SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PHD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
(Sus
scrofa) 		4 / 6 GLY A 709
ASP A 714
GLY A 213
SER A 368
 PHD  A 369 ( 3.5A)
PHD  A 369 ( 2.9A)
PHD  A 369 ( 2.8A)
PHD  A 369 ( 2.6A)
 0.79A 1eswA-3n23A:
undetectable		 1eswA-3n23A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3crn RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN, CHEY-LIKE
(Methanospirillum
hungatei) 		5 / 12 PHE A  51
PHE A  90
GLY A  60
GLY A  37
LEU A  38
 None
None
PHD  A  52 ( 3.3A)
None
None
 0.97A 1fe2A-3crnA:
undetectable		 1fe2A-3crnA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3crn RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN, CHEY-LIKE
(Methanospirillum
hungatei) 		4 / 5 ASP A   8
LEU A  63
ALA A  31
LEU A  14
 PHD  A  52 ( 3.6A)
None
None
None
 1.12A 1nh8A-3crnA:
undetectable		 1nh8A-3crnA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		5 / 12 ALA A  90
LEU A  50
LEU A  63
ILE A  62
LEU A  54
 None
PHD  A  51 ( 3.8A)
None
None
PHD  A  51 ( 4.3A)
 1.17A 1xdkB-1zy2A:
undetectable		 1xdkB-1zy2A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
(Sus
scrofa) 		3 / 3 GLY A 709
ASP A 714
SER A 718
 PHD  A 369 ( 3.5A)
PHD  A 369 ( 2.9A)
None
 0.71A 2qhfA-3n23A:
undetectable		 2qhfA-3n23A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 4uhk TRANSCRIPTIONAL
REGULATORY PROTEIN
CPXR
(Escherichia
coli) 		4 / 8 GLY A  93
ALA A  94
ASP A  95
THR A  78
 None
None
None
PHD  A  51 ( 3.6A)
 0.58A 3el0A-4uhkA:
undetectable		 3el0A-4uhkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
(Sus
scrofa) 		4 / 4 PRO A 588
THR A 375
GLY A 611
THR A 686
 None
None
PHD  A 369 ( 4.5A)
None
 1.11A 3ib1A-3n23A:
undetectable		 3ib1A-3n23A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
(Sus
scrofa) 		3 / 3 ASN A 713
ASP A 710
ARG A 544
 PHD  A 369 ( 3.6A)
MG  A1017 (-3.2A)
None
 0.93A 3k13C-3n23A:
undetectable		 3k13C-3n23A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
(Sus
scrofa) 		4 / 6 GLY A 372
THR A 373
LEU A 374
ASP A 586
 PHD  A 369 ( 4.9A)
PHD  A 369 ( 3.3A)
PHD  A 369 ( 3.9A)
None
 0.98A 3ps9A-3n23A:
undetectable		 3ps9A-3n23A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		5 / 12 ASP A 211
ILE A 404
ASP A 235
ARG A 219
PHE A 397
 PHD  A 359 ( 3.1A)
None
None
PO4  A1406 (-3.7A)
None
 1.26A 3wenA-2ybxA:
undetectable		 3wenA-2ybxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		5 / 12 ASP A 211
ILE A 404
ASP A 235
ARG A 219
PHE A 397
 PHD  A 359 ( 3.1A)
None
None
PO4  A1406 (-3.7A)
None
 1.23A 3weoA-2ybxA:
undetectable		 3weoA-2ybxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		4 / 8 THR A  86
LEU A  63
LEU A  60
GLY A  59
 None
None
None
PHD  A  51 ( 3.9A)
 0.86A 4c9nA-1zy2A:
undetectable		 4c9nA-1zy2A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4otp SERINE/THREONINE-PRO
TEIN KINASE RIO1
(Homo
sapiens) 		5 / 11 VAL A 194
ALA A 206
LYS A 208
LEU A 331
ILE A 340
 ADP  A 501 (-4.3A)
ADP  A 501 ( 4.0A)
ADP  A 501 (-3.0A)
None
PHD  A 341 (-3.5A)
 0.37A 4iaaA-4otpA:
13.4		 4iaaA-4otpA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3rqi RESPONSE REGULATOR
PROTEIN
(Burkholderia
pseudomallei) 		5 / 9 ALA A  43
ILE A  51
VAL A  53
ALA A  33
ILE A   9
 None
None
PHD  A  54 ( 3.1A)
None
None
 1.01A 4lbgB-3rqiA:
5.4		 4lbgB-3rqiA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		5 / 11 ILE A 358
LEU A 361
LEU A 266
ILE A 357
TYR A 339
 PHD  A 359 ( 3.6A)
None
None
None
None
 1.17A 4p66A-2ybxA:
undetectable		 4p66A-2ybxA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens) 		4 / 7 ILE A 194
ILE A 360
ILE A 158
LEU A 175
 None
PHD  A 359 ( 4.1A)
None
None
 0.59A 5fukA-2ybxA:
undetectable
5fukB-2ybxA:
undetectable		 5fukA-2ybxA:
19.40
5fukB-2ybxA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4otp SERINE/THREONINE-PRO
TEIN KINASE RIO1
(Homo
sapiens) 		4 / 5 CYH A 264
ILE A 339
LEU A 254
HIS A 322
 None
None
None
PHD  A 341 ( 3.9A)
 1.46A 5hrqC-4otpA:
undetectable
5hrqD-4otpA:
undetectable
5hrqL-4otpA:
undetectable		 5hrqC-4otpA:
4.58
5hrqD-4otpA:
4.83
5hrqL-4otpA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 4gyi RIO2 KINASE
(Chaetomium
thermophilum) 		5 / 11 ASP A 229
VAL A 277
ILE A 217
ILE A 235
ILE A 255
 PHD  A 257 ( 4.0A)
None
None
None
None
 1.15A 5hw8G-4gyiA:
undetectable		 5hw8G-4gyiA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		5 / 12 GLU A  61
LEU A  50
ASP A  56
GLY A  33
LEU A  40
 None
PHD  A  51 ( 3.8A)
None
None
None
 1.26A 5kbwA-1zy2A:
2.0		 5kbwA-1zy2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		5 / 12 GLU A  61
LEU A  50
ASP A  56
GLY A  33
LEU A  40
 None
PHD  A  51 ( 3.8A)
None
None
None
 1.34A 5kc4E-1zy2A:
1.8		 5kc4E-1zy2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
(Sus
scrofa) 		4 / 6 ALA A 621
GLY A 611
THR A 686
ILE A 694
 None
PHD  A 369 ( 4.5A)
None
None
 0.75A 6f8cA-3n23A:
0.8		 6f8cA-3n23A:
5.66