.6A)
None
PHT  A 302 (-3.8A)
 0.68A 1oe2A-6g74A:
undetectable		 1oe2A-6g74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		3 / 3 HIS A  19
MET A  59
MET A 257
 PHT  A 302 (-4.0A)
PHT  A 302 ( 4.9A)
None
 1.30A 2vj1A-6g74A:
undetectable		 2vj1A-6g74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		3 / 3 HIS A  19
MET A 257
MET A  59
 PHT  A 302 (-4.0A)
None
PHT  A 302 ( 4.9A)
 1.40A 2vj1A-6g74A:
undetectable		 2vj1A-6g74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		5 / 11 MET A  59
LEU A  66
ALA A  43
GLY A  34
HIS A  19
 PHT  A 302 ( 4.9A)
None
None
None
PHT  A 302 (-4.0A)
 1.18A 4pxmB-6g74A:
undetectable		 4pxmB-6g74A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		5 / 10 MET A  59
LEU A  66
ALA A  43
GLY A  34
HIS A  19
 PHT  A 302 ( 4.9A)
None
None
None
PHT  A 302 (-4.0A)
 1.17A 5dx3A-6g74A:
undetectable		 5dx3A-6g74A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		5 / 11 MET A  59
LEU A  66
ALA A  43
GLY A  34
HIS A  19
 PHT  A 302 ( 4.9A)
None
None
None
PHT  A 302 (-4.0A)
 1.19A 5dxgB-6g74A:
undetectable		 5dxgB-6g74A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		3 / 3 MET A 257
HIS A  19
GLY A 232
 None
PHT  A 302 (-4.0A)
None
 0.86A 5gwzB-6g74A:
undetectable		 5gwzB-6g74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		5 / 12 HIS A 193
ASN A  20
GLY A  34
HIS A  19
MET A  59
 PHT  A 302 (-3.8A)
None
None
PHT  A 302 (-4.0A)
PHT  A 302 ( 4.9A)
 1.28A 6exiD-6g74A:
undetectable		 6exiD-6g74A:
24.18