SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PGT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 3mtx PROTEIN MD-1
(Gallus
gallus) 		5 / 12 LEU A 104
ILE A  73
ALA A  78
VAL A 147
LEU A 123
 None
None
PGT  A 300 ( 3.9A)
None
None
 1.08A 1cbsA-3mtxA:
undetectable		 1cbsA-3mtxA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		5 / 11 ILE A 107
SER A 101
GLY A  72
GLY A 105
PHE A  79
 PGT  A 309 ( 4.8A)
None
None
BOG  A 303 ( 4.1A)
None
 0.91A 1ho5A-5azbA:
undetectable		 1ho5A-5azbA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 3mtx PROTEIN MD-1
(Gallus
gallus) 		5 / 12 LEU A 104
ILE A  73
ALA A  78
VAL A 147
LEU A 123
 None
None
PGT  A 300 ( 3.9A)
None
None
 1.06A 2fr3A-3mtxA:
undetectable		 2fr3A-3mtxA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 7 ILE A  74
GLY A  75
PHE A  79
ILE A 107
 PGT  A 309 ( 4.2A)
None
None
PGT  A 309 ( 4.8A)
 0.82A 2y7wC-5azbA:
undetectable		 2y7wC-5azbA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 7 ILE A 233
GLY A 234
PHE A 238
ILE A 213
 PGT  A 307 (-4.2A)
None
None
None
 0.84A 2y7wC-5azbA:
undetectable		 2y7wC-5azbA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A  71
GLY A  75
LEU A 106
GLY A 105
GLY A 108
 PGT  A 309 ( 3.7A)
None
None
BOG  A 303 ( 4.1A)
PGT  A 309 (-3.6A)
 0.81A 3axzA-5azbA:
undetectable		 3axzA-5azbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C
(Methylocystis
sp.
ATCC
49242) 		5 / 11 TYR K 157
ILE K  65
PHE K  34
GLU K  73
ILE K 156
 None
None
None
None
PGT  K 302 ( 4.9A)
 1.31A 3q5rA-4phzK:
undetectable		 3q5rA-4phzK:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3mtx PROTEIN MD-1
(Gallus
gallus) 		4 / 6 LEU A  76
GLU A  94
VAL A  80
ALA A 137
 None
None
None
PGT  A 300 ( 3.9A)
 1.00A 4nkxA-3mtxA:
undetectable		 4nkxA-3mtxA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3mtx PROTEIN MD-1
(Gallus
gallus) 		5 / 12 LEU A 123
ILE A  63
ILE A 135
ALA A 137
ILE A  35
 None
None
PGT  A 300 (-4.7A)
PGT  A 300 ( 3.9A)
PGT  A 300 ( 4.6A)
 1.09A 4rp8C-3mtxA:
undetectable		 4rp8C-3mtxA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 6 LEU A 134
ASN A 215
PRO A 133
ARG A 122
 PGT  A 305 ( 4.7A)
None
None
None
 1.40A 4yv5B-5azbA:
undetectable		 4yv5B-5azbA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 6 LEU A 134
ASN A 215
PRO A 133
ARG A 122
 PGT  A 305 ( 4.7A)
None
None
None
 1.42A 4yv5A-5azbA:
undetectable		 4yv5A-5azbA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A  71
GLY A  75
LEU A 106
GLY A 105
GLY A 108
 PGT  A 309 ( 3.7A)
None
None
BOG  A 303 ( 4.1A)
PGT  A 309 (-3.6A)
 0.86A 4yvgA-5azbA:
undetectable		 4yvgA-5azbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 8 ILE A 271
MET A 278
ILE A 213
TYR A 235
 PGT  A 311 ( 4.1A)
PGT  A 307 (-4.0A)
None
PLM  A 301 (-4.7A)
 0.87A 5ieoA-5azbA:
undetectable		 5ieoA-5azbA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C
(Methylocystis
sp.
ATCC
49242) 		5 / 12 VAL K 234
LEU K  80
GLY K 163
ALA K 164
LEU K 111
 None
PGT  K 302 (-4.6A)
PGT  K 302 (-3.7A)
None
None
 1.13A 5iktA-4phzK:
0.8		 5iktA-4phzK:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C
(Methylocystis
sp.
ATCC
49242) 		5 / 12 VAL K 234
LEU K  80
GLY K 163
ALA K 164
LEU K 111
 None
PGT  K 302 (-4.6A)
PGT  K 302 (-3.7A)
None
None
 1.14A 5iktB-4phzK:
undetectable		 5iktB-4phzK:
17.50