SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PHB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 THR A 147
PRO A 149
GLY A 150
LEU A 141
GLY A 115
 PHB  A 602 (-4.5A)
PHB  A 602 (-4.7A)
None
GOL  A 603 (-4.5A)
None
 1.11A 1h4oA-5w1eA:
undetectable
1h4oB-5w1eA:
undetectable		 1h4oA-5w1eA:
undetectable
1h4oB-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 SER A 220
SER A 236
VAL A 238
GLY A 150
LEU A 152
 PHB  A 602 ( 4.6A)
PHB  A 602 ( 3.9A)
PHB  A 602 (-4.7A)
None
None
 1.42A 1i9jH-5w1eA:
undetectable
1i9jL-5w1eA:
undetectable		 1i9jH-5w1eA:
16.13
1i9jL-5w1eA:
15.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)
(Pseudomonas
fluorescens) 		10 / 10 GLY A  46
VAL A  47
TRP A 185
LEU A 199
TYR A 201
LEU A 210
SER A 212
ARG A 214
TYR A 222
ALA A 296
 PHB  A 396 ( 3.6A)
FAD  A 395 (-4.1A)
None
None
PHB  A 396 ( 4.6A)
None
PHB  A 396 ( 2.7A)
PHB  A 396 ( 3.0A)
PHB  A 396 (-4.6A)
FAD  A 395 (-3.6A)
 0.25A 1pbcA-1cj2A:
67.3		 1pbcA-1cj2A:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)
(Pseudomonas
fluorescens) 		6 / 9 TRP A 185
LEU A 199
TYR A 201
SER A 212
ARG A 214
ARG A 220
 None
None
PHB  A 396 ( 4.6A)
PHB  A 396 ( 2.7A)
PHB  A 396 ( 3.0A)
None
 0.71A 1pbfA-1cj2A:
67.3		 1pbfA-1cj2A:
99.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)
(Pseudomonas
fluorescens) 		8 / 9 VAL A  47
TRP A 185
LEU A 199
TYR A 201
LEU A 210
SER A 212
ARG A 214
ALA A 296
 FAD  A 395 (-4.1A)
None
None
PHB  A 396 ( 4.6A)
None
PHB  A 396 ( 2.7A)
PHB  A 396 ( 3.0A)
FAD  A 395 (-3.6A)
 0.33A 1pbfA-1cj2A:
67.3		 1pbfA-1cj2A:
99.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT
(Rhodopseudomonas
palustris) 		5 / 11 LEU A  49
ILE A  53
ASN A 130
TYR A 178
GLY A 105
 None
None
PHB  A 406 (-3.7A)
PHB  A 406 ( 4.3A)
None
 1.35A 2bxeA-4evqA:
undetectable		 2bxeA-4evqA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT
(Rhodopseudomonas
palustris) 		5 / 10 PHE A 257
PHE A 362
GLN A 154
GLY A 156
PHE A 150
 PHB  A 406 (-3.8A)
None
None
None
None
 1.27A 2ok6A-4evqA:
undetectable
2ok6H-4evqA:
undetectable		 2ok6A-4evqA:
22.52
2ok6H-4evqA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 THR A 147
PRO A 149
GLY A 150
LEU A 141
 PHB  A 602 (-4.5A)
PHB  A 602 (-4.7A)
None
GOL  A 603 (-4.5A)
 0.95A 2vl2B-5w1eA:
undetectable		 2vl2B-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT
(Rhodopseudomonas
palustris) 		3 / 3 PHE A 306
ASN A 130
PHE A 150
 PHB  A 406 (-4.4A)
PHB  A 406 (-3.7A)
None
 1.00A 2zbuD-4evqA:
4.4		 2zbuD-4evqA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		5 / 11 HIS A 145
ILE A 175
LEU A 234
ILE A 150
ILE A 203
 PHB  A 401 ( 4.2A)
None
None
None
None
 1.05A 3b2rB-5i5pA:
undetectable		 3b2rB-5i5pA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 ALA A 148
GLY A 150
LEU A 211
SER A 236
SER A 220
 PHB  A 602 (-3.8A)
None
None
PHB  A 602 ( 3.9A)
PHB  A 602 ( 4.6A)
 0.98A 3g2oA-5w1eA:
undetectable		 3g2oA-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 GLY A 150
ILE A 123
SER A 111
LEU A 112
VAL A 234
 None
None
PHB  A 602 (-2.5A)
None
None
 1.25A 3gyqB-5w1eA:
undetectable		 3gyqB-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT
(Rhodopseudomonas
palustris) 		4 / 8 GLY A 369
ILE A 240
PHE A 257
PHE A 306
 None
None
PHB  A 406 (-3.8A)
PHB  A 406 (-4.4A)
 0.97A 3ko0K-4evqA:
undetectable
3ko0S-4evqA:
undetectable		 3ko0K-4evqA:
13.40
3ko0S-4evqA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		5 / 12 VAL A 171
GLY A 130
VAL A 132
SER A  12
PRO A 265
 None
None
PHB  A 302 (-4.6A)
