SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PHO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD6_0
(GRAMICIDIN D)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 TRP D  48
TRP D 111
ALA D 177
VAL D  78
 PHO  D1039 ( 3.5A)
None
None
None
 1.50A 1w5uC-3a0hD:
undetectable
1w5uD-3a0hD:
undetectable		 1w5uC-3a0hD:
4.00
1w5uD-3a0hD:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC6_0
(GRAMICIDIN D)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 ALA D 177
VAL D  78
TRP D  48
TRP D 111
 None
None
PHO  D1039 ( 3.5A)
None
 1.48A 2izqC-3a0hD:
undetectable
2izqD-3a0hD:
undetectable		 2izqC-3a0hD:
4.00
2izqD-3a0hD:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 PHE B 464
TYR D 141
ARG D 128
LEU D 122
 MGE  B1060 ( 3.9A)
None
None
PHO  D1039 (-4.7A)
 1.31A 3sueA-3a0hB:
0.0		 3sueA-3a0hB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 TRP D 191
LEU D 279
GLY D 278
VAL D 152
ALA D 151
 CLA  D1004 (-4.8A)
PHO  D1039 ( 4.0A)
PQ9  D1042 ( 4.9A)
CLA  D1004 (-3.9A)
None
 1.05A 4fqsA-3a0hD:
undetectable		 4fqsA-3a0hD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 TRP D 191
LEU D 279
GLY D 278
VAL D 152
ALA D 151
 CLA  D1004 (-4.8A)
PHO  D1039 ( 4.0A)
PQ9  D1042 ( 4.9A)
CLA  D1004 (-3.9A)
None
 1.07A 4fqsB-3a0hD:
undetectable		 4fqsB-3a0hD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 4 ALA A 149
ALA A 152
ALA A 153
ALA A 156
 PHO  A 404 ( 3.8A)
None
CLA  A 402 ( 3.7A)
None
 0.00A 4oadA-5mdxA:
undetectable		 4oadA-5mdxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 4 ALA A 149
ALA A 152
ALA A 153
ALA A 156
 PHO  A 404 ( 3.8A)
None
CLA  A 402 ( 3.7A)
None
 0.00A 4oaeA-5mdxA:
undetectable		 4oaeA-5mdxA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4il6 PHOTOSYSTEM Q(B)
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 11 GLY A 171
PHE A 158
LEU A 120
ALA A 154
PHE A 186
 None
PHO  A1007 ( 4.9A)
LMG  A1012 ( 4.1A)
CLA  A1005 ( 4.3A)
CLA  A1005 (-4.0A)
 1.17A 4wnuA-4il6A:
undetectable		 4wnuA-4il6A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 6 ALA A 153
THR A 155
VAL A 157
VAL A 123
 CLA  A 402 ( 3.7A)
None
None
PHO  A 404 ( 4.7A)
 1.04A 5eckA-5mdxA:
undetectable		 5eckA-5mdxA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 6 ALA A 153
THR A 155
VAL A 157
VAL A 123
 CLA  A 402 ( 3.7A)
None
None
PHO  A 404 ( 4.7A)
 1.02A 5eckD-5mdxA:
undetectable		 5eckD-5mdxA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5mdx PHOTOSYSTEM II
PROTEIN D1
PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		4 / 5 ILE A 283
PHE C 435
SER A 148
ALA A 153
 PHO  A 404 (-4.1A)
None
None
CLA  A 402 ( 3.7A)
 1.20A 5msdA-5mdxA:
undetectable		 5msdA-5mdxA:
14.77