SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PGU'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SGU_B_MK1B2632_1 (POL POLYPROTEIN)	2oga	TRANSAMINASE (Streptomyces venezuelae)	5 / 8	ASP A 164 ALA A 166 GLY A 201 GLY A 202 ALA A 99	PGU A1020 (-2.6A) PGU A1020 (-3.5A) None None None	1.00A	1sguA-2ogaA: undetectable	1sguA-2ogaA: 11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2UVN_B_ECNB1406_1 (CYTOCHROME P450 130)	2zyj	ALPHA-AMINODIPATE AMINOTRANSFERASE (Thermus thermophilus)	5 / 11	ASP A 202 PRO A 170 THR A 180 GLY A 178 THR A 176	PGU A 500 (-2.8A) None None None None	1.49A	2uvnB-2zyjA: undetectable	2uvnB-2zyjA: 21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZN_B_SAMB402_0 (UNCHARACTERIZED PROTEIN MJ0883)	2zyj	ALPHA-AMINODIPATE AMINOTRANSFERASE (Thermus thermophilus)	5 / 12	LEU A 305 PHE A 172 ILE A 169 ASN A 174 ASP A 203	None None PGU A 500 ( 4.3A) PGU A 500 (-3.5A) None	1.34A	2zznB-2zyjA: undetectable	2zznB-2zyjA: 24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_A_TFPA202_1 (PROTEIN S100-A4)	2zyj	ALPHA-AMINODIPATE AMINOTRANSFERASE (Thermus thermophilus)	5 / 12	LEU A 218 SER A 217 GLU A 201 LEU A 168 ASP A 202	None None None None PGU A 500 (-2.8A)	1.25A	3ko0A-2zyjA: undetectable 3ko0B-2zyjA: undetectable 3ko0C-2zyjA: undetectable 3ko0D-2zyjA: undetectable	3ko0A-2zyjA: 14.80 3ko0B-2zyjA: 14.80 3ko0C-2zyjA: 14.80 3ko0D-2zyjA: 14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDN_G_EVPG2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	2oga	TRANSAMINASE (Streptomyces venezuelae)	4 / 6	GLU A 46 GLY A 67 ASP A 69 GLY A 201	None PGU A1020 (-3.4A) None None	0.88A	5cdnA-2ogaA: 0.8 5cdnB-2ogaA: undetectable	5cdnA-2ogaA: 21.65 5cdnB-2ogaA: 17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HIE_D_P06D801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2zyj	ALPHA-AMINODIPATE AMINOTRANSFERASE (Thermus thermophilus)	4 / 8	ILE A 129 GLY A 127 ASN A 174 ASP A 202	None None PGU A 500 (-3.5A) PGU A 500 (-2.8A)	0.93A	5hieD-2zyjA: undetectable	5hieD-2zyjA: 22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L0Z_A_SAMA304_0 (PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY)	2oga	TRANSAMINASE (Streptomyces venezuelae)	5 / 12	THR A 92 ILE A 94 LEU A 98 LEU A 71 ALA A 95	None None None None PGU A1020 (-3.5A)	1.04A	5l0zA-2ogaA: undetectable	5l0zA-2ogaA: 23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MXT_A_K5YA1401_0 (ENDOLYSIN, BETA-2 ADRENERGIC RECEPTOR CHIMERA)	2zyj	ALPHA-AMINODIPATE AMINOTRANSFERASE (Thermus thermophilus)	5 / 12	VAL A 352 PHE A 326 TYR A 205 ILE A 169 ASN A 174	None None PGU A 500 (-4.5A) PGU A 500 ( 4.3A) PGU A 500 (-3.5A)	1.09A	6mxtA-2zyjA: undetectable	6mxtA-2zyjA: 22.90

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1SGU_B_MK1B2632_1","POL POLYPROTEIN;POL POLYPROTEIN","2oga","TRANSAMINASE","Streptomyces venezuelae",5,"ASP A 164;ALA A 166;GLY A 201;GLY A 202;ALA A  99","PGU A1020 (-2.6A);PGU A1020 (-3.5A);None;None;None","1.00A","1sguA-2ogaA:undetectable",null],["2UVN_B_ECNB1406_1","CYTOCHROME P450 130","2zyj","ALPHA-AMINODIPATE AMINOTRANSFERASE","Thermus thermophilus",5,"ASP A 202;PRO A 170;THR A 180;GLY A 178;THR A 176","PGU A 500 (-2.8A);None;None;None;None","1.49A","2uvnB-2zyjA:undetectable","1sguA-2ogaA:11.92"],["2ZZN_B_SAMB402_0","UNCHARACTERIZED PROTEIN MJ0883","2zyj","ALPHA-AMINODIPATE AMINOTRANSFERASE","Thermus thermophilus",5,"LEU A 305;PHE A 172;ILE A 169;ASN A 174;ASP A 203","None;None;PGU A 500 ( 4.3A);PGU A 500 (-3.5A);None","1.34A","2zznB-2zyjA:undetectable","2uvnB-2zyjA:21.66"],["3KO0_A_TFPA202_1","PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4","2zyj","ALPHA-AMINODIPATE AMINOTRANSFERASE","Thermus thermophilus",5,"LEU A 218;SER A 217;GLU A 201;LEU A 168;ASP A 202","None;None;None;None;PGU A 500 (-2.8A)","1.25A","3ko0A-2zyjA:undetectable;3ko0B-2zyjA:undetectable;3ko0C-2zyjA:undetectable;3ko0D-2zyjA:undetectable","2zznB-2zyjA:24.58"],["5CDN_G_EVPG2101_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B","2oga","TRANSAMINASE","Streptomyces venezuelae",4,"GLU A  46;GLY A  67;ASP A  69;GLY A 201","None;PGU A1020 (-3.4A);None;None","0.88A","5cdnA-2ogaA:0.8;5cdnB-2ogaA:undetectable","3ko0A-2zyjA:14.80;3ko0B-2zyjA:14.80;3ko0C-2zyjA:14.80;3ko0D-2zyjA:14.80"],["5HIE_D_P06D801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","2zyj","ALPHA-AMINODIPATE AMINOTRANSFERASE","Thermus thermophilus",4,"ILE A 129;GLY A 127;ASN A 174;ASP A 202","None;None;PGU A 500 (-3.5A);PGU A 500 (-2.8A)","0.93A","5hieD-2zyjA:undetectable","5cdnA-2ogaA:21.65;5cdnB-2ogaA:17.00"],["5L0Z_A_SAMA304_0","PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY","2oga","TRANSAMINASE","Streptomyces venezuelae",5,"THR A  92;ILE A  94;LEU A  98;LEU A  71;ALA A  95","None;None;None;None;PGU A1020 (-3.5A)","1.04A","5l0zA-2ogaA:undetectable","5hieD-2zyjA:22.46"],["6MXT_A_K5YA1401_0","ENDOLYSIN, BETA-2 ADRENERGIC RECEPTOR CHIMERA","2zyj","ALPHA-AMINODIPATE AMINOTRANSFERASE","Thermus thermophilus",5,"VAL A 352;PHE A 326;TYR A 205;ILE A 169;ASN A 174","None;None;PGU A 500 (-4.5A);PGU A 500 ( 4.3A);PGU A 500 (-3.5A)","1.09A","6mxtA-2zyjA:undetectable","5l0zA-2ogaA:23.23"]]