GST  A 301 ( 4.1A)
None
 1.42A 4bvaA-4od5A:
undetectable		 4bvaA-4od5A:
24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT
(Rhodopseudomonas
palustris) 		11 / 11 TYR A  46
LEU A  49
VAL A 107
SER A 109
ASN A 130
PHE A 150
TYR A 178
ALA A 180
PHE A 230
SER A 232
PHE A 257
 PHB  A 406 (-4.1A)
None
PHB  A 406 (-4.9A)
PHB  A 406 (-2.6A)
PHB  A 406 (-3.7A)
None
PHB  A 406 ( 4.3A)
PHB  A 406 (-3.2A)
PHB  A 406 (-4.8A)
PHB  A 406 (-2.7A)
PHB  A 406 (-3.8A)
 0.12A 4evrA-4evqA:
65.8		 4evrA-4evqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT
(Rhodopseudomonas
palustris) 		5 / 11 TYR A 178
SER A 232
PHE A 150
TYR A  46
SER A 109
 PHB  A 406 ( 4.3A)
PHB  A 406 (-2.7A)
None
PHB  A 406 (-4.1A)
PHB  A 406 (-2.6A)
 1.17A 4evrA-4evqA:
65.8		 4evrA-4evqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT
(Rhodopseudomonas
palustris) 		5 / 12 TYR A  46
ALA A  47
ALA A 236
GLY A 235
LEU A 237
 PHB  A 406 (-4.1A)
None
None
None
None
 1.05A 4oaeA-4evqA:
undetectable		 4oaeA-4evqA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 LEU A 211
GLY A 150
LEU A 152
ALA A 218
SER A 220
 None
None
None
PHB  A 602 (-3.6A)
PHB  A 602 ( 4.6A)
 1.34A 4wnuC-5w1eA:
undetectable		 4wnuC-5w1eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 9 GLY A 150
ILE A 123
SER A 111
LEU A 112
VAL A 234
 None
None
PHB  A 602 (-2.5A)
None
None
 1.11A 4x3mB-5w1eA:
undetectable		 4x3mB-5w1eA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT
(Rhodopseudomonas
palustris) 		5 / 12 LEU A  49
VAL A 305
PHE A 306
HIS A 278
TYR A 178
 None
None
PHB  A 406 (-4.4A)
None
PHB  A 406 ( 4.3A)
 1.26A 5i8fA-4evqA:
undetectable		 5i8fA-4evqA:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		5 / 12 PHE A  33
TRP A  90
HIS A 145
PRO A 171
PHE A 239
 PHB  A 401 ( 4.5A)
None
PHB  A 401 ( 4.2A)
PHB  A 401 (-4.2A)
PHB  A 401 ( 4.1A)
 0.61A 5im2A-5i5pA:
49.0		 5im2A-5i5pA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IM2_A_BEZA401_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		4 / 4 TYR A  95
ARG A 169
PRO A 209
GLU A 211
 PHB  A 401 (-4.5A)
PHB  A 401 (-3.0A)
PHB  A 401 ( 4.0A)
PHB  A 401 (-3.1A)
 0.28A 5im2A-5i5pA:
49.0		 5im2A-5i5pA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)
(Pseudomonas
fluorescens) 		4 / 6 ILE A 381
VAL A 349
TYR A 201
TRP A 345
 None
None
PHB  A 396 ( 4.6A)
None
 0.90A 5jwaH-1cj2A:
4.5		 5jwaH-1cj2A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		4 / 6 HIS A 128
VAL A 132
LEU A 113
THR A 114
 None
PHB  A 302 (-4.6A)
None
None
 1.19A 5ogjA-4od5A:
undetectable		 5ogjA-4od5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		4 / 6 HIS A 128
VAL A 132
LEU A 113
THR A 114
 None
PHB  A 302 (-4.6A)
None
None
 1.19A 5ogjB-4od5A:
undetectable		 5ogjB-4od5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		4 / 5 HIS A 128
VAL A 132
LEU A 113
THR A 114
 None
PHB  A 302 (-4.6A)
None
None
 1.19A 5ohhA-4od5A:
undetectable		 5ohhA-4od5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 ASP A 209
PRO A 149
ARG A 146
THR A 147
 None
PHB  A 602 (-4.7A)
None
PHB  A 602 (-4.5A)
 1.39A 5uxcA-5w1eA:
undetectable		 5uxcA-5w1eA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4f06 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 6 SER A 140
ASP A 385
GLN A 358
THR A 102
 None
None
None
PHB  A 401 ( 3.7A)
 1.47A 6djzA-4f06A:
undetectable		 6djzA-4f06A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 ARG A 121
PHE A 122
GLY A 139
 GOL  A 603 (-3.3A)
PHB  A 602 (-4.0A)
None
 0.65A 6fgdA-5w1eA:
undetectable		 6fgdA-5w1eA:
undetectable